Acute and chronic noradrenergic regulation of neurotrophin messenger RNA expression in rat hippocampus: evidence from lesions and organotypic cultures.

abstract：:Beta-amyloid (Aβ) deposition and neuroinflammation are involved in Alzheimer's disease (AD)-type neurodegeneration with cognitive deficits. Phosphodiesterase-5 (PDE5) inhibitors have recently been studied as a potential target for cognitive enhancement by reducing inflammatory responses and Aβ levels. The present stud...

journal_title：Neuroscience

authors： Yin C,Deng Y,Gao J,Li X,Liu Y,Gong Q

更新日期：2016-07-22 00:00:00

abstract：:Long-term unilateral hearing impairment (UHI) results in changes in hearing and psychoacoustic performance that are likely related to cortical reorganization. However, the underlying functional changes in the brain are not yet fully understood. Here, we studied alterations in inter- and intra-hemispheric resting-state...

journal_title：Neuroscience

authors： Zhang Y,Mao Z,Feng S,Liu X,Zhang J,Yu X

更新日期：2018-02-10 00:00:00

abstract：:While chronic pain is a main symptom in endometriosis, the underlying mechanisms and effective therapy remain elusive. We developed an animal model enabling the exploration of ectopic endometrium as a source of endometriosis pain. Rats were surgically implanted with autologous uterus in the gastrocnemius muscle. Withi...

journal_title：Neuroscience

authors： Alvarez P,Chen X,Hendrich J,Irwin JC,Green PG,Giudice LC,Levine JD

更新日期：2012-12-06 00:00:00

abstract：:γ oscillations (30-120 Hz) are generated intrinsically within local networks in the mammalian olfactory bulb (OB). The OB directly receives peripheral input from olfactory sensory neurons (OSNs) that can respond to nasal airflow, and centrifugal input from neuromodulatory systems whose activities are affected by the b...

journal_title：Neuroscience

authors： Zhuang L,Zhang B,Qin Z,Wang P

更新日期：2019-02-01 00:00:00

abstract：:Adolescence is a time of continued brain maturation, particularly in limbic and cortical regions, which undoubtedly plays a role in the physiological and emotional changes coincident with adolescence. An emerging line of research has indicated that stressors experienced during this crucial developmental stage may affe...

journal_title：Neuroscience

authors： Eiland L,Romeo RD

更新日期：2013-09-26 00:00:00

abstract：:A diet high in total fat (HF) reduces hippocampal levels of brain-derived neurotrophic factor (BDNF), a crucial modulator of synaptic plasticity, and a predictor of learning efficacy. We have evaluated the capacity of voluntary exercise to interact with the effects of diet at the molecular level. Animal groups were ex...

journal_title：Neuroscience

authors： Molteni R,Wu A,Vaynman S,Ying Z,Barnard RJ,Gómez-Pinilla F

更新日期：2004-01-01 00:00:00

abstract：:Local cerebral glucose utilization was assessed during whisker stimulation by 2-deoxyglucose autoradiography. Whisker stimulation increased local cerebral glucose utilization in brainstem, thalamus and whisker sensory cortex in normal rats. Whereas whisker stimulation increased glucose metabolism in brainstem, whisker...

journal_title：Neuroscience

authors： Ciricillo SP,Hill MP,Gonzalez MF,Smalley S,Morton MT,Sharp FR

更新日期：1994-04-01 00:00:00

abstract：:Contraversive turning movements of the head were elicited in alert cats by unilateral electrical stimulation of the entopeduncular nucleus. To determine the relative functional importance of ascending and descending pathways activated by the stimulation, the animals were submitted to thalamocortical or midbrain lesion...

journal_title：Neuroscience

authors： Filion M,Hébert R

更新日期：1983-09-01 00:00:00

abstract：:Two major systems of cholinergic projection neurons are found within the centrum of the mammalian brain: the basal nuclear complex, projecting predominantly to the cerebral cortex, amygdala, and hippocampus, and the pontomesencephalotegmental network, innervating primarily the thalamus. Neurons comprising the latter n...

journal_title：Neuroscience

authors： Consolo S,Bertorelli R,Forloni GL,Butcher LL

更新日期：1990-01-01 00:00:00

abstract：:The glycine transporter GLYT2 is present in axonal boutons throughout the spinal cord, and its laminar distribution matches that of glycine-enriched axons, which are presumed to be glycinergic. In order to determine whether boutons which possess GLYT2 are glycine-enriched, we have carried out pre-embedding immunocytoc...

journal_title：Neuroscience

authors： Spike RC,Watt C,Zafra F,Todd AJ

更新日期：1997-03-01 00:00:00

abstract：:Interleukin-1 (IL-1) plays a crucial role in stress responses and its mRNA is induced in the brain by stress load; however, the precise role of IL-1 in higher brain functions and their abnormalities is largely unknown. Here, we report that IL-1 receptor antagonist (IL-1Ra) knockout (KO) mice, which lack IL-1Ra molecul...

journal_title：Neuroscience

authors： Wakabayashi C,Kiyama Y,Kunugi H,Manabe T,Iwakura Y

更新日期：2011-09-29 00:00:00

abstract：:The goal of the present experiments was to examine the relationships of the zona incerta with two structures associated with visuomotor behavior, the superior colliculus and pretectum. The experiments were carried out in the cat, a species commonly used in studies of visuomotor integration, and utilized wheat germ agg...

journal_title：Neuroscience

authors： May PJ,Sun W,Hall WC

更新日期：1997-04-01 00:00:00

abstract：:The vertebrate blood-brain barrier (BBB) creates an obstacle for central nervous system-related drug delivery. Claudin-5 (Cldn5), expressed in large quantities in BBB, plays a vital role in restricting BBB permeability. The C-terminal domain of Clostridium perfringens enterotoxin (cCPE) has been verified as binding to...

journal_title：Neuroscience

authors： Liao Z,Yang Z,Piontek A,Eichner M,Krause G,Li L,Piontek J,Zhang J

更新日期：2016-07-07 00:00:00

abstract：:In synaptosomes prepared from dentate gyrus, activation of the metabotropic glutamate receptor by the specific agonist, trans-1-amino-cyclopentyl-1,3-dicarboxylate, increases release of glutamate in the presence of a low concentration of arachidonic acid. A similar interaction between trans-1-amino-cyclopentyl-1,3-dic...

journal_title：Neuroscience

authors： McGahon B,Lynch MA

更新日期：1996-06-01 00:00:00

abstract：:The mesopontine tegmentum, which contains both cholinergic and non-cholinergic neurons, plays a crucial role in behavioral state control. Using microiontophoresis in unanesthetized cats, we have examined the effect of cholinergic and monoaminergic drugs on two putative cholinergic neurons located mostly in the laterod...

journal_title：Neuroscience

authors： Koyama Y,Sakai K

更新日期：2000-01-01 00:00:00

abstract：OBJECTIVE:The spontaneous action potential of isolated sinoatrial node (SAN) cells is regulated by a coupled-clock system of two clocks: the calcium clock and membrane clock. However, it remains unclear whether calcium clock inhibitors have a direct effect on the membrane clock. The purpose of this study was to investi...

journal_title：Neuroscience

authors： Chen Q,Chen JQ,Zhu PL,Wu HL,Xie XT,Dong Y,Xiang GJ,Chen MY,Li Y,Zhang JC

更新日期：2020-05-01 00:00:00

abstract：:We have investigated a potential mechanism by which a diet, similar in composition to the typical diet of most industrialized western societies rich in saturated fat and refined sugar (HFS), can influence brain structure and function via regulation of neurotrophins. We show that animals that learn a spatial memory tas...

journal_title：Neuroscience

authors： Molteni R,Barnard RJ,Ying Z,Roberts CK,Gómez-Pinilla F

更新日期：2002-01-01 00:00:00

abstract：:The neuronal uptake and laminar distribution of cortically injected tritium-labeled gamma-aminobutyrate (GABA), aspartic acid, glutamate and glycine was examined in the prestriate cortex of squirrel monkeys. The intent of this investigation was not to examine the role of these amino acids as neurotransmitters, but to ...

journal_title：Neuroscience

authors： Carroll EW,Wong-Riley M

更新日期：1987-08-01 00:00:00

abstract：:Activation of cardiac sympathetic afferents elicits pain and excitatory cardiovascular reflexes including acute hypertension and tachyarrhythmias. Our previous studies have shown that specific regions in the medulla, such as the nucleus of solitary tract and ventrolateral medulla, are involved in central regulation of...

journal_title：Neuroscience

authors： Guo Z-,Li P,Longhurst JC

更新日期：2002-01-01 00:00:00

abstract：:To determine the role of the frontal cortex in the generalization of limbic seizures, we first produced unilateral cortical spreading depression to reversibly suppress neuronal activity in the motor cortex and then triggered an amygdala-kindled seizure. Three minutes following induction of unilateral spreading depress...

journal_title：Neuroscience

authors： Kelly ME,Battye RA,McIntyre DC

更新日期：1999-01-01 00:00:00

abstract：:Transthyretin is the major thyroxine-binding protein in the plasma of rodents, and the main thyroxine-binding protein in the cerebrospinal fluid of both rodents and humans. The choroid plexus synthesizes transthyretin and secretes it to the cerebrospinal fluid. Although it was suggested that transthyretin might play a...

journal_title：Neuroscience

authors： Palha JA,Nissanov J,Fernandes R,Sousa JC,Bertrand L,Dratman MB,Morreale de Escobar G,Gottesman M,Saraiva MJ

更新日期：2002-01-01 00:00:00

abstract：:Sulfoglucuronyl carbohydrate is the terminal moiety of neolacto-oligosaccharides, expressed on several glycoproteins of the immunoglobulin superfamily involved in cell-cell recognition and on two glycolipids. Sulfoglucuronyl carbohydrate is temporally and spatially regulated in the developing nervous system. It appear...

journal_title：Neuroscience

authors： Nair SM,Zhao Z,Chou DK,Tobet SA,Jungalwala FB

更新日期：1998-08-01 00:00:00

abstract：:The protective effect of diphenyliodonium, known as an inhibitor of flavin enzymes including nitric oxide synthases, was examined against the neurotoxicity of excitatory amino acids on cultured spinal neurons of the rat. Diphenyliodonium reduced the neuronal damage induced by 15-min exposure to glutamate or N-methyl-D...

journal_title：Neuroscience

authors： Nakamura Y,Tsuji K,Shuto M,Ogita K,Yoneda Y,Shimamoto K,Shibata T,Kataoka K

更新日期：1997-01-01 00:00:00

abstract：:Mast cells and their location in the cat lateral geniculate complex of the thalamus were examined by means of histamine immunohistochemistry and the mast cell stain pinacyanol erythrosinate. Brain sections from seven normal adult pigmented cats were processed for light or electron microscopy. Histamine-containing and ...

journal_title：Neuroscience

authors： Manning KA,Pienkowski TP,Uhlrich DJ

更新日期：1994-11-01 00:00:00

abstract：:The distribution of putative melatonin receptors in the brains of two Old World primates of the superfamily Catarrhina, Cercopithecus aethiops and Papio ursinus, was characterized using 2-[125I]iodomelatonin autoradiography. The specific binding demonstrated a discrete distribution pattern. The median eminence was int...

journal_title：Neuroscience

authors： Stankov B,Capsoni S,Lucini V,Fauteck J,Gatti S,Gridelli B,Biella G,Cozzi B,Fraschini F

更新日期：1993-01-01 00:00:00

abstract：:In contrast to other rhythmic tasks such as running, the preferred movement rate in cycling does not minimize energy consumption. It is possible that neurophysiological mechanisms contribute to the choice of cadence, however this phenomenon is not well understood. Eleven participants cycled at a fixed workload of 125 ...

journal_title：Neuroscience

authors： Sidhu SK,Lauber B

更新日期：2020-08-10 00:00:00

abstract：:By employing both in vivo and in vitro labeling techniques, opiate receptors were labeled with tritiated diprenorphine in the monkey brain and localized by light microscopic autoradiography. Both methods of labeling gave similar results, allowing a description of discrete areas having opiate binding sites. High concen...

journal_title：Neuroscience

authors： Wamsley JK,Zarbin MA,Young WS 3rd,Kuhar MJ

更新日期：1982-03-01 00:00:00

abstract：:Excitatory amino acid carrier 1 (EAAC1) is one important subtype of the excitatory amino acid transporters (EAATs), and its absence can increase the vulnerability to oxidative stress in neural tissue. Enhanced expression of EAAC1 can provide neuroprotection in multiple disorders, including ischemia and multiple sclero...

journal_title：Neuroscience

authors： Huang C,Yuan P,Wu J,Huang J

更新日期：2016-04-05 00:00:00

abstract：:Spatial memory retrieval and hippocampal long-term potentiation (LTP) are impaired by stress. KCNQ/Kv7 channels are closely associated with memory and the KCNQ/Kv7 channel activator flupirtine represents neuroprotective effects. This study aims to test whether KCNQ/Kv7 channel activation prevents acute stress-induced ...

journal_title：Neuroscience

authors： Li C,Huang P,Lu Q,Zhou M,Guo L,Xu X

更新日期：2014-11-07 00:00:00

abstract：:In amyotrophic lateral sclerosis (ALS) there is a selective degeneration of motor neurons leading to muscle paralysis and death. The mechanism underlying cell demise in ALS is not fully understood, but involves the activation of different proteolytic enzymes, including the caspase family of cysteine proteases. We have...

journal_title：Neuroscience

authors： Wootz H,Weber E,Korhonen L,Lindholm D

更新日期：2006-12-01 00:00:00