Serotonin and N-acetylserotonin effects on pigment cells of the toad Bufo ictericus: pharmacological characterization of melatonin receptors.

Abstract:

:Melatonin is a skin lightening agonist of the toad Bufo ictericus. The hormone also exhibits an autodesensitizing action as well as an inhibitory activity on the darkening response to alpha-MSH. In an attempt to pharmacologically characterize the melatonin receptor of the toad pigment cells, serotonin and N-acetylserotonin (intermediate products of melatonin biosynthesis) biological activities were compared to melatonin effects. Serotonin (6.4 x 10(-5) to 10(-9) M) exhibited no lightening or inhibitory activity on MSH-elicited darkening responses or melatonin-elicited lightening responses. N-acetylserotonin, although less potent than melatonin, elicited a significant lightening response on previously MSH-darkened skins. Previous exposure of the skins with N-acetylserotonin reduced both MSH-induced darkening and melatonin-induced lightening in MSH-darkened skins. These results suggest a competitive inhibition of melatonin by N-acetylserotonin and indicate that melatonin receptors in B. ictericus pigment cells may be similar to ML-1 type found in chicken retina.

journal_name

Gen Comp Endocrinol

authors

Filadelfi AM,Castrucci AM

doi

10.1006/gcen.1996.0110

subject

Has Abstract

pub_date

1996-08-01 00:00:00

pages

192-9

issue

2

eissn

0016-6480

issn

1095-6840

pii

S0016-6480(96)90110-0

journal_volume

103

pub_type

杂志文章