The pel1 mutant of Saccharomyces cerevisiae is deficient in cardiolipin and does not survive the disruption of the CHO1 gene encoding phosphatidylserine synthase.

Abstract:

:Cells of the pel1 mutant of Saccharomyces cerevisiae were found to contain an extremely low content of cardiolipin, a decreased level of phosphatidylcholine and an increased level of phosphatidylinositol. Disruption of the PEL1 gene in cells containing a null mutation in the CHO1 gene was lethal. Despite its putative functional homology with CHO1, the overexpression of the PEL1 gene in the cho1 null mutant did not restore the wild-type properties of the transformed cells and failed to stimulate the incorporation of L-[3-3H]serine into total lipids of the intact yeast cells.

journal_name

FEMS Microbiol Lett

authors

Janitor M,Obernauerová M,Kohlwein SD,Subík J

doi

10.1111/j.1574-6968.1996.tb08312.x

subject

Has Abstract

pub_date

1996-06-15 00:00:00

pages

43-7

issue

1

eissn

0378-1097

issn

1574-6968

pii

0378109796001553

journal_volume

140

pub_type

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