Fractal mechanisms and heart rate dynamics. Long-range correlations and their breakdown with disease.

Abstract:

:Under healthy conditions, the normal cardiac (sinus) interbeat interval fluctuates in a complex manner. Quantitative analysis using techniques adapted from statistical physics reveals the presence of long-range power-law correlations extending over thousands of heartbeats. This scale-invariant (fractal) behavior suggests that the regulatory system generating these fluctuations is operating far from equilibrium. In contrast, it is found that for subjects at high risk of sudden death (e.g., congestive heart failure patients), these long-range correlations break down. Application of fractal scaling analysis and related techniques provides new approaches to assessing cardiac risk and forecasting sudden cardiac death, as well as motivating development of novel physiologic models of systems that appear to be heterodynamic rather than homeostatic.

journal_name

J Electrocardiol

authors

Peng CK,Havlin S,Hausdorff JM,Mietus JE,Stanley HE,Goldberger AL

doi

10.1016/s0022-0736(95)80017-4

subject

Has Abstract

pub_date

1995-01-01 00:00:00

pages

59-65

eissn

0022-0736

issn

1532-8430

journal_volume

28 Suppl

pub_type

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