Chronic infection with Trypanosoma musculi in congenitally athymic nude mice.

Abstract:

:Trypanosoma musculi produces a chronic infection with a consistently elevated parasitemia in nude mice. Thymic reconstitution of nude mice restores immunity to the infection.

journal_name

Infect Immun

journal_title

Infection and immunity

authors

Rank RG,Roberts DW,Weidanz WP

doi

10.1128/IAI.16.2.715-716.1977

subject

Has Abstract

pub_date

1977-05-01 00:00:00

pages

715-6

issue

2

eissn

0019-9567

issn

1098-5522

journal_volume

16

pub_type

杂志文章
  • Identification of Burkholderia pseudomallei genes required for the intracellular life cycle and in vivo virulence.

    abstract::The bacterial pathogen Burkholderia pseudomallei invades host cells, escapes from endocytic vesicles, multiplies intracellularly, and induces the formation of actin tails and membrane protrusions, leading to direct cell-to-cell spreading. This study was aimed at the identification of B. pseudomallei genes responsible ...

    journal_title:Infection and immunity

    pub_type: 杂志文章

    doi:10.1128/IAI.01262-05

    authors: Pilatz S,Breitbach K,Hein N,Fehlhaber B,Schulze J,Brenneke B,Eberl L,Steinmetz I

    更新日期:2006-06-01 00:00:00

  • Rickettsial hemolysis: adsorption, desorption, readsorption, and hemagglutination.

    abstract::The energy-dependent adsorption of radioiodinated rickettsiae to sheep erythrocytes was demonstrated. The iodination procedure, however, decreased the hemolytic activity of the rickettsiae. No desorption of rickettsiae from isolated rickettsia-erythrocyte complexes (prevented from lysing by NaF) could be measured. On ...

    journal_title:Infection and immunity

    pub_type: 杂志文章

    doi:10.1128/IAI.17.3.607-612.1977

    authors: Winkler HH

    更新日期:1977-09-01 00:00:00

  • Antibodies to laminin in American cutaneous leishmaniasis.

    abstract::We found that serum samples from patients with different clinical forms of American cutaneous leishmaniasis (ACL) contained immunoglobulin G and immunoglobulin M antibodies which reacted with laminin but not with various other purified connective tissue components, such as collagen types I, III, IV, and V and fibronec...

    journal_title:Infection and immunity

    pub_type: 杂志文章

    doi:10.1128/IAI.43.1.402-406.1984

    authors: Avila JL,Rojas M,Rieber M

    更新日期:1984-01-01 00:00:00

  • Cryptococcus neoformans enters the endolysosomal pathway of dendritic cells and is killed by lysosomal components.

    abstract::Cryptococcus neoformans is an opportunistic fungal pathogen that primarily causes disease in immunocompromised individuals. Dendritic cells (DCs) can phagocytose C. neoformans, present cryptococcal antigen, and kill C. neoformans. However, early events following C. neoformans phagocytosis by DCs are not well defined. ...

    journal_title:Infection and immunity

    pub_type: 杂志文章

    doi:10.1128/IAI.00660-08

    authors: Wozniak KL,Levitz SM

    更新日期:2008-10-01 00:00:00

  • Infection-immunity in tularemia: specificity of cellular immunity.

    abstract::The relationship between hypersensitivity and cellular resistance to infection with facultative intracellular parasites was studied in mice by using infection-immunity in tularemia as a model system. Delayed hypersensitivity to antigenic fractions of Francisella tularensis was first detected 6 to 7 days after immuniza...

    journal_title:Infection and immunity

    pub_type: 杂志文章

    doi:10.1128/IAI.5.3.311-318.1972

    authors: Claflin JL,Larson CL

    更新日期:1972-03-01 00:00:00

  • Antibody response to antigens distinct from smooth lipopolysaccharide complex in Brucella infection.

    abstract::The smooth lipopolysaccharide complex of the outer surface of smooth Brucella abortus cells is believed to be the antigenic component involved in serological tests routinely used for the diagnosis of brucellosis. Sera from cattle vaccinated or infected with B. abortus generally contain antibody directed toward the smo...

    journal_title:Infection and immunity

    pub_type: 杂志文章

    doi:10.1128/IAI.21.3.994-1002.1978

    authors: Schurig GG,Jones LM,Speth SL,Berman DT

    更新日期:1978-09-01 00:00:00

  • Oncogenicity of avian leukosis viruses of different subgroups and of mutants of sarcoma viruses.

    abstract::Leukosis viruses of seven subgroups were tested for oncogenicity in chickens susceptible to virus infection and to development of lymphoid leukosis (LL) tumors. All subgroup A viruses and the subgroup B virus tested produced a high incidence of LL and other related neoplasms. Viruses of subgroup C and RAV-61 of subgro...

    journal_title:Infection and immunity

    pub_type: 杂志文章

    doi:10.1128/IAI.15.2.423-428.1977

    authors: Purchase HG,Okazaki W,Vogt PK,Hanafusa H,Burmester BR,Crittenden LB

    更新日期:1977-02-01 00:00:00

  • A constitutively active variant of the quorum-sensing regulator LuxO affects protease production and biofilm formation in Vibrio cholerae.

    abstract::Vibrio cholerae normally inhabits aquatic habitats but can cause a severe diarrheal illness in humans. Its arsenal of virulence factors includes a secreted hemagglutinin (HA) protease. An HA protease-deficient mutant of V. cholerae was isolated and designated E7946 mpc. E7946 mpc was found to contain a point mutation ...

    journal_title:Infection and immunity

    pub_type: 杂志文章

    doi:10.1128/iai.71.5.2571-2576.2003

    authors: Vance RE,Zhu J,Mekalanos JJ

    更新日期:2003-05-01 00:00:00

  • Molecular and Functional Characterization of Fcγ Receptor IIIb-Ligand Interaction: Implications for Neutrophil-Mediated Immune Mechanisms in Malaria.

    abstract::The Fcγ receptor IIIb (FcγRIIIb) is a low-affinity receptor of IgG and is essential in neutrophil-mediated effector functions. Different allelic forms of FcγRIIIb carrying human neutrophil antigen (HNA-1a, -1b, -1c, and -1d) have been identified. Here, we have generated stable transfected HEK293 cell lines expressing ...

    journal_title:Infection and immunity

    pub_type: 杂志文章

    doi:10.1128/IAI.00924-17

    authors: Simtong P,Romphruk AV,Traum A,Burg-Roderfeld M,Bein G,Jakubowski K,Dominik A,Theisen M,Kana IH,Sachs UJ,Santoso S

    更新日期:2018-07-23 00:00:00

  • Antigenic characterization of an intrinsically unstructured protein, Plasmodium falciparum merozoite surface protein 2.

    abstract::Merozoite surface protein 2 (MSP2) is an abundant glycosylphosphatidylinositol (GPI)-anchored protein of Plasmodium falciparum, which is a potential component of a malaria vaccine. As all forms of MSP2 can be categorized into two allelic families, a vaccine containing two representative forms of MSP2 may overcome the ...

    journal_title:Infection and immunity

    pub_type: 杂志文章

    doi:10.1128/IAI.00665-12

    authors: Adda CG,MacRaild CA,Reiling L,Wycherley K,Boyle MJ,Kienzle V,Masendycz P,Foley M,Beeson JG,Norton RS,Anders RF

    更新日期:2012-12-01 00:00:00

  • Diversity of the T-cell response to pulmonary Cryptococcus neoformans infection.

    abstract::Cell-mediated immunity plays an important role in immunity to the pathogenic fungus Cryptococcus neoformans. However, the antigen specificity of the T-cell response to C. neoformans remains largely unknown. In this study, we used two approaches to determine the antigen specificity of the T-cell response to C. neoforma...

    journal_title:Infection and immunity

    pub_type: 杂志文章

    doi:10.1128/IAI.00080-06

    authors: Lindell DM,Ballinger MN,McDonald RA,Toews GB,Huffnagle GB

    更新日期:2006-08-01 00:00:00

  • Bordetella parapertussis invasion of HeLa 229 cells and human respiratory epithelial cells in primary culture.

    abstract::Bordetella parapertussis, a respiratory tract pathogen commonly regarded as noninvasive, was found to invade HeLa 229 cell monolayers. Following treatment of the monolayers with gentamicin, numbers of viable B. parapertussis recovered were comparable to those of invasive Salmonella and Shigella isolates. Invasion occu...

    journal_title:Infection and immunity

    pub_type: 杂志文章

    doi:10.1128/IAI.57.4.1240-1247.1989

    authors: Ewanowich CA,Sherburne RK,Man SF,Peppler MS

    更新日期:1989-04-01 00:00:00

  • The dominant epitope of Borrelia garinii outer surface protein C recognized by sera from patients with neuroborreliosis has a surface-exposed conserved structural motif.

    abstract::Epitope mapping of outer surface protein C (OspC) by using sera from patients with neuroborreliosis led to the identification of one single major immunodominant epitope within the C-terminal 10 amino acid residues. Peptide binding studies and alanine replacement scanning of the C-terminal decapeptide, PVVAESPKKP, reve...

    journal_title:Infection and immunity

    pub_type: 杂志文章

    doi:

    authors: Mathiesen MJ,Holm A,Christiansen M,Blom J,Hansen K,Ostergaard S,Theisen M

    更新日期:1998-09-01 00:00:00

  • Host and tissue specificity of Trichomonas vaginalis is not mediated by its known adhesion proteins.

    abstract::Adhesion of Trichomonas vaginalis is believed to be dependent on four adhesion proteins, which are thought to bind to vaginal epithelial cells in a specific manner with a ligand-receptor type of interaction. However, the specific receptors on the host cell have not yet been identified. In this work, the ability of the...

    journal_title:Infection and immunity

    pub_type: 杂志文章

    doi:10.1128/iai.68.7.4358-4360.2000

    authors: Addis MF,Rappelli P,Fiori PL

    更新日期:2000-07-01 00:00:00

  • Opportunist mycobacteria express ligands that stimulate production of human V gamma 9V delta 2 T lymphocytes.

    abstract::Human gamma delta T cells are known to respond at high frequencies to pathogenic mycobacteria. Here we show that opportunistic strains of mycobacteria share with pathogenic mycobacteria the ability to trigger at high frequencies human V gamma 9V delta 2 T-cell-receptor-positive T lymphocytes. Stimulating ligands were ...

    journal_title:Infection and immunity

    pub_type: 杂志文章

    doi:10.1128/IAI.60.7.2753-2757.1992

    authors: Häcker G,Kromer S,Heeg K,Ivanyi J,Wagner H,Pfeffer K

    更新日期:1992-07-01 00:00:00

  • Purification and properties of proline-rich antimicrobial peptides from sheep and goat leukocytes.

    abstract::We purified three proline-rich antimicrobial peptides from elastase-treated extracts of sheep and goat leukocytes and subjected two of them, OaBac5alpha and ChBac5, to detailed analysis. OaBac5alpha and ChBac5 were homologous to each other and to bovine Bac5. Both exhibited potent, broad-spectrum antimicrobial activit...

    journal_title:Infection and immunity

    pub_type: 杂志文章

    doi:10.1128/IAI.67.8.4106-4111.1999

    authors: Shamova O,Brogden KA,Zhao C,Nguyen T,Kokryakov VN,Lehrer RI

    更新日期:1999-08-01 00:00:00

  • Monoclonal antibodies that recognize a specific surface antigen of Treponema denticola.

    abstract::Spirochetes have been implicated as potential etiologic agents of periodontitis in humans. Murine monoclonal antibodies (MAbs) specific for a serogroup of Treponema denticola, an oral spirochete, were developed and characterized in this study. Antibodies secreted by clone IAA11 were judged to be the most useful, since...

    journal_title:Infection and immunity

    pub_type: 杂志文章

    doi:10.1128/IAI.56.1.60-63.1988

    authors: Simonson LG,Rouse RF,Bockowski SW

    更新日期:1988-01-01 00:00:00

  • p38 mitogen-activated protein kinase controls NF-kappaB transcriptional activation and tumor necrosis factor alpha production through RelA phosphorylation mediated by mitogen- and stress-activated protein kinase 1 in response to Borrelia burgdorferi antig

    abstract::The interaction of Borrelia burgdorferi, the causative agent of Lyme borreliosis, with phagocytic cells induces the activation of NF-kappaB and the expression of proinflammatory cytokines including tumor necrosis factor alpha (TNF-alpha). B. burgdorferi-induced TNF-alpha production is also dependent on the activation ...

    journal_title:Infection and immunity

    pub_type: 杂志文章

    doi:10.1128/IAI.01412-06

    authors: Olson CM,Hedrick MN,Izadi H,Bates TC,Olivera ER,Anguita J

    更新日期:2007-01-01 00:00:00

  • Dendritic cells induce immunity and long-lasting protection against blood-stage malaria despite an in vitro parasite-induced maturation defect.

    abstract::Dendritic cells (DC) suffer a maturation defect following interaction with erythrocytes infected with malaria parasites and become unable to induce protective malaria liver-stage immunity. Here we show that, by contrast, maturation-arrested DC in vitro are capable of the successful induction of antigen-specific gamma ...

    journal_title:Infection and immunity

    pub_type: 杂志文章

    doi:10.1128/IAI.72.9.5331-5339.2004

    authors: Pouniotis DS,Proudfoot O,Bogdanoska V,Apostolopoulos V,Fifis T,Plebanski M

    更新日期:2004-09-01 00:00:00

  • FcgammaRIII mediates immunoglobulin G-induced interleukin-10 and is required for chronic Leishmania mexicana lesions.

    abstract::FcRgamma and interleukin-10 (IL-10) are both required for chronic disease in C57BL/6 mice with Leishmania mexicana parasite infection. FcRgamma is a component of several different FcRs and may be a component of some T-cell receptors. The initial antibody response to L. mexicana is an immunoglobulin G1 (IgG1) response,...

    journal_title:Infection and immunity

    pub_type: 杂志文章

    doi:10.1128/IAI.00316-07

    authors: Thomas BN,Buxbaum LU

    更新日期:2008-02-01 00:00:00

  • Effects of the antioxidant alpha-lipoic acid on human umbilical vein endothelial cells infected with Rickettsia rickettsii.

    abstract::Rickettsia rickettsii infection of endothelial cells is manifested in very distinctive changes in cell morphology, consisting of extensive dilatation of the membranes of the endoplasmic reticulum and outer nuclear envelope and blebbing of the plasma membrane, as seen by transmission electron microscopy (D. J. Silverma...

    journal_title:Infection and immunity

    pub_type: 杂志文章

    doi:10.1128/IAI.66.5.2290-2299.1998

    authors: Eremeeva ME,Silverman DJ

    更新日期:1998-05-01 00:00:00

  • Virulent Shigella flexneri affects secretion, expression, and glycosylation of gel-forming mucins in mucus-producing cells.

    abstract::Mucin glycoproteins are secreted in large amounts by the intestinal epithelium and constitute an efficient component of innate immune defenses to promote homeostasis and protect against enteric pathogens. In this study, our objective was to investigate how the bacterial enteropathogen Shigella flexneri, which causes b...

    journal_title:Infection and immunity

    pub_type: 杂志文章

    doi:10.1128/IAI.00551-13

    authors: Sperandio B,Fischer N,Joncquel Chevalier-Curt M,Rossez Y,Roux P,Robbe Masselot C,Sansonetti PJ

    更新日期:2013-10-01 00:00:00

  • Effects of cell source, mouse strain, and immunosuppressive treatment on production of virulent and attenuated murine cytomegalovirus.

    abstract::Murine cytomegalovirus pools from various in vitro and in vivo sources were compared for virulence in suckling mice in an effort to identify the conditions which were necessary for the production of virulent and attenuated viruses. Virus passaged in tracheal ring and salivary gland organ cultures, where virus is produ...

    journal_title:Infection and immunity

    pub_type: 杂志文章

    doi:10.1128/IAI.33.3.840-847.1981

    authors: Selgrade MK,Nedrud JG,Collier AM,Gardner DE

    更新日期:1981-09-01 00:00:00

  • Human and rat macrophages mediate fungistatic activity against Rhizopus species differently: in vitro and ex vivo studies.

    abstract::Both rat alveolar macrophages and a human macrophages cell line with characteristics of human tissue (e.g., alveolar) macrophages (THP-1) were found to inhibit the germination of Rhizopus spores. However, the conditions under which fungistatic activity occurs are different for these two cell types. The inhibition of R...

    journal_title:Infection and immunity

    pub_type: 杂志文章

    doi:10.1128/IAI.63.11.4489-4494.1995

    authors: Jorens PG,Boelaert JR,Halloy V,Zamora R,Schneider YJ,Herman AG

    更新日期:1995-11-01 00:00:00

  • Coxiella burnetii isolates cause genogroup-specific virulence in mouse and guinea pig models of acute Q fever.

    abstract::Q fever is a zoonotic disease of worldwide significance caused by the obligate intracellular bacterium Coxiella burnetii. Humans with Q fever may experience an acute flu-like illness and pneumonia and/or chronic hepatitis or endocarditis. Various markers demonstrate significant phylogenetic separation between and clus...

    journal_title:Infection and immunity

    pub_type: 杂志文章

    doi:10.1128/IAI.00851-09

    authors: Russell-Lodrigue KE,Andoh M,Poels MW,Shive HR,Weeks BR,Zhang GQ,Tersteeg C,Masegi T,Hotta A,Yamaguchi T,Fukushi H,Hirai K,McMurray DN,Samuel JE

    更新日期:2009-12-01 00:00:00

  • Identification of srv, a PrfA-like regulator of group A streptococcus that influences virulence.

    abstract::We have identified a Crp/Fnr-like transcriptional regulator of Streptococcus pyogenes that when inactivated attenuates virulence. The gene, named srv for streptococcal regulator of virulence, encodes a 240-amino-acid protein with 53% amino acid similarity to PrfA, a transcriptional activator of virulence in Listeria m...

    journal_title:Infection and immunity

    pub_type: 杂志文章

    doi:10.1128/iai.72.3.1799-1803.2004

    authors: Reid SD,Montgomery AG,Musser JM

    更新日期:2004-03-01 00:00:00

  • Protection of rabbits against local vaccinia virus infection by Brucella abortus and polyacrylic acid in the absence of systemic interferon production.

    abstract::Brucella abortus and polyacrylic acid, two agents whose interferon-inducing capacity in the mouse has been well established, failed to stimulate circulating interferon production in rabbits, yet protected rabbits against local vaccinia virus infection. ...

    journal_title:Infection and immunity

    pub_type: 杂志文章

    doi:10.1128/IAI.8.4.669-673.1973

    authors: De Clercq E,De Somer P

    更新日期:1973-10-01 00:00:00

  • In vitro production of an extracellular protease by Legionella pneumophila.

    abstract::Extracellular protease activity was measured in liquid cultures of representative strains from six serotypes of Legionella pneumophila. A variety of substrates were degraded, including denatured casein, skim milk, gelatin, and hide powder azure, but not elastin. ...

    journal_title:Infection and immunity

    pub_type: 杂志文章

    doi:10.1128/IAI.34.1.299-302.1981

    authors: Thompson MR,Miller RD,Iglewski BH

    更新日期:1981-10-01 00:00:00

  • Borrelia burgdorferi RevA antigen binds host fibronectin.

    abstract::Borrelia burgdorferi, the Lyme disease-causing spirochete, can persistently infect its vertebrate hosts for years. B. burgdorferi is often found associated with host connective tissue, where it interacts with components of the extracellular matrix, including fibronectin. Some years ago, a borrelial surface protein, na...

    journal_title:Infection and immunity

    pub_type: 杂志文章

    doi:10.1128/IAI.00227-09

    authors: Brissette CA,Bykowski T,Cooley AE,Bowman A,Stevenson B

    更新日期:2009-07-01 00:00:00

  • TREM-1 signaling promotes host defense during the early stage of infection with highly pathogenic Streptococcus suis.

    abstract::Infection with highly pathogenic Streptococcus suis can cause septic shock, which is characterized by high levels of inflammatory cytokines and a high mortality rate. Our previous study indicated that TREM-1 (triggering receptor expressed on myeloid cells 1) was upregulated in swine spleen cells in response to S. suis...

    journal_title:Infection and immunity

    pub_type: 杂志文章

    doi:10.1128/IAI.00440-15

    authors: Yang C,Chen B,Zhao J,Lin L,Han L,Pan S,Fu L,Jin M,Chen H,Zhang A

    更新日期:2015-08-01 00:00:00