当前位置： SCI文献检索 > NEUROSCIENCE期刊下所有文献 > Promoter elements conferring neuron-specific expression of the beta 2-subunit of the neuronal nicotinic acetylcholine receptor studied in vitro and in transgenic mice.

Promoter elements conferring neuron-specific expression of the beta 2-subunit of the neuronal nicotinic acetylcholine receptor studied in vitro and in transgenic mice.

Abstract：

:Several genes encoding subunits of the neuronal nicotinic acetylcholine receptors have been cloned and regulatory elements involved in the transcription of the alpha 2 and alpha 7-subunit genes have been described. Yet, the detailed mechanisms governing the neuron-specific transcription and the spatio-temporal expression pattern of these genes remain largely uninvestigated. The beta 2-subunit is the most widely expressed neuronal nicotinic receptor subunit in the nervous system. We have studied the structural and regulatory properties of the 5' sequence of this gene. A fragment of 1163 bp of upstream sequence is sufficient to drive the cell-specific transcription of a reporter gene in both transient transfection assays and in transgenic mice. Deletion analysis and site-directed mutagenesis of this promoter reveal two negative elements and one positive element. The positively-acting sequence includes one functional E-box. One of the repressor elements is located in the transcribed region and is the NRSE/RE1 sequence already described in promoters of neuronal genes. In this paper, we describe the neuron-specific promoter of the gene encoding the neuronal nicotinic acetylcholine receptor beta 2-subunit.

journal_name

Neuroscience

journal_title

Neuroscience

authors

Bessis A,Salmon AM,Zoli M,Le Novère N,Picciotto M,Changeux JP

doi

10.1016/0306-4522(95)00303-z

subject

Has Abstract

pub_date

1995-12-01 00:00:00

pages

807-19

issue

3

eissn

0306-4522

issn

1873-7544

pii

0306-4522(95)00303-Z

journal_volume

69

pub_type

杂志文章

相关文献

NEUROSCIENCE文献大全
  • Postnatal ontogeny of GABAB binding in rat brain.

    abstract：:The postnatal development of GABAB binding sites in rat brain was studied by quantitative receptor autoradiography using [3H]GABA under selective conditions. Binding levels peak at regionally specific times during the first three weeks of life and then decline to adult levels. GABAB binding peaked in the globus pallid...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/0306-4522(94)90392-1

    authors： Turgeon SM,Albin RL

    更新日期：1994-09-01 00:00:00

  • Maintaining stable memory engrams: new roles for Nogo-A in the CNS.

    abstract：:Nogo-A interaction with its different receptors (Nogo receptor 1 (NgR1), S1P receptor 2 (S1PR2), paired immunoglobulin-like receptor B (PirB)) restricts plasticity and growth-dependent processes leading, via the activation of different signaling pathway to the stabilization of the neuronal networks (either development...

    journal_title：Neuroscience

    pub_type： 杂志文章,评审

    doi：10.1016/j.neuroscience.2014.08.030

    authors： Zagrebelsky M,Korte M

    更新日期：2014-12-26 00:00:00

  • Local alpha-bungarotoxin-sensitive nicotinic receptors in the nucleus accumbens modulate nicotine-stimulated dopamine secretion in vivo.

    abstract：:Nicotinic cholinergic receptors in the ventral tegmental area are required for the accumbal dopamine response to systemic nicotine. In contrast, the role of nicotinic receptors located within the nucleus accumbens itself has not been clarified for systemically administered nicotine. In the present study, in vivo micro...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/s0306-4522(00)00371-7

    authors： Fu Y,Matta SG,Gao W,Sharp BM

    更新日期：2000-01-01 00:00:00

  • The localization of nitric oxide synthase in the rat eye and related cranial ganglia.

    abstract：:Nitric oxide synthase is the biosynthetic enzyme for the free radical neurotransmitter nitric oxide. Using an affinity-purified antiserum, nitric oxide synthase was found to be localized to peripheral ocular nerve fibers, related cranial ganglia, and the retina of the rat. In the eye, nitric oxide synthase-like immuno...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/0306-4522(93)90393-t

    authors： Yamamoto R,Bredt DS,Snyder SH,Stone RA

    更新日期：1993-05-01 00:00:00

  • It Pays to Prepare: Human Motor Preparation Depends on the Relative Value of Potential Response Options.

    abstract：:Alternative motor responses can be prepared in parallel. Here, we used electroencephalography (EEG) to test whether the parallel preparation of alternative response options is modulated by their relative value. Participants performed a choice response task with three potential actions: isometric contraction of the lef...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/j.neuroscience.2018.01.055

    authors： Reuter EM,Marinovic W,Beikoff J,Carroll TJ

    更新日期：2018-03-15 00:00:00

  • Stimulus exposure duration alters implicit processing of neutral and emotional faces.

    abstract：:Stimulus exposure duration in emotion perception research is often chosen pragmatically; however, little work exists on the consequences of stimulus duration for the processing of emotional faces. We utilized the spatiotemporal resolution capabilities of magnetoencephalography (MEG) to characterize early implicit proc...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/j.neuroscience.2016.11.030

    authors： Kouptsova JE,Leung RC,Taylor MJ

    更新日期：2017-01-26 00:00:00

  • The Effects of Mobile Phone Radiofrequency Electromagnetic Fields on β-Amyloid-Induced Oxidative Stress in Human and Rat Primary Astrocytes.

    abstract：:Amyloid beta peptide (Aβ) is implicated in the development of pathological reactions associated with Alzheimer's disease (AD), such as oxidative stress, neuro-inflammation and death of brain cells. Current pharmacological approaches to treat AD are not able to control the deposition of Aβ and suppression of Aβ-induced...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/j.neuroscience.2019.03.058

    authors： Tsoy A,Saliev T,Abzhanova E,Turgambayeva A,Kaiyrlykyzy A,Akishev M,Saparbayev S,Umbayev B,Askarova S

    更新日期：2019-06-01 00:00:00

  • Getting ahead of oneself: anticipation and the vestibulo-ocular reflex.

    abstract：:Compensatory counter-rotations of the eyes provoked by head turns are commonly attributed to the vestibulo-ocular reflex (VOR). A recent study in guinea pigs demonstrates, however, that this assumption is not always valid. During voluntary head turns, guinea pigs make highly accurate compensatory eye movements that oc...

    journal_title：Neuroscience

    pub_type： 杂志文章,评审

    doi：10.1016/j.neuroscience.2012.12.032

    authors： King WM

    更新日期：2013-04-16 00:00:00

  • Zonal organization of flocculo-vestibular connections in rats.

    abstract：:Anatomical and electrophysiological evidence has contributed to the hypothesis that microzones in the mammalian flocculus are organized to reflect control of eye movements in the planes of semicircular canals. Adult male Long-Evans rats received iontophoretic injections of FluoroGold and/or tetramethylrhodamine dextra...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/s0306-4522(00)00232-3

    authors： Balaban CD,Schuerger RJ,Porter JD

    更新日期：2000-01-01 00:00:00

  • Oral Dyskinesias and striatal lesions in rats after long-term co-treatment with haloperidol and 3-nitropropionic acid.

    abstract：:The pathophysiologic basis of tardive dyskinesia remains unclear. It has been proposed that tardive dyskinesia may be a result of excitotoxic neurodegeneration in the striatum caused by a neuroleptic-induced increase in striatal glutamate release and impaired energy metabolism. To investigate this hypothesis, haloperi...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/s0306-4522(98)00160-2

    authors： Andreassen OA,Ferrante RJ,Beal MF,Jørgensen HA

    更新日期：1998-12-01 00:00:00

  • The contribution of the fusiform gyrus and superior temporal sulcus in processing facial attractiveness: neuropsychological and neuroimaging evidence.

    abstract：:Current cognitive models suggest that the processing of dynamic facial attributes, including social signals such as gaze direction and facial expression, involves the superior temporal sulcus, whereas the processing of invariant facial structure such as the individuals' identity involves the fusiform face area. Where ...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/j.neuroscience.2008.05.046

    authors： Iaria G,Fox CJ,Waite CT,Aharon I,Barton JJ

    更新日期：2008-08-13 00:00:00

  • Glutamate transporter type 3 knockout mice have a decreased isoflurane requirement to induce loss of righting reflex.

    abstract：:Excitatory amino acid transporters (EAAT) uptake extracellular glutamate, the major excitatory neurotransmitter in the brain. EAAT type 3 (EAAT3), the main neuronal EAAT, is expressed widely in the CNS. We have shown that the volatile anesthetic isoflurane increases EAAT3 activity and trafficking to the plasma membran...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/j.neuroscience.2010.09.044

    authors： Lee SN,Li L,Zuo Z

    更新日期：2010-12-15 00:00:00

  • X-irradiation causes a prolonged reduction in cell proliferation in the dentate gyrus of adult rats.

    abstract：:The effects of X-irradiation on proliferating cells in the dentate subgranular zone were assessed in young adult Fisher 344 rats exposed to a range of X-ray doses and followed for up to 120 days. Apoptosis was quantified using morphology and end-labeling immunohistochemistry, and cell proliferation was detected using ...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/s0306-4522(00)00151-2

    authors： Tada E,Parent JM,Lowenstein DH,Fike JR

    更新日期：2000-01-01 00:00:00

  • Frequency bands and spatiotemporal dynamics of beta burst stimulation induced afterdischarges in hippocampus in vivo.

    abstract：:Temporal and spatial characteristics of hippocampal neuronal network activation are modified during epileptiform afterdischarges. We developed a beta burst stimulation protocol to investigate subregional variations and substrates of rhythmic population spike discharges in vivo in urethane anesthetized Wistar rat hippo...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/j.neuroscience.2004.08.039

    authors： Mikkonen JE,Penttonen M

    更新日期：2005-01-01 00:00:00

  • Protracted abstinence from chronic ethanol exposure alters the structure of neurons and expression of oligodendrocytes and myelin in the medial prefrontal cortex.

    abstract：:In rodents, chronic intermittent ethanol vapor exposure (CIE) produces alcohol dependence, alters the structure and activity of pyramidal neurons and decreases the number of oligodendroglial progenitors in the medial prefrontal cortex (mPFC). In this study, adult Wistar rats were exposed to seven weeks of CIE and were...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/j.neuroscience.2015.02.043

    authors： Navarro AI,Mandyam CD

    更新日期：2015-05-07 00:00:00

  • Responses of medullary reticulospinal neurons to sinusoidal rotation of neck in the decerebrate cat.

    abstract：:The electrical activity of 132 neurons located in the inhibitory area of the medullary reticular formation, namely, in the medial aspects of the nucleus reticularis gigantocellularis, magnocellularis and ventralis has been recorded in precollicular decerebrate cats during sinusoidal displacement of the neck. This was ...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/0306-4522(84)90038-1

    authors： Srivastava UC,Manzoni D,Pompeiano O,Stampacchia G

    更新日期：1984-02-01 00:00:00

  • Working memory and the homeostatic control of brain adenosine by adenosine kinase.

    abstract：:The neuromodulator adenosine maintains brain homeostasis and regulates complex behaviour via activation of inhibitory and excitatory adenosine receptors (ARs) in a brain region-specific manner. AR antagonists such as caffeine have been shown to ameliorate cognitive impairments in animal disease models but their effect...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/j.neuroscience.2012.03.051

    authors： Singer P,McGarrity S,Shen HY,Boison D,Yee BK

    更新日期：2012-06-28 00:00:00

  • Induction of Fos expression in the rat forebrain after intragastric administration of monosodium L-glutamate, glucose and NaCl.

    abstract：:l-glutamate, an umami taste substance, is a key molecule coupled to a food intake signaling pathway. Furthermore, recent studies have unveiled new roles for dietary glutamate on gut-brain axis communication via activation of gut glutamate receptors and subsequent vagus nerve. In the present study, we mapped activation...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/j.neuroscience.2011.09.003

    authors： Otsubo H,Kondoh T,Shibata M,Torii K,Ueta Y

    更新日期：2011-11-24 00:00:00

  • Charting of type II glucocorticoid receptor-like immunoreactivity in the rat central nervous system.

    abstract：:The rat brain and spinal cord have been mapped for Type II glucocorticoid receptor-like immunoreactivity in neurons and glia, using a monoclonal antibody, BUGR2, which recognizes an epitope close to the DNA-binding domain of the rat Type II receptor. The study revealed a widespread distribution of Type II-like immunor...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/0306-4522(90)90244-x

    authors： Ahima RS,Harlan RE

    更新日期：1990-01-01 00:00:00

  • Synaptic abnormalities of mice lacking toll-like receptor (TLR)-9.

    abstract：:Motor, sensory, and autonomic abnormalities are reported for toll-like receptor 9 (TLR9) knock-out (KO) mice. However, a physiological role of TLR9 in the nervous system is largely unknown. Since altered synaptic transmission can contribute to sensory and motor abnormalities, we evaluated neuromuscular junction (NMJ) ...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/j.neuroscience.2016.03.001

    authors： Patel V,Patel AM,McArdle JJ

    更新日期：2016-06-02 00:00:00

  • Monoaminergic dysregulation in glutathione-deficient mice: possible relevance to schizophrenia?

    abstract：:Several lines of research have implicated glutathione (GSH) in schizophrenia. For instance, GSH deficiency has been reported in the prefrontal cortex of schizophrenics in vivo. Further, in rats postnatal GSH-deficiency combined with hyperdopaminergia led to cognitive impairments in the adult. In the present report we ...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/j.neuroscience.2005.01.059

    authors： Jacobsen JP,Rodriguiz RM,Mørk A,Wetsel WC

    更新日期：2005-01-01 00:00:00

  • Expression of alpha3, beta3 and gamma1 GABA(A) receptor subunit messenger RNAs in visual cortex and lateral geniculate nucleus of normal and monocularly deprived monkeys.

    abstract：:Complementary RNA probes derived from complementary DNA specifically subcloned from monkey tissue were used to localize, by in situ hybridization histochemistry, the relatively rare alpha3, beta3 and gamma1 subunit transcripts of the GABA(A) receptor in visual cortex and lateral geniculate nucleus of normal monkeys an...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/s0306-4522(98)00140-7

    authors： Huntsman MM,Jones EG

    更新日期：1998-11-01 00:00:00

  • Regulation of phosphatidylinositide transduction system in the rat spinal cord during aging.

    abstract：:Age-related functional alterations in a variety of neurotransmitter systems result in modulation of interneuronal communications which has some relevance in neurological deficits observed in the aging process. The synergistic interactions between protein kinase and inositol 1,4,5-trisphosphate (insP3)/Ca2+ pathways un...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/0306-4522(95)00298-w

    authors： Igwe OJ,Filla MB

    更新日期：1995-12-01 00:00:00

  • Ultrastructural localization of calbindin-D28k and GABA in the matrix compartment of the rat caudate-putamen nuclei.

    abstract：:The calcium binding protein, Calbindin-D28k, is known to be localized within spiny neurons of the matrix of the dorsal striatum, caudate-putamen nuclei. This compartment is also known to contain an abundance of GABAergic neurons and to receive extensive input from excitatory limbic and cortical afferents whose activat...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/0306-4522(95)00441-6

    authors： Pickel VM,Heras A

    更新日期：1996-03-01 00:00:00

  • Modulation of late phases of long-term potentiation in rat dentate gyrus by stimulation of the medial septum.

    abstract：:The prolonged maintenance of hippocampal long-term potentiation (LTP) seems to require heterosynaptic events during its induction. We have previously shown that stimulation of the basolateral nucleus of the amygdala (BLA) within a distinct time window can reinforce a transient early-LTP into a long-lasting late-LTP in...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/s0306-4522(03)00029-0

    authors： Frey S,Bergado JA,Frey JU

    更新日期：2003-01-01 00:00:00

  • Dorsal root ganglia isolated from Nf1+/- mice exhibit increased levels of mRNA expression of voltage-dependent sodium channels.

    abstract：:We reported previously that sensory neurons isolated from mice with a heterozygous mutation of the Nf1 gene (Nf1+/-) exhibited greater excitability and increased sodium current densities compared with wildtype mice. This raises the question as to whether the increased current density resulted from post-translational m...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/j.neuroscience.2011.12.045

    authors： Hodgdon KE,Hingtgen CM,Nicol GD

    更新日期：2012-03-29 00:00:00

  • Ultrastructure of vestibular commissural neurons related to velocity storage in the monkey.

    abstract：:The angular vestibulo-ocular reflex maintains gaze during head movements. It is thought to be mediated by two components: direct and velocity storage pathways. The direct angular vestibulo-ocular reflex is conveyed by a three neuron chain from the labyrinth to the ocular motoneurons. The indirect pathway involves a mo...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/s0306-4522(99)00142-6

    authors： Holstein GR,Martinelli GP,Wearne S,Cohen B

    更新日期：1999-01-01 00:00:00

  • Transient populations of presumptive macrophages in the brain of the developing hamster, as indicated by endocytosis of blood-borne horseradish peroxidase.

    abstract：:During postnatal development, clusters of cells associated with the mononuclear phagocytic system appear within the white matter of rodents and cats. We studied the distribution and morphology of these cells in the hamster's brain during the first 2 weeks after birth. In animals of different ages, horseradish peroxida...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/0306-4522(85)90263-5

    authors： Lent R,Linden R,Cavalcante LA

    更新日期：1985-08-01 00:00:00

  • HMGB1 may act via RAGE to promote angiogenesis in the later phase after intracerebral hemorrhage.

    abstract：:Following intracerebral hemorrhage (ICH), high-mobility group box 1 protein (HMGB1) may promote vascular remodeling. Whether HMGB1 supports angiogenesis after ICH is unclear, as are the receptors and downstream signaling pathway(s) involved. We used the rat model of collagenase-induced ICH to determine whether HMGB1 a...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/j.neuroscience.2015.03.032

    authors： Lei C,Zhang S,Cao T,Tao W,Liu M,Wu B

    更新日期：2015-06-04 00:00:00

  • Non-oscillatory discharges of an F-prostaglandin responsive neuron population in the olfactory bulb-telencephalon transition area in lake whitefish.

    abstract：:Our previous studies on olfactory bulbar responses in salmonid fishes suggest that pheromone signals might be processed by a mechanism distinct from that of other odorants. Using in vivo single-unit and electroencephalographic recordings, we investigated response characteristics of olfactory neurons in lake whitefish,...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/s0306-4522(02)00717-0

    authors： Laberge F,Hara TJ

    更新日期：2003-01-01 00:00:00