Abstract：
:FlyBase is a database of genetic and molecular data concerning Drosophila. FlyBase is maintained as a relational database (in Sybase). The scope of FlyBase includes: genes, alleles (and phenotypes), aberrations, pointers to sequence data, clones, stock lists, Drosophila workers and bibliographic references. FlyBase is also available on CD-ROM for Macintosh systems (Encyclopaedia of Drosophila).
journal_name
Nucleic Acids Resjournal_title
Nucleic acids researchauthors
Flybase Consortium.doi
10.1093/nar/24.1.53subject
Has Abstractpub_date
1996-01-01 00:00:00pages
53-6issue
1eissn
0305-1048issn
1362-4962pii
5s1047journal_volume
24pub_type
杂志文章abstract：:The synthesis of a pentadecamer of the 5'-phosphate of the antiviral nucleoside ribavirin (1'-beta-D-ribofuranosyl-1H-1,2,4-triazole-3-carboxamide) has been achieved. This homoribopolymer is terminated at the 5'-position with an (6-aminohexyl)phosphate group to permit conjugation to a carrier and at the 3'-position by...
journal_title：Nucleic acids research
pub_type： 杂志文章
doi：10.1093/nar/18.5.1099
更新日期：1990-03-11 00:00:00
abstract：:We have characterized elongation complexes (ECs) of RNA polymerase from the extremely thermophilic bacterium, Thermus thermophilus. We found that complexes assembled on nucleic acid scaffolds are transcriptionally competent at high temperature (50-80 degrees C) and, depending upon the organization of the scaffold, pos...
journal_title：Nucleic acids research
pub_type： 杂志文章
doi：10.1093/nar/gkl559
更新日期：2006-01-01 00:00:00
abstract：:Using two primers corresponding to helix 1 and helix 3 regions in the homeodomain, we subjected genomic DNA from Caenorhabditis elegans to amplification by the polymerase chain reaction. Sequence analysis of the amplified products revealed a new homeobox-containing gene, designated ceh-19. This gene was located betwee...
journal_title：Nucleic acids research
pub_type： 杂志文章
doi：10.1093/nar/20.12.2967
更新日期：1992-06-25 00:00:00
abstract：:Activation of the transcription factor NF-kappaB is critical for the tumor necrosis factor-alpha (TNF-alpha)-induced inflammatory response. Here we report the complete gene expression profile from activated microvascular endothelial cells emphasizing the direct contribution of the NF-kappaB pathway. Human microvascula...
journal_title：Nucleic acids research
pub_type： 杂志文章
doi：10.1093/nar/gki836
更新日期：2005-09-21 00:00:00
abstract：:The active 3D conformation of the spliceosome's catalytic U2/U6 RNA core is stabilised by a network of secondary and tertiary RNA interactions, but also depends on spliceosomal proteins for its formation. To determine the contribution towards splicing of specific RNA secondary and tertiary interactions in the U2/U6 RN...
journal_title：Nucleic acids research
pub_type： 杂志文章
doi：10.1093/nar/gky966
更新日期：2018-12-14 00:00:00
abstract：:Adjustable transgene expression is considered key for next-generation molecular interventions in gene therapy scenarios, therapeutic reprogramming of clinical cell phenotypes for tissue engineering and sophisticated gene-function analyses in the post-genomic era. We have designed a portfolio of latest generation self-...
journal_title：Nucleic acids research
pub_type： 杂志文章
doi：10.1093/nar/gnh104
更新日期：2004-07-16 00:00:00
abstract：:The complete nucleotide sequence of the mitochondrial DNA of the amphioxus Branchiostoma lanceolatum has been determined. This mitochondrial genome is small (15 076 bp) because of the short size of the two rRNA genes and the tRNA genes. In addition, this genome contains a very short non-coding region (57 bp) with no s...
journal_title：Nucleic acids research
pub_type： 杂志文章
doi：10.1093/nar/26.13.3279
更新日期：1998-07-01 00:00:00
abstract：:Inducible promoters are a central regulatory component in synthetic biology, metabolic engineering, and protein production for laboratory and commercial uses. Many of these applications utilize two or more exogenous promoters, imposing a currently unquantifiable metabolic burden on the living system. Here, we engineer...
journal_title：Nucleic acids research
pub_type： 杂志文章
doi：10.1093/nar/gkaa734
更新日期：2020-09-25 00:00:00
abstract：:Ribonuclease MRP is an endonuclease, related to RNase P, which functions in eukaryotic pre-rRNA processing. In Saccharomyces cerevisiae, RNase MRP comprises an RNA subunit and ten proteins. To improve our understanding of subunit roles and enzyme architecture, we have examined protein-protein and protein-RNA interacti...
journal_title：Nucleic acids research
pub_type： 杂志文章
doi：10.1093/nar/gkm553
更新日期：2007-01-01 00:00:00
abstract：:A number of meiosis-specific transcripts are selectively eliminated during the mitotic cell cycle in fission yeast. Mmi1, an RNA-binding protein, plays a crucial role in this selective elimination. Mmi1 recognizes a specific region, namely, the determinant of selective removal (DSR) on meiotic transcripts and induces ...
journal_title：Nucleic acids research
pub_type： 杂志文章
doi：10.1093/nar/gkt763
更新日期：2013-11-01 00:00:00
abstract：:The expression of Herpes Simplex Virus 1 (HSV-1) glycoprotein C (gC), a well defined herpesvirus late gene, was studied by linking the promoter-regulatory region of this gene to the coding sequences for the bacterial enzyme, beta-galactosidase (beta-gal). A chimeric gene, containing the beta-gal gene under the control...
journal_title：Nucleic acids research
pub_type： 杂志文章
doi：10.1093/nar/16.21.10267
更新日期：1988-11-11 00:00:00
abstract：:MicroRNAs (miRNAs) are short, non-protein coding RNAs that direct the widespread phenomenon of post-transcriptional regulation of metazoan genes. The mature approximately 22-nt long RNA molecules are processed from genome-encoded stem-loop structured precursor genes. Hundreds of such genes have been experimentally val...
journal_title：Nucleic acids research
pub_type： 杂志文章
doi：10.1093/nar/gkn707
更新日期：2009-01-01 00:00:00
abstract：:A previously elaborated technique for fixing a chosen partially melted state of DNA with glyoxal was used in a study of the melting process of the replicative form (RF III) of phi X174 DNA. Electron-microscopic maps corresponding to five points of the melting curve of RF III were obtained and compared with the theoret...
journal_title：Nucleic acids research
pub_type： 杂志文章
doi：10.1093/nar/10.6.1867
更新日期：1982-03-25 00:00:00
abstract：:Virtually the whole region of the mobile dispersed genetic element mdg1 including the direct repeats that frame mdg1 /1/ is transcribed. The end of the transcriptional unit is located within the direct repeat. Although the transcription of mdg1 is symmetric, one direction is transcribed preferentially and is a full-le...
journal_title：Nucleic acids research
pub_type： 杂志文章
doi：10.1093/nar/8.22.5347
更新日期：1980-11-25 00:00:00
abstract：:We report the nucleotide sequence of the Group IV RNA bacteriophage SP. The entire sequence is 4276 nucleotides long. Four cistrons have been identified by comparison with the related Group III phage Q beta. The maturation protein contains 449 amino acids, the coat protein contains 131 amino acids, the read-through pr...
journal_title：Nucleic acids research
pub_type： 杂志文章
doi：10.1093/nar/16.13.6205
更新日期：1988-07-11 00:00:00
abstract：:The allele frequency net database (http://www.allelefrequencies.net) is an online repository that contains information on the frequencies of immune genes and their corresponding alleles in different populations. The extensive variability observed in genes and alleles related to the immune system response and its signi...
journal_title：Nucleic acids research
pub_type： 杂志文章
doi：10.1093/nar/gkq1128
更新日期：2011-01-01 00:00:00
abstract：:The molecular mechanisms that underlie the neurological manifestations of patients with inherited diseases of vitamin B12 (cobalamin) metabolism remain to date obscure. We observed transcriptomic changes of genes involved in RNA metabolism and endoplasmic reticulum stress in a neuronal cell model with impaired cobalam...
journal_title：Nucleic acids research
pub_type： 杂志文章
doi：10.1093/nar/gky634
更新日期：2018-09-06 00:00:00
abstract：:The increasing availability of multi-omic platforms poses new challenges to data analysis. Joint visualization of multi-omics data is instrumental in better understanding interconnections across molecular layers and in fully utilizing the multi-omic resources available to make biological discoveries. We present here P...
journal_title：Nucleic acids research
pub_type： 杂志文章
doi：10.1093/nar/gky466
更新日期：2018-07-02 00:00:00
abstract：:A novel, site-specific, DNA backbone S-modification (phosphorothioation) has been discovered, but its in vivo function(s) have remained obscure. Here, we report that the enteropathogenic Salmonella enterica serovar Cerro 87, which possesses S-modified DNA, restricts DNA isolated from Escherichia coli, while protecting...
journal_title：Nucleic acids research
pub_type： 杂志文章
doi：10.1093/nar/gkq610
更新日期：2010-11-01 00:00:00
abstract：:Human prostatic acid phosphatase (PAcP) is a prostate epithelium-specific differentiation antigen. Cellular PAcP functions as a neutral protein tyrosine phosphatase and is involved in regulating androgen-promoted prostate cancer cell proliferation. Despite the fact that the promoter of the PAcP gene has been cloned, t...
journal_title：Nucleic acids research
pub_type： 杂志文章
doi：10.1093/nar/gkh677
更新日期：2004-07-07 00:00:00
abstract：:Prokaryotes evolved numerous systems that defend against predation by bacteriophages. In addition to well-known restriction-modification and CRISPR-Cas immunity systems, many poorly characterized systems exist. One class of such systems, named BREX, consists of a putative phosphatase, a methyltransferase and four othe...
journal_title：Nucleic acids research
pub_type： 杂志文章
doi：10.1093/nar/gky1125
更新日期：2019-01-10 00:00:00
abstract：:From a library of nucleic acid molecules, which are randomized in parts of their sequence, unique sequence variants can be selected for specific properties. The planning of such an in vitro selection experiment requires some consideration regarding how much DNA template or RNA transcript should be used initially. The ...
journal_title：Nucleic acids research
pub_type： 杂志文章
doi：10.1093/nar/24.17.3437
更新日期：1996-09-01 00:00:00
abstract：:We have isolated an eight kilobase fragment of Bacillus subtilis DNA by specific integration and excision of a plasmid containing a sequence adjacent to ribosomal operon rrn O. The genetic locus of the cloned fragment was verified by linkage of the integrated vector to nearby genetic markers using both transduction an...
journal_title：Nucleic acids research
pub_type： 杂志文章
doi：10.1093/nar/12.15.6307
更新日期：1984-08-10 00:00:00
abstract：:Transcriptional interference between adjacent genes has been demonstrated in a variety of biological systems. To study this process in RNA polymerase II (pol II) transcribed genes we have analysed the effect of transcription on tandem HIV-1 promoters integrated into the genome of HeLa cells. We show that transcription...
journal_title：Nucleic acids research
pub_type： 杂志文章
doi：10.1093/nar/26.5.1294
更新日期：1998-03-01 00:00:00
abstract：:We have previously described a partial Drosophila cDNA, clone P19, which bears homology to members of the RNA recognition motif (RRM) family of proteins [Haynes et al. (1987) Proc. Natl. Acad. Sci. USA, 84, 1819-1823]. RNA binding as well as involvement in RNA processing has been demonstrated for some RRM proteins. We...
journal_title：Nucleic acids research
pub_type： 杂志文章
doi：10.1093/nar/23.5.835
更新日期：1995-03-11 00:00:00
abstract：:Topoisomerases (topos) maintain DNA topology and influence DNA transaction processes by catalysing relaxation, supercoiling and decatenation reactions. In the cellular milieu, division of labour between different topos ensures topological homeostasis and control of central processes. In Escherichia coli, DNA gyrase is...
journal_title：Nucleic acids research
pub_type： 杂志文章
doi：10.1093/nar/gks843
更新日期：2012-11-01 00:00:00
abstract：:A normal human population has been screened for the existence of further restriction fragment length polymorphisms (RFLPs) in the clotting factor IX gene in addition to the TaqI polymorphism already characterised (1,2). Two polymorphic loci were found, both within 6 Kb of the TaqI polymorphism within the body of the f...
journal_title：Nucleic acids research
pub_type： 杂志文章
doi：10.1093/nar/12.23.8861
更新日期：1984-12-11 00:00:00
abstract：:The Ensembl project (https://www.ensembl.org) annotates genomes and disseminates genomic data for vertebrate species. We create detailed and comprehensive annotation of gene structures, regulatory elements and variants, and enable comparative genomics by inferring the evolutionary history of genes and genomes. Our int...
journal_title：Nucleic acids research
pub_type： 杂志文章
doi：10.1093/nar/gkaa942
更新日期：2021-01-08 00:00:00
abstract：:The high similarity of tunicates and vertebrates during their development coupled with the transparency of tunicate larvae, their well-studied cell lineages and the availability of simple and efficient transgenesis methods makes of this subphylum an ideal system for the investigation of vertebrate physiological and de...
journal_title：Nucleic acids research
pub_type： 杂志文章
doi：10.1093/nar/gkj064
更新日期：2006-01-01 00:00:00
abstract：:The PathoSystems Resource Integration Center (PATRIC) is the bacterial Bioinformatics Resource Center funded by the National Institute of Allergy and Infectious Diseases (https://www.patricbrc.org). PATRIC supports bioinformatic analyses of all bacteria with a special emphasis on pathogens, offering a rich comparative...
journal_title：Nucleic acids research
pub_type： 杂志文章
doi：10.1093/nar/gkz943
更新日期：2020-01-08 00:00:00
