FlyBase: the Drosophila database.


:FlyBase is a database of genetic and molecular data concerning Drosophila. FlyBase is maintained as a relational database (in Sybase). The scope of FlyBase includes: genes, alleles (and phenotypes), aberrations, pointers to sequence data, clones, stock lists, Drosophila workers and bibliographic references. FlyBase is also available on CD-ROM for Macintosh systems (Encyclopaedia of Drosophila).


Nucleic Acids Res


Nucleic acids research


Flybase Consortium.




Has Abstract


1996-01-01 00:00:00














  • Synthesis and characterization of a ribavirin-3',5'-phosphate pentadecamer homoribopolymer bearing a 5'-amino tether group and a 3'-thymidine.

    abstract::The synthesis of a pentadecamer of the 5'-phosphate of the antiviral nucleoside ribavirin (1'-beta-D-ribofuranosyl-1H-1,2,4-triazole-3-carboxamide) has been achieved. This homoribopolymer is terminated at the 5'-position with an (6-aminohexyl)phosphate group to permit conjugation to a carrier and at the 3'-position by...

    journal_title:Nucleic acids research

    pub_type: 杂志文章


    authors: Dawson MI,Jina AN,Torkelson S,Rhee S,Moore M,Zarling DA,Hobbs PD

    更新日期:1990-03-11 00:00:00

  • Elongation complexes of Thermus thermophilus RNA polymerase that possess distinct translocation conformations.

    abstract::We have characterized elongation complexes (ECs) of RNA polymerase from the extremely thermophilic bacterium, Thermus thermophilus. We found that complexes assembled on nucleic acid scaffolds are transcriptionally competent at high temperature (50-80 degrees C) and, depending upon the organization of the scaffold, pos...

    journal_title:Nucleic acids research

    pub_type: 杂志文章


    authors: Kashkina E,Anikin M,Tahirov TH,Kochetkov SN,Vassylyev DG,Temiakov D

    更新日期:2006-01-01 00:00:00

  • Identification of a homeobox-containing gene located between lin-45 and unc-24 on chromosome IV in the nematode Caenorhabditis elegans.

    abstract::Using two primers corresponding to helix 1 and helix 3 regions in the homeodomain, we subjected genomic DNA from Caenorhabditis elegans to amplification by the polymerase chain reaction. Sequence analysis of the amplified products revealed a new homeobox-containing gene, designated ceh-19. This gene was located betwee...

    journal_title:Nucleic acids research

    pub_type: 杂志文章


    authors: Naito M,Kohara Y,Kurosawa Y

    更新日期:1992-06-25 00:00:00

  • NF-kappaB controls the global pro-inflammatory response in endothelial cells: evidence for the regulation of a pro-atherogenic program.

    abstract::Activation of the transcription factor NF-kappaB is critical for the tumor necrosis factor-alpha (TNF-alpha)-induced inflammatory response. Here we report the complete gene expression profile from activated microvascular endothelial cells emphasizing the direct contribution of the NF-kappaB pathway. Human microvascula...

    journal_title:Nucleic acids research

    pub_type: 杂志文章


    authors: Kempe S,Kestler H,Lasar A,Wirth T

    更新日期:2005-09-21 00:00:00

  • Multiple RNA-RNA tertiary interactions are dispensable for formation of a functional U2/U6 RNA catalytic core in the spliceosome.

    abstract::The active 3D conformation of the spliceosome's catalytic U2/U6 RNA core is stabilised by a network of secondary and tertiary RNA interactions, but also depends on spliceosomal proteins for its formation. To determine the contribution towards splicing of specific RNA secondary and tertiary interactions in the U2/U6 RN...

    journal_title:Nucleic acids research

    pub_type: 杂志文章


    authors: Bao P,Boon KL,Will CL,Hartmuth K,Lührmann R

    更新日期:2018-12-14 00:00:00

  • Design and in vivo characterization of self-inactivating human and non-human lentiviral expression vectors engineered for streptogramin-adjustable transgene expression.

    abstract::Adjustable transgene expression is considered key for next-generation molecular interventions in gene therapy scenarios, therapeutic reprogramming of clinical cell phenotypes for tissue engineering and sophisticated gene-function analyses in the post-genomic era. We have designed a portfolio of latest generation self-...

    journal_title:Nucleic acids research

    pub_type: 杂志文章


    authors: Mitta B,Weber CC,Rimann M,Fussenegger M

    更新日期:2004-07-16 00:00:00

  • Complete sequence of the amphioxus (Branchiostoma lanceolatum) mitochondrial genome: relations to vertebrates.

    abstract::The complete nucleotide sequence of the mitochondrial DNA of the amphioxus Branchiostoma lanceolatum has been determined. This mitochondrial genome is small (15 076 bp) because of the short size of the two rRNA genes and the tRNA genes. In addition, this genome contains a very short non-coding region (57 bp) with no s...

    journal_title:Nucleic acids research

    pub_type: 杂志文章


    authors: Spruyt N,Delarbre C,Gachelin G,Laudet V

    更新日期:1998-07-01 00:00:00

  • Engineered signal-coupled inducible promoters: measuring the apparent RNA-polymerase resource budget.

    abstract::Inducible promoters are a central regulatory component in synthetic biology, metabolic engineering, and protein production for laboratory and commercial uses. Many of these applications utilize two or more exogenous promoters, imposing a currently unquantifiable metabolic burden on the living system. Here, we engineer...

    journal_title:Nucleic acids research

    pub_type: 杂志文章


    authors: Davey JA,Wilson CJ

    更新日期:2020-09-25 00:00:00

  • Interactions between subunits of Saccharomyces cerevisiae RNase MRP support a conserved eukaryotic RNase P/MRP architecture.

    abstract::Ribonuclease MRP is an endonuclease, related to RNase P, which functions in eukaryotic pre-rRNA processing. In Saccharomyces cerevisiae, RNase MRP comprises an RNA subunit and ten proteins. To improve our understanding of subunit roles and enzyme architecture, we have examined protein-protein and protein-RNA interacti...

    journal_title:Nucleic acids research

    pub_type: 杂志文章


    authors: Aspinall TV,Gordon JM,Bennett HJ,Karahalios P,Bukowski JP,Walker SC,Engelke DR,Avis JM

    更新日期:2007-01-01 00:00:00

  • A novel factor Iss10 regulates Mmi1-mediated selective elimination of meiotic transcripts.

    abstract::A number of meiosis-specific transcripts are selectively eliminated during the mitotic cell cycle in fission yeast. Mmi1, an RNA-binding protein, plays a crucial role in this selective elimination. Mmi1 recognizes a specific region, namely, the determinant of selective removal (DSR) on meiotic transcripts and induces ...

    journal_title:Nucleic acids research

    pub_type: 杂志文章


    authors: Yamashita A,Takayama T,Iwata R,Yamamoto M

    更新日期:2013-11-01 00:00:00

  • The use of beta-galactosidase as a marker gene to define the regulatory sequences of the herpes simplex virus type 1 glycoprotein C gene in recombinant herpesviruses.

    abstract::The expression of Herpes Simplex Virus 1 (HSV-1) glycoprotein C (gC), a well defined herpesvirus late gene, was studied by linking the promoter-regulatory region of this gene to the coding sequences for the bacterial enzyme, beta-galactosidase (beta-gal). A chimeric gene, containing the beta-gal gene under the control...

    journal_title:Nucleic acids research

    pub_type: 杂志文章


    authors: Weir JP,Narayanan PR

    更新日期:1988-11-11 00:00:00

  • miROrtho: computational survey of microRNA genes.

    abstract::MicroRNAs (miRNAs) are short, non-protein coding RNAs that direct the widespread phenomenon of post-transcriptional regulation of metazoan genes. The mature approximately 22-nt long RNA molecules are processed from genome-encoded stem-loop structured precursor genes. Hundreds of such genes have been experimentally val...

    journal_title:Nucleic acids research

    pub_type: 杂志文章


    authors: Gerlach D,Kriventseva EV,Rahman N,Vejnar CE,Zdobnov EM

    更新日期:2009-01-01 00:00:00

  • A comparison of experimental and theoretical melting maps for replicative form of phi X174 DNA.

    abstract::A previously elaborated technique for fixing a chosen partially melted state of DNA with glyoxal was used in a study of the melting process of the replicative form (RF III) of phi X174 DNA. Electron-microscopic maps corresponding to five points of the melting curve of RF III were obtained and compared with the theoret...

    journal_title:Nucleic acids research

    pub_type: 杂志文章


    authors: Lyubchenko YuL,Kalambet YuA,Lyamichev VI,Borovik AS

    更新日期:1982-03-25 00:00:00

  • Mobile dispersed genetic element MDG1 of Drosophila melanogaster: transcription pattern.

    abstract::Virtually the whole region of the mobile dispersed genetic element mdg1 including the direct repeats that frame mdg1 /1/ is transcribed. The end of the transcriptional unit is located within the direct repeat. Although the transcription of mdg1 is symmetric, one direction is transcribed preferentially and is a full-le...

    journal_title:Nucleic acids research

    pub_type: 杂志文章


    authors: Ilyin Y,Chmeliauskaite VG,Kulguskin VV,Georgiev GP

    更新日期:1980-11-25 00:00:00

  • Analysis of the complete nucleotide sequence of the group IV RNA coliphage SP.

    abstract::We report the nucleotide sequence of the Group IV RNA bacteriophage SP. The entire sequence is 4276 nucleotides long. Four cistrons have been identified by comparison with the related Group III phage Q beta. The maturation protein contains 449 amino acids, the coat protein contains 131 amino acids, the read-through pr...

    journal_title:Nucleic acids research

    pub_type: 杂志文章


    authors: Inokuchi Y,Jacobson AB,Hirose T,Inayama S,Hirashima A

    更新日期:1988-07-11 00:00:00

  • Allele frequency net: a database and online repository for immune gene frequencies in worldwide populations.

    abstract::The allele frequency net database ( is an online repository that contains information on the frequencies of immune genes and their corresponding alleles in different populations. The extensive variability observed in genes and alleles related to the immune system response and its signi...

    journal_title:Nucleic acids research

    pub_type: 杂志文章


    authors: Gonzalez-Galarza FF,Christmas S,Middleton D,Jones AR

    更新日期:2011-01-01 00:00:00

  • Inherited disorders of cobalamin metabolism disrupt nucleocytoplasmic transport of mRNA through impaired methylation/phosphorylation of ELAVL1/HuR.

    abstract::The molecular mechanisms that underlie the neurological manifestations of patients with inherited diseases of vitamin B12 (cobalamin) metabolism remain to date obscure. We observed transcriptomic changes of genes involved in RNA metabolism and endoplasmic reticulum stress in a neuronal cell model with impaired cobalam...

    journal_title:Nucleic acids research

    pub_type: 杂志文章


    authors: Battaglia-Hsu SF,Ghemrawi R,Coelho D,Dreumont N,Mosca P,Hergalant S,Gauchotte G,Sequeira JM,Ndiongue M,Houlgatte R,Alberto JM,Umoret R,Robert A,Paoli J,Jung M,Quadros EV,Guéant JL

    更新日期:2018-09-06 00:00:00

  • PaintOmics 3: a web resource for the pathway analysis and visualization of multi-omics data.

    abstract::The increasing availability of multi-omic platforms poses new challenges to data analysis. Joint visualization of multi-omics data is instrumental in better understanding interconnections across molecular layers and in fully utilizing the multi-omic resources available to make biological discoveries. We present here P...

    journal_title:Nucleic acids research

    pub_type: 杂志文章


    authors: Hernández-de-Diego R,Tarazona S,Martínez-Mira C,Balzano-Nogueira L,Furió-Tarí P,Pappas GJ Jr,Conesa A

    更新日期:2018-07-02 00:00:00

  • A novel host-specific restriction system associated with DNA backbone S-modification in Salmonella.

    abstract::A novel, site-specific, DNA backbone S-modification (phosphorothioation) has been discovered, but its in vivo function(s) have remained obscure. Here, we report that the enteropathogenic Salmonella enterica serovar Cerro 87, which possesses S-modified DNA, restricts DNA isolated from Escherichia coli, while protecting...

    journal_title:Nucleic acids research

    pub_type: 杂志文章


    authors: Xu T,Yao F,Zhou X,Deng Z,You D

    更新日期:2010-11-01 00:00:00

  • Transcriptional activation of the human prostatic acid phosphatase gene by NF-kappaB via a novel hexanucleotide-binding site.

    abstract::Human prostatic acid phosphatase (PAcP) is a prostate epithelium-specific differentiation antigen. Cellular PAcP functions as a neutral protein tyrosine phosphatase and is involved in regulating androgen-promoted prostate cancer cell proliferation. Despite the fact that the promoter of the PAcP gene has been cloned, t...

    journal_title:Nucleic acids research

    pub_type: 杂志文章


    authors: Zelivianski S,Glowacki R,Lin MF

    更新日期:2004-07-07 00:00:00

  • BREX system of Escherichia coli distinguishes self from non-self by methylation of a specific DNA site.

    abstract::Prokaryotes evolved numerous systems that defend against predation by bacteriophages. In addition to well-known restriction-modification and CRISPR-Cas immunity systems, many poorly characterized systems exist. One class of such systems, named BREX, consists of a putative phosphatase, a methyltransferase and four othe...

    journal_title:Nucleic acids research

    pub_type: 杂志文章


    authors: Gordeeva J,Morozova N,Sierro N,Isaev A,Sinkunas T,Tsvetkova K,Matlashov M,Truncaite L,Morgan RD,Ivanov NV,Siksnys V,Zeng L,Severinov K

    更新日期:2019-01-10 00:00:00

  • Representation of unique sequences in libraries of randomized nucleic acids.

    abstract::From a library of nucleic acid molecules, which are randomized in parts of their sequence, unique sequence variants can be selected for specific properties. The planning of such an in vitro selection experiment requires some consideration regarding how much DNA template or RNA transcript should be used initially. The ...

    journal_title:Nucleic acids research

    pub_type: 杂志文章


    authors: Tabler M,Benos P,Dörr M

    更新日期:1996-09-01 00:00:00

  • Cloning the gyrA gene of Bacillus subtilis.

    abstract::We have isolated an eight kilobase fragment of Bacillus subtilis DNA by specific integration and excision of a plasmid containing a sequence adjacent to ribosomal operon rrn O. The genetic locus of the cloned fragment was verified by linkage of the integrated vector to nearby genetic markers using both transduction an...

    journal_title:Nucleic acids research

    pub_type: 杂志文章


    authors: Lampe MF,Bott KF

    更新日期:1984-08-10 00:00:00

  • Transcriptional interference perturbs the binding of Sp1 to the HIV-1 promoter.

    abstract::Transcriptional interference between adjacent genes has been demonstrated in a variety of biological systems. To study this process in RNA polymerase II (pol II) transcribed genes we have analysed the effect of transcription on tandem HIV-1 promoters integrated into the genome of HeLa cells. We show that transcription...

    journal_title:Nucleic acids research

    pub_type: 杂志文章


    authors: Greger IH,Demarchi F,Giacca M,Proudfoot NJ

    更新日期:1998-03-01 00:00:00

  • Cabeza, a Drosophila gene encoding a novel RNA binding protein, shares homology with EWS and TLS, two genes involved in human sarcoma formation.

    abstract::We have previously described a partial Drosophila cDNA, clone P19, which bears homology to members of the RNA recognition motif (RRM) family of proteins [Haynes et al. (1987) Proc. Natl. Acad. Sci. USA, 84, 1819-1823]. RNA binding as well as involvement in RNA processing has been demonstrated for some RRM proteins. We...

    journal_title:Nucleic acids research

    pub_type: 杂志文章


    authors: Stolow DT,Haynes SR

    更新日期:1995-03-11 00:00:00

  • Binding of two DNA molecules by type II topoisomerases for decatenation.

    abstract::Topoisomerases (topos) maintain DNA topology and influence DNA transaction processes by catalysing relaxation, supercoiling and decatenation reactions. In the cellular milieu, division of labour between different topos ensures topological homeostasis and control of central processes. In Escherichia coli, DNA gyrase is...

    journal_title:Nucleic acids research

    pub_type: 杂志文章


    authors: Kumar R,Riley JE,Parry D,Bates AD,Nagaraja V

    更新日期:2012-11-01 00:00:00

  • Carrier detection in haemophilia B using two further intragenic restriction fragment length polymorphisms.

    abstract::A normal human population has been screened for the existence of further restriction fragment length polymorphisms (RFLPs) in the clotting factor IX gene in addition to the TaqI polymorphism already characterised (1,2). Two polymorphic loci were found, both within 6 Kb of the TaqI polymorphism within the body of the f...

    journal_title:Nucleic acids research

    pub_type: 杂志文章


    authors: Winship PR,Anson DS,Rizza CR,Brownlee GG

    更新日期:1984-12-11 00:00:00

  • Ensembl 2021.

    abstract::The Ensembl project ( annotates genomes and disseminates genomic data for vertebrate species. We create detailed and comprehensive annotation of gene structures, regulatory elements and variants, and enable comparative genomics by inferring the evolutionary history of genes and genomes. Our int...

    journal_title:Nucleic acids research

    pub_type: 杂志文章


    authors: Howe KL,Achuthan P,Allen J,Allen J,Alvarez-Jarreta J,Amode MR,Armean IM,Azov AG,Bennett R,Bhai J,Billis K,Boddu S,Charkhchi M,Cummins C,Da Rin Fioretto L,Davidson C,Dodiya K,El Houdaigui B,Fatima R,Gall A,Garcia G

    更新日期:2021-01-08 00:00:00

  • DBTGR: a database of tunicate promoters and their regulatory elements.

    abstract::The high similarity of tunicates and vertebrates during their development coupled with the transparency of tunicate larvae, their well-studied cell lineages and the availability of simple and efficient transgenesis methods makes of this subphylum an ideal system for the investigation of vertebrate physiological and de...

    journal_title:Nucleic acids research

    pub_type: 杂志文章


    authors: Sierro N,Kusakabe T,Park KJ,Yamashita R,Kinoshita K,Nakai K

    更新日期:2006-01-01 00:00:00

  • The PATRIC Bioinformatics Resource Center: expanding data and analysis capabilities.

    abstract::The PathoSystems Resource Integration Center (PATRIC) is the bacterial Bioinformatics Resource Center funded by the National Institute of Allergy and Infectious Diseases ( PATRIC supports bioinformatic analyses of all bacteria with a special emphasis on pathogens, offering a rich comparative...

    journal_title:Nucleic acids research

    pub_type: 杂志文章


    authors: Davis JJ,Wattam AR,Aziz RK,Brettin T,Butler R,Butler RM,Chlenski P,Conrad N,Dickerman A,Dietrich EM,Gabbard JL,Gerdes S,Guard A,Kenyon RW,Machi D,Mao C,Murphy-Olson D,Nguyen M,Nordberg EK,Olsen GJ,Olson RD,Overb

    更新日期:2020-01-08 00:00:00