Antibody recognition of calcium-binding proteins depends on their calcium-binding status.

abstract：:The technique of intracerebral dialysis in combination with a sensitive and specific radioenzymatic method was used for recovery and quantification of endogenous extracellular acetylcholine from the striata of freely moving rats. A thin dialysis tube was inserted transversally through the caudate nuclei, and the tube ...

journal_title：Journal of neurochemistry

authors： Consolo S,Wu CF,Fiorentini F,Ladinsky H,Vezzani A

更新日期：1987-05-01 00:00:00

abstract：:Neurofibrillary tangles, one of the major pathological hallmarks of Alzheimer-diseased brains, consist primarily of aggregated paired helical filaments (PHFs) of hyperphosphorylated tau protein. Tau from normal brain and especially from foetal brain is also phosphorylated on some of the sites phosphorylated in PHFs, m...

journal_title：Journal of neurochemistry

authors： Reynolds CH,Nebreda AR,Gibb GM,Utton MA,Anderton BH

更新日期：1997-07-01 00:00:00

abstract：:In all the species examined thus far, the behavior of microglia during development appears to be highly stereotyped. This reproducibility supports the notion that these cells have a physiological role in development. Microglia are macrophages that migrate from the yolk sac and colonize the central nervous system early...

journal_title：Journal of neurochemistry

authors： Pont-Lezica L,Béchade C,Belarif-Cantaut Y,Pascual O,Bessis A

更新日期：2011-12-01 00:00:00

abstract：:Previous evidence has suggested that brain catecholamine levels are important in the regulation of central angiotensin II receptors. In the present study, the effects of norepinephrine and 3,4-dihydroxyphenylethylamine (dopamine) on angiotensin II receptor regulation in neuronal cultures from rat hypothalamus and brai...

journal_title：Journal of neurochemistry

authors： Sumners C,Watkins LL,Raizada MK

更新日期：1986-10-01 00:00:00

abstract：:We previously reported that nerve terminals and glial cells lack an active uptake system capable of terminating transmitter action of substance P (SP). In the present study, we demonstrated the existence of an active uptake system for SP carboxy-terminal heptapeptide, (5-11)SP. When the slices from either rat brain or...

journal_title：Journal of neurochemistry

authors： Nakata Y,Kusaka Y,Yajima H,Segawa T

更新日期：1981-12-01 00:00:00

abstract：:We have tested the hypothesis that exocytosis is a possible export route for calcium from bovine adrenal medullary cells. After prelabelling cells in primary tissue culture with 45Ca, evoked 45Ca export and catecholamine secretion show the same time course, a similar fraction of the total pool of 45Ca and catecholamin...

journal_title：Journal of neurochemistry

authors： von Grafenstein HR,Powis DA

更新日期：1989-08-01 00:00:00

abstract：:The regulation of glial and neuronal Na+-dependent glutamate/aspartate transporters is of interest because abnormal glutamate transport may be responsible for certain neurological diseases. Because expression of the Wnt-1 protooncogene results in induction of the glial-type glutamate transporter GLAST in PC12 neuron-l...

journal_title：Journal of neurochemistry

authors： Palos TP,Zheng S,Howard BD

更新日期：1999-09-01 00:00:00

abstract：:Neuronal nitric oxide synthase (nNOS) is a component of the dystrophin complex in skeletal muscle. The absence of dystrophin protein in Duchenne muscular dystrophy and in mdx mouse causes a redistribution of nNOS from the plasma membrane to the cytosol in muscle cells. Aberrant nNOS activity in the cytosol can induce ...

journal_title：Journal of neurochemistry

authors： Chao DS,Silvagno F,Bredt DS

更新日期：1998-08-01 00:00:00

abstract：:Young rats (21 days old) made nutritionally iron deficient, by feeding them a semisynthetic diet containing skimmed milk for 5 weeks, had significantly lowered hemoglobin levels (5.2 +/- 4 g/100 ml). The nonheme iron content in caudate nucleus was decreased by 47%. The behavioral response of iron-deficient rats to apo...

journal_title：Journal of neurochemistry

authors： Youdim MB,Sills MA,Heydorn WE,Creed GJ,Jacobowitz DM

更新日期：1986-09-01 00:00:00

abstract：:PEA-15 has recently been identified as a major phosphoprotein in astrocytes and an endogenous substrate for protein kinase C. This 15-kDa protein exists under three molecular forms, an unphosphorylated form, N, and two phosphorylated forms, Pa and Pb. Antisera were raised against synthetic peptides corresponding to th...

journal_title：Journal of neurochemistry

authors： Danziger N,Yokoyama M,Jay T,Cordier J,Glowinski J,Chneiweiss H

更新日期：1995-03-01 00:00:00

abstract：:Serotonin N-acetyltransferase, an enzyme of the pineal gland, converts serotonin to N-acetylserotonin. The activity of this enzyme is induced by norepinephrine in the evening to reach high levels during the dark phase. Delta-sleep-inducing peptide, a humoral sleep factor, also seems to affect circadian rhythms. Intrav...

journal_title：Journal of neurochemistry

authors： Graf MV,Kastin AJ,Schoenenberger GA

更新日期：1985-02-01 00:00:00

abstract：:Nigrostriatal neurodegeneration in Parkinson's disease (PD) has been postulated to be caused by various pathological conditions, such as mitochondrial defects, oxidative stress, and ubiquitin-proteasome system (UPS) dysfunction. Pharmacological strategies designed to interfere with these pathological pathways may effe...

journal_title：Journal of neurochemistry

authors： Zhu W,Xie W,Pan T,Jankovic J,Li J,Youdim MB,Le W

更新日期：2008-06-01 00:00:00

abstract：:Perhaps the most reproducible early event induced by the interaction of amyloid beta peptide (A beta) with the cell is the inhibition of cellular 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) reduction. We recently demonstrated that cytotoxic amyloid peptides such as A beta and human amylin inhibi...

journal_title：Journal of neurochemistry

authors： Liu Y,Schubert D

更新日期：1998-12-01 00:00:00

abstract：:It is generally accepted that in mammalian brain histamine is metabolized solely by histamine methyltransferase (HMT), to form tele-methylhistamine, then oxidized to tele-methylimidazoleacetic acid. However, histamine's oxidative metabolite in the periphery, imidazoleacetic acid (IAA), is also present in brain and CSF...

journal_title：Journal of neurochemistry

authors： Thomas B,Prell GD

更新日期：1995-08-01 00:00:00

abstract：:The molecular basis of neuroendocrine-specific expression of chromogranin B gene (Chgb) has remained elusive. Utilizing wild-type and mutant Chgb promoter/luciferase reporter constructs, this study established a crucial role for the cAMP response element (CRE) box at -102/-95 bp in endocrine [rat pheochromocytoma (chr...

journal_title：Journal of neurochemistry

authors： Mahapatra NR,Mahata M,Ghosh S,Gayen JR,O'Connor DT,Mahata SK

更新日期：2006-10-01 00:00:00

abstract：:3 alpha-Hydroxysteroid oxidoreductase (EC 1.1.1.50) was localized in the rat brain by cryostat sectioning, microassay, and neurochemical lesions. Single 16-microns sections were cut, homogenized, and assayed. In the olfactory tubercle 3 alpha-hydroxysteroid oxidoreductase activity is high in the piaglial layer at the ...

journal_title：Journal of neurochemistry

authors： Krieger NR,Scott RG

更新日期：1989-06-01 00:00:00

abstract：:Hippocampal neurons are affected by chronic stress and have a high density of cytoplasmic mineralocorticoid and glucocorticoid receptors (MR and GR). Detailed studies on the genomic effects of the stress hormone corticosterone at physiologically relevant concentrations on different steps in synaptic transmission are l...

journal_title：Journal of neurochemistry

authors： Chatterjee S,Sikdar SK

更新日期：2014-02-01 00:00:00

abstract：:By using two structurally unrelated hydrogen sulfide (H2 S) donors 5-(4-methoxyphenyl) -3H-1, 2-dithiole-3-thione (ADT) and sodium hydrosulfide (NaHS), this study investigated if H2 S protected blood-brain barrier (BBB) integrity following middle cerebral artery occlusion (MCAO). ICR mice underwent MCAO and received H...

journal_title：Journal of neurochemistry

authors： Wang Y,Jia J,Ao G,Hu L,Liu H,Xiao Y,Du H,Alkayed NJ,Liu CF,Cheng J

更新日期：2014-06-01 00:00:00

abstract：:In contrast with most other lipid substrates, in this article we show that liposomes prepared from the total myelin lipids exhibited a negligible proton permeability. Neither the generation of valinomycin-induced potassium diffusion potentials as high as -177 mV nor the imposition of large pH gradients (up to three un...

journal_title：Journal of neurochemistry

authors： Díaz RS,Monreal J

更新日期：1994-05-01 00:00:00

abstract：:D-serine is a co-agonist of NMDA receptor (NMDAR) and plays important roles in synaptic plasticity mechanisms. Serine racemase (SR) is a brain-enriched enzyme that converts L-serine to D-serine. SR interacts with the protein interacting with C-kinase 1 (PICK1), which is known to direct protein kinase C (PKC) to its ta...

journal_title：Journal of neurochemistry

authors： Vargas-Lopes C,Madeira C,Kahn SA,Albino do Couto I,Bado P,Houzel JC,De Miranda J,de Freitas MS,Ferreira ST,Panizzutti R

更新日期：2011-01-01 00:00:00

abstract：:The characteristics of spiperone inhibition of [3H]5-hydroxytryptamine [(3H]5-HT; [3H]serotonin) binding were examined in dorsal (DH) and ventral (VH) hippocampus, corpus striatum (CS) or caudate nucleus (CN), and frontal cortex (FC) in the rabbit, guinea pig, and cat. Some of the properties of spiperone inhibition of...

journal_title：Journal of neurochemistry

authors： Schnellmann RG,Waters SJ,Nelson DL

更新日期：1984-01-01 00:00:00

abstract：:Signaling by muscarinic agonists is thought to result from the activation of cell surface acetylcholine receptors (mAChRs) that transmit extracellular signals to intracellular systems. In N1E-115 neuroblastoma cells, we detected both plasma membrane and intracellular M(1) -mAChRs using both biochemical and pharmacolog...

journal_title：Journal of neurochemistry

authors： Uwada J,Anisuzzaman AS,Nishimune A,Yoshiki H,Muramatsu I

更新日期：2011-09-01 00:00:00

abstract：:The X11-like (X11L) protein was originally isolated as a protein bound to the cytoplasmic domain of the beta-amyloid precursor protein (APP), which is associated with Alzheimer's disease. In mammals, X11L is believed to play an important role in the regulation of APP metabolism. Here we isolated and characterized the ...

journal_title：Journal of neurochemistry

authors： Hase M,Yagi Y,Taru H,Tomita S,Sumioka A,Hori K,Miyamoto K,Sasamura T,Nakamura M,Matsuno K,Suzuki T

更新日期：2002-06-01 00:00:00

abstract：:The formation and refinement of synaptic connections are key steps of neural development to establish elaborate brain networks. To investigate the functional role of protein tyrosine phosphatase (PTP) σ, we employed an olfactory sensory neuron (OSN)-specific gene manipulation system in combination with in vivo imaging...

journal_title：Journal of neurochemistry

authors： Chen X,Yoshida T,Sagara H,Mikami Y,Mishina M

更新日期：2011-11-01 00:00:00

abstract：:The selective metabotropic glutamate receptor agonist trans-1-aminocyclopentane-1,3-dicarboxylic acid (trans-ACPD) stimulates phosphoinositide hydrolysis and elicits several physiological responses in rat hippocampal slices. However, recent studies suggest that the physiological effects of trans-ACPD in the hippocampu...

journal_title：Journal of neurochemistry

authors： Winder DG,Conn PJ

更新日期：1992-07-01 00:00:00

abstract：:In slices of young rat cerebellum, the glutamate analogue kainate induced a large accumulation of cyclic GMP, which was inhibited by non-N-methyl-D-aspartate antagonists. Quisqualate and alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionate evoked only small cyclic GMP responses and inhibited the effect of kainate. Whe...

journal_title：Journal of neurochemistry

authors： Garthwaite J,Southam E,Anderton M

更新日期：1989-12-01 00:00:00

abstract：:Although accumulating evidence demonstrates that white matter degeneration contributes to pathology in Alzheimer's disease (AD), the underlying mechanisms are unknown. In order to study the roles of the amyloid-beta peptide in inducing oxidative stress damage in white matter of AD, we investigated the effects of amylo...

journal_title：Journal of neurochemistry

authors： Zeng C,Lee JT,Chen H,Chen S,Hsu CY,Xu J

更新日期：2005-08-01 00:00:00

abstract：:Calcitonin gene-related peptide-like immunoreactivity (CGRP-LI) was measured in selected regions of the cervical, thoracic, and lumbar spinal cord of untreated rabbits and, following intrathecal injection of the serotonergic neurotoxin 5,7-dihydroxytryptamine (5,7-DHT), in the thoracolumbar cord in rats using a sheep ...

journal_title：Journal of neurochemistry

authors： Fone KC

更新日期：1992-10-01 00:00:00

abstract：:Adenosine transport by rat and guinea pig synaptosomes was studied to establish the basis for the marked differences in the potency of some transport inhibitors in these species. An analysis of transport kinetics in the presence and absence of nitrobenzylthioinosine (NBTI) using synaptosomes derived from several areas...

journal_title：Journal of neurochemistry

authors： Shank RP,Baldy WJ

更新日期：1990-08-01 00:00:00

abstract：:Alzheimer's disease (AD) is marked by the presence of neurofibrillary tangles and amyloid plaques in the brain of patients. To study plaque formation, we report on further quantitative and qualitative analysis of human and mouse amyloid beta peptides (Abeta) from brain extracts of transgenic mice overexpressing the Lo...

journal_title：Journal of neurochemistry

authors： Pype S,Moechars D,Dillen L,Mercken M

更新日期：2003-02-01 00:00:00