Antibody recognition of calcium-binding proteins depends on their calcium-binding status.

abstract：:A continuous enzyme-linked fluorometric assay was used for determining the characteristics for glutamate exocytosis from guinea-pig cerebrocortical synaptosomes. Ca2+-dependent release can be induced not only by K+, but also by the Na+ channel activator veratridine and the Ca2+ ionophore ionomycin. K+-induced release ...

journal_title：Journal of neurochemistry

authors： Sanchez-Prieto J,Sihra TS,Nicholls DG

更新日期：1987-07-01 00:00:00

abstract：:This review summarizes the latest advances that have been made to elucidate the somatostatinergic system in respect to somatostatin receptor evolution, the development of receptor agonists/antagonists, receptor regulation, signal transduction, effects on cell proliferation, receptor-receptor or receptor-protein intera...

journal_title：Journal of neurochemistry

authors： Olias G,Viollet C,Kusserow H,Epelbaum J,Meyerhof W

更新日期：2004-06-01 00:00:00

abstract：:The effect of depolarizing concentrations of potassium (56 mM) on the release of [3H]taurine was examined in two types of cultured neurons from mouse brain: cerebral cortex neurons, which are largely GABAergic, and cerebellar neurons, which after treatment with kainate consist almost entirely of glutamatergic granule ...

journal_title：Journal of neurochemistry

authors： Schousboe A,Pasantes-Morales H

更新日期：1989-10-01 00:00:00

abstract：:Ischemic postconditioning is increasingly being investigated as a therapeutic approach for cerebral ischemia. However, the majority of studies are focused on the acute protection of neurons per se. Whether and how postconditioning affects multiple cells in the recovering neurovascular unit remains to be fully elucidat...

journal_title：Journal of neurochemistry

authors： Esposito E,Hayakawa K,Ahn BJ,Chan SJ,Xing C,Liang AC,Kim KW,Arai K,Lo EH

更新日期：2018-07-01 00:00:00

abstract：:We have shown that following heat shock (42.5 degree C for 30 min), mouse-derived C1300 N2A neuroblastoma cells contain increased levels of mRNA coding for the inducible form of heat shock protein 70 and for ubiquitin. Incubation of C1300 cells with iron also induces an elevation in content of mRNAs coding for the sam...

journal_title：Journal of neurochemistry

authors： Uney JB,Anderton BH,Thomas SM

更新日期：1993-02-01 00:00:00

abstract：:Exposure of primary astrocyte cultures to isosmotic ethanol from 10-100 mM led to both swelling of the cells and release of [3H]taurine and D-[3H]aspartate. Exposure to hyperosmotic ethanol, in the same concentration range, caused neither swelling nor release. Release was inhibited by the anion transport blocker L-644...

journal_title：Journal of neurochemistry

authors： Kimelberg HK,Cheema M,O'Connor ER,Tong H,Goderie SK,Rossman PA

更新日期：1993-05-01 00:00:00

abstract：:Niemann Pick type C (NPC1) is a rare fatal hereditary cholesterol storage disease associated with a massive Purkinje cells loss. The mechanisms leading to neurodegeneration are still poorly understood. Different laboratories pointed to hypersensitivity to cytotoxic effects of statins (HMG-CoA reductase inhibitors) in ...

journal_title：Journal of neurochemistry

authors： Marschalek N,Albert F,Afshordel S,Meske V,Eckert GP,Ohm TG

更新日期：2015-04-01 00:00:00

abstract：:Several derivatives of conantokin-T (con-T), a naturally occurring, gamma-carboxyglutamate (Gla)-containing peptide with NMDA receptor (NMDAR) antagonist properties, were synthesized and evaluated for their ability to displace [(3)H]MK-801 from adult rat forebrain membranes. Analyses of progressive C-terminal truncati...

journal_title：Journal of neurochemistry

authors： Warder SE,Blandl T,Klein RC,Castellino FJ,Prorok M

更新日期：2001-05-01 00:00:00

abstract：:Transamination of the branched-chain amino acids produces glutamate and branched-chain alpha-ketoacids. The reaction is catalyzed by branched-chain aminotransferase (BCAT), of which there are cytosolic and mitochondrial isoforms (BCATc and BCATm). BCATc accounts for 70% of brain BCAT activity, and contributes at least...

journal_title：Journal of neurochemistry

authors： García-Espinosa MA,Wallin R,Hutson SM,Sweatt AJ

更新日期：2007-03-01 00:00:00

abstract：:The distributions of glutamate decarboxylase (EC 4.1.1.15), gamma-aminobutyric acid transaminase (EC 2.6.1.19), and succinate semialdehyde dehydrogenase (EC 1.2.1.24) were determined in monkey retina. The decarboxylase was almost restricted to the inner plexiform layer. The transaminase was also highest in this layer,...

journal_title：Journal of neurochemistry

authors： Pusateri ME,Carter JG,Berger SJ,Lowry OH

更新日期：1984-05-01 00:00:00

abstract：:Tanycytes are glial cells in the hypothalamus that are functionally part of the blood-brain barrier. They can sense nutrients and metabolites in the circulation such as glucose, then signal to neuronal systems to influence ingestive behaviour and energy storage, and ultimately affect body weight. The complex structure...

journal_title：Journal of neurochemistry

authors： Ebling FJP

更新日期：2020-11-09 00:00:00

abstract：:Light stimulates dopamine release in the retina and has been shown to rapidly up-regulate rod opsin mRNA. In the present study, we tested the effect of dopamine on rod opsin mRNA expression and examined the hypothesis that dopamine can mediate a light-evoked increase in opsin gene expression. Northern blots showed tha...

journal_title：Journal of neurochemistry

authors： Alfinito PD,Townes-Anderson E

更新日期：2001-02-01 00:00:00

abstract：:Kainate receptors (KARs) have been described as modulators of synaptic transmission at different synapses. However, this role of KARs has not been well characterized in the amygdala. We have explored the effect of kainate receptor activation at the synapse established between fibers originating at medial geniculate nu...

journal_title：Journal of neurochemistry

authors： Negrete-Díaz JV,Duque-Feria P,Andrade-Talavera Y,Carrión M,Flores G,Rodríguez-Moreno A

更新日期：2012-04-01 00:00:00

abstract：:Two GABAA receptor subunit-specific antibodies anti-alpha 6 and anti-alpha 1 have been used for elucidating the relationship between the presence of alpha 1 and/or alpha 6 subunits in the cerebellar GABAA receptors and the benzodiazepine-binding specificity. Receptor immunoprecipitation with the subunit-specific antib...

journal_title：Journal of neurochemistry

authors： Khan ZU,Gutiérrez A,De Blas AL

更新日期：1996-02-01 00:00:00

abstract：:Activation of microglia, the resident macrophages of the brain, around the amyloid plaques is a key hallmark of Alzheimer's disease (AD). Recent evidence in mouse models indicates that microglia are required for the neurodegenerative process of AD. Amyloid-β (Aβ) peptides, the core components of the amyloid plaques, c...

journal_title：Journal of neurochemistry

authors： Capiralla H,Vingtdeux V,Zhao H,Sankowski R,Al-Abed Y,Davies P,Marambaud P

更新日期：2012-02-01 00:00:00

abstract：:Much has been learned in recent years about the genetics of familial Parkinson's disease. However, far less is known about those malfunctioning genes which contribute to the emergence and/or progression of the vast majority of cases, the 'sporadic Parkinson's disease', which is the focus of our current review. Drastic...

journal_title：Journal of neurochemistry

authors： Benmoyal-Segal L,Soreq H

更新日期：2006-06-01 00:00:00

abstract：:Tau, a microtubule-associated protein, is encoded by a single gene, whose expression is primarily neuronal. In this work, we defined an 80-bp region of the tau promoter that confers tau protein with neuronal expression. This fragment works in conjunction with an endogenous initiation region to activate neuronal precur...

journal_title：Journal of neurochemistry

authors： Heicklen-Klein A,Ginzburg I

更新日期：2000-10-01 00:00:00

abstract：:Glial uptake of neurotransmitter glutamate (GLU) from the extracellular fluid was studied in vivo in rat brain by (13)C NMR and microdialysis combined with gas-chromatography/mass-spectrometry. Brain GLU C5 was (13)C enriched by intravenous [2,5-(13)C]glucose infusion, followed by [(12)C]glucose infusion to chase (13)...

journal_title：Journal of neurochemistry

authors： Kanamori K,Ross BD,Kondrat RW

更新日期：2002-11-01 00:00:00

abstract：:Ten-minute incubation with 1 mM S-nitroso-L-cysteine (NO-CYS), a nitric oxide (NO) generator, induced a 3.5-fold increase in the basal dopamine (DA) efflux from rat striatal slices. Reduced hemoglobin (100 microM), a NO scavenger, blocked this response. Nomifensine (10 microM), an inhibitor of high-affinity DA transpo...

journal_title：Journal of neurochemistry

authors： Lonart G,Johnson KM

更新日期：1994-12-01 00:00:00

abstract：:Poly A(+) messenger RNA (mRNA) was isolated from the brains of 3-week-old mice and translated in a cell-free system derived from wheat germ. Maximal stimulation of the system by brain mRNA was observed at a relatively low K+ concentration (45 mM) and low mRNA concentration (1-10 microgram/ml). The translational system...

journal_title：Journal of neurochemistry

authors： Matthees J,Campagnoni AT

更新日期：1980-10-01 00:00:00

abstract：:Galactosyltransferase activities were examined in the cerebellum, cerebral cortex, and brain stem of reeler and wild-type mice. Galactosyltransferase assays were optimal for all required substrates, linear with incubation time, and proportional to protein concentration. In brain areas affected by the reeler mutation (...

journal_title：Journal of neurochemistry

authors： Shur BD

更新日期：1982-07-01 00:00:00

abstract：:The effects of heat stress on protein synthesis and fast axonal transport were examined in an in vitro bullfrog primary afferent neuron preparation. The magnitude of effect was determined for individual [35S]methionine-labelled protein species separated via two-dimensional gel electrophoresis. Elevation of temperature...

journal_title：Journal of neurochemistry

authors： Stone GC,Dougher MM

更新日期：1988-09-01 00:00:00

abstract：:Reactive oxygen species are believed to play a crucial role in situations where dopamine neurons die, such as in Parkinson's disease or during intracerebral transplantation of embryonic mesencephalic tissue. The present study was designed to address the question whether, and to what extent, the glutathione redox syste...

journal_title：Journal of neurochemistry

authors： Grasbon-Frodl EM,Andersson A,Brundin P

更新日期：1996-10-01 00:00:00

abstract：:D-serine is a co-agonist of NMDA receptor (NMDAR) and plays important roles in synaptic plasticity mechanisms. Serine racemase (SR) is a brain-enriched enzyme that converts L-serine to D-serine. SR interacts with the protein interacting with C-kinase 1 (PICK1), which is known to direct protein kinase C (PKC) to its ta...

journal_title：Journal of neurochemistry

authors： Vargas-Lopes C,Madeira C,Kahn SA,Albino do Couto I,Bado P,Houzel JC,De Miranda J,de Freitas MS,Ferreira ST,Panizzutti R

更新日期：2011-01-01 00:00:00

abstract：:Microdialysis in the awake, freely moving rat was used to determine the effect of pyrithiamine-induced thiamine deficiency on the levels of amino acids in the brain. Studies were carried out on (a) presymptomatic animals immediately before the development of behavioral changes and (b) acute symptomatic animals within ...

journal_title：Journal of neurochemistry

authors： Hazell AS,Butterworth RF,Hakim AM

更新日期：1993-09-01 00:00:00

abstract：:Spinal muscular atrophy (SMA) is a motor neuron disease caused by loss of function mutations in the Survival Motor Neuron 1 (SMN1) gene and reduced expression of the SMN protein, leading to spinal motor neuron death, muscle weakness and atrophy. Although humans harbour the highly homologous SMN2 gene, its defective sp...

journal_title：Journal of neurochemistry

authors： Pagliarini V,Guerra M,Di Rosa V,Compagnucci C,Sette C

更新日期：2020-04-01 00:00:00

abstract：:Chick pineal glands in organ culture showed a circadian rhythm in the rate of thymidine incorporation. Thymidine incorporation was very markedly inhibited when 3-isobutyl-l-methylxanthine (IBMX) was continuously present. When IBMX was added to cultures in control medium during the photoperiod of the second day in cult...

journal_title：Journal of neurochemistry

authors： Wainwright SD,Wainwright LK

更新日期：1991-05-01 00:00:00

abstract：:Semaphorins are a family of secreted and membrane-associated proteins involved in growth cone guidance during development. Here, we describe the interaction of Semaphorin4F (Sema4F) with the post-synaptic density protein SAP90/PSD-95. Using the yeast two-hybrid system and coprecipitation assays we were able to show an...

journal_title：Journal of neurochemistry

authors： Schultze W,Eulenburg V,Lessmann V,Herrmann L,Dittmar T,Gundelfinger ED,Heumann R,Erdmann KS

更新日期：2001-08-01 00:00:00

abstract：:Trichloroethylene, a common industrial solvent and a metabolic precursor of chloral hydrate, occurs widely in the environment. Chloral hydrate, which is also used as a hypnotic, has been found to condense spontaneously with tryptamine, in vivo, to give rise to a highly unpolar 1-trichloromethyl-1,2,3,4-tetrahydro-beta...

journal_title：Journal of neurochemistry

authors： Akundi RS,Macho A,Muñoz E,Lieb K,Bringmann G,Clement HW,Hüll M,Fiebich BL

更新日期：2004-10-01 00:00:00

abstract：:Adult neurogenesis was first observed nearly 60 years ago, and it has since grown into an important neurochemistry research field. Much recent research has focused on the treatment of brain diseases through neuronal regeneration with endogenously generated neurons. In the adult brain, immature neurons called neuroblas...

journal_title：Journal of neurochemistry

authors： Kaneko N,Sawada M,Sawamoto K

更新日期：2017-06-01 00:00:00