Pre-embryo research.


:The subject is first identified in terms of the new understanding of a pre-embryonic phase preceding the traditional embryonic and fetal periods of formation and development. Sample fields and purposes of pre-embryonic research are instanced, some with direct therapeutic intent, others with foreseeable but not immediate clinical application. The ethics are discussed, first to answer the question, should it be done at all, and then, how it may be properly done.


J Assist Reprod Genet


Dunstan GR




Has Abstract


1995-09-01 00:00:00












  • Expression of cell cycle regulatory proteins (p53, pRb) in the human female genital tract.

    abstract:PURPOSE:Recent studies have shown that proliferation and differentiation of various cell types is regulated by cell-cycle-related proteins, such as protein p53 and retinoblastoma protein pRb. METHODS:Three monoclonal antibodies to p53 (PAb240, PAb421, and PAb1801) and 3H9 monoclonal antibody to pRb were utilized for l...

    journal_title:Journal of assisted reproduction and genetics

    pub_type: 杂志文章


    authors: Bukovsky A,Caudle MR,Keenan JA,Wimalasena J,Foster JS,Upadhyaya NB,van Meter SE

    更新日期:1995-02-01 00:00:00

  • Gender inequality in leadership and academic rank in academic reproductive endocrinology programs.

    abstract:PURPOSE:To identify gender differences in leadership and academic rank within academic reproductive endocrinology (REI) programs with fellowships in the USA. METHODS:Official institutional websites of the 2017-2018 American Board of Obstetrics and Gynecology (ABOG)-accredited reproductive endocrinology fellowship prog...

    journal_title:Journal of assisted reproduction and genetics

    pub_type: 杂志文章


    authors: Selter JH,Spurlin EE,Brady PC

    更新日期:2020-08-01 00:00:00

  • Follicular fluid hydrogen peroxide and lipid hydroperoxide in bovine antral follicles of various size, atresia, and dominance status.

    abstract:PURPOSE:To avoid inducing a state of oxidative stress (OS), assisted reproductive technologies (ART) must maintain a balance of reactive oxygen species (ROS) and antioxidants during the in vitro culture of oocytes. However, oocyte requirements and tolerance thresholds for ROS during in vivo development are still unclea...

    journal_title:Journal of assisted reproduction and genetics

    pub_type: 杂志文章


    authors: Hennet ML,Yu HY,Combelles CM

    更新日期:2013-03-01 00:00:00

  • Effects of supplement therapy on sperm parameters, protamine content and acrosomal integrity of varicocelectomized subjects.

    abstract:PURPOSE:Surgical repair of varicocele has long been a procedure to correct spermatogenesis. However, the outcome has been reported to be inadequate. We combined varicocelectomy with supplement therapy to evaluate the concurrent effect of these procedures. METHODS:A prospective randomized controlled study was undertake...

    journal_title:Journal of assisted reproduction and genetics

    pub_type: 杂志文章,随机对照试验


    authors: Azizollahi G,Azizollahi S,Babaei H,Kianinejad M,Baneshi MR,Nematollahi-mahani SN

    更新日期:2013-04-01 00:00:00

  • Performance comparison of two whole genome amplification techniques in frame of multifactor preimplantation genetic testing.

    abstract:PURPOSE:To compare multiple displacement amplification and OmniPlex whole genome amplification technique performance during array comparative genome hybridization (aCGH), Sanger sequencing, SNaPshot and fragment size analysis downstream applications in frame of multifactor embryo preimplantation genetic testing. METHO...

    journal_title:Journal of assisted reproduction and genetics

    pub_type: 杂志文章


    authors: Volozonoka L,Perminov D,Korņejeva L,Alkšere B,Novikova N,Pīmane EJ,Blumberga A,Kempa I,Miskova A,Gailīte L,Fodina V

    更新日期:2018-08-01 00:00:00

  • Deleterious mutation in SYCE1 is associated with non-obstructive azoospermia.

    abstract:PURPOSE:To determine the molecular basis of familial, autosomal-recessive, non-obstructive azoospermia in a consanguineous Iranian Jewish family. METHODS:We investigated the genetic cause of non-obstructive azoospermia in two affected siblings from a consanguineous family. Homozygosity mapping in the DNA samples of th...

    journal_title:Journal of assisted reproduction and genetics

    pub_type: 杂志文章


    authors: Maor-Sagie E,Cinnamon Y,Yaacov B,Shaag A,Goldsmidt H,Zenvirt S,Laufer N,Richler C,Frumkin A

    更新日期:2015-06-01 00:00:00

  • Pre-implantation developmental potential from in vivo and in vitro matured mouse oocytes: a cytoskeletal perspective on oocyte quality.

    abstract:PURPOSE:In the present study, fertilization and developmental potential of mouse oocytes matured in different conditions were tested. The efficiency of in vitro fertilization (IVF), pre-implantation development and some important aspects of cytokinesis during early cleavages are discussed. METHODS:In vivo matured (IVO...

    journal_title:Journal of assisted reproduction and genetics

    pub_type: 杂志文章


    authors: Sanfins A,Plancha CE,Albertini DF

    更新日期:2015-01-01 00:00:00

  • Isolated teratozoospermia and in vitro fertilization.

    abstract:PURPOSE:To show whether increased amounts of spermatozoa used in insemination of preovulatory oocytes in isolated teratozoospermia according to Kruger's strict criteria gives good fertilization rates. METHODS:This study was carried out from September 1993 to November 1994 for a total of 77 cycles, with sperm samples c...

    journal_title:Journal of assisted reproduction and genetics

    pub_type: 杂志文章


    authors: Figueiredo H,Tavares A,Ferrás L,Couceiro A,Chaves I

    更新日期:1996-01-01 00:00:00

  • Morphokinetic parameters from a time-lapse monitoring system cannot accurately predict the ploidy of embryos.

    abstract:PURPOSE:This study aimed to test whether there is an association between embryo morphokinetic parameters and ploidy status. METHODS:Patients with high risk of aneuploidy were analyzed by time-lapse microscopy combined with preimplantation genetic screening (PGS). Accordingly, 256 blastocysts from 75 patients were subj...

    journal_title:Journal of assisted reproduction and genetics

    pub_type: 杂志文章


    authors: Zhang J,Tao W,Liu H,Yu G,Li M,Ma S,Wu K

    更新日期:2017-09-01 00:00:00

  • Karyotype analysis in large-sample infertile couples living in Central China: a study of 14965 couples.

    abstract:OBJECTIVE:To explore that it is necessary to routinely detect chromosomes in fertile couples, we detected peripheral blood lymphocyte karyotype in 14965 infertile couples living in Central China and analyzed the incidence and type of chromosomal anomaly. METHODS:G-banding karyotype analysis of peripheral blood lymphoc...

    journal_title:Journal of assisted reproduction and genetics

    pub_type: 杂志文章


    authors: Liu Y,Kong XD,Wu QH,Li G,Song L,Sun YP

    更新日期:2013-04-01 00:00:00

  • Guidelines informing counseling on female age-related fertility decline: a systematic review.

    abstract:PURPOSE:To identify, appraise, and assess clinical practice guidelines informing patient counseling on female age-related fertility decline. METHODS:Searched electronic database records from January 1, 2006, to September 10, 2018, and professional society websites. The search terms included iterations of "guideline," ...

    journal_title:Journal of assisted reproduction and genetics

    pub_type: 杂志文章


    authors: Trawick E,Pecoriello J,Quinn G,Goldman KN

    更新日期:2021-01-01 00:00:00

  • A randomized prospective cross-over study of highly purified follicle-stimulating hormone and human menopausal gonadotrophin for ovarian hyperstimulation in women aged 37-41 years.

    abstract:PURPOSE:In the present study, we investigated the benefits of highly purified FSH (H.P. FSH) in comparison with human menopausal gonadotrophin (hMG) in IVF patients aged 37-41 years. METHODS:Twenty patients experienced within a period of four months both preparations in subsequent cycles through a prospective randomiz...

    journal_title:Journal of assisted reproduction and genetics

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Bassil S,Wyns C,Donnez J

    更新日期:2000-02-01 00:00:00

  • Effect of the site of assisted hatching on vitrified-warmed blastocyst transfer cycles: a prospective randomized study.

    abstract:PURPOSE:To assess the effect of assisted hatching (AH) site on the clinical outcomes in vitrified-warmed blastocyst transfer cycles. METHODS:A total of 160 women who underwent vitrified-warmed blastocyst transfer cycles were randomized to either the ICM group (AH performing at the site near the inner cell mess, ICM), ...

    journal_title:Journal of assisted reproduction and genetics

    pub_type: 杂志文章,随机对照试验


    authors: Ren X,Liu Q,Chen W,Zhu G,Zhang H

    更新日期:2013-06-01 00:00:00

  • Novel variants in women with premature ovarian function decline identified via whole-exome sequencing.

    abstract:PURPOSE:To investigate the potential etiologies of premature ovarian insufficiency (POI) and diminished ovarian reserve (DOR). METHODS:Fourteen women with sporadic POI and 6 women with DOR were enrolled. We used whole-exome sequencing (WES) and bioinformatics analysis to identify variants in a subset of 599 selected P...

    journal_title:Journal of assisted reproduction and genetics

    pub_type: 杂志文章


    authors: Tang R,Yu Q

    更新日期:2020-10-01 00:00:00

  • Female infertility, infertility-associated diagnoses, and comorbidities: a review.

    abstract:PURPOSE:The purpose of the study is to evaluate existing literature for possible associations between female infertility, infertility-associated diagnoses, and the following areas of disease: psychiatric disorders, breast cancer, ovarian cancer, endometrial cancer, cardiovascular disease, and metabolic dysfunction. ME...

    journal_title:Journal of assisted reproduction and genetics

    pub_type: 杂志文章,评审


    authors: Hanson B,Johnstone E,Dorais J,Silver B,Peterson CM,Hotaling J

    更新日期:2017-02-01 00:00:00

  • Development of vitrified-warmed mouse embryos co-cultured with polarized or non-polarized uterine epithelial cells using sequential culture media.

    abstract:PURPOSE:To our knowledge, little is known about the effect of polarized and non-polarized uterine epithelial cells on cryopreserved embryo growth. This study was, therefore, set up to investigate the effect of these monolayers together with sequential culture media on vitrified-warmed mouse embryos in terms of blastocy...

    journal_title:Journal of assisted reproduction and genetics

    pub_type: 杂志文章


    authors: Azadbakht M,Valojerdi MR

    更新日期:2008-06-01 00:00:00

  • Comparison of pregnancy outcomes after vitrification at the cleavage and blastocyst stage: a meta-analysis.

    abstract:OBJECTIVE:This systematic review sought to evaluate the clinical outcomes of vitrification at the cleavage stage and blastocyst stage for embryo transfer in patients undergoing assisted reproductive technology (ART) treatment. METHODS:We searched for related comparative studies published in the PubMed, EMBASE, and Coc...

    journal_title:Journal of assisted reproduction and genetics

    pub_type: 杂志文章,meta分析,评审


    authors: Zeng M,Su S,Li L

    更新日期:2018-01-01 00:00:00

  • Oxidative DNA damage impairs global sperm DNA methylation in infertile men.

    abstract:PURPOSE:Methylation of sperm DNA is impaired in many infertile men potentially adversely effecting reproductive outcomes. In somatic cells oxidative damage to DNA and hyperhomocysteinaemia are linked with DNA hypomethylation. The objective of this study was to investigate if these pathologies also impair sperm DNA meth...

    journal_title:Journal of assisted reproduction and genetics

    pub_type: 杂志文章


    authors: Tunc O,Tremellen K

    更新日期:2009-09-01 00:00:00

  • Editing the human genome: where ART and science intersect.

    abstract::The rapid development of gene-editing technologies has led to an exponential rise in both basic and translational research initiatives studying molecular processes and investigating possible clinical applications. Early experiments using genome editing to study human embryo development have contradicted findings in st...

    journal_title:Journal of assisted reproduction and genetics

    pub_type: 社论


    authors: Hershlag A,Bristow SL

    更新日期:2018-08-01 00:00:00

  • Serum progesterone concentrations on the day after human chorionic gonadotropin administration and progesterone/oocyte ratios predict in vitro fertilization/embryo transfer outcome.

    abstract:PURPOSE:In gonadotropin-releasing hormone analogue-pretreated in vitro fertilization-embryo transfer cycles, pregnancy rates are inversely related to serum progesterone levels on the day of administration of human chorionic gonadotropin. The relationship of the progesterone concentration on other days in the periovulat...

    journal_title:Journal of assisted reproduction and genetics

    pub_type: 临床试验,杂志文章


    authors: Burns WN,Witz CA,Klein NA,Silverberg KM,Schenken RS

    更新日期:1994-01-01 00:00:00

  • Mini-swim-up: a new technique of sperm preparation for intracytoplasmic sperm injection.

    abstract:PURPOSE:The male factor is nowadays one of the major problems in the treatment of infertility. New methods of assisted fertilization such as the intracytoplasmic sperm injection (ICSI) show better fertilization and pregnancy rates than classical IVF. METHOD:In this study, we present a new technique of sperm preparatio...

    journal_title:Journal of assisted reproduction and genetics

    pub_type: 杂志文章


    authors: Al Hasani S,Küpker W,Baschat AA,Sturm R,Bauer O,Diedrich C,Diedrich K

    更新日期:1995-08-01 00:00:00

  • Influence of post-thaw culture on the developmental potential of human frozen embryos.

    abstract:PURPOSE:Apart from freezing/thawing related cryodamage, several additional factors have been identified as major players in the reduction of success rates after frozen embryo transfers. The post-thaw culture is particularly relevant as it may amplify environmental influences over a stressed embryo. In the present study...

    journal_title:Journal of assisted reproduction and genetics

    pub_type: 杂志文章


    authors: Rato ML,Gouveia-Oliveira A,Plancha CE

    更新日期:2012-08-01 00:00:00

  • Combinational approach of retrospective clinical evidence and transcriptomics highlight AMH superiority to FSH, as successful ICSI outcome predictor.

    abstract:OBJECTIVE:Combination of transcriptomic and retrospective clinical data, to assess anti-Mullerian hormone (AMH) functionality at a cumulus cell level and evaluate AMH potential as a suitable marker for IVF outcomes (oocytes retrieved, number of day 3 embryos, gestation outcomes). DESIGN:Raw RNA-sequencing data of cumu...

    journal_title:Journal of assisted reproduction and genetics

    pub_type: 杂志文章


    authors: Kastora SL,Triantafyllidou O,Kolovos G,Kastoras A,Sigalos G,Vlahos N

    更新日期:2020-07-01 00:00:00

  • Serum progesterone levels greater than 20 ng/dl on day of embryo transfer are associated with lower live birth and higher pregnancy loss rates.

    abstract:BACKGROUND:Progesterone (P4) is essential for support of the endometrium and implantation of an embryo in the normal menstrual cycle. In programed frozen embryo transfer cycles using exogenous P4 is necessary, as the endogenous production of P4 requires a functioning corpus luteum that is not present in programed cycle...

    journal_title:Journal of assisted reproduction and genetics

    pub_type: 杂志文章


    authors: Kofinas JD,Blakemore J,McCulloh DH,Grifo J

    更新日期:2015-09-01 00:00:00

  • Serum leptin elevation in obese women with PCOs: a continuing controversy.

    abstract:PURPOSE:To evaluate leptin levels in a sample of obese women with PCOS and compare the results with obese and non-obese control, to be ultimately correlated with BMI, and insulin sensitivity. METHODS:Leptin and insulin assays by immuno-radiometric method, glucose assay by enzymatic colorimetric method. RESULTS:Leptin...

    journal_title:Journal of assisted reproduction and genetics

    pub_type: 杂志文章


    authors: Saleh HA,El-Nwaem MA,El-Bordiny MM,Maqlad HM,El-Mohandes AA,Eldaqaq EM

    更新日期:2004-10-01 00:00:00

  • Patient-centered communication, patient satisfaction, and retention in care in assisted reproductive technology visits.

    abstract:PURPOSE:To explore the association between patient-centered communication, patients' satisfaction, and retention in care in assisted reproductive technology (ART) visits. METHODS:ART visits at eight Italian clinics were videotaped and coded using the Roter Interaction Analysis System, which includes a Patient-Centered...

    journal_title:Journal of assisted reproduction and genetics

    pub_type: 杂志文章


    authors: Borghi L,Leone D,Poli S,Becattini C,Chelo E,Costa M,De Lauretis L,Ferraretti AP,Filippini C,Giuffrida G,Livi C,Luehwink A,Palermo R,Revelli A,Tomasi G,Tomei F,Vegni E

    更新日期:2019-06-01 00:00:00

  • Constitutional complex chromosomal rearrangements in a klinefelter patient: case report and review of literature.

    abstract:BACKGROUNDS:While XXY aneuploidy is the most common disorder of sex chromosomes in men, complex chromosomal rearrangements (CCRs) are rare in humans. CASE DESCRIPTION:Here we describe clinical and cytogenetic findings in a male referred to our cytogenetic laboratory by an infertility clinic. The patient's age was 35 a...

    journal_title:Journal of assisted reproduction and genetics

    pub_type: 杂志文章,评审


    authors: Mahjoubi F,Razazian F

    更新日期:2012-05-01 00:00:00

  • Endometrial preparation for in vitro oocyte maturation: early use of estrogen increases endometrial tissue and requires lower daily dosage: a cross over trial in 'mock' cycles.

    abstract:PURPOSE:Determine if estrogen used since the beginning of the menstrual flow could improve endometrial tissue compared to standard endometrial preparation for in vitro maturation cycles. METHODS:Twenty polycystic ovary syndrome women were submitted to two estrogen therapy schedules: standard schedule; estrogen began o...

    journal_title:Journal of assisted reproduction and genetics

    pub_type: 杂志文章,随机对照试验


    authors: Martins Wde P,dos Reis RM,Ferriani RA,de Araújo CH,Nastri CO,Filho FM

    更新日期:2006-05-01 00:00:00

  • Preimplantation genetic diagnosis of aneuploidy: were we looking at the wrong chromosomes?

    abstract:PURPOSE:Our purpose was to study aneuploidy frequencies of chromosomes 1, 4, 6, 7, 14, 15, 17, 18, and 22 in cleavage-stage embryos. These frequencies were compared to spontaneous abortion data to determine differences in survival rate of their aneuploidies. METHODS:One hundred ninety-four embryos were analyzed with m...

    journal_title:Journal of assisted reproduction and genetics

    pub_type: 杂志文章


    authors: Bahçe M,Cohen J,Munné S

    更新日期:1999-04-01 00:00:00

  • Genotyping single-sperm cells by universal MARSALA enables the acquisition of linkage information for combined pre-implantation genetic diagnosis and genome screening.

    abstract:PURPOSE:This paper aims to investigate the feasibility of performing pre-implantation genetic diagnosis (PGD) and pre-implantation genetic screening (PGS) simultaneously by a universal strategy without the requirement of genotyping relevant affected family members or lengthy preliminary work on linkage analysis. METHO...

    journal_title:Journal of assisted reproduction and genetics

    pub_type: 杂志文章


    authors: Wu H,Shen X,Huang L,Zeng Y,Gao Y,Shao L,Lu B,Zhong Y,Miao B,Xu Y,Wang Y,Li Y,Xiong L,Lu S,Xie XS,Zhou C

    更新日期:2018-06-01 00:00:00