Sequence analysis of the complete mitochondrial DNA molecule of the hedgehog, Erinaceus europaeus, and the phylogenetic position of the Lipotyphla.


:The sequence of the mitochondrial DNA (mtDNA) molecule of the European hedgehog (Erinaceus europaeus) was determined. The length of the sequence presented is 17,442 nucleotides (nt). The molecule is thus the largest eutherian mtDNA molecule so far reported. The organization of the molecule conforms with that of other eutherians, but the control region of the molecule is exceptionally long, 1,988 nt, due to the presence of repeated motifs at two different positions in the 3' part of the control region. The length of the control region is not absolute due to pronounced heteroplasmy caused by variable numbers of the motif TACGCA in one of the repetitive regions. The sequence presented includes 46 repeats of this type. The other repeated region is composed of different AT-rich repeats. This region was identical among four clones studied. Comparison of mitochondrial peptide-coding genes identified a separate position of the hedgehog among several mammalian orders. The concatenated protein sequence of the 13 peptide-coding genes was used in a phylogenetic study using the opossum as outgroup. The position of the hedgehog sequence was basal among the other eutherian sequences included: human, rat, mouse, cow, blue whale, harbor seal, and horse. The analysis did not resolve the relationship among carnivores, perissodactyls, and artiodactyls/cetaceans, suggesting a closer relationship among these orders than acknowledged by classical approaches.


J Mol Evol


Krettek A,Gullberg A,Arnason U




Has Abstract


1995-12-01 00:00:00












  • Looking for organization patterns of highly expressed genes: purine-pyrimidine composition of precursor mRNAs.

    abstract::We analyzed precursor messenger RNAs (pre-mRNAs) of 12 eukaryotic species. In each species, three groups of highly expressed genes, ribosomal proteins, heat shock proteins, and amino-acyl tRNA synthetases, were compared with a control group (randomly selected genes). The purine-pyrimidine (R-Y) composition of pre-mRNA...

    journal_title:Journal of molecular evolution

    pub_type: 杂志文章


    authors: Paz A,Mester D,Nevo E,Korol A

    更新日期:2007-02-01 00:00:00

  • Comparative analysis of evolution in a rodent histone H2a pseudogene.

    abstract::Sequences were obtained from five species of rodents that are orthologous to an H2a histone pseudogene from Mus musculus. The pseudogene is part of the cluster of replication-dependent histone genes found on Mus musculus chromosome 13. Comparative analysis of these five sequences together with the previously published...

    journal_title:Journal of molecular evolution

    pub_type: 杂志文章


    authors: DeBry RW

    更新日期:1998-03-01 00:00:00

  • Response regulators of bacterial signal transduction systems: selective domain shuffling during evolution.

    abstract::Response regulators of bacterial sensory transduction systems generally consist of receiver module domains covalently linked to effector domains. The effector domains include DNA binding and/or catalytic units that are regulated by sensor kinase-catalyzed aspartyl phosphorylation within their receiver modules. Most re...

    journal_title:Journal of molecular evolution

    pub_type: 杂志文章


    authors: Pao GM,Saier MH Jr

    更新日期:1995-02-01 00:00:00

  • Evolution of isozyme loci and their differential tissue expression. Creatine kinase as a model system.

    abstract::The phylogeny of the creatine kinase (CK, EC isozyme loci and their differential tissue expressions were determined for representatives of 65 families of vertebrates, with emphasis on the fishes. The transition from the single creatine kinase locus, characteristic of certain echinoderms, to the two creatine k...

    journal_title:Journal of molecular evolution

    pub_type: 杂志文章


    authors: Fisher SE,Whitt GS

    更新日期:1978-10-27 00:00:00

  • FLAVI: An Amino Acid Substitution Model for Flaviviruses.

    abstract::Amino acid substitution models represent substitution rates among amino acids during the evolution. The models play an important role in analyzing protein sequences, especially inferring phylogenies. The rapid evolution of flaviviruses is expanding the threat in public health. A number of models have been estimated fo...

    journal_title:Journal of molecular evolution

    pub_type: 杂志文章


    authors: Le TK,Vinh LS

    更新日期:2020-07-01 00:00:00

  • Evolution of the autosomal chorion cluster in Drosophila. IV. The Hawaiian Drosophila: rapid protein evolution and constancy in the rate of DNA divergence.

    abstract::Autosomal chorion genes s18, s15, and s19 are shown to diverge at extremely rapid rates in closely related taxa of Hawaiian Drosophila. Their nucleotide divergence rates are at least as fast as those of intergenic regions that are known to evolve more extensively between distantly related species. Their amino acid div...

    journal_title:Journal of molecular evolution

    pub_type: 杂志文章


    authors: Martínez-Cruzado JC

    更新日期:1990-11-01 00:00:00

  • Phylogenetic measurement in procaryotes by primary structural characterization.

    abstract::Oligonucleotide cataloguing has been used to characterize a number of 5S RNA species from various Procaryotes. Such catalogs can be used to establish certain and detailed phylogenetic relationships among organisms. Confining attention at present to four Families of Procaryotes, theEnterobacteriaceae, theBacillaceae, t...

    journal_title:Journal of molecular evolution

    pub_type: 杂志文章


    authors: Sogin SJ,Sogin ML,Woese CR

    更新日期:1972-06-01 00:00:00

  • Evolution of EF-hand calcium-modulated proteins. IV. Exon shuffling did not determine the domain compositions of EF-hand proteins.

    abstract::In the previous three reports in this series we demonstrated that the EF-hand family of proteins evolved by a complex pattern of gene duplication, transposition, and splicing. The dendrograms based on exon sequences are nearly identical to those based on protein sequences for troponin C, the essential light chain myos...

    journal_title:Journal of molecular evolution

    pub_type: 杂志文章


    authors: Kretsinger RH,Nakayama S

    更新日期:1993-05-01 00:00:00

  • Evolution of the "OR37" subfamily of olfactory receptors: a cross-species comparison.

    abstract::Genes encoding the olfactory receptors of the "OR37" subfamily of the mouse are characterized by special features including a clustered expression pattern, assembly in two distinct gene clusters, and highly conserved putative promoter motifs. Mining the rat and dog databases revealed that these two species possess hig...

    journal_title:Journal of molecular evolution

    pub_type: 杂志文章


    authors: Hoppe R,Lambert TD,Samollow PB,Breer H,Strotmann J

    更新日期:2006-04-01 00:00:00

  • Changes in the pattern of twisted gastrulation gene expression among Drosophila species.

    abstract::A long-standing hypothesis posits that morphological changes may be more likely to result from changes in regulation of gene expression than from changes in the protein coding sequences of genes. We have compared the expression pattern of the twisted gastrulation (tsg) gene among five Drosophila species: D. melanogast...

    journal_title:Journal of molecular evolution

    pub_type: 杂志文章


    authors: Mason ED,Marsh JL

    更新日期:1998-02-01 00:00:00

  • What can 18S rDNA do for bivalve phylogeny?

    abstract::Molecular characteristics, especially 18S rDNA sequences, may be of great value for the study of bivalve evolution and its numerous morphological convergencies once the reliability of these data can be evaluated. The analysis of 11 published complete molluscan sequences and two new ones, Arca noae and Atrina pectinata...

    journal_title:Journal of molecular evolution

    pub_type: 杂志文章


    authors: Steiner G,Müller M

    更新日期:1996-07-01 00:00:00

  • Elucidating the population histories and transmission dynamics of papillomaviruses using phylogenetic trees.

    abstract::Using gene genealogies constructed from gene sequence data, we show that both the mucosal and cutaneous papillomaviruses (PV)-supergroups A and B-appear to have been transmitted through susceptible populations faster than exponentially. The data and methods involved (1) examining the PV database for phylogenetic signa...

    journal_title:Journal of molecular evolution

    pub_type: 杂志文章


    authors: Ong CK,Nee S,Rambaut A,Bernard HU,Harvey PH

    更新日期:1997-02-01 00:00:00

  • Evolution of the vertebrate cytosolic malate dehydrogenase gene family: duplication and divergence in actinopterygian fish.

    abstract::A general correlation between neural expression and negative charge in isozymes suggests charge represents an adaptation to the neural environment. Interestingly, a notable exception exists in teleost fish. Two cytosolic malate dehydrogenase (MDH) isozymes have different spatial expression patterns in certain fishes: ...

    journal_title:Journal of molecular evolution

    pub_type: 杂志文章


    authors: Merrit TJ,Quattro M

    更新日期:2003-03-01 00:00:00

  • Phylogenetic analysis of 18S rRNA and the mitochondrial genomes of the wombat, Vombatus ursinus, and the spiny anteater, Tachyglossus aculeatus: increased support for the Marsupionta hypothesis.

    abstract::The monotremes, the duck-billed platypus and the echidnas, are characterized by a number of unique morphological characteristics, which have led to the common belief that they represent the living survivors of an ancestral stock of mammals. Analysis of new data from the complete mitochondrial (mt) genomes of a second ...

    journal_title:Journal of molecular evolution

    pub_type: 杂志文章


    authors: Janke A,Magnell O,Wieczorek G,Westerman M,Arnason U

    更新日期:2002-01-01 00:00:00

  • A tandem duplication of manganese superoxide dismutase in Nosema bombycis and its evolutionary origins.

    abstract::Microsporidia are a group of obligate intracellular eukaryotic parasites with small genomes. They infect animals from a wide variety of phyla, including humans. Two manganese superoxide dismutase (MnSOD) genes, designated NbMnSOD1 and NbMnSOD2, were found to be organized in a tandem array within the Nosema bombycis ge...

    journal_title:Journal of molecular evolution

    pub_type: 杂志文章


    authors: Xiang H,Pan G,Vossbrinck CR,Zhang R,Xu J,Li T,Zhou Z,Lu C,Xiang Z

    更新日期:2010-12-01 00:00:00

  • Evolution of spliceosomal snRNA genes in metazoan animals.

    abstract::While studies of the evolutionary histories of protein families are commonplace, little is known on noncoding RNAs beyond microRNAs and some snoRNAs. Here we investigate in detail the evolutionary history of the nine spliceosomal snRNA families (U1, U2, U4, U5, U6, U11, U12, U4atac, and U6atac) across the completely o...

    journal_title:Journal of molecular evolution

    pub_type: 杂志文章


    authors: Marz M,Kirsten T,Stadler PF

    更新日期:2008-12-01 00:00:00

  • ThiD-TenA: a gene pair fusion in eukaryotes.

    abstract::Computational analysis of the hypothetical open reading frame MJ0236 from Methanococcus jannaschii reveals its membership to a family of bacterial and eukaryotic proteins, predicted to be the HMP-P kinases involved in thiamin biosyntheis (ThiD). The eukaryotic members of this family contain a C-terminal extension simi...

    journal_title:Journal of molecular evolution

    pub_type: 信件


    authors: Ouzounis CA,Kyrpides NC

    更新日期:1997-12-01 00:00:00

  • The influence of historical geneflow, bathymetry and distribution patterns on the population genetics of morphologically diverse Galápagos' Opuntia echios.

    abstract::Throughout history, remote archipelagos have repeatedly been designated natural laboratories to study evolutionary processes. The extensive, geographically structured, morphological variation within Galápagos' Opuntia cacti has been presumed to be another example of how such processes shape diversity. However, recent ...

    journal_title:Journal of molecular evolution

    pub_type: 杂志文章


    authors: Helsen P,Verdyck P,Van Dongen S

    更新日期:2011-03-01 00:00:00

  • A test of amino acid reversibility.

    abstract::In studies of molecular evolution, the assumption that protein evolution is reversible has often been made, but rarely tested. Here we use a large set of orthologous murid protein coding sequences to perform a simple test of reversibility, and find no evidence to reject the assumption of reversibility in protein evolu...

    journal_title:Journal of molecular evolution

    pub_type: 杂志文章


    authors: Smith NG,Eyre-Walker A

    更新日期:2001-05-01 00:00:00

  • Reconstruction of cyclooxygenase evolution in animals suggests variable, lineage-specific duplications, and homologs with low sequence identity.

    abstract::Cyclooxygenase (COX) enzymatically converts arachidonic acid into prostaglandin G/H in animals and has importance during pregnancy, digestion, and other physiological functions in mammals. COX genes have mainly been described from vertebrates, where gene duplications are common, but few studies have examined COX in in...

    journal_title:Journal of molecular evolution

    pub_type: 杂志文章


    authors: Havird JC,Kocot KM,Brannock PM,Cannon JT,Waits DS,Weese DA,Santos SR,Halanych KM

    更新日期:2015-04-01 00:00:00

  • Group Selection May Explain Cancer Predisposition and Other Human Traits' Evolution.

    abstract::Group selection is a matter of acute controversy among evolutionary biologists. The most well-publicized debate in this regard is that between Edward O. Wilson and Richard Dawkins. As is widely known, Edward O. Wilson is very excited about the idea of social selection and eusociality; by contrast Richard Dawkins favor...

    journal_title:Journal of molecular evolution

    pub_type: 社论


    authors: Voskarides K

    更新日期:2018-04-01 00:00:00

  • Possible evolutionary relationships of the nitrogenase proteins.

    abstract::Comparisons of the amino acid compositions of the nitrogenase proteins from different organisms and their correlation with cross-reactivities and taxonomical data suggest an evolution within bacterial genomes rather than within plasmids. Comparisons of the amino acid compositions of nitrogenases and other ATP-ases sho...

    journal_title:Journal of molecular evolution

    pub_type: 杂志文章


    authors: Kleiner D,Littke W,Bender H,Wallenfels K

    更新日期:1976-03-29 00:00:00

  • Optimal design of feedback control by inhibition: dynamic considerations.

    abstract::The local stability of unbranched biosynthetic pathways is examined by mathematical analysis and computer simulation using a novel nonlinear formalism that appears to accurately describe biochemical systems. Four factors affecting the stability are examined: strength of feedback inhibition, equalization of the values...

    journal_title:Journal of molecular evolution

    pub_type: 杂志文章


    authors: Savageau MA

    更新日期:1975-08-05 00:00:00

  • On the evolution of protamines in bony fish: alternatives to the "retroviral horizontal transmission" hypothesis.

    abstract::Fish protamines are highly specialized molecules which are responsible for chromatin condensation during the last stages of spermatogenesis (spermiogenesis). However, not all fish contain protamines in their sperm nuclei; rather, there seems to be a random distribution of protamines within this group. The origin of th...

    journal_title:Journal of molecular evolution

    pub_type: 杂志文章


    authors: Saperas N,Ausio J,Lloris D,Chiva M

    更新日期:1994-09-01 00:00:00

  • Error in estimation of rate and time inferred from the early amniote fossil record and avian molecular clocks.

    abstract::The best reconstructions of the history of life will use both molecular time estimates and fossil data. Errors in molecular rate estimation typically are unaccounted for and no attempts have been made to quantify this uncertainty comprehensively. Here, focus is primarily on fossil calibration error because this error ...

    journal_title:Journal of molecular evolution

    pub_type: 杂志文章


    authors: van Tuinen M,Hadly EA

    更新日期:2004-08-01 00:00:00

  • Penguin evolution: protein comparisons demonstrate phylogenetic relationship to flying aquatic birds.

    abstract::Quantitative immunological comparisons of three avian proteins, transferrin, ovalbumin, and penalbumin, indicate that penguins are phylogenetically most closely related to loons, albatrosses, herons, and grebes. These data support the theory that the ancestors of penguins were flying oceanic birds and that flightlessn...

    journal_title:Journal of molecular evolution

    pub_type: 杂志文章


    authors: Ho CY,Prager EM,Wilson AC,Osuga DT,Feeney RE

    更新日期:1976-10-27 00:00:00

  • The evolution of long interspersed repeated DNA (L1, LINE 1) as revealed by the analysis of an ancient rodent L1 DNA family.

    abstract::All modern mammals contain a distinctive, highly repeated (> or = 50,000 members) family of long interspersed repeated DNA called the L1 (LINE 1) family. While the modern L1 families were derived from a common ancestor that predated the mammalian radiation approximately 80 million years ago, most of the members of the...

    journal_title:Journal of molecular evolution

    pub_type: 杂志文章


    authors: Pascale E,Liu C,Valle E,Usdin K,Furano AV

    更新日期:1993-01-01 00:00:00

  • Phylogeny of ultra-rapidly evolving dinoflagellate chloroplast genes: a possible common origin for sporozoan and dinoflagellate plastids.

    abstract::Complete chloroplast 23S rRNA and psbA genes from five peridinin-containing dinoflagellates (Heterocapsa pygmaea, Heterocapsa niei, Heterocapsa rotun-data, Amphidinium carterae, and Protoceratium reticulatum) were amplified by PCR and sequenced; partial sequences were obtained from Thoracosphaera heimii and Scrippsiel...

    journal_title:Journal of molecular evolution

    pub_type: 杂志文章


    authors: Zhang Z,Green BR,Cavalier-Smith T

    更新日期:2000-07-01 00:00:00

  • ApA dinucleotide periodicity in prokaryote, eukaryote, and organelle genomes.

    abstract::Computer analyses of various genome sequences revealed the existence of certain periodical patterns of adenine-adenine dinucleotides (ApA). For each genome sequence of 13 eubacteria, 3 archaebacteria, 10 eukaryotes, 60 mitochondria, and 9 chloroplasts, we counted frequencies of ApA dinucleotides at each downstream pos...

    journal_title:Journal of molecular evolution

    pub_type: 杂志文章


    authors: Tomita M,Wada M,Kawashima Y

    更新日期:1999-08-01 00:00:00

  • The extension reached by the minimization of the polarity distances during the evolution of the genetic code.

    abstract::The level reached by the optimization of the polarity distances during the evolution of the genetic code was investigated. The results, although not conclusive, indicate that this optimization level is higher than the data reported in the literature. The results seem compatible with the reaching of an evolutionary min...

    journal_title:Journal of molecular evolution

    pub_type: 杂志文章


    authors: Di Giulio M

    更新日期:1989-10-01 00:00:00