Sequence analysis of the complete mitochondrial DNA molecule of the hedgehog, Erinaceus europaeus, and the phylogenetic position of the Lipotyphla.


:The sequence of the mitochondrial DNA (mtDNA) molecule of the European hedgehog (Erinaceus europaeus) was determined. The length of the sequence presented is 17,442 nucleotides (nt). The molecule is thus the largest eutherian mtDNA molecule so far reported. The organization of the molecule conforms with that of other eutherians, but the control region of the molecule is exceptionally long, 1,988 nt, due to the presence of repeated motifs at two different positions in the 3' part of the control region. The length of the control region is not absolute due to pronounced heteroplasmy caused by variable numbers of the motif TACGCA in one of the repetitive regions. The sequence presented includes 46 repeats of this type. The other repeated region is composed of different AT-rich repeats. This region was identical among four clones studied. Comparison of mitochondrial peptide-coding genes identified a separate position of the hedgehog among several mammalian orders. The concatenated protein sequence of the 13 peptide-coding genes was used in a phylogenetic study using the opossum as outgroup. The position of the hedgehog sequence was basal among the other eutherian sequences included: human, rat, mouse, cow, blue whale, harbor seal, and horse. The analysis did not resolve the relationship among carnivores, perissodactyls, and artiodactyls/cetaceans, suggesting a closer relationship among these orders than acknowledged by classical approaches.


J Mol Evol


Krettek A,Gullberg A,Arnason U




Has Abstract


1995-12-01 00:00:00












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    abstract::The question of whether natural selection favors genetic stability or genetic variability is a fundamental problem in evolutionary biology. Bioinformatic analyses demonstrate that selection favors genetic stability by avoiding unstable nucleotide sequences in protein encoding DNA. Yet, such unstable sequences are main...

    journal_title:Journal of molecular evolution

    pub_type: 杂志文章


    authors: Falster DS,Nakken S,Bergem-Ohr M,Rødland EA,Breivik J

    更新日期:2010-03-01 00:00:00

  • Evaluating Neanderthal genetics and phylogeny.

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    journal_title:Journal of molecular evolution

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    authors: Hebsgaard MB,Wiuf C,Gilbert MT,Glenner H,Willerslev E

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  • Many independent origins of trans splicing of a plant mitochondrial group II intron.

    abstract::We examined the cis- vs. trans-splicing status of the mitochondrial group II intron nad1i728 in 439 species (427 genera) of land plants, using both Southern hybridization results (for 416 species) and intron sequence data from the literature. A total of 164 species (157 genera), all angiosperms, was found to have a tr...

    journal_title:Journal of molecular evolution

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    authors: Qiu YL,Palmer JD

    更新日期:2004-07-01 00:00:00

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    journal_title:Journal of molecular evolution

    pub_type: 杂志文章


    authors: Gatherer D,McEwan NR

    更新日期:2005-04-01 00:00:00

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    journal_title:Journal of molecular evolution

    pub_type: 杂志文章


    authors: Saperas N,Ausio J,Lloris D,Chiva M

    更新日期:1994-09-01 00:00:00

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    authors: Wang HC,Susko E,Spencer M,Roger AJ

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    pub_type: 杂志文章


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    journal_title:Journal of molecular evolution

    pub_type: 杂志文章


    authors: Jermiin LS,Graur D,Lowe RM,Crozier RH

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  • The molecular evolution of visual pigments of freshwater crayfishes (Decapoda: Cambaridae).

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  • The Evolutionary History of Human Skin Pigmentation.

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    journal_title:Journal of molecular evolution

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    authors: Kumazaki T,Hori H,Osawa S

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    journal_title:Journal of molecular evolution

    pub_type: 杂志文章


    authors: Felsenstein J

    更新日期:1987-01-01 00:00:00

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    journal_title:Journal of molecular evolution

    pub_type: 杂志文章


    authors: Vargas-Madrazo E,Lara-Ochoa F,Jiménez-Montaño M

    更新日期:1994-01-01 00:00:00