Abstract:
:The sequence of the mitochondrial DNA (mtDNA) molecule of the European hedgehog (Erinaceus europaeus) was determined. The length of the sequence presented is 17,442 nucleotides (nt). The molecule is thus the largest eutherian mtDNA molecule so far reported. The organization of the molecule conforms with that of other eutherians, but the control region of the molecule is exceptionally long, 1,988 nt, due to the presence of repeated motifs at two different positions in the 3' part of the control region. The length of the control region is not absolute due to pronounced heteroplasmy caused by variable numbers of the motif TACGCA in one of the repetitive regions. The sequence presented includes 46 repeats of this type. The other repeated region is composed of different AT-rich repeats. This region was identical among four clones studied. Comparison of mitochondrial peptide-coding genes identified a separate position of the hedgehog among several mammalian orders. The concatenated protein sequence of the 13 peptide-coding genes was used in a phylogenetic study using the opossum as outgroup. The position of the hedgehog sequence was basal among the other eutherian sequences included: human, rat, mouse, cow, blue whale, harbor seal, and horse. The analysis did not resolve the relationship among carnivores, perissodactyls, and artiodactyls/cetaceans, suggesting a closer relationship among these orders than acknowledged by classical approaches.
journal_name
J Mol Evoljournal_title
Journal of molecular evolutionauthors
Krettek A,Gullberg A,Arnason Udoi
10.1007/BF00173175subject
Has Abstractpub_date
1995-12-01 00:00:00pages
952-7issue
6eissn
0022-2844issn
1432-1432journal_volume
41pub_type
杂志文章abstract::The question of whether natural selection favors genetic stability or genetic variability is a fundamental problem in evolutionary biology. Bioinformatic analyses demonstrate that selection favors genetic stability by avoiding unstable nucleotide sequences in protein encoding DNA. Yet, such unstable sequences are main...
journal_title:Journal of molecular evolution
pub_type: 杂志文章
doi:10.1007/s00239-010-9328-0
更新日期:2010-03-01 00:00:00
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journal_title:Journal of molecular evolution
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journal_title:Journal of molecular evolution
pub_type: 杂志文章
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pub_type: 杂志文章
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更新日期:2005-04-01 00:00:00
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journal_title:Journal of molecular evolution
pub_type: 杂志文章
doi:10.1007/BF00160152
更新日期:1994-09-01 00:00:00
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journal_title:Journal of molecular evolution
pub_type: 杂志文章
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更新日期:2008-01-01 00:00:00
abstract::EcoRI restriction of the B. nigra rDNA recombinants, isolated from a lambda genomic library, showed that the 3.9-kb fragment corresponded to the Intergenic Spacer (IGS), which was sequenced and found to be 3,928 bp in size. Sequence and dot-matrix analyses showed that the organization of the B. nigra rDNA IGS was typi...
journal_title:Journal of molecular evolution
pub_type: 杂志文章
doi:10.1007/BF02337518
更新日期:1996-11-01 00:00:00
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journal_title:Journal of molecular evolution
pub_type: 杂志文章
doi:10.1007/BF00163805
更新日期:1994-08-01 00:00:00
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journal_title:Journal of molecular evolution
pub_type: 杂志文章
doi:10.1007/BF00160400
更新日期:1994-12-01 00:00:00
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journal_title:Journal of molecular evolution
pub_type: 杂志文章
doi:10.1007/BF02101752
更新日期:1987-01-01 00:00:00
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journal_title:Journal of molecular evolution
pub_type: 杂志文章
doi:10.1007/pl00006257
更新日期:1997-11-01 00:00:00
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journal_title:Journal of molecular evolution
pub_type: 杂志文章
doi:10.1007/s00239-004-0020-0
更新日期:2005-03-01 00:00:00
abstract::The human Rh blood group locus consists of two structurally related genes (D and CcEe) in Rh-positive haplotypes but a single gene (CcEe) in Rh-negative haplotypes. The genome of rhesus monkeys (Macaca mulatta), while not expressing any of the human Rh D, C, c, E, or e specificities, carries a Rh-like locus strongly r...
journal_title:Journal of molecular evolution
pub_type: 杂志文章
doi:10.1007/BF00166163
更新日期:1994-02-01 00:00:00
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journal_title:Journal of molecular evolution
pub_type: 杂志文章
doi:10.1007/s00239-004-0318-y
更新日期:2005-09-01 00:00:00
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journal_title:Journal of molecular evolution
pub_type: 杂志文章
doi:10.1007/s00239-008-9165-6
更新日期:2008-11-01 00:00:00
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journal_title:Journal of molecular evolution
pub_type: 杂志文章
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更新日期:1988-01-01 00:00:00
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journal_title:Journal of molecular evolution
pub_type: 杂志文章
doi:10.1007/s00239-006-0141-8
更新日期:2007-03-01 00:00:00
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journal_title:Journal of molecular evolution
pub_type: 杂志文章
doi:10.1007/s002399910042
更新日期:2000-04-01 00:00:00
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journal_title:Journal of molecular evolution
pub_type: 杂志文章
doi:10.1007/s002390010257
更新日期:2001-12-01 00:00:00
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journal_title:Journal of molecular evolution
pub_type: 杂志文章
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更新日期:1994-12-01 00:00:00
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journal_title:Journal of molecular evolution
pub_type: 杂志文章
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更新日期:1993-06-01 00:00:00
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journal_title:Journal of molecular evolution
pub_type: 杂志文章
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更新日期:1988-01-01 00:00:00
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journal_title:Journal of molecular evolution
pub_type: 杂志文章
doi:10.1007/BF01795752
更新日期:1981-01-01 00:00:00
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journal_title:Journal of molecular evolution
pub_type: 杂志文章
doi:10.1007/s00239-006-0048-4
更新日期:2006-12-01 00:00:00
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journal_title:Journal of molecular evolution
pub_type: 杂志文章,评审
doi:10.1007/s00239-019-09902-7
更新日期:2020-01-01 00:00:00
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journal_title:Journal of molecular evolution
pub_type: 杂志文章
doi:10.1007/BF00173421
更新日期:1994-11-01 00:00:00
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journal_title:Journal of molecular evolution
pub_type: 杂志文章
doi:10.1007/BF02099952
更新日期:1986-01-01 00:00:00
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journal_title:Journal of molecular evolution
pub_type: 杂志文章
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更新日期:1983-01-01 00:00:00
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journal_title:Journal of molecular evolution
pub_type: 杂志文章
doi:10.1007/BF02111286
更新日期:1987-01-01 00:00:00
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journal_title:Journal of molecular evolution
pub_type: 杂志文章
doi:10.1007/BF00175497
更新日期:1994-01-01 00:00:00