Clonal CD3+CD8+ large granular lymphocyte (LGL)/NK-associated (NKa) expansions: primary malignancies or secondary reactive phenomena?


:This study reports the clinical, haematological and immunophenotypic features of a series of 25 patients with clonal expansions of large granular lymphocytes (LGL)/NK-associated (NKa) cells. These showed a male predominance (16:9) with a median age of 67 (range 38-91) years; four had a documented history of rheumatoid arthritis, a further 18 had diverse clinical disorders, and the remaining three were clinically well. Mild anaemia was found in approximately half the patients and a lymphocytosis (seen in approximately 70% of the cases) was usually modest (< 10.0 x 10(9)/l). Neutropenia was the most frequently observed feature, and this was typically persistent in nature. Serum studies revealed few consistent features although positive rheumatoid factor and increased soluble CD8 levels were noted in 67% and 87% of those cases tested. Phenotypically, all cases were CD2+CD3+CD8+ and expressed membrane TCR alpha beta chains; most (17/22) were additionally CD5+ and (19/22) CD7+. The staining intensities of CD5 and CD7 antigens were however lower than that of normal CD4+ and CD8+ blood lymphocytes. Expression of NKa antigens was variable although 16/22 cases were CD16+CD56- and 19/22 were CD57+. Clonal CD3+CD8+ LGL/NKa expansions with a CD16+CD56+ composite phenotype were not seen in this patient series. Analyses of 'activation' antigens showed a consistent lack of CD25 expression by CD3+ cells, but increased CD3/Ia co-expression was found in a high proportion (19/25) of cases. Studies of CD45R isoform expression by CD8+ LGL/NKa cell fractions revealed a consistent CD45RA+RO- profile for all cases tested.(ABSTRACT TRUNCATED AT 250 WORDS)


Leuk Lymphoma


Leukemia & lymphoma


Richards SJ,Short M,Scott CS




Has Abstract


1995-04-01 00:00:00












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    journal_title:Leukemia & lymphoma

    pub_type: 杂志文章,评审


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    authors: Jevtovic-Stoimenov T,Kocic G,Pavlovic D,Macukanovic-Golubovic L,Marjanovic G,Djordjevic V,Tosić N,Pavlović S

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    journal_title:Leukemia & lymphoma

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    authors: Burke LP,Kukoly CA

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    journal_title:Leukemia & lymphoma

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    journal_title:Leukemia & lymphoma

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    authors: Lonial S,Arellano M,Hutcherson D,Langston A,Flowers C,Heffner LT,Winton E,Jo Lechowicz M,Waller EK

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    journal_title:Leukemia & lymphoma

    pub_type: 杂志文章,评审


    authors: Gholam D,Bibeau F,El Weshi A,Bosq J,Ribrag V

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    journal_title:Leukemia & lymphoma

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    authors: Pleyer C,Wiestner A,Sun C

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    journal_title:Leukemia & lymphoma

    pub_type: 杂志文章


    authors: Gover-Proaktor A,Granot G,Pasmanik-Chor M,Pasvolsky O,Shapira S,Raz O,Raanani P,Leader A

    更新日期:2019-01-01 00:00:00

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    journal_title:Leukemia & lymphoma

    pub_type: 杂志文章,评审


    authors: Garattini E,Gianni M

    更新日期:1996-11-01 00:00:00

  • Characterization of cancer comorbidity prior to allogeneic hematopoietic cell transplantation.

    abstract::Higher comorbidity by the hematopoietic cell transplantation-comorbidity index increases rates of non-relapse mortality (NRM) and impairs survival following allogeneic hematopoietic transplantation. We explored the effects of cancer as a comorbid condition prior to allogeneic transplantation. Among 356 adult transplan...

    journal_title:Leukemia & lymphoma

    pub_type: 杂志文章


    authors: D'Angelo CR,Novitsky B,Mee Lee S,Godley LA,Kline J,Larson RA,Liu H,Odenike O,Stock W,Bishop MR,Artz AS

    更新日期:2019-03-01 00:00:00

  • Primary and isolated anaplastic large cell lymphoma of the bone marrow.

    abstract::Anaplastic large cell lymphoma (ALCL) is a T-cell lymphoma in which the majority of patients present with advanced stage III or IV disease. Here we report a case of ALCL where bone marrow was the only site of disease, in a 60-year-old man with pyrexia and pancytopenia. The diagnosis of ALCL was made on detection of CD...

    journal_title:Leukemia & lymphoma

    pub_type: 杂志文章


    authors: Gudgin E,Rashbass J,Pulford KJ,Erber WN

    更新日期:2005-03-01 00:00:00