Distribution of the basic fibroblast growth factor and its receptor gene expression in normal and degenerated rat intervertebral discs.


STUDY DESIGN:Using a rat spondylosis model, the distributions of cells expressing the basic fibroblast growth factor and its receptor were investigated in normal and degenerated intervertebral discs. Cell-proliferating activity in degenerated discs was also assessed. OBJECTIVES:This study was conducted to determine whether basic fibroblast growth factor is related to intervertebral disc degeneration. SUMMARY OF BACKGROUND DATA:Basic fibroblast growth factor stimulates proliferation and matrix synthesis of cultured intervertebral disc cells. METHODS:Immunohistochemistry and in situ hybridization histochemistry were conducted to detect cells with basic fibroblast growth factor-like immunoreactivity and fibroblast growth factor receptor messenger RNA, respectively. Cell-proliferating activity was evaluated by AgNOR staining. RESULTS:In degenerated discs, round chondrocytes with basic fibroblast growth factor-like immunoreactivity and fibroblast growth factor receptor messenger RNA are scattered instead of spindle-shaped cells in the normal anulus (normal anular cells), which are devoid of basic fibroblast growth factor-like immunoreactivity and fibroblast growth factor receptor messenger RNA. The proliferating activity of these chondrocytes is suggested to exceed that of normal anular cells. CONCLUSION:Basic fibroblast growth factor is suggested to promote proliferation of chondrocytes in degenerated discs in an autocrine or paracrine manner. Basic fibroblast growth factor may be related to intervertebral disc degeneration as a proliferation-stimulating factor of chondrocytes that replace normal anular cells during disc degeneration.


Spine (Phila Pa 1976)




Nagano T,Yonenobu K,Miyamoto S,Tohyama M,Ono K




Has Abstract


1995-09-15 00:00:00














  • Long-term clinical outcomes following en bloc resections for sacral chordomas and chondrosarcomas: a series of twenty consecutive patients.

    abstract:STUDY DESIGN:Retrospective study of 20 consecutive patients who underwent en bloc tumor excision of sacral chordomas and chondrosarcomas. OBJECTIVE:To evaluate the functional and oncological outcomes following en bloc tumor excision for sacral chordomas and chondrosarcomas. SUMMARY OF BACKGROUND DATA:Chordomas and ch...


    pub_type: 杂志文章


    authors: Hsieh PC,Xu R,Sciubba DM,McGirt MJ,Nelson C,Witham TF,Wolinksy JP,Gokaslan ZL

    更新日期:2009-09-15 00:00:00

  • Inhibition of p21-Activated Kinase 1 by IPA-3 Promotes Locomotor Recovery After Spinal Cord Injury in Mice.

    abstract:STUDY DESIGN:Ninety-six male adult CD-1 mice were randomly divided into sham, spinal cord injury (SCI) + vehicle, and SCI + IPA-3 groups. Expression of matrix metalloproteinase (MMP)-2 and MMP-9, production of tumor necrosis factors (TNF)-α and interleukin (IL)-1β, tissue edema, blood-spinal cord barrier penetrability,...


    pub_type: 杂志文章


    authors: Ji X,Zhang Y,Zhang L,Chen H,Peng Y,Tang P

    更新日期:2016-06-01 00:00:00

  • Characterization of gait function in patients with postsurgical sagittal (flatback) deformity: a prospective study of 21 patients.

    abstract:STUDY DESIGN:This study prospectively analyzed gait in 21 patients with flatback and reviewed radiographs and charts. OBJECTIVE:To analyze the effect of sagittal imbalance on gait and hip and knee joints. SUMMARY OF BACKGROUND DATA:Loss of lumbar lordosis causes anterior displacement of the center of gravity, which c...


    pub_type: 临床试验,杂志文章


    authors: Sarwahi V,Boachie-Adjei O,Backus SI,Taira G

    更新日期:2002-11-01 00:00:00

  • The applied anatomy of the thoracolumbar fascia.

    abstract::The thoracolumbar fascia was studied by dissection in ten adult human cadavers. The posterior layer of this fascia was found to consist of two laminae. The superficial lamina is formed by the aponeurosis of latissimus dorsi. The deep lamina consists of bands of fibers passing caudolaterally from the midline. Both lami...


    pub_type: 杂志文章


    authors: Bogduk N,Macintosh JE

    更新日期:1984-03-01 00:00:00

  • Can the interpedicular distance reliably assess the severity of thoracolumbar burst fractures?

    abstract:STUDY DESIGN:Retrospective analysis of 260 patients with acute spine fractures treated at a tertiary trauma center from 1989 to 2009. OBJECTIVE:To correlate the Interpedicular distance (IPD) to the percentage of narrowing of the spinal canal and to the presence of neurological deficit and laminar fracture in thoracolu...


    pub_type: 杂志文章


    authors: Caffaro MF,Avanzi O

    更新日期:2012-02-15 00:00:00

  • Cell-based screening test for idiopathic scoliosis using cellular dielectric spectroscopy.

    abstract:STUDY DESIGN:A cell-based assay was developed to identify asymptomatic children at risk of developing idiopathic scoliosis (IS) and to stratify IS patients at an earlier stage in order to better predict their clinical outcome. Clinical validation of this assay was performed by testing IS patients at different stages, h...


    pub_type: 杂志文章


    authors: Akoume MY,Azeddine B,Turgeon I,Franco A,Labelle H,Poitras B,Rivard CH,Grimard G,Ouellet J,Parent S,Moreau A

    更新日期:2010-06-01 00:00:00

  • Dual Time-Point 18F-FDG PET/CT in Spinal Sarcoidosis: A Single Institution Case Series.

    abstract:STUDY DESIGN:A case series of dual time-point F-fluoro-2-deoxy-D-glucose positron emission tomography/computed tomography (F-FDG PET/CT) for the diagnosis of spinal cord sarcoidosis. OBJECTIVE:The aim of this study was to illustrate three cases of spinal sarcoidosis with occult presentation and subsequent identificati...


    pub_type: 杂志文章


    authors: Ordóñez-Rubiano EG,Solano-Noguera DF,Row W,Weinberg J,Tatsui CE,Johnson JM,Gule-Monroe MK

    更新日期:2019-11-01 00:00:00

  • Correction of thoracic adolescent idiopathic scoliosis with segmental hooks, rods, and Wisconsin wires posteriorly: it's bad and obsolete, correct?

    abstract:STUDY DESIGN:Forty-four consecutive thoracic idiopathic adolescent curves surgically treated between 1995 and 1999 at one institution were analyzed. All were thoracic curves; there were no lumbar curves, double major curves, or triple major curves. OBJECTIVES:To study the clinical and radiographic results for these 44...


    pub_type: 临床试验,杂志文章


    authors: Bridwell KH,Hanson DS,Rhee JM,Lenke LG,Baldus C,Blanke K

    更新日期:2002-09-15 00:00:00

  • Direct current electrical bone growth stimulation for spinal fusion.

    abstract::An electronic bone growth stimulator (EBGS) had been devised to facilitate lumbosacral fusion in the early 1970s, using a totally implanted device which delivers a steady 5 microA at each of four cathodes. The use of the device is reserved for patients in whom painful and abnormal motion is demonstrated to be the majo...


    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Kane WJ

    更新日期:1988-03-01 00:00:00

  • Spine update: the biopsychosocial model and spine care.

    abstract:STUDY DESIGN:Spine Update on the biopsychosocial model. OBJECTIVE:To review and discuss the strengths and weaknesses of the application of the model to spine care. SUMMARY OF BACKGROUND DATA:The biopsychosocial model of illness has had (and will continue to have) a significant impact on spine care. It has changed-in ...


    pub_type: 杂志文章


    authors: Weiner BK

    更新日期:2008-01-15 00:00:00

  • Evaluation of the flexion relaxation phenomenon of the trunk muscles in sitting.

    abstract:STUDY DESIGN:A normative, single-group study was conducted. OBJECTIVE:To investigate the flexion relaxation phenomenon in the thoraco-lumbopelvic muscles among a pain-free population when moving from an upright to a slump sitting posture. SUMMARY OF BACKGROUND DATA:The presence of the flexion relaxation phenomenon (F...


    pub_type: 杂志文章


    authors: O'Sullivan P,Dankaerts W,Burnett A,Chen D,Booth R,Carlsen C,Schultz A

    更新日期:2006-08-01 00:00:00

  • Seven-year follow-up of vertebral excision and reconstruction for malignant hemangioendothelioma of bone.

    abstract:STUDY DESIGN:This study reports the 7-year follow-up of an L5 vertebral hemangioendothelioma treated with tumor excision and allograft reconstruction stabilized with transpedicular fixation. OBJECTIVES:A review of vertebral hemangioendotheliomas is provided to outline the rationale for surgical excision in such cases....


    pub_type: 杂志文章,评审


    authors: Sybert DR,Steffee AD,Keppler L,Biscup RS,Enker P

    更新日期:1995-04-01 00:00:00

  • Preoperative and postoperative anesthetic and analgesic techniques for minimally invasive surgery of the spine.

    abstract:STUDY DESIGN:A review of methods to optimize anesthesia and analgesia for minimally invasive spine procedures. OBJECTIVE:To provide information to surgeons and anesthesiologists of methods to provide optimal anesthesia and pain control for minimally invasive spine surgery with an emphasis on preoperative planning. SU...


    pub_type: 杂志文章,评审


    authors: Buvanendran A,Thillainathan V

    更新日期:2010-12-15 00:00:00

  • Vertebral rotatory subluxation in degenerative scoliosis: facet joint tropism is related.

    abstract:STUDY DESIGN:A cross-sectional study. OBJECTIVE:To identify facet tropism as one of the possible risk factors leading to vertebral rotatory subluxation (VRS). SUMMARY OF BACKGROUND DATA:VRS has been considered as one of the prognostic factors for degenerative scoliosis. Although several risk factors of VRS, including...


    pub_type: 杂志文章


    authors: Bao H,Zhu F,Liu Z,Bentley M,Mao S,Zhu Z,Ding Y,Qiu Y

    更新日期:2014-12-15 00:00:00

  • Surgical treatment of vertebral osteomyelitis with recombinant human bone morphogenetic protein-2.

    abstract:STUDY DESIGN:A retrospective clinical study. OBJECTIVE:To evaluate the use of recombinant human bone morphogenetic protein-2 (rhBMP-2) as the primary graft material for the surgical treatment of vertebral osteomyelitis. SUMMARY OF BACKGROUND DATA:The clinical and radiographic results using allograft, autograft, and v...


    pub_type: 杂志文章,多中心研究


    authors: O'Shaughnessy BA,Kuklo TR,Ondra SL

    更新日期:2008-03-01 00:00:00

  • Factors predicting the result of surgery for lumbar intervertebral disc herniation.

    abstract::The prospective study was undertaken to find out preoperative or perioperative factors predicting the results of the first surgery for lumbar disc herniation. The results were evaluated 1 and 6 months postoperatively using, in addition to the patient evaluation, indices for pain, activities of daily living (ADL), and ...


    pub_type: 杂志文章


    authors: Hurme M,Alaranta H

    更新日期:1987-11-01 00:00:00

  • Three-dimensional movements of the whole lumbar spine and lumbosacral joint.

    abstract::Knowledge of the normal movements of whole lumbar spine and lumbosacral joint is important for evaluating clinical pathologic conditions that may potentially produce unstable situations in these regions. At present there are few studies that report systemic three-dimensional movement analysis of these regions. The pur...


    pub_type: 杂志文章


    authors: Yamamoto I,Panjabi MM,Crisco T,Oxland T

    更新日期:1989-11-01 00:00:00

  • Facet Sagittal Orientation: Possible Role in the Pathology of Degenerative Lumbar Spinal Stenosis.

    abstract:STUDY DESIGN:A retrospective case-control study. OBJECTIVE:This study aimed to elucidate the association between facet joint orientation and degenerative lumbar spinal stenosis (DLSS). SUMMARY OF BACKGROUND DATA:Many studies have demonstrated the relationship between sagittal facet orientation and degenerative lumbar...


    pub_type: 杂志文章


    authors: Liu X,Zhao X,Long Y,Huang K,Xie D,Wang F,Chen G,Yuan Z,Wang J

    更新日期:2018-07-15 00:00:00

  • Accuracy and interobserver agreement for determinations of rabbit posterolateral spinal fusion.

    abstract:STUDY DESIGN:The accuracy and interobserver agreement of fine detail radiography and computed tomography (CT) determination of spinal fusion were evaluated in an established animal spine fusion model. OBJECTIVE:To determine the accuracy and interobserver agreement of radiographic determinations of spinal fusion in rab...


    pub_type: 杂志文章


    authors: Yee AJ,Bae HW,Friess D,Robbin M,Johnstone B,Yoo JU

    更新日期:2004-06-15 00:00:00

  • Patients with adult spinal deformity treated operatively report greater baseline pain and disability than patients treated nonoperatively; however, deformities differ between age groups.

    abstract:STUDY DESIGN:Multicenter, prospective analysis of consecutive patients with adult spinal deformity (ASD). OBJECTIVE:Identify age-related radiographical parameters associated with poor health-related quality of life (HRQOL) and treatment preferences for ASD. SUMMARY OF BACKGROUND DATA:Patients with ASD report discrepa...


    pub_type: 杂志文章


    authors: Fu KM,Bess S,Shaffrey CI,Smith JS,Lafage V,Schwab F,Burton DC,Akbarnia BA,Ames CP,Boachie-Adjei O,Deverin V,Hart RA,Hostin R,Klineberg E,Gupta M,Kebaish K,Mundis G,Mummaneni PV,International Spine Study Group.

    更新日期:2014-08-01 00:00:00

  • Molecular interactions between human cartilaginous endplates and nucleus pulposus cells: a preliminary investigation.

    abstract:STUDY DESIGN:Conditioned media (CM) of cartilaginous endplates (CEPs) of intervertebral discs were analyzed in a bioassay with regard to their influence on matrix turnover and inflammatory factors on nucleus pulposus (NP) cells of the same patient. CEP tissue underwent further histological and ultrastructural analysis....


    pub_type: 杂志文章


    authors: Neidlinger-Wilke C,Boldt A,Brochhausen C,Galbusera F,Carstens C,Copf F,Schultheiss M,Lazary A,Brayda-Bruno M,Ignatius A,Wilke HJ

    更新日期:2014-08-01 00:00:00

  • Acute axis fractures. Analysis of management and outcome in 340 consecutive cases.

    abstract:STUDY DESIGN:Retrospective review of acute axis fractures treated at a tertiary referral center. OBJECTIVE:To determine the optimal treatment of axis fractures based on 340 cases from a single institution. SUMMARY OF BACKGROUND DATA:Axis fractures account for almost 20% of acute cervical spine fractures. However, the...


    pub_type: 杂志文章


    authors: Greene KA,Dickman CA,Marciano FF,Drabier JB,Hadley MN,Sonntag VK

    更新日期:1997-08-15 00:00:00

  • Back surface curvature and measurement of lumbar spinal motion.

    abstract::Lumbar spinal flexion and extension motion was measured radiographically and from the back surface curvature in 42 patients with low-back pain to determine whether the surface measurements provided accurate measurement of the total lumbar spinal motion and its distribution by vertebral level. Also, a biomechanical mod...


    pub_type: 杂志文章


    authors: Stokes IA,Bevins TM,Lunn RA

    更新日期:1987-05-01 00:00:00

  • Late operative site pain with isola posterior instrumentation requiring implant removal: infection or metal reaction?

    abstract:OBJECTIVES:To elucidate the cause of late operative site pain in six cases of scoliosis managed with Isola posterior instrumentation that required removal of the implants. METHOD:Microbiologic examination of wound swabs and enriched culture of operative tissue specimens was undertaken in all cases. Histologic study of...


    pub_type: 杂志文章


    authors: Gaine WJ,Andrew SM,Chadwick P,Cooke E,Williamson JB

    更新日期:2001-03-01 00:00:00

  • Primary solitary cervical amyloidosis: case report and review of the literature.

    abstract:STUDY DESIGN:A case report and literature review are presented. OBJECTIVE:To describe and review the clinical presentations, characteristic findings from imaging studies, types, differential diagnosis, prognosis, and treatment of amyloidoma arising within the vertebrae. SUMMARY OF BACKGROUND DATA:Amyloidoma can occur...


    pub_type: 杂志文章,评审


    authors: Iplikcioglu AC,Bek S,Gokduman CA,Cosar M,Sav A

    更新日期:2007-01-01 00:00:00

  • Postlaminectomy kyphosis in the skeletally immature achondroplast.

    abstract:STUDY DESIGN:Retrospective review. OBJECTIVES:To determine the risk of postlaminectomy thoracolumbar kyphosis in skeletally immature achondroplasts and evaluate the need for concurrent fusion at multilevel decompression. SUMMARY OF BACKGROUND DATA:Spinal stenosis is a relatively common complication of achondroplasia....


    pub_type: 杂志文章


    authors: Ain MC,Shirley ED,Pirouzmanesh A,Hariri A,Carson BS

    更新日期:2006-01-15 00:00:00

  • Patients with neck pain demonstrate reduced electromyographic activity of the deep cervical flexor muscles during performance of the craniocervical flexion test.

    abstract:STUDY DESIGN:Cross-sectional study. OBJECTIVE:The present study compared activity of deep and superficial cervical flexor muscles and craniocervical flexion range of motion during a test of craniocervical flexion between 10 patients with chronic neck pain and 10 controls. SUMMARY OF BACKGROUND DATA:Individuals with c...


    pub_type: 杂志文章


    authors: Falla DL,Jull GA,Hodges PW

    更新日期:2004-10-01 00:00:00

  • Increased expression of vascular endothelial growth factor protein in dorsal root ganglion exposed to nucleus pulposus on the nerve root in rats.

    abstract:STUDY DESIGN:An experimental rat study. OBJECTIVE:To assess pain-related behavior and vascular endothelial growth factor (VEGF) expression induced by nucleus pulposus (NP) applied to nerve roots in rats. SUMMARY OF BACKGROUND DATA:Radiculopathy from disc herniation is caused by nerve compression and chemical inflamma...


    pub_type: 杂志文章


    authors: Miyoshi S,Sekiguchi M,Konno S,Kikuchi S,Kanaya F

    更新日期:2011-01-01 00:00:00

  • The role of steroids and their effects on phospholipase A2. An animal model of radiculopathy.

    abstract:STUDY DESIGN:The possible role of phospholipase A2 in an animal model for lumbar radiculopathy and mechanisms of epidural steroid injections were studied. OBJECTIVES:To clarify the pathophysiologic mechanism of the recently proved animal model for lumbar radiculopathy and to characterize further the mechanisms of acti...


    pub_type: 杂志文章


    authors: Lee HM,Weinstein JN,Meller ST,Hayashi N,Spratt KF,Gebhart GF

    更新日期:1998-06-01 00:00:00

  • Correlations of spinal mobility with degree of chronic low back pain after correction for age and anthropometric factors.

    abstract::Correlations of age, height, weight, lordosis, and kyphosis with noninvasive spinal mobility measurements were studied in 301 men and 175 women, aged 35-55 years, who suffered from chronic or recurrent low back pain (LBP). Correlations of the different spinal movements with the degree of LBP were analyzed, with correc...


    pub_type: 杂志文章


    authors: Mellin G

    更新日期:1987-06-01 00:00:00