Distribution of the basic fibroblast growth factor and its receptor gene expression in normal and degenerated rat intervertebral discs.


STUDY DESIGN:Using a rat spondylosis model, the distributions of cells expressing the basic fibroblast growth factor and its receptor were investigated in normal and degenerated intervertebral discs. Cell-proliferating activity in degenerated discs was also assessed. OBJECTIVES:This study was conducted to determine whether basic fibroblast growth factor is related to intervertebral disc degeneration. SUMMARY OF BACKGROUND DATA:Basic fibroblast growth factor stimulates proliferation and matrix synthesis of cultured intervertebral disc cells. METHODS:Immunohistochemistry and in situ hybridization histochemistry were conducted to detect cells with basic fibroblast growth factor-like immunoreactivity and fibroblast growth factor receptor messenger RNA, respectively. Cell-proliferating activity was evaluated by AgNOR staining. RESULTS:In degenerated discs, round chondrocytes with basic fibroblast growth factor-like immunoreactivity and fibroblast growth factor receptor messenger RNA are scattered instead of spindle-shaped cells in the normal anulus (normal anular cells), which are devoid of basic fibroblast growth factor-like immunoreactivity and fibroblast growth factor receptor messenger RNA. The proliferating activity of these chondrocytes is suggested to exceed that of normal anular cells. CONCLUSION:Basic fibroblast growth factor is suggested to promote proliferation of chondrocytes in degenerated discs in an autocrine or paracrine manner. Basic fibroblast growth factor may be related to intervertebral disc degeneration as a proliferation-stimulating factor of chondrocytes that replace normal anular cells during disc degeneration.


Spine (Phila Pa 1976)




Nagano T,Yonenobu K,Miyamoto S,Tohyama M,Ono K




Has Abstract


1995-09-15 00:00:00














  • Index level mobility after total lumbar disc replacement: is it beneficial or detrimental?

    abstract:STUDY DESIGN:Analysis of segmental and total lumbar range of motion (ROM) before and after total lumbar disc replacement. OBJECTIVE:To examine the relationship between absolute segmental and total lumbar ROM and evolution of ROM on clinical outcome. SUMMARY OF BACKGROUND DATA:At the moment, data are scarce with regar...


    pub_type: 杂志文章


    authors: Cakir B,Schmidt R,Mattes T,Fraitzl CR,Reichel H,Käfer W

    更新日期:2009-04-20 00:00:00

  • Direct current electrical bone growth stimulation for spinal fusion.

    abstract::An electronic bone growth stimulator (EBGS) had been devised to facilitate lumbosacral fusion in the early 1970s, using a totally implanted device which delivers a steady 5 microA at each of four cathodes. The use of the device is reserved for patients in whom painful and abnormal motion is demonstrated to be the majo...


    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Kane WJ

    更新日期:1988-03-01 00:00:00

  • Zebris versus Myrin: a comparative study between a three-dimensional ultrasound movement analysis and an inclinometer/compass method: intradevice reliability, concurrent validity, intertester comparison, intratester reliability, and intraindividual variab

    abstract:STUDY DESIGN:Experimental study. OBJECTIVES:To compare two devices for measuring cervical range of motion, a three-dimensional ultrasound motion device (Zebris) and a gravity-reference goniometer (Myrin). SUMMARY OF BACKGROUND DATA:Assessment of cervical range of motion is used to evaluate the effect of different tre...


    pub_type: 杂志文章


    authors: Malmström EM,Karlberg M,Melander A,Magnusson M

    更新日期:2003-11-01 00:00:00

  • Discography and magnetic resonance imaging in the diagnosis of lumbar disc disruption.

    abstract::Four cases of patients with normal magnetic resonance (MR) studies of the lumbar spine and abnormal discography are presented to illustrate that normal lumbar disc signal intensity does not necessarily rule out disc degeneration. ...


    pub_type: 杂志文章


    authors: Kornberg M

    更新日期:1989-12-01 00:00:00

  • Spine update. Degenerative lumbar spondylolisthesis.

    abstract::Degenerative lumbar spondylolisthesis associated with spinal stenosis is a common condition of the aging spine. This article presents a detailed description of the pathophysiology, clinical presentation, and nonoperative and operative intervention of this condition. ...


    pub_type: 杂志文章,评审


    authors: Herkowitz HN

    更新日期:1995-05-01 00:00:00

  • Pseudo-aneurysm of a lumbar artery after flexion-distraction injury of the thoraco-lumbar spine and surgical realignment: rupture treated by endovascular embolization.

    abstract:STUDY DESIGN:A unique case of pseudo-aneurysm of a lumbar artery after injury of the thoracolumbar spine was presented. OBJECTIVE:To describe the exceptional occurrence of pseudo-aneurysm of a lumbar artery after flexion-distraction fracture of thoracolumbar junction and to discuss the mechanism of formation and the t...


    pub_type: 杂志文章


    authors: Domenicucci M,Ramieri A,Lenzi J,Fontana E,Martini S

    更新日期:2008-02-01 00:00:00

  • Efficacy of percutaneous vertebroplasty in the treatment of intravertebral pseudarthrosis associated with noninfected avascular necrosis of the vertebral body.

    abstract:STUDY DESIGN:A retrospective clinical study on the effect of percutaneous vertebroplasty (PVP) in the treatment of intravertebral pseudarthrosis caused by avascular necrosis of a vertebral body. OBJECTIVES:To evaluate the efficacy of PVP in the treatment of spinal instability associated with avascular necrosis. SUMMA...


    pub_type: 杂志文章


    authors: Jang JS,Kim DY,Lee SH

    更新日期:2003-07-15 00:00:00

  • Spondylothoracic dysplasia. A report of ten cases with follow-up.

    abstract::Details of ten new cases of spondylothoracic dysplasia (the Jarcho-Levin syndrome) are presented. During follow-up, lasting between 8 and 21 years, two children in this group died. Our observations did not confirm Heilbronner's theory concerning the existence of two distinctive types of this syndrome: Type 1 or fatal,...


    pub_type: 杂志文章


    authors: Herold HZ,Edlitz M,Baruchin A

    更新日期:1988-05-01 00:00:00

  • Spinal manipulation for low back pain. An updated systematic review of randomized clinical trials.

    abstract:STUDY DESIGN:Systematic review of randomized clinical trials. OBJECTIVES:To assess the efficacy of spinal manipulation for patients with low back pain. SUMMARY OF BACKGROUND DATA:The management of low back pain remains controversial. Spinal manipulation is a widely used treatment option for low back pain. Recently is...


    pub_type: 杂志文章,评审


    authors: Koes BW,Assendelft WJ,van der Heijden GJ,Bouter LM

    更新日期:1996-12-15 00:00:00

  • Global Spinal Alignment in Patients With Cervical Spondylotic Myelopathy.

    abstract:STUDY DESIGN:A prospective radiographic analysis of cervical spondylotic myelopathy (CSM). OBJECTIVE:The aim of this study was to clarify the pathophysiology of CSM, and use the characteristic of global spinal alignment for determining the surgical strategy. SUMMARY OF BACKGROUND DATA:Radiographic evaluation of CSM, ...


    pub_type: 杂志文章


    authors: Yoshida G,Alzakri A,Pointillart V,Boissiere L,Obeid I,Matsuyama Y,Vital JM,Gille O

    更新日期:2018-02-01 00:00:00

  • The magnitude of mechanical allodynia in a rodent model of lumbar radiculopathy is dependent on strain and sex.

    abstract:STUDY DESIGN:This study examined the differences in tactile hypersensitivity across 6 different strains of male mice, and between male and female rats of 3 different strains in a rodent model of low back pain associated with lumbar radiculopathy. OBJECTIVE:We investigated the possibility that differences in tactile al...


    pub_type: 杂志文章


    authors: LaCroix-Fralish ML,Rutkowski MD,Weinstein JN,Mogil JS,Deleo JA

    更新日期:2005-08-15 00:00:00

  • Five-year results from chemonucleolysis with chymopapain or collagenase: a prospective randomized study.

    abstract:STUDY DESIGN:A 5-year clinical follow-up assessment of a prospective randomized study of chemonucleolysis using chymopapain (4000 IU) or collagenase (400 ABC units) was performed. SUMMARY OF BACKGROUND DATA:Intradiscal therapy can be performed for patients with contained discs by chemonucleolysis, percutaneous discect...


    pub_type: 杂志文章


    authors: Wittenberg RH,Oppel S,Rubenthaler FA,Steffen R

    更新日期:2001-09-01 00:00:00

  • Sagittal alignment of the cervical spine after the laminoplasty.

    abstract:STUDY DESIGN:Prospective study. OBJECTIVE:To identify the impact of laminoplasty on range of motion (ROM) and sagittal alignment of the cervical spine. SUMMARY OF BACKGROUND DATA:Cervical laminoplasty is an effective procedure decompressing multilevel spinal cord compression. Preoperative lordosis of the cervical spi...


    pub_type: 杂志文章


    authors: Suk KS,Kim KT,Lee JH,Lee SH,Lim YJ,Kim JS

    更新日期:2007-11-01 00:00:00

  • Effectiveness and cost-effectiveness analysis of neuroreflexotherapy for subacute and chronic low back pain in routine general practice: a cluster randomized, controlled trial.

    abstract:STUDY DESIGN:A cluster randomized, controlled trial was performed. OBJECTIVES:To assess the clinical effectiveness and cost-effectiveness of adding patients' referral to neuroreflexotherapy intervention to the usual management of subacute and chronic low back pain in routine general practice. SUMMARY OF BACKGROUND DA...


    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Kovacs FM,Llobera J,Abraira V,Lázaro P,Pozo F,Kleinbaum D,KAP Group.

    更新日期:2002-06-01 00:00:00

  • Surgical mystery: where is the missing pituitary rongeur tip?

    abstract:STUDY DESIGN:Case report. OBJECTIVE:We report the unusual case of a patient who was referred to our institution after she sustained an intraoperative injury to the common iliac vein during posterior lumbar discectomy at L5-S1 with a pituitary rongeur. There was only minimal bleeding with spontaneous hemostasis and no ...


    pub_type: 杂志文章


    authors: Bydon A,Xu R,Conte JV,Gokaslan ZL,Brinker JA,Witham TF,Yassari R

    更新日期:2010-08-01 00:00:00

  • Anatomic considerations for plate-screw fixation of the cervical spine.

    abstract::A cadaveric study was done to investigate the variability of interfacet distances from C3 to C7, to learn pedicle morphology at C7-T2, and to determine potential dangers of plate-screw osteosynthesis technique of the cervical spine. Twenty-two cadavers were dissected from C2 to C7 to expose the lateral masses and nerv...


    pub_type: 杂志文章


    authors: An HS,Gordin R,Renner K

    更新日期:1991-10-01 00:00:00

  • Correlation between range of motion and outcome after lumbar total disc replacement: 8.6-year follow-up.

    abstract:STUDY DESIGN:Retrospective radiographic and chart review. OBJECTIVE:To examine the relationship between lumbar total disc replacement (TDR) range of motion (ROM) and clinical outcome at 8.6-year follow-up. SUMMARY OF BACKGROUND DATA:There are no studies on the relationship between TDR motion and clinical outcomes. M...


    pub_type: 杂志文章


    authors: Huang RC,Girardi FP,Cammisa FP Jr,Lim MR,Tropiano P,Marnay T

    更新日期:2005-06-15 00:00:00

  • Three-level en bloc spondylectomy for desmoplastic fibroma of the thoracic spine: a case report.

    abstract:STUDY DESIGN:A case of desmoplastic fibroma of the thoracic spine treated by a three-level en bloc spondylectomy is reported. OBJECTIVES:To present a rare case of desmoplastic fibroma of the spine, and to emphasize the importance of at least a marginal resection of this tumor entity. SUMMARY OF BACKGROUND DATA:Desmop...


    pub_type: 杂志文章


    authors: Hardes J,Gosheger G,Halm H,Winkelmann W,Liljenqvist U

    更新日期:2003-05-01 00:00:00

  • The response of the nucleus pulposus of the lumbar intervertebral discs to functionally loaded positions.

    abstract:STUDY DESIGN:Asymptomatic volunteers underwent magnetic resonance imaging to investigate how different positions affect lumbar intervertebral discs. OBJECTIVE:To quantify sagittal migration of the lumbar nucleus pulposus in 6 functional positions. SUMMARY OF BACKGROUND DATA:Previous studies of the intervertebral disc...


    pub_type: 杂志文章


    authors: Alexander LA,Hancock E,Agouris I,Smith FW,MacSween A

    更新日期:2007-06-15 00:00:00

  • Juvenile idiopathic scoliosis: the effectiveness of part-time bracing.

    abstract:STUDY DESIGN:A retrospective review of 34 patients with juvenile idiopathic scoliosis (JIS) treated with a nighttime bending brace. OBJECTIVE:To determine the effectiveness of part-time bracing in JIS. SUMMARY OF BACKGROUND DATA:Although previous bracing studies have focused on adolescent idiopathic scoliosis, no aut...


    pub_type: 杂志文章


    authors: Jarvis J,Garbedian S,Swamy G

    更新日期:2008-05-01 00:00:00

  • Metastatic pulmonary intimal sarcoma presenting as cauda equina syndrome: first report of a case.

    abstract:STUDY DESIGN:Case report and clinical discussion. OBJECTIVE:To describe a rare case of metastatic pulmonary intimal sarcoma presenting as cauda equine syndrome. SUMMARY OF BACKGROUND DATA:Pulmonary artery sarcoma is a rare tumor, frequently misdiagnosed as pulmonary embolism, and although it is highly aggressive, met...


    pub_type: 杂志文章


    authors: Rashid A,Molloy S,Lehovsky J,Tirabosco R,Hughes R,Butt S

    更新日期:2008-07-01 00:00:00

  • Surgery for lumbar spinal stenosis. Attempted meta-analysis of the literature.

    abstract::A meta-analysis was undertaken to determine the effects of surgery for lumbar spinal stenosis on pain and disability. Seventy-four journal articles met inclusion criteria and were independently reviewed by two readers. On average, 64% of patients treated surgically for lumbar spinal stenosis were reported to have good...


    pub_type: 杂志文章,meta分析


    authors: Turner JA,Ersek M,Herron L,Deyo R

    更新日期:1992-01-01 00:00:00

  • Intermittent distracting rod for correction of high neurologic risk congenital scoliosis.

    abstract:STUDY DESIGN:Report of three cases of severe congenital scoliosis corrected by a new device. OBJECTIVES:To show a new, safe alternative for treatment to achieve and maintain correction of the most severe spinal deformity. SUMMARY OF BACKGROUND DATA:Because of neurologic risk, severe congenital scoliosis is usually no...


    pub_type: 杂志文章


    authors: Grass PJ,Soto AV,Araya HP

    更新日期:1997-08-15 00:00:00

  • Collagenolytic enzyme systems in human intervertebral disc: their control, mechanism, and their possible role in the initiation of biomechanical failure.

    abstract::Changes in the macromolecular matrix of the intervertebral disc may predispose to biomechanical failure of the disc. Such changes would involve extracellular enzymes capable of altering the collagen and proteoglycan of the disc matrix. In this study, extracts from homogenates of both annuli fibrosi and nuclei pulposi ...


    pub_type: 杂志文章


    authors: Sedowofia KA,Tomlinson IW,Weiss JB,Hilton RC,Jayson MI

    更新日期:1982-05-01 00:00:00

  • Using segmental renal artery as recipient artery for spinal reconstructive surgery.

    abstract:STUDY DESIGN:Report of the use of one segmental artery from the left renal artery as inflow source for reconstructing a spine with recalcitrant osteomyelitis. OBJECTIVE:To describe one difficult case of spinal osteomyelitis and our reconstruction procedure. SUMMARY OF BACKGROUND DATA:The use of a vascularized fibular...


    pub_type: 杂志文章


    authors: Yen YH,Hsieh TS,Hou SM,Wu SJ,Chen SC,Pu CM

    更新日期:2010-12-01 00:00:00

  • A study of the cutaneous nerves encountered during thoracoplasty.

    abstract:STUDY DESIGN:Ten cadavers were dissected to describe the cutaneous branches of the dorsal rami nerves that should be identified and protected throughout the thoracoplasty procedure. OBJECTIVE:To identify the anatomic distribution of the cutaneous branches of the dorsal rami in the thoracic spine. SUMMARY OF BACKGROUN...


    pub_type: 杂志文章


    authors: Hoernschemeyer D,Farjoodi P,Cheng J,Sponseller P

    更新日期:2007-02-01 00:00:00

  • The role of bone graft force in stabilizing the multilevel anterior cervical spine plate system.

    abstract:STUDY DESIGN:The role of bone graft force in stabilizing an instrumented cervical spine was evaluated for one-level and three-level corpectomy models using in vitro experiments. OBJECTIVES:To investigate the role of bone graft force in enhancing stability of anterior cervical plate, and to study effects of fatigue loa...


    pub_type: 杂志文章


    authors: Wang JL,Panjabi MM,Isomi T

    更新日期:2000-07-01 00:00:00

  • Feasibility and Accuracy of Thoracolumbar Minimally Invasive Pedicle Screw Placement With Augmented Reality Navigation Technology.

    abstract:STUDY DESIGN:Cadaveric laboratory study. OBJECTIVE:To assess the feasibility and accuracy of minimally invasive thoracolumbar pedicle screw placement using augmented reality (AR) surgical navigation. SUMMARY OF BACKGROUND DATA:Minimally invasive spine (MIS) surgery has increasingly become the method of choice for a w...


    pub_type: 杂志文章


    authors: Elmi-Terander A,Nachabe R,Skulason H,Pedersen K,Söderman M,Racadio J,Babic D,Gerdhem P,Edström E

    更新日期:2018-07-15 00:00:00

  • Intradiscal pressure measurements above an instrumented fusion. A cadaveric study.

    abstract:STUDY DESIGN:An in vitro study to determine the intradiscal pressure changes during flexion in levels above a simulated fusion was performed. OBJECTIVES:To determine if intradiscal pressure increases more during flexion in discs above an instrumented spinal segment compared to an uninstrumented segment. SUMMARY OF BA...


    pub_type: 杂志文章


    authors: Weinhoffer SL,Guyer RD,Herbert M,Griffith SL

    更新日期:1995-03-01 00:00:00

  • Operative versus nonoperative treatment of leg pain in adults with scoliosis: a retrospective review of a prospective multicenter database with two-year follow-up.

    abstract:STUDY DESIGN:Retrospective review of a prospective, multicenter study. OBJECTIVE:The purpose of this study was to assess the prevalence and severity of leg pain in adults with scoliosis and to assess whether surgery significantly improved leg pain compared with nonoperative management. SUMMARY OF BACKGROUND DATA:Pati...


    pub_type: 杂志文章


    authors: Smith JS,Shaffrey CI,Berven S,Glassman S,Hamill C,Horton W,Ondra S,Schwab F,Shainline M,Fu KM,Bridwell K,Spinal Deformity Study Group.

    更新日期:2009-07-15 00:00:00