Identification of influenza C virus phosphoproteins.

Abstract:

:The HMV-II cells infected with influenza C virus were labeled with inorganic [32P]phosphate to identify phosphorylated proteins. Analysis by radioimmunoprecipitation with antiviral serum or monoclonal antibodies revealed that three major structural proteins of the virus, hemagglutinin-esterase (HE), nucleoprotein (NP), and matrix protein (M1) are all phosphorylated in both infected cells and virions. It was also observed that, in the presence of trypsin (10 micrograms/ml), the unphosphorylated form of the HE glycoprotein was cleaved efficiently whereas the phosphorylated form was not, raising the possibility that phosphorylation of HE may influence its susceptibility to degradation by proteolytic enzymes.

journal_name

Microbiol Immunol

authors

Nishimura H,Sugawara K,Gao P,Muraki Y,Hongo S,Kitame F,Nakamura K

doi

10.1111/j.1348-0421.1995.tb03251.x

subject

Has Abstract

pub_date

1995-01-01 00:00:00

pages

737-40

issue

9

eissn

0385-5600

issn

1348-0421

journal_volume

39

pub_type

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