Acute toxicological effects in rats treated with a mixture of commercially formulated products containing methyl parathion and permethrin.


:The study examined the interactions between a commercial formulation of methyl parathion (CF-MP) and a commercially formulated product of permethrin (CF-PMT) in male rats. The acute toxicity (LD50 values) and brain cholinesterase activity were investigated as toxicological endpoints. Results indicated that CF-MP modified the acute toxicity of CF-PMT. When animals were treated with a mixture, the addition of 380 mg/kg of CF-MP reduced the LD50 of CF-PMT by only 9.0%; however, when rats received CF-MP at 464 mg/kg, the LD50 of CF-PMT was reduced by 37% (P < 0.001). Also, CF-PMT decreased the CF-MP-induced inhibition of cholinesterase activity by 50% (P < 0.05). It was interesting to observe that xylene, which is the most abundant component in the vehicle of both formulations, had no effect on the CF-MP-induced inhibition of the cholinesterase activity. There was no relation between lethality and the inhibition of the brain cholinesterase activity in rats treated with mixtures containing CF-MP+CF-PMT or with either commercially formulated product alone. Considering the increased toxicity observed in rats treated with CF-PMT+CF-MP, it would be advisable to investigate further the interactions between both pesticides.


Ecotoxicol Environ Saf


Ortiz D,Yáñez L,Gómez H,Martínez-Salazar JA,Díaz-Barriga F




Has Abstract


1995-11-01 00:00:00














  • Novel chromium tolerant microorganisms: isolation, characterization and their biosorption capacity.

    abstract::Effluent from tannery, electroplating and electronic industries contain chromium which is highly toxic. This paper reports isolation of chromium tolerant microorganisms from solid waste as well as liquid effluent of an electroplating industry. Nine isolates were obtained that can tolerate chromium concentration up to ...

    journal_title:Ecotoxicology and environmental safety

    pub_type: 杂志文章


    authors: Mishra S,Doble M

    更新日期:2008-11-01 00:00:00

  • Environmental properties of long chain alcohols. Part 1: Physicochemical, environmental fate and acute aquatic toxicity properties.

    abstract::This paper summarises the physicochemical, biodegradation and acute aquatic ecotoxicity properties of long chain aliphatic alcohols. Properties of pure compounds are shown to follow somewhat predictable trends, which are amenable to estimation by quantitative structure-activity relationships ((Q)SARs). This allows pre...

    journal_title:Ecotoxicology and environmental safety

    pub_type: 杂志文章,评审


    authors: Fisk PR,Wildey RJ,Girling AE,Sanderson H,Belanger SE,Veenstra G,Nielsen A,Kasai Y,Willing A,Dyer SD,Stanton K

    更新日期:2009-05-01 00:00:00

  • The susceptibility of early developmental phases of an acid-tolerant and acid-sensitive fish species to acidity and aluminum.

    abstract::The mortality of roach (Rutilus rutilus) embryos increased during the early embryonic phase following exposure to Al and acidity from pH 6.7 to 5.0. No roach hatched at pH<5.00 or at pH 5.00 in the presence of Al. By contrast, increased embryonic mortality in pike (Esox lucius) occurred mainly during and after the nor...

    journal_title:Ecotoxicology and environmental safety

    pub_type: 杂志文章


    authors: Keinänen M,Tigerstedt C,Peuranen S,Vuorinen PJ

    更新日期:2004-06-01 00:00:00

  • Does diclofenac act like a photosynthetic herbicide on green algae? Chlamydomonas reinhardtii synchronous culture-based study with atrazine as reference.

    abstract::The non-steroidal anti-inflammatory drug diclofenac (DCF) is one of the commonly used and frequently detected drugs in water bodies, and several studies indicate its toxic effect on plants and algae. Studies performed with asynchronous Chlamydomonas reinhardtii cultures indicated that DCF inhibit the growth of populat...

    journal_title:Ecotoxicology and environmental safety

    pub_type: 杂志文章


    authors: Majewska M,Harshkova D,Pokora W,Baścik-Remisiewicz A,Tułodziecki S,Aksmann A

    更新日期:2021-01-15 00:00:00

  • Assessing pollution in coastal ecosystems: a preliminary survey using the micronucleus test in the mussel Mytilus edulis.

    abstract::Mussels Mytilus edulis were sampled at increasing distances from urban effluents in two very different locations, Gijon (northern Spain, Europe, 43 degrees N) and Puerto Madryn (Argentina, South America, 43 degrees S), and from an industry effluent in Puerto Madryn. The micronucleus test was performed on branchial cel...

    journal_title:Ecotoxicology and environmental safety

    pub_type: 杂志文章


    authors: Izquierdo JI,Machado G,Ayllon F,d'Amico VL,Bala LO,Vallarino E,Elias R,Garcia-Vazquez E

    更新日期:2003-05-01 00:00:00

  • Does speciation matter for tungsten ecotoxicology?

    abstract::Tungsten is a widely used transition metal that has not been thoroughly investigated with regards to its ecotoxicological effects. Tungsten anions polymerize in environmental systems as well as under physiological conditions in living organisms. These polymerization/condensation reactions result in the development of ...

    journal_title:Ecotoxicology and environmental safety

    pub_type: 杂志文章,评审


    authors: Strigul N

    更新日期:2010-09-01 00:00:00

  • Antarctic Adélie penguin feathers as bio-indicators of geographic and temporal variations in heavy metal concentrations in their habitats.

    abstract::Seabird feathers are effective indicators of heavy metal contamination. To propose a biological detection method suitable for the long-term monitoring of heavy metals in the Antarctic environment, eight heavy metals (As, Cd, Cr, Cu, Hg, Ni, Pb, and Zn) in Adélie penguin feathers from different body parts, years, and m...

    journal_title:Ecotoxicology and environmental safety

    pub_type: 杂志文章


    authors: Sun Y,Lu Z,Xiao K,Zeng L,Wang J,Gabrielsen GW

    更新日期:2020-12-15 00:00:00

  • The toxicity testing of double-walled nanotubes-contaminated food to Eisenia veneta earthworms.

    abstract::Nanotechnology is playing an increasing role in the society, but very little is known about the environmental toxicity of nanotechnological products. Few previous studies have been published with regard to the effect of nanoparticles on soil organisms. The present paper deals with the toxicity of carbon double-walled ...

    journal_title:Ecotoxicology and environmental safety

    pub_type: 杂志文章


    authors: Scott-Fordsmand JJ,Krogh PH,Schaefer M,Johansen A

    更新日期:2008-11-01 00:00:00

  • Effect of cerium on growth and antioxidant metabolism of Lemna minor L.

    abstract::An increasing input rate of rare earth elements in the environment is expected because of the intense extraction of such elements form their ores to face human technological needs. In this study Lemna minor L. plants were grown under laboratory conditions and treated with increasing concentrations of cerium (Ce) ions ...

    journal_title:Ecotoxicology and environmental safety

    pub_type: 杂志文章


    authors: Zicari MA,d'Aquino L,Paradiso A,Mastrolitti S,Tommasi F

    更新日期:2018-11-15 00:00:00

  • Ultraviolet damages sperm mitochondrial function and membrane integrity in the sea urchin Anthocidaris crassispina.

    abstract::Effects of ultraviolet A (UVA) and ultraviolet B (UVB) on mitochondrial function and membrane integrity of sea urchin sperm were investigated using flow cytometry and fluorescent probes. Both UVA and UVB impaired sperm mitochondrial function in a dose-dependent manner. Covariance analysis further showed that the slope...

    journal_title:Ecotoxicology and environmental safety

    pub_type: 杂志文章


    authors: Lu XY,Wu RS

    更新日期:2005-05-01 00:00:00

  • Fluoride contamination in groundwater sources in Southwestern Nigeria: Assessment using multivariate statistical approach and human health risk.

    abstract::The present study investigated the ionic and fluoride concentrations in tap water and its associated health risk to local dwellers of Ogun State (Abeokuta south), Nigeria. 63 samples were collected from twenty-one different locations. Results obtained revealed the mean concentration of fluoride (F-) as 1.23 mg/L. Othe...

    journal_title:Ecotoxicology and environmental safety

    pub_type: 杂志文章


    authors: Emenike CP,Tenebe IT,Jarvis P

    更新日期:2018-07-30 00:00:00

  • Temporal dynamics of the compositions and activities of soil microbial communities post-application of the insecticide chlorantraniliprole in paddy soils.

    abstract::Chlorantraniliprole (CAP) is a newly developed insecticide widely used in rice fields in China. There has been few studies evaluating the toxicological effects of CAP on soil-associated microbes. An 85-day microcosm experiment was performed to reveal the dissipation dynamics of CAP in three types of paddy soils in sub...

    journal_title:Ecotoxicology and environmental safety

    pub_type: 杂志文章


    authors: Wu M,Liu J,Li W,Liu M,Jiang C,Li Z

    更新日期:2017-10-01 00:00:00

  • Bioavailability and health risk of some potentially toxic elements (Cd, Cu, Pb and Zn) in street dust of Asansol, India.

    abstract::Street dust samples were collected from five different types of land use patterns (busy traffic zone, urban residential area, national highways, industrial area and sensitive area) in a medium sized industrial city Asansol, India. The samples were fractionated into ≤53µm and analyzed for potential toxic elements (PTEs...

    journal_title:Ecotoxicology and environmental safety

    pub_type: 杂志文章


    authors: Gope M,Masto RE,George J,Hoque RR,Balachandran S

    更新日期:2017-04-01 00:00:00

  • Induction and characterization of cytochromes P450IA and -IIB in the newt, Pleurodeles waltl.

    abstract::The newt (Pleurodeles waltl) is an amphibian species used in a mutagenicity test (micronucleus). This study was carried out to establish if the inducibility of hepatic cytochromes P450 of this species is similar to that of the rat. Our results showed that the newt is characterized by a lower level of hepatic cytochrom...

    journal_title:Ecotoxicology and environmental safety

    pub_type: 杂志文章


    authors: Marty J,Rivière JL,Guinaudy MJ,Kremers P,Lesca P

    更新日期:1992-10-01 00:00:00

  • Effect of biochar amendment on the bioavailability of pesticide chlorantraniliprole in soil to earthworm.

    abstract::To evaluate the effect of biochar amendment on the bioavailability of chlorantraniliprole (CAP) in soils with different physico-chemical properties, the uptake of CAP from various soils by earthworms was studied. It was observed that the biochar amendment of the soils affected the sorption of CAP, but the magnitude of...

    journal_title:Ecotoxicology and environmental safety

    pub_type: 杂志文章


    authors: Wang TT,Cheng J,Liu XJ,Jiang W,Zhang CL,Yu XY

    更新日期:2012-09-01 00:00:00

  • Toxic effects of bleached and unbleached paper mill effluents in primary cultures of rainbow trout hepatocytes.

    abstract::Toxic effects of unbleached (sulfate or sulfite) and bleached (sulfate) paper mill effluents were studied in a primary culture of rainbow trout liver cells. The effluents and control water from a clean area were extracted with diethyl ether and added to the cultures dissolved in dimethyl sulfoxide. Plasma membrane int...

    journal_title:Ecotoxicology and environmental safety

    pub_type: 杂志文章


    authors: Pesonen M,Andersson T

    更新日期:1992-08-01 00:00:00

  • Measuring and modelling mixture toxicity of imidacloprid and thiacloprid on Caenorhabditis elegans and Eisenia fetida.

    abstract::While the standard models of concentration addition and independent action predict overall toxicity of multicomponent mixtures reasonably, interactions may limit the predictive capability when a few compounds dominate a mixture. This study was conducted to test if statistically significant systematic deviations from c...

    journal_title:Ecotoxicology and environmental safety

    pub_type: 杂志文章


    authors: Gomez-Eyles JL,Svendsen C,Lister L,Martin H,Hodson ME,Spurgeon DJ

    更新日期:2009-01-01 00:00:00

  • Organic contaminants and heavy metals in indoor dust from e-waste recycling, rural, and urban areas in South China: Spatial characteristics and implications for human exposure.

    abstract::The concentrations of several organic contaminants (OCs) and heavy metals were measured in indoor dust from e-waste recycling, rural, and urban areas in South China to illustrate the spatial characteristics of these pollutants and to further evaluate human exposure risks. The median concentrations of polychlorinated b...

    journal_title:Ecotoxicology and environmental safety

    pub_type: 杂志文章


    authors: He CT,Zheng XB,Yan X,Zheng J,Wang MH,Tan X,Qiao L,Chen SJ,Yang ZY,Mai BX

    更新日期:2017-06-01 00:00:00

  • Genotoxic and morphological damage in Hippocampus reidi exposed to crude oil.

    abstract::The present article investigates the responses of Hippocampus reidi exposed to crude oil (10mL/L) for time periods that are characteristic of acute (12, 24, 48 and 96h) and subchronic (168 and 336h) and its recovery at 168h, such as to assess H. reidi as a good sentinel species. These responses were examined by genoto...

    journal_title:Ecotoxicology and environmental safety

    pub_type: 杂志文章,评审


    authors: Cariello Delunardo FA,Ferreira da Silva B,Paulino MG,Narciso Fernandes M,Chippari-Gomes AR

    更新日期:2013-01-01 00:00:00

  • Environmental occurrences, fate, and impacts of microplastics.

    abstract::Microplastics (MPs) are small plastic pieces with size less than 5 mm that have entered and polluted the environment. While many investigations including several critical reviews on MPs in the environment have been conducted, most of them are focused on their occurrences in marine environment. Current understanding on...

    journal_title:Ecotoxicology and environmental safety

    pub_type: 杂志文章,评审


    authors: Wu P,Huang J,Zheng Y,Yang Y,Zhang Y,He F,Chen H,Quan G,Yan J,Li T,Gao B

    更新日期:2019-11-30 00:00:00

  • Assessment of the exposure to heavy metals in Griffon vultures (Gyps fulvus) from the Iberian Peninsula.

    abstract::Griffon vultures (Gyps fulvus), by virtue of their position at the top of the food chain and as obligate scavengers, are at risk of accumulating and concentrating heavy metals in their tissues and may be more predisposed to their toxic effects. The aim of this study is to investigate heavy metal concentrations in Grif...

    journal_title:Ecotoxicology and environmental safety

    pub_type: 杂志文章


    authors: Carneiro M,Colaço B,Brandão R,Azorín B,Nicolas O,Colaço J,Pires MJ,Agustí S,Casas-Díaz E,Lavin S,Oliveira PA

    更新日期:2015-03-01 00:00:00

  • Chemical characteristics and mutagenic activity of PM₂.₅ at a site in the Indo-Gangetic plain, India.

    abstract::Airborne fine particulate matter PM2.5 was collected from May 2010 to December 2012 at Agra, a semi-urban site in north-central India. PM2.5 samples were chemically characterized for 16 polycyclic aromatic hydrocarbons by gas chromatography. PM2.5 values varied between 8.4 and 300 µg m(-3) with 55% of the values excee...

    journal_title:Ecotoxicology and environmental safety

    pub_type: 杂志文章


    authors: Dubey J,Kumari KM,Lakhani A

    更新日期:2015-04-01 00:00:00

  • Effect of landfill leachate on oxidative stress of brain structures and liver from rodents: modulation by photoelectrooxidation process.

    abstract::The decomposition of solid waste in landfill is responsible for the formation of leachate, a dark liquid with an unpleasant odor; studies investigating its toxicity on mammals are rare. Oxidative stress has been considered as an important biochemical mechanism of the toxicity of several xenobiotics. The aim of this st...

    journal_title:Ecotoxicology and environmental safety

    pub_type: 杂志文章


    authors: Bertoldi K,Spindler C,dos Santos Moysés F,Vanzella C,Lovatel GA,Elsner VR,Rodrigues MA,Siqueira IR

    更新日期:2012-10-01 00:00:00

  • Residue-based interpretation of toxicity and bioconcentration QSARs from aquatic bioassays: polar narcotic organics.

    abstract::Bioconcentration and toxicity estimation for a group of substituted phenols often categorized as "polar narcotics" can be confounded by pH-dependent ionization. Two methods of correction for ionization were applied to toxicity data obtained by U.S. EPA-Duluth for fathead minnows exposed to 30 different phenols in 37 b...

    journal_title:Ecotoxicology and environmental safety

    pub_type: 杂志文章


    authors: McCarty LS,Mackay D,Smith AD,Ozburn GW,Dixon DG

    更新日期:1993-06-01 00:00:00

  • Accumulation characteristics and potential risk of PAHs in vegetable system grow in home garden under straw burning condition in Jilin, Northeast China.

    abstract::The accumulation characteristics and potential risk posed by polycyclic aromatic hydrocarbons (PAHs) in soils and vegetables grown in the home garden and agricultural field were investigated in this research. The average concentrations of 16 PAHs in soils and vegetables in the home garden were 508.9 ng/g and 197.3 ng/...

    journal_title:Ecotoxicology and environmental safety

    pub_type: 杂志文章


    authors: Chen Y,Zhang F,Zhang J,Zhou M,Li F,Liu X

    更新日期:2018-10-30 00:00:00

  • Using rotifer population demographic parameters to assess impacts of the degradation products from trinitrotoluene phytoremediation.

    abstract::The objective of this study was to evaluate the chronic lethal and sublethal aquatic toxicity effects associated with the phytoremediation of water contaminated with 2,4,6-trinitrotoluene (TNT) by the wetland plant species Myriophyllum aquaticum (parrot feather). Rotifers (Brachionus calyciflorus) feeding on an algal ...

    journal_title:Ecotoxicology and environmental safety

    pub_type: 杂志文章


    authors: Hitchcock DR,McCutcheon SC,Smith MC

    更新日期:2003-06-01 00:00:00

  • Absorption, accumulation and distribution of metals and nutrient elements in poplars planted in land amended with composted sewage sludge: A field trial.

    abstract::Interest in the application of sewage sludge as amendments to grow trees has continued to increase, especially for fast-growing trees such as poplars. In this study, two-year field trial was conducted to determine the effects of compost sewage sludge (CSS) soil application on the distributions of metal and nutrient el...

    journal_title:Ecotoxicology and environmental safety

    pub_type: 杂志文章


    authors: Guoqing X,Xiuqin C,Liping B,Hongtao Q,Haibo L

    更新日期:2019-10-30 00:00:00

  • D151 resin preloaded with Fe3+ as a salt resistant adsorbent for glyphosate from water in the presence 16% NaCl.

    abstract::D151 resin preloaded with Fe3+ [denoted as R-Fe3+] was to investigate R-Fe3+ as an adsorbent for glyphosate from water in the presence high concentration of salt. The adsorption mechanism revealed the coordination of Fe3+ inside R-Fe3+ with O atoms of P-O and N atoms in glyphosate molecule. The adsorption capacity of ...

    journal_title:Ecotoxicology and environmental safety

    pub_type: 杂志文章


    authors: Xiao G,Meng Q

    更新日期:2020-03-01 00:00:00

  • Characteristics of concentration-inhibition curves of individual chemicals and applicability of the concentration addition model for mixture toxicity prediction.

    abstract::The concentration addition (CA) model has been widely applied to predict mixture toxicity. However, its applicability is difficult to evaluate due to the complexity of interactions among substances. Considering that the concentration-response curve (CRC) of each component of the mixture is closely related to the predi...

    journal_title:Ecotoxicology and environmental safety

    pub_type: 杂志文章


    authors: Wang N,Wang XC,Ma X

    更新日期:2015-03-01 00:00:00

  • Sb(III)-resistance mechanisms of a novel bacterium from non-ferrous metal tailings.

    abstract::Understanding the mechanism(s) of microbial resistance to antimony (Sb) is critical in the bioremediation of Sb polluted environments. Here a novel bacterium (Acinetobacter sp. JH7) isolated from mine tailings decreased the Microtox toxicity of a Sb(III)-containing medium. DNA sequencing and physiological testing were...

    journal_title:Ecotoxicology and environmental safety

    pub_type: 杂志文章


    authors: Gu J,Sunahara G,Duran R,Yao J,Cui Y,Tang C,Li H,Mihucz VG

    更新日期:2019-12-30 00:00:00