Reduction of extracellular superoxide dismutase activity by decapeptide derived from FGF-receptor.

Abstract:

:Several synthetic decapeptides containing an HAV tripeptide motif were tested for their ability to modulate the enzymatic activity of rat extracellular SOD, an enzyme which also contains an HAV motif. Out of nine decapeptides that were tested, only a FGF-receptor derived peptide was active as a negative modulator of enzyme activity. These results strengthen the thesis that HAV motifs are not only involved in homophilic interactions and suggest that soluble FGF-receptor molecules might moderate the activity of extracellular SOD.

journal_name

Cell Biol Int

authors

Willems J,Noppe W,Slegers H

doi

10.1006/cbir.1995.1032

subject

Has Abstract

pub_date

1995-11-01 00:00:00

pages

935-7

issue

11

eissn

1065-6995

issn

1095-8355

pii

S1065-6995(85)71032-3

journal_volume

19

pub_type

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