Concurrent presentation of erythrocytic and megakaryocytic aplasia.

Abstract:

:A case of a patient presenting with idiopathic concurrent erythrocytic and megakaryocytic aplasia is reported. The patient's response to immunosuppressive therapy and her bone marrow pathology clearly suggest an immune mechanism. Based on the lack of suppression of erythroid colony growth, several mechanisms are postulated. Well-established molecular and genetic evidence, along with clinical observations, suggests that a relationship exists between the erythrocytic and megakaryocytic cell lines. This may be related to a common bipotential stem cell or common cell surface markers. This case provides strong clinical evidence to support this relationship.

journal_name

Am J Hematol

authors

Canavan BF,Huhn RD,Kim HC,Kosmin M,Sheay W,Saidi P

doi

10.1002/(SICI)1096-8652(199601)51:1<68::AID-AJH11>

subject

Has Abstract

pub_date

1996-01-01 00:00:00

pages

68-72

issue

1

eissn

0361-8609

issn

1096-8652

pii

10.1002/(SICI)1096-8652(199601)51:1<68::AID-AJH11>

journal_volume

51

pub_type

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