Concurrent presentation of erythrocytic and megakaryocytic aplasia.


:A case of a patient presenting with idiopathic concurrent erythrocytic and megakaryocytic aplasia is reported. The patient's response to immunosuppressive therapy and her bone marrow pathology clearly suggest an immune mechanism. Based on the lack of suppression of erythroid colony growth, several mechanisms are postulated. Well-established molecular and genetic evidence, along with clinical observations, suggests that a relationship exists between the erythrocytic and megakaryocytic cell lines. This may be related to a common bipotential stem cell or common cell surface markers. This case provides strong clinical evidence to support this relationship.


Am J Hematol


Canavan BF,Huhn RD,Kim HC,Kosmin M,Sheay W,Saidi P




Has Abstract


1996-01-01 00:00:00














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    abstract::We evaluated possible prognostic factors just before salvage therapy with vincristine, doxorubicin, and dexamethasone (VAD) for 36 patients with refractory multiple myeloma. The median duration from diagnosis to the first VAD salvage was 14 months (range 2-76 months). Among parameters that have been shown to be associ...

    journal_title:American journal of hematology

    pub_type: 杂志文章


    authors: Suguro M,Kanda Y,Yamamoto R,Chizuka A,Hamaki T,Matsuyama T,Takezako N,Miwa A,Togawa A

    更新日期:2000-10-01 00:00:00

  • Microangiopathic hemolytic anemia complicating FK506 (tacrolimus) therapy.

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    journal_title:American journal of hematology

    pub_type: 杂志文章


    authors: Mach-Pascual S,Samii K,Beris P

    更新日期:1996-08-01 00:00:00

  • Serum antibodies to distinct epitopes of the tissue-type plasminogen activator (t-PA) in patients with systemic lupus erythematosus.

    abstract::Defective fibrinolysis due to decreased tissue-type plasminogen activator (t-PA) activity is a well-established finding in patients with systemic lupus erythematosus (SLE). The possibility that this decrease in t-PA activity may be related to the presence of autoantibodies directed against t-PA, and the possible role ...

    journal_title:American journal of hematology

    pub_type: 杂志文章


    authors: Ruiz-Arguelles A,Angles-Cano E,Perez-Romano B,Ruiz-Arguelles GJ,Deleze M,Alarcon-Segovia D,Gaussem P

    更新日期:1995-06-01 00:00:00

  • Intensive short-term chemotherapy regimen induces high remission rate (over 90%) and event-free survival both in children and adult patients with advanced sporadic Burkitt lymphoma/leukemia.

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    journal_title:American journal of hematology

    pub_type: 杂志文章


    authors: Todeschini G,Bonifacio M,Tecchio C,Balter R,Carli G,Stefani PM,Adami F,Zamò A,Dei Tos AP,Marino F,Gherlinzoni F,Marradi P,Semenzato G,Pizzolo G

    更新日期:2012-01-01 00:00:00

  • Change of enzyme properties caused by cross-linking treatment of human erythrocytes.

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    journal_title:American journal of hematology

    pub_type: 杂志文章


    authors: Ikawa M,Yoshida A

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  • Evidence that circulating immune complexes remove transfused platelets from the circulation.

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    journal_title:American journal of hematology

    pub_type: 杂志文章


    authors: Kutti J,Zaroulis CG,Safai-Kutti S,Dinsmore RE,Day NK,Good RA

    更新日期:1981-11-01 00:00:00

  • Thrombosis following desmopressin for uremic bleeding.

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    journal_title:American journal of hematology

    pub_type: 杂志文章


    authors: Byrnes JJ,Larcada A,Moake JL

    更新日期:1988-05-01 00:00:00

  • Patterns of survival in lymphoplasmacytic lymphoma/Waldenström macroglobulinemia: a population-based study of 1,555 patients diagnosed in Sweden from 1980 to 2005.

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    journal_title:American journal of hematology

    pub_type: 杂志文章


    authors: Kristinsson SY,Eloranta S,Dickman PW,Andersson TM,Turesson I,Landgren O,Björkholm M

    更新日期:2013-01-01 00:00:00

  • Prospective validation of a risk score based on biological markers for predicting progression free survival in Binet stage A chronic lymphocytic leukemia patients: results of the multicenter O-CLL1-GISL study.

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    journal_title:American journal of hematology

    pub_type: 杂志文章,多中心研究


    authors: Gentile M,Cutrona G,Mosca L,Matis S,Fabris S,Lionetti M,Ilariucci F,Zupo S,Musolino C,Levato L,Molica S,Di Raimondo F,Vincelli I,Di Rienzo N,Pesce EA,Angrilli F,Federico M,Neri A,Ferrarini M,Morabito F

    更新日期:2014-07-01 00:00:00

  • Detection of human herpesvirus 6 and JC virus in progressive multifocal leukoencephalopathy complicating follicular lymphoma.

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    journal_title:American journal of hematology

    pub_type: 杂志文章


    authors: Daibata M,Hatakeyama N,Kamioka M,Nemoto Y,Hiroi M,Miyoshi I,Taguchi H

    更新日期:2001-07-01 00:00:00

  • Laboratory testing for cobalamin deficiency in megaloblastic anemia.

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    journal_title:American journal of hematology

    pub_type: 杂志文章,评审


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    journal_title:American journal of hematology

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    journal_title:American journal of hematology

    pub_type: 杂志文章


    authors: Chan G,DiVenuti G,Miller K

    更新日期:2002-11-01 00:00:00

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    journal_title:American journal of hematology

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    authors: Long M,Kalish LA,Neufeld EJ,Grace RF

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    journal_title:American journal of hematology

    pub_type: 杂志文章,评审


    authors: Petrella TM,Walker IR,Jones GW,Leber B

    更新日期:1999-12-01 00:00:00

  • Cell-mediated immune-pancytopenia complicating primary Sjögren's syndrome.

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    authors: Seki T,Kiyosawa K,Monno S,Imai Y,Furukawa K,Kumazawa S,Ota M,Saito H,Furuta S,Nakahata T

    更新日期:1993-07-01 00:00:00

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    journal_title:American journal of hematology

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    authors: Nijjar TS,Bonacosa IA,Israels LG

    更新日期:1987-06-01 00:00:00

  • Relative iron deficiency in hereditary spherocytosis.

    abstract::Seventy-three patients with hereditary spherocytosis (HS) (58 nonsplenectomized, 15 splenectomized) were studied to evaluate iron status and the adequacy of iron availability for erythropoiesis. Splenectomized patients, who had hemoglobin levels in the normal or upper normal range, had higher levels of serum iron, tra...

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    pub_type: 杂志文章


    authors: Zanella A,Barosi G,Berzuini A,Colombo MB,Quaglini S,Volpes D,Sirchia G

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    journal_title:American journal of hematology

    pub_type: 杂志文章,评审


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  • Isolation and characterization of granulocyte lysosomal proteins and study of their effects on the clotting system.

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    pub_type: 杂志文章


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  • Serum ferritin concentrations and body iron stores in a multicenter, multiethnic primary-care population.

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    journal_title:American journal of hematology

    pub_type: 杂志文章,多中心研究


    authors: Gordeuk VR,Reboussin DM,McLaren CE,Barton JC,Acton RT,McLaren GD,Harris EL,Reiss JA,Adams PC,Speechley M,Phatak PD,Sholinsky P,Eckfeldt JH,Chen WP,Passmore L,Dawkins FW

    更新日期:2008-08-01 00:00:00

  • Effects of granulocyte-macrophage colony-stimulating factor (GM-CSF) on neutrophil kinetics and function in normal human volunteers.

    abstract::Granulocyte-macrophage colony-stimulating factor (GM-CSF) (250 microg/m2) was administered subcutaneously to 7 normal volunteers for up to 14 days to study its effects on neutrophil kinetics and function. With treatment, blood neutrophil counts rose gradually to peak at 3 1/2 times baseline by day 14. At day 5 marrow ...

    journal_title:American journal of hematology

    pub_type: 杂志文章


    authors: Dale DC,Liles WC,Llewellyn C,Price TH

    更新日期:1998-01-01 00:00:00

  • Circumstances of death in adult sickle cell disease patients.

    abstract::The purpose of the study was to analyze clinical and/or autopsy findings at the time of death among adults with sickle cell disease (SCD) at Howard University in Washington, DC over a 25-year period. A single physician recorded circumstances of death among 141 adult SCD patients he treated and knew well from 1976 to 2...

    journal_title:American journal of hematology

    pub_type: 杂志文章


    authors: Darbari DS,Kple-Faget P,Kwagyan J,Rana S,Gordeuk VR,Castro O

    更新日期:2006-11-01 00:00:00

  • The prognostic value of monosomal karyotype (MK) in higher-risk patients with myelodysplastic syndromes treated with 5-Azacitidine: A retrospective analysis of the Hellenic (Greek) Myelodysplastic syndromes Study Group.

    abstract::In this study, we investigated the incidence and prognostic impact of monosomal karyotype (MK) in 405 higher-risk Myelodysplastic Syndromes (MDS) patients treated with 5-AZA. The MK was present in 66 out of 405 (16.3%) patients, most of whom had complex karyotype (CK). MK was strongly associated with CK and the cytoge...

    journal_title:American journal of hematology

    pub_type: 杂志文章


    authors: Papageorgiou SG,Vasilatou D,Kontos CK,Kotsianidis I,Symeonidis A,Galanopoulos AG,Hatzimichael E,Megalakaki A,Poulakidas E,Diamantopoulos P,Vassilakopoulos TP,Zikos P,Papadaki H,Mparmparousi D,Bouronikou E,Panayiotidis P,V

    更新日期:2018-07-01 00:00:00

  • Enhanced botrocetin-induced type IIB von Willebrand factor binding to platelet glycoprotein Ib initiates hyperagglutination of normal platelets.

    abstract::Botrocetin, a protein isolated from the venom of the snake Bothrops jararaca, induces platelet aggregation/agglutination by von Willebrand factor (vWF) binding to the membrane glycoprotein (GP) Ib, an action resembling that of ristocetin. However, some differences in the interaction between vWF and platelet GPIb induc...

    journal_title:American journal of hematology

    pub_type: 杂志文章


    authors: Nishio K,Fujimura Y,Niinomi K,Takahashi Y,Yoshioka A,Fukui H,Usami Y,Titani K,Ruggeri ZM,Zimmerman TS

    更新日期:1990-04-01 00:00:00

  • Effect of tranexamic acid on platelet ADP during extracorporeal circulation.

    abstract::Seventeen adults received the antifibrinolytic drug tranexamic acid during cardiac surgery utilizing extracorporeal circulation (ECC). In 8 patients, drug administration began prior to skin incision (pre-ECC); infusions commenced after ECC and protamine administration in another 9 patients (post-ECC). Compared with th...

    journal_title:American journal of hematology

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Soslau G,Horrow J,Brodsky I

    更新日期:1991-10-01 00:00:00

  • History and implications of the neutrophil glycoprotein deficiencies.

    abstract::This review focuses on the initial clinical descriptions and subsequent investigation of the syndrome of recurrent infections associated with neutrophil membrane glycoprotein deficiencies. Characterization of the missing group of three glycoprotein heterodimers and their role in adhesion-related neutrophil function is...

    journal_title:American journal of hematology

    pub_type: 杂志文章,评审


    authors: Styrt B

    更新日期:1989-08-01 00:00:00

  • Improved method for diagnosis of polycythemia vera based on flow cytometric analysis of autonomous growth of erythroid precursors in liquid culture.

    abstract::"Autonomous" development of erythroid colonies in erythropoietin (EPO)-free semi-solid culture has been used as an in vitro assay for diagnosis of polycythemia vera (PV). These colonies, however, are small and poorly hemoglobinized, rendering the assay in many cases unreliable. We report here on the use of a novel ass...

    journal_title:American journal of hematology

    pub_type: 杂志文章


    authors: Manor D,Rachmilewitz EA,Fibach E

    更新日期:1997-01-01 00:00:00

  • Potentiation of vincristine cytotoxicity by hormones: corticosteroids, androgens, estrogens and progestins.

    abstract::Using an in vitro system to evaluate the simultaneous use of two drugs, we previously have confirmed the synergism of vincristine and prednisolone cytotoxicity against lymphoid cells. Experiments were now carried out to determine whether other steroid hormones can be substituted for prednisolone. Partial or complete p...

    journal_title:American journal of hematology

    pub_type: 杂志文章


    authors: Rosner F,Hirshaut Y,Grünwald HW,Deutsch S

    更新日期:1978-01-01 00:00:00

  • Anti-lymphoma effect of naproxen and indomethacin in a patient with relapsed diffuse large B-cell lymphoma.

    abstract::A 77-year-old man with relapsed non-Hodgkin's lymphoma, diffuse large B-cell type, was treated with naproxen, a nonsteroidal anti-inflammatory drug (NSAID), for paraneoplastic fever. A dramatic disappearance of not only the fever but also generalized lymphadenopathy was observed. Naproxen was continued, and he maintai...

    journal_title:American journal of hematology

    pub_type: 杂志文章


    authors: Yoshinaga K,Teramura M,Iwabe K,Kobayashi S,Masuda M,Motoji T,Mizoguchi H

    更新日期:2001-03-01 00:00:00