Abstract:
:A method is presented by whichcomputed tomography scans carried out at a number of energies may be utilized to obtain cross-sectional images of density and atomic number in addition to the conventional array of linear attenuation coefficients. This type of analysis has been carried out for various substances of biological relevance. Computer simulated reconstructions of clinical situations suggest that the method shows promise for providing additional diagnostic information and might dispense to some extent with the necessity of injecting contrast agents into the patient.
journal_name
Invest Radioljournal_title
Investigative radiologyauthors
McDavid WD,Waggener RG,Dennis MJ,Sank VJ,Payne WHdoi
10.1097/00004424-197703000-00016subject
Has Abstractpub_date
1977-03-01 00:00:00pages
189-94issue
2eissn
0020-9996issn
1536-0210journal_volume
12pub_type
杂志文章abstract::The effect of intravenous urography (IVU) on the excretion rate and precipitation of Tamm-Horsfall glycoprotein (THG) has been evaluated in 19 patients. Urine samples were collected immediately before the administration of contrast medium (U1) and then during the period of the excretion urogram (U2). The urinary THG: ...
journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/00004424-198501000-00014
更新日期:1985-01-01 00:00:00
abstract:RATIONALE AND OBJECTIVES:Tools for monitoring modern target-specific antiangiogenic and antivascular therapies are highly desirable because treatment strategies are time consuming, expensive, and yet sometimes ineffective. Therefore, the aim of this experimental study was to evaluate the predictive value of steady-stat...
journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/RLI.0b013e3180d5cbd9
更新日期:2007-12-01 00:00:00
abstract::A method and associated algorithm are presented which allow a simple and accurate determination to be made of the location of small symmetric areas presented in roentgenological images. The method utilizes an operator to visually spot object positions but eliminates the need for critical positoning accuracy on the ope...
journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/00004424-197603000-00007
更新日期:1976-03-01 00:00:00
abstract::The authors present a numerical deconvolution technique to compensate for image degrading effects caused by scattered photons in radiographic chest images. Fourier transform techniques are used to deconvolve a shift invariant model of the two dimensional point spread response functions of the scattered radiation. This...
journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/00004424-198901000-00008
更新日期:1989-01-01 00:00:00
abstract:PURPOSE:The aim of this study was to develop a method to delineate the lethally frozen-tissue region (temperature less than -40°C) arising from interventional cryoablation procedures using a short tau inversion-recovery ultrashort echo-time (STIR-UTE) magnetic resonance (MR) imaging sequence. This method could serve as...
journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/RLI.0000000000000642
更新日期:2020-05-01 00:00:00
abstract::Skeletal abnormalities have been reported on numerous occasions in patients who have received high doses of vitamin A and its derivatives. Recently, a new derivative, isotretinoin (Accutane, Hoffman-LaRoche, Inc.), has become available for the treatment of cystic acne. Ninety-six patients treated for a minimum of four...
journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/00004424-198601000-00007
更新日期:1986-01-01 00:00:00
abstract::Post-angioplasty restenosis (PARS) in atherosclerotic lesions of medium and small arteries occurs in about one-third of cases in the first year following percutaneous transluminal angioplasty (PTA) (early PARS). PARS includes acute spasm, dissection with reclosure, elastic recoil, fibrocellular proliferative response,...
journal_title:Investigative radiology
pub_type: 临床试验,杂志文章,多中心研究
doi:10.1097/00004424-198811000-00002
更新日期:1988-11-01 00:00:00
abstract:OBJECTIVES:The objective of this study was to evaluate the use of dielectric pads for improving high spatial resolution imaging of the inner ear at 7 T. MATERIALS AND METHODS:Two sets of dielectric pads were designed using electromagnetic simulations and implemented using a deuterated suspension of barium titanate. Th...
journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/RLI.0000000000000026
更新日期:2014-05-01 00:00:00
abstract:RATIONALE AND OBJECTIVES:To summarize the chemical synthesis, physicochemical characterization, pharmacokinetic behavior, and biological evaluation of P743, a new macromolecular iodinated contrast medium. METHODS:The synthesis and molecular modeling of the iodinated macromolecule P743 are described. The pharmacokineti...
journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/00004424-200101000-00006
更新日期:2001-01-01 00:00:00
abstract:PURPOSE:We sought to evaluate the potential of dynamic contrast enhancement after the intravenous administration of an iodine-based contrast medium in full-field digital mammography. MATERIAL AND METHODS:A protocol for image acquisition was established for contrast-enhanced mammography and the mammography unit (Senogr...
journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/01.rli.0000167421.83203.4e
更新日期:2005-07-01 00:00:00
abstract:OBJECTIVE:: The final event leading to myocardial infarction is adhesion and activation of platelets after rupture of an atherosclerotic plaque, ending in thrombotic occlusion of the coronary artery. Imaging of imminent vessel occlusion may improve patient care. The feasibility of molecular magnetic resonance imaging (...
journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/RLI.0b013e31821e62fb
更新日期:2011-10-01 00:00:00
abstract::We present a new method for evaluating in vivo changes in bone mineralization in the peripheral skeleton, using computed tomography (CT). A set of bone mineralization indices are generated from numerous CT images of the patient's distal radius. The cross-sectional anatomy displayed by the CT scan allows for separate e...
journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/00004424-197903000-00003
更新日期:1979-03-01 00:00:00
abstract::Blood samples from previous contrast reactors and nonreactor controls were incubated with diatrizoate and several contrast analogues. Total complement levels were assayed. All the agents caused complement activation generally proportional to their concentration. Reactors' sera responded to lower concentrations of cont...
journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/00004424-198307000-00018
更新日期:1983-07-01 00:00:00
abstract:OBJECTIVES:The aim of this study was to evaluate the feasibility of a computed tomography (CT) protocol enabling the visualization of the prostatic artery (PA) before prostatic artery embolization (PAE) in benign prostatic hyperplasia, which provides quantitative perfusion information of the prostate gland. MATERIALS ...
journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/RLI.0000000000000582
更新日期:2019-10-01 00:00:00
abstract::The purpose of our investigation was to determine whether iopanoyl glucuronide, the major metabolite of iopanoic acid (Telepaque), undergoes hydrolysis by bacterial beta-glucuronidase in dogs. The conjugated compound was identified and quantitated by elemental analysis, fluorescent excitation analysis, thin-layer chro...
journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/00004424-197805000-00011
更新日期:1978-05-01 00:00:00
abstract::Radiolabeled blood cells are widely used for both clinical and research studies. In vitro and in vivo studies have shown the tagging process does not significantly affect function. The labeling techniques and clinical uses of labeled leukocytes and platelets are reviewed. ...
journal_title:Investigative radiology
pub_type: 杂志文章,评审
doi:10.1097/00004424-198603000-00001
更新日期:1986-03-01 00:00:00
abstract::An allergic, immunologic mechanism for certain adverse reactions to radiocontrast agents has been postulated on the basis of clinical and theoretical considerations. One obstacle to the acceptance of this allergic theory has been the inability to demonstrate significant antibodies with specificity for these agents. In...
journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/00004424-197609000-00002
更新日期:1976-09-01 00:00:00
abstract:OBJECTIVES:To investigate image quality and interstudy reproducibility of aortic atherosclerosis imaging at 1.5 T, and to explore the impact of parallel imaging techniques at 3 T. MATERIALS AND METHODS:Institutional review board approval and informed consent were obtained. Thirty-two subjects (20 normal, 12 patients w...
journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/RLI.0b013e318181538a
更新日期:2008-09-01 00:00:00
abstract::Iohexol and meglumine-sodium diatrizoate were injected intravenously into 18 pigs as either a 99:1 or 1:99 mixture. Blood samples were taken for 30 minutes and the concentration of each of the two contrast media was measured by means of a double labeling technique with 125I and 131I. Relative concentrations of iohexol...
journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/00004424-198511000-00016
更新日期:1985-11-01 00:00:00
abstract::A diatrizoate compound (Renografin-76) and low osmolality Hexabrix were compared in a double-blind study of 50 adults undergoing arteriographic examination. Subjective and objective assessment of pain reaction for each contrast injection rated lower overall for Hexabrix. Discomfort associated with Renografin was great...
journal_title:Investigative radiology
pub_type: 临床试验,杂志文章
doi:10.1097/00004424-198411001-00012
更新日期:1984-11-01 00:00:00
abstract:OBJECTIVES:This clinical study investigated the pharmacokinetics and safety of gadobutrol, a magnetic resonance (MR) imaging extracellular contrast agent, in pediatric patients aged 2 to 17 years. MATERIALS AND METHODS:In this open-label, multicenter study, patients scheduled for routine contrast-enhanced MR imaging o...
journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/RLI.0b013e3181bfe2d2
更新日期:2009-12-01 00:00:00
abstract::Polylysine covalently linked to moieties of gadopentetate (Gd-DTPA), for use as a macromolecular blood pool marker for contrast material-enhanced magnetic resonance imaging (MRI), was characterized by means of physicochemical measurements and pharmacokinetics in rats and rabbits and compared with Gd-DTPA. Gd-DTPA-poly...
journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/00004424-199111000-00008
更新日期:1991-11-01 00:00:00
abstract:OBJECTIVES AND RATIONALE:Negative enhancement of implanted liver tumors has been achieved in preclinical studies on manganese dipyridoxal-diphosphate (Mn-DPDP), a new hepatobiliary specific contrast agent for magnetic resonance imaging (MRI). The authors investigated the effects of Mn-DPDP on primary liver cancer and i...
journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/00004424-199306000-00011
更新日期:1993-06-01 00:00:00
abstract::The results of an in vitro mixed hemadsorption (MHA) assay predicted the success of in vivo tumor localization using a radioiodinated, monoclonal, IgG1 antibody (A2) with reactivity to the human bladder carcinoma cell line RT4. In vitro, murine monoclonal antibodies A2 and G6, demonstrated reactivity to RT4 with titer...
journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/00004424-198411000-00011
更新日期:1984-11-01 00:00:00
abstract::A feasibility study is described to provide quantitative texture measures to distinguish between normal lung, alveolar infiltrates and interstitial infiltrates. Advanced computer imaging technology and decision making processes were applied to distinguish between these textural patterns. The results, based on computer...
journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/00004424-197807000-00005
更新日期:1978-07-01 00:00:00
abstract:OBJECTIVES:The purpose of this study was to evaluate the extent to which various commercially available gadolinium-containing contrast-enhancing (CE) agents can interfere with the measurement of calcium levels by currently used laboratory methods, suggesting (spurious) hypocalcemia or hypercalcemia with a potential ris...
journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/01.rli.0000170447.45577.5e
更新日期:2005-08-01 00:00:00
abstract::The effect of contrast media (CM) dilution on contrast enhancement was studied using CM representing four structurally different molecular types at osmolalities ranging from 135 to 1340 mosm/kg. Diatrizoate (ionic monomer), iopamidol (nonionic monomer), ioxaglate (ionic dimer), and iodecol (nonionic dimer) were each g...
journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/00004424-198809001-00014
更新日期:1988-09-01 00:00:00
abstract:RATIONALE AND OBJECTIVES:The efficacy of gadoteridol for contrast enhancement of central nervous system pathology was assessed in a multicenter clinical trial involving 411 patients suspected of having intracranial or spinal pathology. METHODS:Magnetic resonance imaging was performed before and after intravenous admin...
journal_title:Investigative radiology
pub_type: 临床试验,杂志文章,多中心研究,随机对照试验
doi:
更新日期:1992-08-01 00:00:00
abstract::The retropsoas recess, a previously undescribed normal anatomic variant, is reported. In most individuals, the space posterior to the belly of the psoas muscle contains fat within the posterior pararenal space. However, a retrospective review of 250 consecutive CT examinations of the abdomen revealed 11 cases (4.4%) i...
journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/00004424-198707000-00004
更新日期:1987-07-01 00:00:00
abstract::We developed a new, cineangiographic method to accurately measure the dynamic changes in the internal diameter of human arteries in vivo. Cine films were digitized at a spatial resolution of 4 microns/pixel, using a line image sensor. The vessel edges, with a Gaussian fit to a unilateral profile curve of the vessel, w...
journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/00004424-198909000-00005
更新日期:1989-09-01 00:00:00