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Adaptation to chronic hypoxia alters cardiac metabolic response to beta stimulation: novel face of phosphocreatine overshoot phenomenon.

Abstract：

:The dynamics of the changes in myocardial phosphorylated compound contents (inorganic phosphate: Pi; phosphocreatine: PCr; ATP) induced by 10(-6)M isoprenaline administration was studied, using 31P-NMR spectroscopy, in hearts isolated from rats adapted for three weeks to normobaric hypoxia (10% of oxygen). When compared with the behaviour of control hearts, the inotropic response to Ca2+ and isoprenaline was larger in the hearts from hypoxic rats, while the oxygen consumption was similar. During administration of isoprenaline, a decrease in the myocardial contents of high energy phosphates (ATP and PCr) and an accumulation of Pi was observed in both groups. After action of isoprenaline, the hearts from hypoxic animals showed significant overshoot of PCr, that was not seen in hearts from normoxic rats. The mechanisms of these alterations are analysed and the phosphocreatine overshoot, as well as the increased rate pressure product to oxygen consumption ratio, are assumed to indicate more efficient energy conversion in the heart from animals adapted to chronic hypoxia.

journal_name

J Mol Cell Cardiol

journal_title

Journal of molecular and cellular cardiology

authors

Novel-Chaté V,Aussedat J,Saks VA,Rossi A

doi

10.1016/s0022-2828(95)90755-6

subject

Has Abstract

pub_date

1995-08-01 00:00:00

pages

1679-87

issue

8

eissn

0022-2828

issn

1095-8584

journal_volume

27

pub_type

杂志文章

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