Abstract:
:Recent studies on iron-loaded transferrins have revealed a conformational change upon binding iron due to a domain closure. It has been suggested that the domain closure may be the key for the receptor recognition of the metal loaded transferrin (Grossmann et al., 1992). Small angle X-ray scattering has been used to provide direct structural information on the conformational changes that may take place upon the binding and release of different metals to the transferrins in solution. The data show that In3+ and Cu2+ induce the same domain closure as Fe3+; Al3+ causes a conformational change of somewhat smaller magnitude while Hf4+ does not induce any conformational change. The results are discussed in terms of the molecular recognition of metal loaded transferrin by the receptor.
journal_name
J Mol Bioljournal_title
Journal of molecular biologyauthors
Grossmann JG,Neu M,Evans RW,Lindley PF,Appel H,Hasnain SSdoi
10.1006/jmbi.1993.1063subject
Has Abstractpub_date
1993-02-05 00:00:00pages
585-90issue
3eissn
0022-2836issn
1089-8638pii
S0022-2836(83)71063-6journal_volume
229pub_type
杂志文章abstract::Galanthus nivalis agglutinin (GNA, a 50 kDa tetramer) is a mannose-specific lectin of the Amaryllidaceae family of bulb lectins. Crystal structures of GNA complexed with methyl-alpha-D-mannose (MeMan) and mannose-alpha 1,3-D-mannose-alpha-OMe (MeMan-2) have been determined and analyzed in terms of internal structural ...
journal_title:Journal of molecular biology
pub_type: 杂志文章
doi:10.1006/jmbi.1996.0532
更新日期:1996-10-04 00:00:00
abstract::Insertion and deletion mutagenesis within the gene topA of Escherichia coli encoding DNA topoisomerase I was carried out to test the existence of subdomains in the enzyme and the relationship between the slow-growth topA- phenotype and the known DNA relaxation activity of the enzyme. All mutants that show no detectabl...
journal_title:Journal of molecular biology
pub_type: 杂志文章
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journal_title:Journal of molecular biology
pub_type: 杂志文章,评审
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journal_title:Journal of molecular biology
pub_type: 杂志文章
doi:10.1006/jmbi.1996.0345
更新日期:1996-06-21 00:00:00
abstract::In order to study the effect of internal dynamics on the accuracy of NMR structures in detail, we generated NOE distance data from a long molecular dynamics trajectory of BPTI. Cross-relaxation rates were calculated from the trajectory by analysis of the appropriate proton-proton vector autocorrelation functions. A cr...
journal_title:Journal of molecular biology
pub_type: 杂志文章
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journal_title:Journal of molecular biology
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journal_title:Journal of molecular biology
pub_type: 杂志文章
doi:10.1006/jmbi.1993.1270
更新日期:1993-05-20 00:00:00
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journal_title:Journal of molecular biology
pub_type: 杂志文章
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journal_title:Journal of molecular biology
pub_type: 杂志文章
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更新日期:2004-10-22 00:00:00
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pub_type: 杂志文章
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更新日期:2002-07-26 00:00:00
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journal_title:Journal of molecular biology
pub_type: 杂志文章
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更新日期:2004-08-13 00:00:00
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更新日期:2016-11-20 00:00:00
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更新日期:2011-07-22 00:00:00
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更新日期:2012-10-19 00:00:00
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journal_title:Journal of molecular biology
pub_type: 杂志文章
doi:10.1016/0022-2836(90)90381-U
更新日期:1990-12-05 00:00:00
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journal_title:Journal of molecular biology
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journal_title:Journal of molecular biology
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更新日期:2005-07-22 00:00:00
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journal_title:Journal of molecular biology
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journal_title:Journal of molecular biology
pub_type: 杂志文章
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更新日期:1997-04-11 00:00:00
abstract::The late genes of bacteriophage P2 are clustered into four transcription units. We have reported the transcription initiation sites for two of the late messenger RNAs, encoding genes QP and ONMLKRS. We have now located the 5' ends of the two remaining late mRNAs. The first gene in the VJHG transcription unit has been ...
journal_title:Journal of molecular biology
pub_type: 杂志文章
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更新日期:1985-02-05 00:00:00
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journal_title:Journal of molecular biology
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journal_title:Journal of molecular biology
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journal_title:Journal of molecular biology
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abstract::Profile hidden Markov models (HMMs) are used to model protein families and for detecting evolutionary relationships between proteins. Such a profile HMM is typically constructed from a multiple alignment of a set of related sequences. Transition probability parameters in an HMM are used to model insertions and deletio...
journal_title:Journal of molecular biology
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doi:10.1016/j.jmb.2004.03.023
更新日期:2004-05-07 00:00:00
abstract::Research on filoviruses has historically focused on the highly pathogenic ebola- and marburgviruses. Indeed, until recently, these were the only two genera in the filovirus family. Recent advances in sequencing technologies have facilitated the discovery of not only a new ebolavirus, but also three new filovirus gener...
journal_title:Journal of molecular biology
pub_type: 杂志文章,评审
doi:10.1016/j.jmb.2019.06.029
更新日期:2019-10-04 00:00:00