Metal-induced conformational changes in transferrins.

Abstract:

:Recent studies on iron-loaded transferrins have revealed a conformational change upon binding iron due to a domain closure. It has been suggested that the domain closure may be the key for the receptor recognition of the metal loaded transferrin (Grossmann et al., 1992). Small angle X-ray scattering has been used to provide direct structural information on the conformational changes that may take place upon the binding and release of different metals to the transferrins in solution. The data show that In3+ and Cu2+ induce the same domain closure as Fe3+; Al3+ causes a conformational change of somewhat smaller magnitude while Hf4+ does not induce any conformational change. The results are discussed in terms of the molecular recognition of metal loaded transferrin by the receptor.

journal_name

J Mol Biol

authors

Grossmann JG,Neu M,Evans RW,Lindley PF,Appel H,Hasnain SS

doi

10.1006/jmbi.1993.1063

subject

Has Abstract

pub_date

1993-02-05 00:00:00

pages

585-90

issue

3

eissn

0022-2836

issn

1089-8638

pii

S0022-2836(83)71063-6

journal_volume

229

pub_type

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