Abstract：
:Efficient transduction by acousticolateralis organs requires that a stimulus force principally deflect hair bundles, rather than flex other structural elements. Hair bundles might therefore be expected to provide a large fraction of the impedence to shear motions of otolithic membranes and other accessory structures. We measured the stiffness for shear motions of the bullfrog's saccular otolithic membrane, and determined the stiffness due to a single hair bundle and its associated extracellular filaments; this component is termed the elemental stiffness. Stiffness measurements were made by displacing the base of a flexible probe whose tip was coupled to the otolithic membrane, and simultaneously measuring the flexion of the probe and the displacement of the membrane. The average elemental stiffness, about 1350 microN.m-1, only modestly exceeded the stiffness of individual hair bundles. The hair bundles therefore provide the dominant component of stiffness in the bullfrog's sacculus, and thus account for a significant component of impedance to otolithic-membrane shear. As a corollary, stiffness changes or active movements in hair bundles should influence the mechanical responses of this and other receptor organs.
journal_name
Hear Resjournal_title
Hearing researchauthors
Benser ME,Issa NP,Hudspeth AJdoi
10.1016/0378-5955(93)90128-nsubject
Has Abstractpub_date
1993-08-01 00:00:00pages
243-52issue
2eissn
0378-5955issn
1878-5891pii
0378-5955(93)90128-Njournal_volume
68pub_type
杂志文章相关文献
HEARING RESEARCH文献大全abstract：:The purpose of this study was to compare cortical brain responses evoked by amplitude modulated acoustic beats of 3 and 6 Hz in tones of 250 and 1000 Hz with those evoked by their binaural beats counterparts in unmodulated tones to indicate whether the cortical processes involved differ. Event-related potentials (ERPs...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/j.heares.2010.01.013
更新日期：2010-04-01 00:00:00
abstract：:Sudden sensorineural hearing loss (SSNHL) is generally defined as sensorineural hearing loss of 30 dB or greater over at least three contiguous audiometric frequencies and within a three-day period. This hearing loss is usually unilateral and can be associated with tinnitus and vertigo. The pathogenesis of unilateral ...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/j.heares.2016.02.016
更新日期：2016-05-01 00:00:00
abstract：:Adenosine plays a major cytoprotective role during ischemia and conditions of oxidative stress. Previous studies in our laboratory indicate that oxidative stress induces expression of the A1 adenosine receptor (A1AR) via activation of nuclear factor (NF)-kappaB. In this study, we tested whether noise exposure could in...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/S0378-5955(03)00344-7
更新日期：2004-02-01 00:00:00
abstract：:Strial marginal cells are known to take up and metabolize glucose as their main source of metabolic energy. The membrane transport mechanisms for glucose uptake into strial marginal cells, however, are largely unknown. Two types of glucose transporters in mammalian cells have been described, the facilitated glucose tr...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/s0378-5955(97)00157-3
更新日期：1997-12-01 00:00:00
abstract：:Blind cave fish use the lateral line sensory system to detect nearby objects. The fish responds to sudden perturbations in the water column by initiating startle responses in which they swim more rapidly. Normal startle responses disappear after trauma caused by a single 15 s immersion in calcium free water, but retur...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/s0378-5955(01)00226-x
更新日期：2001-04-01 00:00:00
abstract：:The directionality of the cat's pinna was studied by using the amplitude of the cochlear microphonic (CM) as a quantitative indicator of tympanic sound pressure level (SPL). It was found that tympanic SPL varied with the location of a free field stimulator in anechoic space. For high (tonal) frequencies, there was a c...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/0378-5955(82)90031-4
更新日期：1982-09-01 00:00:00
abstract：:Previous studies have shown a reduction of the ototoxicity of furosemide in chinchillas pretreated with organic acid transport inhibitors. The current studies were designed to investigate whether such a protective effect could be observed in chinchillas receiving ethacrynic acid. Chinchillas weighing 400-600 g were in...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/0378-5955(90)90142-c
更新日期：1990-06-01 00:00:00
abstract：:Masking and binaural masking-level differences (BMLDs) were measured using short 400 and 800 Hz test tones masked by uniform masking noise in both pre- and post-masking conditions. The BMLD shows the same dependence on the temporal position of the test signal as masking itself. Additional data produced with interrupte...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/0378-5955(84)90076-5
更新日期：1984-03-01 00:00:00
abstract：:There is accumulating evidence for a purinergic humoral system involved in the control of cochlear function. Evidence of specific P2 purinoceptors on cochlear tissues implies a role for extracellular adenosine triphosphate (ATP) in the cochlea. To further this hypothesis a study was undertaken to determine if there wa...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/0378-5955(95)00151-1
更新日期：1995-10-01 00:00:00
abstract：:Tone-burst-evoked compound action potentials (CAP) from the guinea pig round window (RW) are altered by DC current injection through the RW. The CAP waveform consists of a series of interleaved negative and positive peaks (N(1), P(1), N(2), P(2) etc.) of decreasing amplitude. During positive DC current injection (arou...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/S0378-5955(03)00404-0
更新日期：2004-04-01 00:00:00
abstract：:The primary goal of most cochlear implant procedures is to improve a patient's ability to discriminate speech. To accomplish this, cochlear implants are programmed so as to maximize speech understanding. However, programming a cochlear implant can be an iterative, labor-intensive process that takes place over months. ...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/j.heares.2013.11.007
更新日期：2014-03-01 00:00:00
abstract：:Cochlear implant users with ipsilateral residual hearing combine acoustic and electric hearing in one ear, this is called electric-acoustic stimulation (EAS). In EAS users, masking can be shown for electric probes in the presence of acoustic maskers and vice versa. Masking effects in acoustic hearing are generally att...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/j.heares.2019.107873
更新日期：2020-02-01 00:00:00
abstract：:The rather shallow growth of click-evoked otoacoustic emissions (CEOAE) with click intensity, namely <1 dB/dB, distinguishes genuine CEOAEs from stimulus artifacts, thereby providing the rationale for the popular 'derived nonlinear recording' method. However, other CEOAE nonlinearities regarding phase or envelope depe...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/s0378-5955(02)00745-1
更新日期：2003-01-01 00:00:00
abstract：:High doses of aminoglycoside antibiotics cause massive damage to the avian basilar papilla. The resulting functional loss could conceivably arise from the reduction in the DC endocochlear potential (EP) due to impairment of the tegmentum vasculosum (TV) or to shunting of current through the damaged sensory epithelium....
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/0378-5955(95)00119-5
更新日期：1995-09-01 00:00:00
abstract：:Glutamate is the neurotransmitter of the synapse between vestibular type I hair cells and the afferent nerve calyx. This calyx may also be involved in local feedback, which may modify sensory cell activity via N-methyl-D-aspartate (NMDA) receptors. Glycine is the co-agonist of glutamate in NMDA receptor activation. Bo...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/s0378-5955(99)00194-x
更新日期：2000-02-01 00:00:00
abstract：:We developed a new technique, the isolated in vitro perfused spiral modiolar artery, which allowed the continuous measurement of the vascular diameter and control of the intravascular pressure. An isolated section of the spiral modiolar artery from the gerbil was perfused on one end with a set of concentric pipettes a...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/s0378-5955(97)00184-6
更新日期：1998-01-01 00:00:00
abstract：:The human fetal auditory system is functional around the 25th week of gestational age when the thalamocortical connections are established. Fetal magnetoencephalography (fMEG) provides evidence for fetal auditory brain responses to pure tones and syllables. Fifty-five pregnant women between 31 and 40 weeks of gestatio...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/j.heares.2018.03.005
更新日期：2018-06-01 00:00:00
abstract：:Units in the auditory cortex of cats respond to a large variety of stimuli: pure tones, AM- and FM-modulated signals, clicks, wideband noise, natural sounds, and more. However, no single family of sounds was found to be optimal (in the sense that oriented lines are optimal in the visual cortex). The search for optimal...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/0378-5955(94)90222-4
更新日期：1994-01-01 00:00:00
abstract：:The focus of this study was to gauge the influence of intervening interference on an intensity standard held within auditory working memory through measurement of the just noticeable difference (JND) for intensity. Additionally, the use of interaural phase differences and interaural level differences as spatial cues w...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/j.heares.2008.04.004
更新日期：2008-06-01 00:00:00
abstract：UNLABELLED:This study sought to characterize the response of mammalian primary otolithic neurons to sound and vibration by measuring the resting discharge rates, thresholds for increases in firing rate and supra-threshold sensitivity functions of guinea pig single primary utricular and saccular afferents. Neurons with ...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/j.heares.2015.10.019
更新日期：2016-01-01 00:00:00
abstract：:The objective of the present study was to examine whether mepacrine, a commonly used phospholipase A2 inhibitor, decreases ischemic damage to the cochlea. Transient ischemia of the cochlea was induced in albino guinea pigs for 15, 30 or 60 min by pressing the labyrinthine artery at the porus acusticus internus. The an...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/s0378-5955(00)00038-1
更新日期：2000-06-01 00:00:00
abstract：:No adequate theory for the signal-transmission properties of the peripheral auditory system exists for any vertebrate ear. Because the mammalian ear seems to pose conceptual and technical problems that complicate the development of an adequate theory, it is worthwhile to investigate simpler ears. The ear of the alliga...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/0378-5955(85)90164-9
更新日期：1985-01-01 00:00:00
abstract：:Left ear noise-induced hearing losses are dominant in the army. The common explanation is the asymmetrical effect of the shooting posture. However, firm evidence to support this possibility is still lacking. In the French army shooters, eye preference rather than hand preference for shooting determines the side of sho...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/s0378-5955(98)00104-x
更新日期：1998-08-01 00:00:00
abstract：:Acetylcholine (ACh) is a neuromodulator that is likely to play a role in plasticity as well as other phenomena at many sites in the auditory system. The auditory cortex receives cholinergic innervation from the basal forebrain, whereas the cochlea receives cholinergic innervation from the superior olivary complex. Muc...
journal_title：Hearing research
pub_type： 杂志文章,评审
doi：10.1016/j.heares.2010.12.019
更新日期：2011-09-01 00:00:00
abstract：:Uncoupling proteins (UCPs) are a proton transporter family located in the mitochondrial inner membrane. The molecular expression and activity of UCPs in brown adipose tissue and skeletal muscle are regulated by factors as diverse as chronic overeating and cold exposure, suggesting roles in energy expenditure and heat ...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/j.heares.2004.02.002
更新日期：2004-10-01 00:00:00
abstract：:Inbred strain variants of the Cdh23 gene have been shown to influence the onset and progression of age-related hearing loss (AHL) in mice. In linkage backcrosses, the recessive Cdh23 allele (ahl) of the C57BL/6J strain, when homozygous, confers increased susceptibility to AHL, while the dominant allele (Ahl+) of the C...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/j.heares.2011.11.007
更新日期：2012-01-01 00:00:00
abstract：:This study explored the effects on speech intelligibility of across-formant differences in fundamental frequency (ΔF0) and F0 contour. Sentence-length speech analogues were presented dichotically (left = F1+F3; right = F2), either alone or-because competition usually reveals grouping cues most clearly-accompanied in t...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/j.heares.2016.10.026
更新日期：2017-02-01 00:00:00
abstract：:The lipophilic dye, DiI, was placed into the macula lagena of paraformaldehyde-fixed embryonic chicks. Retrogradely labeled cells were found bilaterally in the pontine reticular formation (RF) between the dorsal facial nucleus and the abducens nerve root. This location is similar to that of the dorsomedial group of ef...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/0378-5955(94)00159-n
更新日期：1995-01-01 00:00:00
abstract：:The primary goal of this study was to characterize the variability in auditory-nerve temporal response patterns obtained with the electrically evoked compound action potential (ECAP) within and across a relatively large group of cochlear-implant recipients. ECAPs were recorded in response to each of 21 pulses in a pul...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/j.heares.2012.01.010
更新日期：2012-03-01 00:00:00
abstract：:During noise-induced temporary threshold shift cytoplasmic vacuoles increase in the synaptic region of auditory hair cells. This structural change in the presynaptic region suggests that afferent synapses between hair cells and auditory nerve fibers fail during the period of threshold elevation, and that synaptic fati...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/0378-5955(90)90096-8
更新日期：1990-11-01 00:00:00
