Effect of intratesticular administration of anti-corticotropin-releasing factor antiserum (a-CRF) on testicular function in neonatal rats.

Abstract:

:The possible physiological role of testicular corticotropin-releasing factor (CRF) in the regulation of testicular functions was studied in neonatal rats. Two microlitres of anti-CRF-antiserum (dilution: 1:10 or 1:100) was injected intratesticularly to 5 d-old rats with two testes and to hemicastrates. Five days after hemicastration and treatment of the remaining testis with the antiserum, serum testosterone concentration and basal testosterone secretion in vitro decreased significantly. Unilateral testicular injection of a-CRF in rats with two testes resulted in a significant drop in serum testosterone level with no change in basal testosterone production. Data indicate that in neonatal rats testicular CRF might be a local stimulator of steroidogenesis.

journal_name

Andrologia

journal_title

Andrologia

authors

Gerendai I,Nemeskéri A,Csernus V

doi

10.1111/j.1439-0272.1993.tb02711.x

subject

Has Abstract

pub_date

1993-07-01 00:00:00

pages

211-5

issue

4

eissn

0303-4569

issn

1439-0272

journal_volume

25

pub_type

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