Abstract:
:Colon cancer is known to be heritable in humans, but the opportunity to investigate the genetic epidemiology of cancer in nonhuman primates has been limited by the size of available populations. The cotton-top tamarin (Saguinus oedipus) colony at the Oak Ridge Associated Universities (ORAU) Marmoset Research Center is a large population with a high rate of spontaneous colon cancer that has been monitored over several years, thus allowing investigation of the genetic basis for colon cancer in this colony. The presence of colon cancer at death was scored in 392 necropsies at the colony. Genealogical and demographic data for these animals were obtained from colony records. The heritability of the liability to colon cancer was estimated using maximum-likelihood-based pedigree analyses after evaluating the effects of gender, origin (wild-born or laboratory-born), and age at death on cancer experience. Cancer rates were not significantly different between males and females or between wild- and laboratory-born animals. Differences in age at death were also statistically insignificant for both laboratory- and wild-born animals. The heritability estimate for the liability to contract colon cancer is 17% for the ORAU cotton-top tamarins. This heritability estimate is not significantly different from zero, indicating no evidence for heritable variation in cancer experience in this population. If genetic factors affect cotton-top tamarin colon cancer, they are fixed or nearly fixed in this population.
journal_name
Hum Bioljournal_title
Human biologyauthors
Cheverud JM,Tardif S,Henke MA,Clapp NKsubject
Has Abstractpub_date
1993-12-01 00:00:00pages
1005-12issue
6eissn
0018-7143issn
1534-6617journal_volume
65pub_type
杂志文章相关文献
HUMAN BIOLOGY文献大全abstract::We studied 3925 individuals in 961 families to determine the mode of inheritance of overweight. As an index of overweight, we examined body mass index. Our analyses indicate that the most likely genetic model for susceptibility to overweight included moderate polygenic inheritance (34% of variance resulting from many ...
journal_title:Human biology
pub_type: 杂志文章
doi:
更新日期:1990-12-01 00:00:00
abstract::Autoregressive integrated moving average (ARIMA) models provide a powerful tool for detecting seasonal patterns in mortality statistics. The strength of ARIMA models lies in their ability to reveal complex structures of temporal interdependence in time series. Moreover, changes in model parameters provide an empirical...
journal_title:Human biology
pub_type: 历史文章,杂志文章
doi:10.1353/hub.2007.0006
更新日期:2006-10-01 00:00:00
abstract::Eight STR systems (THO1, FABP, VWA, FES/FPS, HPRTB, F13A1, CSF1PO, and D6S366) were investigated in different ethnic groups of Argentina. Allele and genotype frequencies, power of exclusion, and discriminative power were investigated. Hardy-Weinberg expectations were calculated from heterozygosity levels. FST and G te...
journal_title:Human biology
pub_type: 杂志文章
doi:
更新日期:1998-10-01 00:00:00
abstract::Genetic diversity among ethnic groups is studied by comparing the genetic fingerprint of the examined groups. This index is constructed by aggregating the differential frequencies of various marker characteristics. Recent advances in the study of human biological rhythms may provide new indexes that will complement th...
journal_title:Human biology
pub_type: 杂志文章
doi:
更新日期:1995-10-01 00:00:00
abstract::4 ethnically, cultural-historically and linguistically distinct subsets of the Sells Reservation Papago population of southern Arizona are identified using ethnographic and demographic data. Breeding patterns of these 4 isolates are described and compared with fertility and mortality parameters. Isolates which exper...
journal_title:Human biology
pub_type: 杂志文章
doi:
更新日期:1980-05-01 00:00:00
abstract::The fertility pattern, in terms of birth intervals, in a rural population not practicing contraception belonging to La Alta Alpujarra Oriental (southeast Spain) is analyzed. During the first half of the 20th century, this population experienced a considerable degree of geographical and cultural isolation. Because of t...
journal_title:Human biology
pub_type: 杂志文章
doi:
更新日期:2000-10-01 00:00:00
abstract::Two microsatellites (CD4 and F13A1) were investigated in seven Brazilian populations: one group each of European- and African-derived subjects from Porto Alegre, southern Brazil, and five Amerindian tribes (three Tupi-Mondé speaking [Gavião, Surui, and Zoró], one Macro-Gê [Xavante], and one Carib [Wai-Wai]). For both ...
journal_title:Human biology
pub_type: 杂志文章
doi:
更新日期:2000-12-01 00:00:00
abstract::GM and KM immunoglobulin (Ig) allotypes were tested in 118 autochthonous Basques from northern Navarre. The results are compared to those obtained for the same genetic markers in 6 other Basque subpopulations, 3 from Spain (Guipúzcoa, Vizcaya, and Alava) and 3 from France: Macaye, Saint-Jean Pied de Port, and Mauleon....
journal_title:Human biology
pub_type: 杂志文章
doi:
更新日期:2000-08-01 00:00:00
abstract::We used 15 short tandem repeat (STR) loci (D8S1179, D21S11, D7S820, CSF1PO, D3S1358, TH01, D13S317, D16S539, D2S1338, D19S433, VWA, TPOX, D18S51, D5S818, and FGA) to genetically characterize 361 individuals from 11 indigenous populations (Amuzgo, Chinanteco, Chontal, Huave, Mazateco, Mixe, Mixteco, Triqui, Zapoteco de...
journal_title:Human biology
pub_type: 杂志文章
doi:10.3378/027.082.0405
更新日期:2010-08-01 00:00:00
abstract::To what extent can ethnic factors contribute to the prevalence of type 2 diabetes and impaired glucose tolerance (IGT) in an urban Brazilian population? Conversely, how can environmental factors such as diet change these prevalences in a given ethnic group, in this case Brazilian Indians? To answer these questions est...
journal_title:Human biology
pub_type: 杂志文章
doi:
更新日期:2002-08-01 00:00:00
abstract::We present the most comprehensive genetic characterization to date of five Fijian island populations: Viti Levu, Vanua Levu, Kadavu, the Lau Islands, and Rotuma, including nonrecombinant Y (NRY) chromosome and mitochondrial DNA (mtDNA) haplotypes and haplogroups. As a whole, Fijians are genetically intermediate betwee...
journal_title:Human biology
pub_type: 杂志文章
doi:10.13110/humanbiology.88.3.0232
更新日期:2016-07-01 00:00:00
abstract::Hematocrit values are normally higher in natives living at high altitude than in natives living at sea level. Here, we have determined the hematocrit levels in relation to adrenal androgens in children living at altitudes of 150 m and 3400 m above sea level. The data demonstrate no association between serum adrenal an...
journal_title:Human biology
pub_type: 杂志文章
doi:
更新日期:1993-02-01 00:00:00
abstract::We describe the gene frequency distributions for 29 different blood group, serum, and erythrocytic proteins for three Mennonite communities from Kansas and Nebraska and compare their gene frequencies with those of Amish, Hutterite, and Mennonite populations using the topological method of Harpending and Jenkins (1973)...
journal_title:Human biology
pub_type: 杂志文章
doi:
更新日期:1989-08-01 00:00:00
abstract::The blood glucose levels of pregnant women with insulin-dependent diabetes mellitus and the blood glucose levels of newborns during the first few hours of life show an association with maternal Rh genotype. Distortions of joint maternal-fetal Rh phenotype distribution have also been observed. Because a cluster of gene...
journal_title:Human biology
pub_type: 杂志文章
doi:
更新日期:1992-02-01 00:00:00
abstract::A recent workshop entitled "The Family Name as Socio-Cultural Feature and Genetic Metaphor: From Concepts to Methods" was held in Paris in December 2010, sponsored by the French National Centre for Scientific Research (CNRS) and by the journal Human Biology. This workshop was intended to foster a debate on questions r...
journal_title:Human biology
pub_type: 杂志文章
doi:10.3378/027.084.0205
更新日期:2012-04-01 00:00:00
abstract::Given the same reproductive span, more children with shorter interbirth intervals and less parental attention per child should not do as well. There should be intermediate optima in family sizes, but only two studies have demonstrated optima. The goal here is to determine whether the relationship between fitness and f...
journal_title:Human biology
pub_type: 历史文章,杂志文章
doi:10.1353/hub.2005.0010
更新日期:2004-10-01 00:00:00
abstract::Dermatoglyphic traits have been used to assess population affinities and structure. Here, we describe the digital patterns of four Eskimo populations from Alaska: two Yupik-speaking villages from St. Lawrence Island and two Inupik groups presently residing on mainland Alaska. For a broader evolutionary perspective, th...
journal_title:Human biology
pub_type: 杂志文章
doi:
更新日期:1992-10-01 00:00:00
abstract::The genetic surveys of the population of Britain conducted by Weale et al. and Capelli et al. produced estimates of the Germani immigration into Britain during the early Anglo-Saxon period, c.430-c.730. These estimates are considerably higher than the estimates of archaeologists. A possible explanation suggests that a...
journal_title:Human biology
pub_type: 历史文章,杂志文章
doi:10.3378/027.083.0604
更新日期:2011-12-01 00:00:00
abstract::Preston's two-census method of demographic estimation is applied to three pairs of reconstructed censuses from the records of a migrating Mennonite church congregation covering the period 1780-1890. The three pairs of censuses correspond to three periods (1780-1790, 1850-1860, and 1880-1890) and to stays in three sett...
journal_title:Human biology
pub_type: 杂志文章
doi:
更新日期:1995-02-01 00:00:00
abstract::The radical improvement in living conditions experienced in Italy during the last century caused a reduction in male extra-mortality during the prereproductive years. As a consequence, a progressive increase in the sex ratio at the beginning of the reproductive age (15-19 years) occurred, so that in recent times the s...
journal_title:Human biology
pub_type: 杂志文章
doi:10.1353/hub.2001.0014
更新日期:2001-02-01 00:00:00
abstract::A random sample of death records of adult males from the period 1967 to 1970 was chosen from the South Australian Registry of Births, Deaths, and Marriages. The natural parents of these individuals were identified by cross-referencing to birth certificates, and an extensive search was made of the death records for the...
journal_title:Human biology
pub_type: 杂志文章
doi:
更新日期:1997-12-01 00:00:00
abstract::In one of the truly classic works in anthropological genetics, Frank Livingstone established the interrelationships between agriculture, mosquito ecology, malaria, and, consequently, the frequencies of sickle cell hemoglobin in West Africa. A major inference from Livingstone's study was the recency of malaria as a sel...
journal_title:Human biology
pub_type: 历史文章,杂志文章,评审
doi:10.1353/hub.2003.0053
更新日期:2003-08-01 00:00:00
abstract::Although much attention has been given to statistical genetic methods for the initial localization and fine mapping of quantitative trait loci (QTLs), little methodological work has been done to date on the problem of statistically identifying the most likely functional polymorphisms using sequence data. In this paper...
journal_title:Human biology
pub_type: 杂志文章
doi:10.1353/hub.2006.0003
更新日期:2005-10-01 00:00:00
abstract::The Sicilian population has a complex history of colonization and invasions that have influenced the genetic composition of the nine provinces of the island. Because surnames are patrilineally inherited, they simulate a Y-chromosome nonrecombinant genetic locus. We used surname data and a specific sampling strategy to...
journal_title:Human biology
pub_type: 杂志文章
doi:10.1353/hub.2005.0015
更新日期:2004-12-01 00:00:00
abstract::The two polymorphic alleles of esterase D (ESD), ESD*5 and ESD*7, are specific to Europeans and Asians, respectively. In this study the molecular basis was characterized: ESD*5, arising from ESD*1, has a G to A transition, resulting in Gly257(GGT) --> Asp(GAT); and ESD*7, originating from ESD*2, has an A to G transiti...
journal_title:Human biology
pub_type: 杂志文章
doi:10.1353/hub.2004.0051
更新日期:2004-06-01 00:00:00
abstract::We have analyzed single nucleotide polymorphisms (SNPs) in the XPC, XPA, and XPG genes of the nucleotide excision repair (NER) pathway in the Indian population. In the XPC gene we observed nine polymorphisms in the coding region, four polymorphisms in the intronic region, and two polymorphisms in the 5' untranslated r...
journal_title:Human biology
pub_type: 杂志文章
doi:10.1353/hub.2008.0005
更新日期:2007-10-01 00:00:00
abstract::In this paper I propose that evolutionary demography and associated theory from human behavioral ecology provide a strong basis for explaining the available evidence for the patterns observed in the first agricultural settlement of Europe in the 7th-5th millennium cal. BC, linking together a variety of what have previ...
journal_title:Human biology
pub_type: 历史文章,杂志文章
doi:10.3378/027.081.0312
更新日期:2009-04-01 00:00:00
abstract::Craniofacial variation is investigated in Latin America and the Caribbean. The samples included in this study are two historic and one prehistoric sample from Ecuador; prehistoric and modern Cuban samples; a prehistoric Peruvian sample; two prehistoric Mexican samples and one contemporary admixed Mexican sample; a 16t...
journal_title:Human biology
pub_type: 历史文章,杂志文章
doi:10.1353/hub.2003.0010
更新日期:2002-12-01 00:00:00
abstract::Viewed as a biological concept, sexual dimorphism does not appear to motivate debate. However, with the aim of measuring such dimorphism, several indexes have been proposed, and not all of them have been regarded as equally reliable by the biological community. The main divergence between the indexes is that their def...
journal_title:Human biology
pub_type: 杂志文章
doi:10.3378/027.082.0205
更新日期:2010-04-01 00:00:00
abstract::Several epidemiological studies have established that elevated serum lipoprotein (a) [Lp(a)] levels are independent risk factors for coronary heart disease, stroke, and restenosis of coronary lesions in white and Asian populations. Serum Lp(a) levels vary over a 1000-fold range among individuals and are under strict g...
journal_title:Human biology
pub_type: 临床试验,杂志文章
doi:
更新日期:1998-06-01 00:00:00