Abstract:
:In Euplotes crassus millions of telomeres are synthesized during the sexual phase of the life cycle. Since these newly synthesized telomeres are longer than normal macronuclear telomeres, they must be trimmed to the mature size. We have examined the timing and mechanism of this trimming step. We have shown that a sudden decrease in telomere length takes place at a specific time during macronuclear development. The decrease in telomere length is not caused by incomplete replication of the most terminal DNA sequences; rather it is the result of an active processing event that occurs independently of DNA replication. The developmentally regulated telomere shortening that takes place in Euplotes is reminiscent of the sudden reductions in telomere length which have been observed in other eukaryotes.
journal_name
Nucleic Acids Resjournal_title
Nucleic acids researchauthors
Vermeesch JR,Williams D,Price CMdoi
10.1093/nar/21.23.5366subject
Has Abstractpub_date
1993-11-25 00:00:00pages
5366-71issue
23eissn
0305-1048issn
1362-4962journal_volume
21pub_type
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