Newer approaches in treating chronic myelogenous leukemia.

Abstract:

:We evaluated the recovery of human hematopoietic progenitors in long-term bone marrow culture (LTBMC) initiated in tissue culture (TC) flasks to that in "Lifecell" bags, which are gas-permeable plastic bags in which feeder-layer cells cannot adhere. Cells were incubated in presence of IL-1 and IL-3. Our experiments reveal sustained hematopoietic stem cell growth in the absence of a feeder layer in plastic gas-permeable bags. Evaluations of marrow from patients with chronic myelogenous leukemia suggests enrichment of normal hematopoietic precursors. Combining effective drugs to decrease Ph(+) clone prior to bone marrow harvest and use of cultured bone marrow may provide a useful method for treating patients with chronic myelogenous leukemia.

journal_name

Leuk Lymphoma

journal_title

Leukemia & lymphoma

authors

Gulati SC,Lemoli R,Van Poznak C

doi

10.3109/10428199309047901

subject

Has Abstract

pub_date

1993-01-01 00:00:00

pages

293-6

eissn

1042-8194

issn

1029-2403

journal_volume

11 Suppl 1

pub_type

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