New occurrence of atrial natriuretic factor and storage in secretorially active granules in adult rat ventricular cardiomyocytes in long-term culture.

Abstract:

:Under normal physiological conditions atrial natriuretic factor (ANF) in rat is stored in secretory granules in fetal and adult atrial cardiomyocytes (Cantin et al., 1984; de Bold, 1985), whereas in fetal and neonatal ventricular cardiomyocytes secretory granules are practically absent and ANF is directly secreted via the constitutive pathway (Bloch et al., 1986; Cantin et al., 1987). In ventricular adult rat cardiomyocytes however, ANF is down-regulated and only expressed in cells of interventricular septum (Reinecke, 1989). These ANF-containing cells seem to constitute part of the Purkinje fibre system. As ventricular adult rat cardiomyocytes (ARC) in longterm culture in many ways re-express the fetal program (Eppenberger et al., 1988; Eppenberger-Eberhardt et al., 1990), it was of interest to investigate whether this was also the case for ANF. Data in the present study show that immunoreactive (IR) ANF is upregulated in cultured ventricular ARC and is stored just as in cultured atrial ARC in "atrial-type" granules and secreted into the medium. A possible analogy with overload heart hypertrophy in vivo, where a reactivation of an early gene program including re-expression of ANF in ventricular myocytes has been described (Izumo et al., 1987; Chien et al., 1991), is proposed.

journal_name

J Mol Cell Cardiol

authors

Eppenberger-Eberhardt M,Messerli M,Eppenberger HM,Reinecke M

doi

10.1006/jmcc.1993.1088

subject

Has Abstract

pub_date

1993-07-01 00:00:00

pages

753-7

issue

7

eissn

0022-2828

issn

1095-8584

pii

S0022-2828(83)71088-6

journal_volume

25

pub_type

杂志文章
  • Myosin phosphorylation decreases the ATPase activity of cardiac myofibrils.

    abstract::Our previous work showed that myosin phosphorylation decreased the ATPase activity of skeletal muscle myofibrils that were lightly fixed with glutaraldehyde. The fixation process prevented sarcomere shortening and destruction of the ordered filament array upon the addition of ATP. We have now extended these results to...

    journal_title:Journal of molecular and cellular cardiology

    pub_type: 杂志文章

    doi:10.1016/s0022-2828(84)80624-0

    authors: Franks K,Cooke R,Stull JT

    更新日期:1984-07-01 00:00:00

  • Coronary vasodilation shifts the diastolic pressure-dimension curve of the left ventricle.

    abstract::The volume of blood in the left ventricular wall increases as coronary perfusion pressure or coronary blood flow increase, but it is unclear whether such an increase in volume can acutely alter the diastolic pressure-dimension relationship of the intact, working left ventricle. In 19 dogs, we measured left ventricular...

    journal_title:Journal of molecular and cellular cardiology

    pub_type: 杂志文章

    doi:10.1016/s0022-2828(86)80966-x

    authors: Verrier ED,Bristow JD,Hoffman JI

    更新日期:1986-06-01 00:00:00

  • Targeting cardiac fibroblasts to treat fibrosis of the heart: focus on HDACs.

    abstract::Cardiac fibrosis is implicated in numerous physiologic and pathologic conditions, including scar formation, heart failure and cardiac arrhythmias. However the specific cells and signaling pathways mediating this process are poorly understood. Lysine acetylation of nucleosomal histone tails is an important mechanism fo...

    journal_title:Journal of molecular and cellular cardiology

    pub_type: 杂志文章,评审

    doi:10.1016/j.yjmcc.2014.02.015

    authors: Schuetze KB,McKinsey TA,Long CS

    更新日期:2014-05-01 00:00:00

  • Increased amounts of collagenase and gelatinase in porcine myocardium following ischemia and reperfusion.

    abstract::We studied the presence of collagen degrading enzymes (matrix metalloproteinases, MMPs) in porcine myocardium following ischemia and late reperfusion. In nine pigs, left anterior descending coronary artery was occluded for 6 h followed by reperfusion for 3 h. Six pigs without coronary occlusion served as controls. Aft...

    journal_title:Journal of molecular and cellular cardiology

    pub_type: 杂志文章

    doi:10.1006/jmcc.1998.0711

    authors: Danielsen CC,Wiggers H,Andersen HR

    更新日期:1998-07-01 00:00:00

  • Selective down-regulation of sub-endocardial ryanodine receptor expression in a rabbit model of left ventricular dysfunction.

    abstract::Defective sarcoplasmic reticulum (SR) Ca2+ handling is evident in cardiomyopathy and may be mediated by selective dysregulation of SR Ca2+ handling proteins. To assess whether regulation of SR Ca2+ release may vary regionally within the normal and diseased heart, left ventricular transmural expression and activity of ...

    journal_title:Journal of molecular and cellular cardiology

    pub_type: 杂志文章

    doi:10.1016/j.yjmcc.2005.04.005

    authors: Currie S,Quinn FR,Sayeed RA,Duncan AM,Kettlewell S,Smith GL

    更新日期:2005-08-01 00:00:00

  • Sustained augmentation of cardiac alpha1A-adrenergic drive results in pathological remodeling with contractile dysfunction, progressive fibrosis and reactivation of matricellular protein genes.

    abstract::We previously reported that transgenic (TG) mice with cardiac-restricted alpha(1A)-adrenergic receptor (alpha(1A)-AR)-overexpression showed enhanced contractility, but no hypertrophy. Since chronic inotropic enhancement may be deleterious, we investigated if long-term, cardiac function and longevity are compromised. a...

    journal_title:Journal of molecular and cellular cardiology

    pub_type: 杂志文章

    doi:10.1016/j.yjmcc.2006.01.015

    authors: Chaulet H,Lin F,Guo J,Owens WA,Michalicek J,Kesteven SH,Guan Z,Prall OW,Mearns BM,Feneley MP,Steinberg SF,Graham RM

    更新日期:2006-04-01 00:00:00

  • Aerobic interval training enhances cardiomyocyte contractility and Ca2+ cycling by phosphorylation of CaMKII and Thr-17 of phospholamban.

    abstract::Cardiac adaptation to aerobic exercise training includes improved cardiomyocyte contractility and calcium handling. Our objective was to determine whether cytosolic calcium/calmodulin-dependent kinase II and its downstream targets are modulated by exercise training. A six-week aerobic interval training program by trea...

    journal_title:Journal of molecular and cellular cardiology

    pub_type: 杂志文章

    doi:10.1016/j.yjmcc.2007.06.013

    authors: Kemi OJ,Ellingsen O,Ceci M,Grimaldi S,Smith GL,Condorelli G,Wisløff U

    更新日期:2007-09-01 00:00:00

  • Appearance and regression of rat pouch tissue.

    abstract::Fibrosis, a consequence of tissue repair, can become a final common pathway to organ failure, if progressive. Prevention and regression of organ fibrosis represent targets of considerable interest. The natural fate of fibrosis differs among various tissues being either persistent, progressive or regressive. Cellular a...

    journal_title:Journal of molecular and cellular cardiology

    pub_type: 杂志文章

    doi:10.1006/jmcc.1999.0944

    authors: Zhang J,Sun Y,Zhang JQ,Ramires FJ,Weber KT

    更新日期:1999-05-01 00:00:00

  • Thioredoxin 1 enhances neovascularization and reduces ventricular remodeling during chronic myocardial infarction: a study using thioredoxin 1 transgenic mice.

    abstract::Oxidative stress plays a crucial role in disruption of neovascularization by alterations in thioredoxin 1 (Trx1) expression and its interaction with other proteins after myocardial infarction (MI). We previously showed that Trx1 has angiogenic properties, but the possible therapeutic significance of overexpressing Trx...

    journal_title:Journal of molecular and cellular cardiology

    pub_type: 杂志文章

    doi:10.1016/j.yjmcc.2010.11.002

    authors: Adluri RS,Thirunavukkarasu M,Zhan L,Akita Y,Samuel SM,Otani H,Ho YS,Maulik G,Maulik N

    更新日期:2011-01-01 00:00:00

  • Ion specificity and stoichiometry of the cardiac inositol transporter.

    abstract::Cardiac myocytes have a high affinity. Mg(2+)-dependent, electrogenic, Na-inositol co-transporter on the plasma or sarcolemma (SL) membrane (Rubin and Hale, 1993). The ion specificity and stoichiometry of this transport process is unknown. Using bovine cardiac SL vesicles, we have determined that transmembrane movemen...

    journal_title:Journal of molecular and cellular cardiology

    pub_type: 杂志文章

    doi:10.1016/0022-2828(95)90048-9

    authors: Hale CC,Rubin LJ

    更新日期:1995-05-01 00:00:00

  • I(f) blocking potency of ivabradine is preserved under elevated endotoxin levels in human atrial myocytes.

    abstract::Lower heart rate is associated with better survival in patients with multiple organ dysfunction syndrome (MODS), a disease mostly caused by sepsis. The benefits of heart rate reduction by ivabradine during MODS are currently being investigated in the MODIfY clinical trial. Ivabradine is a selective inhibitor of the pa...

    journal_title:Journal of molecular and cellular cardiology

    pub_type: 杂志文章

    doi:10.1016/j.yjmcc.2014.02.010

    authors: Scheruebel S,Koyani CN,Hallström S,Lang P,Platzer D,Mächler H,Lohner K,Malle E,Zorn-Pauly K,Pelzmann B

    更新日期:2014-07-01 00:00:00

  • The effect of ouabain on hearts of cardiomyopathic hamsters: potentiation by isoproterenol.

    abstract::The isometric twitch properties of papillary muscles from hearts of 30- to 53-day-old cardiomyopathic hamsters (BIO 14.6) were studied before and after exposure to the cardiac glycoside, ouabain. The diseased tissue was weakly responsive to ouabain (3 to 100 microM), as compared to a more appreciable positive inotropi...

    journal_title:Journal of molecular and cellular cardiology

    pub_type: 杂志文章

    doi:10.1016/s0022-2828(87)80368-1

    authors: Rossner KL,Mascarenhas DA

    更新日期:1987-06-01 00:00:00

  • Overexpression of AMP-activated protein kinase or protein kinase D prevents lipid-induced insulin resistance in cardiomyocytes.

    abstract::During lipid oversupply, the heart becomes insulin resistant, as exemplified by defective insulin-stimulated glucose uptake, and will develop diastolic dysfunction. In the healthy heart, not only insulin, but also increased contractile activity stimulates glucose uptake. Upon increased contraction both AMP-activated p...

    journal_title:Journal of molecular and cellular cardiology

    pub_type: 杂志文章

    doi:10.1016/j.yjmcc.2012.11.005

    authors: Steinbusch LK,Dirkx E,Hoebers NT,Roelants V,Foretz M,Viollet B,Diamant M,van Eys G,Ouwens DM,Bertrand L,Glatz JF,Luiken JJ

    更新日期:2013-02-01 00:00:00

  • BNip3 and signal-specific programmed death in the heart.

    abstract::The BH3-only proteins, including BNip3, are members of the Bcl-2 family of cell death-regulating factors. Whereas proteins such as Bax and Bak play a central role in most forms of apoptosis, the BH3-only proteins appear to modulate apoptosis through cell type- and signal-specific pathways. This review will focus on ou...

    journal_title:Journal of molecular and cellular cardiology

    pub_type: 杂志文章,评审

    doi:10.1016/j.yjmcc.2004.11.007

    authors: Webster KA,Graham RM,Bishopric NH

    更新日期:2005-01-01 00:00:00

  • Systemic hypertension induces disparate localized left ventricular action potential lengthening and altered sensitivity to verapamil in left ventricular myocardium.

    abstract::Previously, we demonstrated that acute exposure to superfusate containing verapamil suppresses action potential plateau to a greater degree in cells at the tip of the anterior papillary muscle compared to those at its base in normal cat left ventricle (LV) studied in tissue bath. To determine the effects of chronic pr...

    journal_title:Journal of molecular and cellular cardiology

    pub_type: 杂志文章

    doi:10.1016/s0022-2828(86)80469-2

    authors: Cameron JS,Miller LS,Kimura S,Kaiser CJ,Campbell DR,Kozlovskis PL,Gaide MS,Myerburg RJ,Bassett AL

    更新日期:1986-02-01 00:00:00

  • Threonine-17 phosphorylation of phospholamban: a key determinant of frequency-dependent increase of cardiac contractility.

    abstract::Multiple studies have shown that phospholamban (PLN) plays a key role in regulation of frequency-dependent increase of cardiac contraction, a hallmark of the contractile reserve in myocardium. However, the mechanisms underlying this relationship remain elusive. Phosphorylation of PLN occurs on residues: serine-16 (Ser...

    journal_title:Journal of molecular and cellular cardiology

    pub_type: 杂志文章

    doi:10.1016/j.yjmcc.2004.05.013

    authors: Zhao W,Uehara Y,Chu G,Song Q,Qian J,Young K,Kranias EG

    更新日期:2004-08-01 00:00:00

  • Mechanical strain induces a pro-fibrotic phenotype in human mitral valvular interstitial cells through RhoC/ROCK/MRTF-A and Erk1/2 signaling pathways.

    abstract::The mitral valve is a complex multilayered structure populated by fibroblast-like cells, valvular interstitial cells (VIC) which are embedded in an extracellular matrix (ECM) scaffold and are submitted to the mechanical deformations affecting valve at each heartbeat, for an average of 40 million times per year. Myxoma...

    journal_title:Journal of molecular and cellular cardiology

    pub_type: 杂志文章

    doi:10.1016/j.yjmcc.2019.08.008

    authors: Blomme B,Deroanne C,Hulin A,Lambert C,Defraigne JO,Nusgens B,Radermecker M,Colige A

    更新日期:2019-10-01 00:00:00

  • Further investigations into the mechanism of antifibrillatory action of the specific IK1 blocker, RP58866, assessed using the rat dual coronary perfusion model.

    abstract::RP58866 (1-[-2-(3,4-dihydro-2H-1-benzopyran-4-yl)ethyl]-4- (3,4-dimethoxyphenyl)-piperidine), a specific blocker of the inwardly rectifying K+ current (IK1), is an extremely effective antiarrhythmic agent in rat, rabbit and primate (marmoset) isolated hearts in the settings of acute ischaemia and reperfusion (Rees and...

    journal_title:Journal of molecular and cellular cardiology

    pub_type: 杂志文章

    doi:10.1006/jmcc.1995.0046

    authors: Rees SA,Curtis MJ

    更新日期:1995-12-01 00:00:00

  • Ischemic preconditioning and morphine-induced cardioprotection involve the delta (delta)-opioid receptor in the intact rat heart.

    abstract::Several investigators have demonstrated that the opioid pathway is involved in tissue preservation during hypoxia or ischemia and that this protection is mediated via the delta (delta)-opioid receptor. Subsequently, we have shown that opioid receptors are involved in ischemic preconditioning (PC) in the rat heart and ...

    journal_title:Journal of molecular and cellular cardiology

    pub_type: 杂志文章

    doi:10.1006/jmcc.1997.0454

    authors: Schultz JJ,Hsu AK,Gross GJ

    更新日期:1997-08-01 00:00:00

  • CaMKII effects on inotropic but not lusitropic force frequency responses require phospholamban.

    abstract::Increasing heart rate enhances cardiac contractility (force frequency relationship, FFR) and accelerates cardiac relaxation (frequency-dependent acceleration of relaxation, FDAR). The positive FFR together with FDAR promotes rapid filling and ejection of blood from the left ventricle (LV) at higher heart rates. Recent...

    journal_title:Journal of molecular and cellular cardiology

    pub_type: 杂志文章

    doi:10.1016/j.yjmcc.2012.06.019

    authors: Wu Y,Luczak ED,Lee EJ,Hidalgo C,Yang J,Gao Z,Li J,Wehrens XH,Granzier H,Anderson ME

    更新日期:2012-09-01 00:00:00

  • Development of the coronary arteries in a murine model of transposition of great arteries.

    abstract::Transposition of great arteries in humans is associated with a wide spectrum of coronary artery patterns. However, no information is available about how this pattern diversity develops. We have studied the development of the coronary arteries in mouse embryos with a targeted mutation of perlecan, a mutation that leads...

    journal_title:Journal of molecular and cellular cardiology

    pub_type: 杂志文章

    doi:10.1016/s0022-2828(03)00134-2

    authors: González-Iriarte M,Carmona R,Pérez-Pomares JM,Macías D,Costell M,Muñoz-Chápuli R

    更新日期:2003-07-01 00:00:00

  • Rare non-coding Desmoglein-2 variant contributes to Arrhythmogenic right ventricular cardiomyopathy.

    abstract::Arrhythmogenic right ventricular cardiomyopathy (ARVC) has been linked to variants in the coding sequence of desmosomal genes. The potential contribution of non-coding desmoglein-2 (DSG2) variants for development of ARVC is undescribed. We sequenced 1450 base pairs upstream of ATG in the DSG2 gene in 65 unrelated pati...

    journal_title:Journal of molecular and cellular cardiology

    pub_type: 杂志文章

    doi:10.1016/j.yjmcc.2019.04.029

    authors: Christensen AH,Andersen CB,Wassilew K,Svendsen JH,Bundgaard H,Brand SM,Schmitz B

    更新日期:2019-06-01 00:00:00

  • Enhanced prostaglandin synthesis due to phospholipid breakdown in ischemic-reperfused myocardium. Control of its production by a phospholipase inhibitor or free radical scavengers.

    abstract::The effects of the inhibition of phospholipid degradation and superoxide radical generation on prostaglandin synthesis associated with myocardial ischemia and reperfusion were studied in the isolated, in-situ pig heart model subjected to 60 mins of regional ischemia and a further 60 mins of hypothermic potassium cardi...

    journal_title:Journal of molecular and cellular cardiology

    pub_type: 杂志文章

    doi:10.1016/s0022-2828(86)80009-8

    authors: Otani H,Engelman RM,Rousou JA,Breyer RH,Das DK

    更新日期:1986-09-01 00:00:00

  • Captopril treatment improves the sarcoplasmic reticular Ca(2+) transport in heart failure due to myocardial infarction.

    abstract::Although captopril, an angiotensin-converting enzyme (ACE) inhibitor, has been shown to exert a beneficial effect on cardiac function in heart failure, its effect on the status of sarcoplasmic reticulum (SR) Ca(2+) transport in the failing heart has not been examined previously. In order to determine whether captopril...

    journal_title:Journal of molecular and cellular cardiology

    pub_type: 杂志文章

    doi:10.1006/jmcc.1999.1000

    authors: Shao Q,Ren B,Zarain-Herzberg A,Ganguly PK,Dhalla NS

    更新日期:1999-09-01 00:00:00

  • Functional abrogation of p53 is required for T-Ag induced proliferation in cardiomyocytes.

    abstract::Targeted expression of the SV40 large T-antigen oncoprotein (T-Ag) induces cardiomyocyte proliferation in the atria and ventricles of transgenic mice. Previous studies have identified the p53 tumor suppressor, p107 (a homologue of the retinoblastoma tumor suppressor), and p193 (a novel BH3 only proapoptosis protein) a...

    journal_title:Journal of molecular and cellular cardiology

    pub_type: 杂志文章

    doi:10.1006/jmcc.2001.1403

    authors: Huh NE,Pasumarthi KB,Soonpaa MH,Jing S,Patton B,Field LJ

    更新日期:2001-08-01 00:00:00

  • Cardioprotective and anti-oxidant effects of the terpenoid constituents of Ginkgo biloba extract (EGb 761).

    abstract::Hemodynamic and electron spin resonance analyses were used to assess the in vivo and in vitro cardioprotective and antioxidant effects of therapeutically relevant doses of Ginkgo biloba extract (EGb 761) and its terpenoid constituents (ginkgolides A and B, bilobalide) in the rat. Significant anti-ischemic effects, ind...

    journal_title:Journal of molecular and cellular cardiology

    pub_type: 杂志文章

    doi:10.1006/jmcc.1996.0316

    authors: Pietri S,Maurelli E,Drieu K,Culcasi M

    更新日期:1997-02-01 00:00:00

  • Il-19 reduces VSMC activation by regulation of mRNA regulatory factor HuR and reduction of mRNA stability.

    abstract::While much is known about the deleterious effects of pro-inflammatory cytokines on development of vascular disease, little is reported on the direct effects of anti-inflammatory cytokines on the vascular smooth muscle cell (VSMC) response to injury. Interleukin-19 (IL-19) is a recently described Th2, anti-inflammatory...

    journal_title:Journal of molecular and cellular cardiology

    pub_type: 杂志文章

    doi:10.1016/j.yjmcc.2010.04.016

    authors: Cuneo AA,Herrick D,Autieri MV

    更新日期:2010-10-01 00:00:00

  • Atomic force and electron microscopic-based study of sarcolemmal surface of living cardiomyocytes unveils unexpected mitochondrial shift in heart failure.

    abstract::Loss of T-tubules (TT), sarcolemmal invaginations of cardiomyocytes (CMs), was recently identified as a general heart failure (HF) hallmark. However, whether TT per se or the overall sarcolemma is altered during HF process is still unknown. In this study, we directly examined sarcolemmal surface topography and physica...

    journal_title:Journal of molecular and cellular cardiology

    pub_type: 杂志文章

    doi:10.1016/j.yjmcc.2014.05.006

    authors: Dague E,Genet G,Lachaize V,Guilbeau-Frugier C,Fauconnier J,Mias C,Payré B,Chopinet L,Alsteens D,Kasas S,Severac C,Thireau J,Heymes C,Honton B,Lacampagne A,Pathak A,Sénard JM,Galés C

    更新日期:2014-09-01 00:00:00

  • Myocardial dysfunction and ultrastructural alterations mediated by oxygen metabolites.

    abstract::The direct effect of oxygen metabolites was studied on isolated perfused rat hearts. Superoxide anion (O2-.) and hydrogen peroxide (H2O2) were generated by adding purine (2.3 mM) and purified xanthine oxidase (0.06 U/ml) to Krebs-Henseleit buffer (pH 7.4). Xanthine oxidase was added to the purine-containing perfusate ...

    journal_title:Journal of molecular and cellular cardiology

    pub_type: 杂志文章

    doi:10.1016/0022-2828(88)90578-0

    authors: Miki S,Ashraf M,Salka S,Sperelakis N

    更新日期:1988-11-01 00:00:00

  • Efficient transmural cardiac gene transfer by intrapericardial injection in neonatal mice.

    abstract::An efficient cardiac gene transfer technique in murine models would greatly facilitate the elucidation of the pathophysiology of cardiomyopathies and the development of genetic therapies. Direct myocardial injection or catheter-based intracoronary infusion is not easily achievable in mice and resultant transgene expre...

    journal_title:Journal of molecular and cellular cardiology

    pub_type: 杂志文章

    doi:10.1006/jmcc.1998.0905

    authors: Zhang JC,Woo YJ,Chen JA,Swain JL,Sweeney HL

    更新日期:1999-04-01 00:00:00