Abstract:
:Ninety neonates were ventilated over a period of 33 months of whom 50 (55.5%) survived. Fifty seven babies received IPPV while 33 CPAP. IPPV mode was being used more frequently recently and survival rates have steadily improved over past 3 years. Survival was cent per cent in babies above 1.5 kg on CPAP mode while 16/26 (57.7%) survived on IPPV mode. Of 22 extremely VLBW (< 1 kg) babies, six survived. HMD was the commonest indication of ventilation (50%), of which 53% (24/45) survived. The other important indications of ventilation were apnea in 13 and transient tachypnea in 11 babies. All babies requiring ventilation for transient tachypnea survived. Nosocomial infections were common in association with ventilation 34/90 (37.7%), out of which in 14 was responsible for about a third of deaths. Pulmonary air leaks developed in 12 babies of which 6 died. Two babies developed BPD and one ROP. Neonatal ventilation should be ventured in centres where basic facilities for level II care already exist. It may not be cost effective to ventilate extremely low birth weight neonates. :During January 1989-September 1991, in India, neonatologists prescribed assisted ventilation (intermittent positive pressure ventilation [IPPV] and continuous positive airway pressure [CPAP]) for 90 neonates born and treated at a tertiary hospital in Delhi. All neonates requiring more than 168 hours of ventilation received IPPV. The smallest surviving neonate weighed 830 g at birth and was born at 26 weeks' gestation. This neonate received 510 hours of ventilation. One neonate received 48 days of ventilation (gestational age at birth, 28 weeks; birth weight, 800 g). This neonate eventually died due to necrotizing enterocolitis (NEC), bronchopulmonary dysplasia (BPD), and sepsis. This infant was the only infant to develop NEC. A total of two newborns developed BPD. One infant developed retinopathy of prematurity (ROP). Indications for ventilation were hyaline membrane disease (HMD) (45/90), apnea (13/90), and transient tachypnea of the newborn (TTNB) (11/90). Almost all HMD cases who weighed more than 1.5 kg at birth on CPAP survived. CPAP successfully treated all TTNB cases. Nine neonates developed pneumothorax. Three of them survived. 34 neonates developed sepsis, the most common complication. 20 sepsis cases also had underlying pneumonia. Sepsis was responsible for 35% of deaths (14/40). Five infants on IPPV developed persistent pulmonary hypertension (persistent fetal circulation). 35 infants developed infection during ventilation, 34 of whom had a nosocomial infection. The nosocomial infection rate was 37.7%. Nosocomial infection was responsible for 35% of deaths. 12 babies (13%) developed pulmonary air leaks, 50% of whom died. 25 of the 33 infants on CPAP survived. Few CPAP cases developed pulmonary air leak, BPD, and ROP. Six of 22 very low birth weight (VLBW) infants (1 kg) survived. These findings led the researchers to recommend that medical centers with basic facilities for level II care should provide neonatal ventilation. They proposed that ventilation may not be cost effective for VLBW newborns, however.
journal_name
Indian Pediatrjournal_title
Indian pediatricsauthors
Singh M,Deorari AK,Paul VK,Mittal M,Shanker S,Munshi U,Jain Ysubject
Has Abstractpub_date
1993-06-01 00:00:00pages
783-9issue
6eissn
0019-6061issn
0974-7559journal_volume
30pub_type
杂志文章abstract::Yunis-Varon syndrome is a rare, autosomal recessive syndrome characterized by growth retardation, defective growth of the cranial bones along with complete or partial absence of the clavicles (cleidocranial dysplasia), characteristic facial features, and/or abnormalities of the fingers and/or toes. ...
journal_title:Indian pediatrics
pub_type: 杂志文章
doi:
更新日期:2005-04-01 00:00:00
abstract:OBJECTIVE:To investigate association between dietary habits and asthma severity in children. DESIGN:Cross-sectional study. SETTING:Two teaching hospitals in Brazil. PARTICIPANTS:Cases (n=268) were children (3-12yr) with persistent asthma and age-matched controls (n=126) were those with intermittent asthma. MAIN OUT...
journal_title:Indian pediatrics
pub_type: 杂志文章
doi:10.1007/s13312-015-0561-x
更新日期:2015-01-01 00:00:00
abstract:BACKGROUND:Mediastinal pancreatic pseudocyst is a rare complication of pancreatitis. CASE CHARACTERISTICS:An 8-year-old boy with chest pain and shortness of breath. Computed tomography of chest showed a cystic mass in the mediastinum. The cyst aspirate revealed high amylase and lipase levels, suggestive of pancreatic ...
journal_title:Indian pediatrics
pub_type: 杂志文章
doi:
更新日期:2018-03-15 00:00:00
abstract::Berardinelli-Seip congenital lipodystrophy (BSCL) is a very rare genetic disorder characterized by lipoatrophy, hypertriglyceridemia, hepatomegaly and acromegaloid features. On the basis of mutational and haplotype analysis, BSCL families have been classified into three types BSCL 1, BSCL2 and BSCLX. We report Berardi...
journal_title:Indian pediatrics
pub_type: 杂志文章
doi:
更新日期:2006-05-01 00:00:00
abstract::We present the case of a 3-month-old girl who was admitted with complaints of loose stools and respiratory distress. She also had a history of rash and alopecia. Laboratory investigations revealed lymphopenia with reduced immunoglobulin G and immunoglobulin A. Lymphocyte subset analysis by flow cytometry revealed T-B+...
journal_title:Indian pediatrics
pub_type: 杂志文章
doi:
更新日期:2018-08-15 00:00:00
abstract::Two hundred and fifty eight newborn babies were studied for the presence of retinal hemorrhages between 1-3 days of birth. The overall incidence of retinal hemorrhages was found to be 18.9%. It was observed that the incidence of retinal hemorrhages was higher in unassisted vaginal deliveries than in assisted births. A...
journal_title:Indian pediatrics
pub_type: 杂志文章
doi:
更新日期:1989-02-01 00:00:00
abstract:OBJECTIVE:To evaluate simple clinical signs of illness in young infants (0 to 2 months) and to correlate with WHO IMCI algorithm (7 days-2 months). DESIGN:Prospective observational. Study conducted in the outpatient department and emergency room of a pediatric tertiary level hospital. METHODS:Four hundred and ninety ...
journal_title:Indian pediatrics
pub_type: 杂志文章
doi:
更新日期:2006-12-01 00:00:00
abstract:OBJECTIVE:To study the clinical profile of children with scrub typhus and its association with hemophagocytic lymphohistiocytosis. METHODS:Children presenting with unexplained fever and multi-systemic involvement between May to December 2011 were tested for scrub typhus using IgM ELISA kits. Occurrence of Hemophagocyt...
journal_title:Indian pediatrics
pub_type: 杂志文章
doi:10.1007/s13312-014-0470-4
更新日期:2014-08-01 00:00:00
abstract:OBJECTIVE:To examine the association between hematological indices and serum uric acid in adolescents with hyperuricemia. METHODS:10-year retrospective cohort study of 607 patients with hyperuricemia registered with the Pediatric Nephrology Department. RESULTS:There was a statistically significant positive correlatio...
journal_title:Indian pediatrics
pub_type: 杂志文章
doi:10.1007/s13312-014-0547-0
更新日期:2014-12-01 00:00:00
abstract::A 5 year old boy and a 10 year old girl presented with acute onset of psychotic disorder, which occurred one week after an upper respiratory infection. MRI images of brain were consistent with the diagnosis of acute disseminated encephalomyelitis (ADEM) in both cases. ADEM is one of the differential diagnoses to be co...
journal_title:Indian pediatrics
pub_type: 杂志文章
doi:
更新日期:2008-12-01 00:00:00
abstract:BACKGROUND:Glycogen storage disease type VI (GSD-VI) presents with failure to thrive and also fibrosis in some cases, without cirrhosis. CASE CHARACTERISTICS:2½-year-old girl presented with short stature, transaminase elevation and significant fibrosis, suggesting GSD-III. OBSERVATION:A pathogenic mutation in PYGL ge...
journal_title:Indian pediatrics
pub_type: 杂志文章
doi:10.1007/s13312-017-1174-3
更新日期:2017-09-15 00:00:00
abstract::We report on long-term follow-up [mean (SD) duration, 44.7 (4.3) mo] of 48 out of 132 children with recurrent abdominal pain, who were a part of an earlier study at our hospital. 31 (64.5%) children still experienced pain; 26 (54.1%) reported their pain to be better than before, 4 children reported it to be same as be...
journal_title:Indian pediatrics
pub_type: 信件
doi:
更新日期:2020-05-15 00:00:00
abstract:OBJECTIVE:To evaluate recovery and survival of severely wasted children without community management of acute malnutrition programme. DESIGN:Single time point follow-up (24th December 2013 - 2nd April, 2014) of severely wasted children identified in a community-based cross-sectional survey (September 2012 - October 20...
journal_title:Indian pediatrics
pub_type: 杂志文章
doi:10.1007/s13312-017-1142-y
更新日期:2017-10-15 00:00:00
abstract::There is a large child work force in India reported to be about 40 million. Child labor is being regarded as a form of modern slavery, as children are forced to work or have no choice to refuse work. Children are employed in a variety of occupations, many of which are hazardous. Exposure to machinery, pesticides, dust...
journal_title:Indian pediatrics
pub_type: 杂志文章
doi:
更新日期:2019-08-15 00:00:00
abstract::The study was undertaken to compare the antibody response of 6-12 weeks old infants after three doses of standard trivalent oral polio vaccine (TOPV) (Groups A; (n = 42) with three doses of double the amount of TOPV (Group B; n = 35). Seroconversions in Group A were 64.2, 80.9% and 57.1% for Types I, II and III poliov...
journal_title:Indian pediatrics
pub_type: 杂志文章
doi:
更新日期:1991-10-01 00:00:00
abstract::Fifty seven male children between ages of 10-16 years engaged in the brassware industry at Moradabad in Northern India were studied for occupational morbidity. The finding were compared with those obtained in the children (n = 29) engaged in other ancillary units which did not involve exposure to the metal fumes and d...
journal_title:Indian pediatrics
pub_type: 杂志文章
doi:
更新日期:1992-02-01 00:00:00
abstract::Testicular adrenal rest tumors (TART) are consequences of delayed diagnosis and/or undertreatment in patients with congenital adrenal hyperplasia (CAH). We describe a case of CAH with TART who presented with bilateral macroorchidism. He was managed with glucocorticoids which led to decrease in testicular size without ...
journal_title:Indian pediatrics
pub_type: 杂志文章
doi:10.1007/s13312-012-0096-3
更新日期:2012-07-01 00:00:00
abstract::A study of infant feeding practices was carried out as part of a larger longitudinal study of an urban birth cohort in an area of South Delhi, India. 802 mothers of children over 1 year of age were selected randomly for interview. The study group is considered to be a representative sampling of the economic, cultura...
journal_title:Indian pediatrics
pub_type: 杂志文章
doi:
更新日期:1976-11-01 00:00:00
abstract::Serial ultrasound scans were done in 300 fetuses between 16 to 24 weeks of gestation to establish the normogram of fetal kidney circumference (FKC) and fetal abdominal circumference (FAC) ratio (FKC/FAC). Of 300 fetuses, 150 fetuses were in the high risk group for fetal malformation and 150 patients were in the contro...
journal_title:Indian pediatrics
pub_type: 杂志文章
doi:
更新日期:1994-09-01 00:00:00
abstract::Decline in malnutrition levels has been dismal since the 1990s. We ascertained decadal trend in childhood nutritional status between 1997 and 2007 in Chandigarh, India and assessed impact of Integrated Child Development Services (ICDS) on childhood undernutrition. A total of 803 under-five children, 547 children betwe...
journal_title:Indian pediatrics
pub_type: 杂志文章
doi:10.1007/s13312-011-0058-1
更新日期:2011-04-01 00:00:00
abstract::The best known muscular dystrophies are X-linked dystrophinopathies. A clinically and genetically heterogeneous group presenting with weakness of the pelvic and shoulder girdles is that of the limb-girdle muscular dystrophies (LGMDs). Sarcoglycanopathies (SGPs) are autosomal recessive LGMDs. We report a rare case of p...
journal_title:Indian pediatrics
pub_type: 杂志文章
doi:
更新日期:2003-11-01 00:00:00
abstract::Immune thrombocytopenic purpura (ITP) has witnessed many changes and updates over the past decade. The definitions of disease subtypes, course and response to treatment have all been standardized recently. Consequent to the lack of an international consensus management guideline, wide variations exist in treatment pra...
journal_title:Indian pediatrics
pub_type: 杂志文章,评审
doi:10.1007/s13312-012-0195-1
更新日期:2012-10-01 00:00:00
abstract:BACKGROUND:High bilirubin level is toxic to developing brain and auditory system but the current debate surrounds the toxicity of bilirubin in healthy term infants. METHODS:Longitudinal observational study to find BERA abnormalities in term newborns with isolated hyperbilirubinemia of 20 mg/dL and more and to follow u...
journal_title:Indian pediatrics
pub_type: 杂志文章
doi:10.1007/s13312-014-0346-7
更新日期:2014-02-01 00:00:00
abstract:BACKGROUND:E-type prostaglandins (PGE1) can effectively maintain the patency of the ductus arteriosus in neonates. Its use, therefore and be life saving in infants born with ductus dependent congenital heart disease. Although PGE1 is available for over two decade in western world, it has been introduced in India only s...
journal_title:Indian pediatrics
pub_type: 临床试验,杂志文章
doi:
更新日期:1998-11-01 00:00:00
abstract::Fluconazole has been used as prophylaxis against systemic fungal infections in preterm neonates. We conducted a study to determine whether cessation of a policy of prophylactic fluconazole results in a resurgence of fungal infections in a unit. Neonates born in the 3 epoches: A 36-month pre-Fluconazole prophylaxis epo...
journal_title:Indian pediatrics
pub_type: 杂志文章
doi:
更新日期:2005-12-01 00:00:00
abstract::Familial chylomicronemia syndrome is a group of rare genetic disorders characterized by deficient activity of an enzyme lipoprotein lipase or apo-protein C-II deficiency. In this paper we present an infant with massive hyperchylomicronemia and severe pancreatitis. Exchange transfusion for controlling hypertriglyceride...
journal_title:Indian pediatrics
pub_type: 杂志文章
doi:
更新日期:2007-04-01 00:00:00
abstract::There is a paucity of data on the incidence of sporadic viral hepatitis in Indian children. Clinical, biochemical and etiological profile of 54 patients with acute viral hepatitis was evaluated. Of these, 32 (59.25%) patients had Hepatitis A, 18 (33.33%) had NANB, 2 (3.7%) had Hepatitis B and 2 (3.7%) concurrent Hepat...
journal_title:Indian pediatrics
pub_type: 杂志文章
doi:
更新日期:1992-05-01 00:00:00
abstract::We prospectively studied the effect of oral paracetamol in closing hemodynamically significant Patent ductus arteriosus in preterm infants (gestational age <32 weeks) where Ibuprofen was contraindicated. 29 of 40 neonates (72.5%) showed successful response while 11 (29.5%) failed to show any response. No major complic...
journal_title:Indian pediatrics
pub_type: 杂志文章
doi:
更新日期:2016-02-01 00:00:00
abstract::Participation in research is important in producing doctors with an understanding of evidence-based medicine. Though a mandatory part in post-graduate medical course, research has largely been invisible from the under graduation medical course in India. Very few research opportunities are available at under graduate l...
journal_title:Indian pediatrics
pub_type: 杂志文章
doi:10.1007/s13312-017-1104-4
更新日期:2017-05-15 00:00:00
abstract::Six hundred and forty six cases in the age group 8-14 years suffering from paralytic poliomyelitis were analysed to find out the immunization status and its correlation with the incidence of poliomyelitis. In 382 cases where the immunization status was known, it was found that 325 (85.02%) cases were not immunized, 23...
journal_title:Indian pediatrics
pub_type: 杂志文章
doi:
更新日期:1989-05-01 00:00:00