Evolutionary and structural influences on light chain constant (CL) region of human and mouse immunoglobulins.

abstract：:Apolipoprotein A-I (apo A-I), the major apolipoprotein in human high density lipoproteins, is involved in the disease atherosclerosis. Cloned apo A-I cDNA (pA1-3) was used as a probe in chromosome mapping studies to detect the human apo A-I structural gene sequence in human-Chinese hamster cell hybrids. Southern blot ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Cheung P,Kao FT,Law ML,Jones C,Puck TT,Chan L

更新日期：1984-01-01 00:00:00

abstract：:Sensitization of defensive gill and siphon withdrawal reflexes in Aplysia results, in part, from presynaptic facilitation of transmitter release from mechanoreceptor sensory neurons that innervate the siphon skin and synapse with interneurons and motor neurons. Presynaptic facilitation also can be elicited by applicat...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hochner B,Klein M,Schacher S,Kandel ER

更新日期：1986-11-01 00:00:00

abstract：:N-type Ca2+ channels mediate Ca2+ influx, which initiates fast exocytosis of neurotransmitters at synapses, and they interact directly with the SNARE proteins syntaxin and SNAP-25 (synaptosome-associated protein of 25 kDa) through a synaptic protein interaction (synprint) site in the intracellular loop connecting doma...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Sheng ZH,Yokoyama CT,Catterall WA

更新日期：1997-05-13 00:00:00

abstract：:MyoD is a master regulatory gene for myogenesis. Its product, the MyoD protein, appears to act by binding to muscle-specific enhancer sequences. We show that MyoD binds cooperatively to two sites in the muscle-specific creatine kinase enhancer; this is dramatically reflected in dissociation-rate measurements. A deleti...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Weintraub H,Davis R,Lockshon D,Lassar A

更新日期：1990-08-01 00:00:00

abstract：:Cytotoxic T lymphocyte antigen-4 (CTLA-4) is essential for immunological (self-) tolerance, but due to the early fatality of CTLA-4 KO mice, its specific function in central and peripheral tolerance and in different systemic diseases remains to be determined. Here, we further examined the role of CTLA-4 by abrogating ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Klocke K,Sakaguchi S,Holmdahl R,Wing K

更新日期：2016-04-26 00:00:00

abstract：:The catalytic activity of low-dimensional electrocatalysts is highly dependent on their local atomic structures, particularly those less-coordinated sites found at edges and corners; therefore, a direct probe of the electrocatalytic current at specified local sites with true nanoscopic resolution has become critically...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Sun T,Wang D,Mirkin MV,Cheng H,Zheng JC,Richards RM,Lin F,Xin HL

更新日期：2019-06-11 00:00:00

abstract：:P transposable elements in Drosophila are mobilized via a cut-and-paste mechanism. The broken DNA ends generated during transposition can be repaired via the homology-directed synthesis-dependent strand annealing or by nonhomologous end joining (NHEJ). Genetic studies have demonstrated an interaction between the gene ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Min B,Weinert BT,Rio DC

更新日期：2004-06-15 00:00:00

abstract：:Normal myeloid precursors and MGI(+)D(+) myeloid leukemic cells can be induced to differentiate to mature cells by the normal protein inducer MGI. The sequence of differentiation is the induction of C3 and Fc rosettes, C3 and Fc immune phagocytosis (IP), synthesis and secretion of lysozyme, and formation of mature mac...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lotem J,Sachs L

更新日期：1977-12-01 00:00:00

abstract：:Tropical forests hold most of Earth's biodiversity. Their continued loss through deforestation and agriculture is the main threat to species globally, more than disease, invasive species, and climate change. However, not all tropical forests have the same ability to sustain biodiversity. Those that have been disturbed...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hedges SB,Cohen WB,Timyan J,Yang Z

更新日期：2018-11-13 00:00:00

abstract：:Fetal exposure to environmental insults increases the susceptibility to late-onset neuropsychiatric disorders. Alcohol is listed as one of such prenatal environmental risk factors and known to exert devastating teratogenetic effects on the developing brain, leading to complex neurological and psychiatric symptoms obse...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hashimoto-Torii K,Kawasawa YI,Kuhn A,Rakic P

更新日期：2011-03-08 00:00:00

abstract：:We have investigated whether the large (5- to 15-fold) stimulation of synthesis of growth hormone (somatotropin) observed upon exposure of a strain of rat pituitary (GH3) cells to dexamethasone (a synthetic glucocorticoid) arises from a stimulation of pregrowth hormone mRNA. A good agreement was observed between the s...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Tushinski RJ,Sussman PM,Yu LY,Bancroft FC

更新日期：1977-06-01 00:00:00

abstract：:Cell migration and spreading involve the coordination of membrane trafficking, actomyosin contraction, and modifications to plasma membrane tension and area. The biochemical or biophysical basis for this coordination is however unknown. In this study, we show that during cell spreading, lamellipodia protrusion flatten...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Gauthier NC,Fardin MA,Roca-Cusachs P,Sheetz MP

更新日期：2011-08-30 00:00:00

abstract：:Cysteine dioxygenase (CDO) catalyzes the oxidation of l-cysteine to cysteine sulfinic acid. Deficiencies in this enzyme have been linked to autoimmune diseases and neurological disorders. The x-ray crystal structure of CDO from Mus musculus was solved to a nominal resolution of 1.75 Angstroms. The sequence is 91% iden...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： McCoy JG,Bailey LJ,Bitto E,Bingman CA,Aceti DJ,Fox BG,Phillips GN Jr

更新日期：2006-02-28 00:00:00

abstract：:The identity of cells that mediate positive selection of CD8(+) T cells was investigated in two T cell receptor (TCR) transgenic systems. Irradiated beta(2)-microglobulin mutant mice or mice with mutations in both the K(b) and D(b) genes were repopulated with fetal liver cells from class I(+) TCR transgenic mice. In t...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Zerrahn J,Volkmann A,Coles MC,Held W,Lemonnier FA,Raulet DH

更新日期：1999-09-28 00:00:00

abstract：:Many studies have reported age-related changes in immune responses that could be due to alterations in lymphoid cell numbers or functions. Here we report the results of studies using immunofluorescent staining and in vitro assays of cellular function to compare the expression of cell surface antigens on lymphocytes fr...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Sidman CL,Luther EA,Marshall JD,Nguyen KA,Roopenian DC,Worthen SM

更新日期：1987-11-01 00:00:00

abstract：:Specific antibodies against types I and III collagens and procollagens were used to localize these proteins in cultured human cells. These studies indicate that the same cell makes both proteins. No type III procollagen synthesis was observed in cells from two patients with two patients with the Ehlers-Danlos type IV ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Gay S,Martin GR,Muller PK,Timpl R,Kuhn K

更新日期：1976-11-01 00:00:00

abstract：:We have investigated the frequency of p53 mutations in B- and T-cell human lymphoid malignancies, including acute lymphoblastic leukemia, the major subtypes of non-Hodgkin lymphoma, and chronic lymphocytic leukemia. p53 exons 5-9 were studied by using genomic DNA from 197 primary tumors and 27 cell lines by single-str...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Gaidano G,Ballerini P,Gong JZ,Inghirami G,Neri A,Newcomb EW,Magrath IT,Knowles DM,Dalla-Favera R

更新日期：1991-06-15 00:00:00

abstract：:We have previously identified by cDNA cloning 5 mRNAs that appear in resting BALB/c 3T3 cells soon after growth stimulation by serum or platelet-derived growth factor. Five additional mRNAs of this class are described in this report. The mRNAs reached peak levels between 40 and 120 min after serum addition and rapidly...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lau LF,Nathans D

更新日期：1987-03-01 00:00:00

abstract：:The migration of lymphocytes into inflammatory tissue requires the migrating cell to overcome mechanical forces produced by blood flow. A generally accepted hypothesis is that these forces are overcome by a multistep sequence of adhesive interactions between lymphocytes and endothelial cells. This hypothesis has been ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Secomb TW,Konerding MA,West CA,Su M,Young AJ,Mentzer SJ

更新日期：2003-06-10 00:00:00

abstract：:The crystal structure of the murine Fab S-20-4 from a protective anti-cholera Ab specific for the lipopolysaccharide Ag of the Ogawa serotype has been determined in its unliganded form and in complex with synthetic fragments of the Ogawa O-specific polysaccharide (O-SP). The upstream terminal O-SP monosaccharide is sh...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Villeneuve S,Souchon H,Riottot MM,Mazie JC,Lei P,Glaudemans CP,Kovác P,Fournier JM,Alzari PM

更新日期：2000-07-18 00:00:00

abstract：:Calcium oxalate monohydrate (COM), which plays a functional role in plant physiology, is a source of chronic human disease, forming the major inorganic component of kidney stones. Understanding molecular mechanisms of biological control over COM crystallization is central to development of effective stone disease ther...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Qiu SR,Wierzbicki A,Orme CA,Cody AM,Hoyer JR,Nancollas GH,Zepeda S,De Yoreo JJ

更新日期：2004-02-17 00:00:00

abstract：:Recent observations suggest that p53 mutations are responsible not only for growth of primary tumors but also for their dissemination. However, mechanisms involved in p53-mediated control of cell motility and invasion remain poorly understood. By using the primary ovarian surface epithelium cell culture, we show that ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hwang CI,Matoso A,Corney DC,Flesken-Nikitin A,Körner S,Wang W,Boccaccio C,Thorgeirsson SS,Comoglio PM,Hermeking H,Nikitin AY

更新日期：2011-08-23 00:00:00

abstract：:Understanding the complexity of anisotropic turbulent processes over a wide range of spatiotemporal scales in engineering shear turbulence as well as climate atmosphere ocean science is a grand challenge of contemporary science with important societal impact. In such inhomogeneous turbulent dynamical systems there is ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Majda AJ

更新日期：2015-07-21 00:00:00

abstract：:The T-cell antigen receptor alpha-chain genes of an alloreactive, H-2Db-specific cytotoxic T-cell clone (3F9) are described. This study and our work on the 3F9 beta-chain genes reveal that the variable region gene segments for the alpha and beta chains expressed in 3F9 are identical to the ones used by a chicken eryth...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Rupp F,Brecher J,Giedlin MA,Mosmann T,Zinkernagel RM,Hengartner H,Joho RH

更新日期：1987-01-01 00:00:00

abstract：:Biotin plays an essential role in growth of mycobacteria. Synthesis of the cofactor is essential for Mycobacterium tuberculosis to establish and maintain chronic infections in a murine model of tuberculosis. Although the late steps of mycobacterial biotin synthesis, assembly of the heterocyclic rings, are thought to f...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hu Z,Cronan JE

更新日期：2020-09-22 00:00:00

abstract：:Physical activity increases energy metabolism in exercising muscle. Whether acute exercise elicits metabolic changes in nonexercising muscles remains unclear. We show that one of the few genes that is more highly induced in nonexercising muscle than in exercising human muscle during acute exercise encodes angiopoietin...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Catoire M,Alex S,Paraskevopulos N,Mattijssen F,Evers-van Gogh I,Schaart G,Jeppesen J,Kneppers A,Mensink M,Voshol PJ,Olivecrona G,Tan NS,Hesselink MK,Berbée JF,Rensen PC,Kalkhoven E,Schrauwen P,Kersten S

更新日期：2014-03-18 00:00:00

abstract：:Domesticated animals formed an important element of farming practices in prehistoric Britain, a fact revealed through the quantity and variety of animal bone typically found at archaeological sites. However, it is not known whether the ruminant animals were raised purely for their tissues (e.g., meat) or alternatively...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Copley MS,Berstan R,Dudd SN,Docherty G,Mukherjee AJ,Straker V,Payne S,Evershed RP

更新日期：2003-02-18 00:00:00

abstract：:Molecular clocks have been used to date the divergence of humans and chimpanzees for nearly four decades. Nonetheless, this date and its confidence interval remain to be firmly established. In an effort to generate a genomic view of the human-chimpanzee divergence, we have analyzed 167 nuclear protein-coding genes and...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kumar S,Filipski A,Swarna V,Walker A,Hedges SB

更新日期：2005-12-27 00:00:00

abstract：:Tissue factor (TF) plays an important role in hemostasis, inflammation, angiogenesis, and the pathophysiology of atherosclerosis and cancer. In this article we uncover a mechanism in which protein S, which is well known as the cofactor of activated protein C, specifically inhibits TF activity by promoting the interact...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hackeng TM,Seré KM,Tans G,Rosing J

更新日期：2006-02-28 00:00:00

abstract：:We have examined the use of our bis(sulfonamide) diol ligand (1) in the asymmetric addition of phenyl groups to cyclic alpha,beta-unsaturated ketones. Good to excellent enantioselectivities have been obtained with cyclic enones bearing alkyl substituents in the 2 position (71-97% enantiomeric excess). Furthermore, exc...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Li H,García C,Walsh PJ

更新日期：2004-04-13 00:00:00