Interactions of H2O2, EGTA and patch pipette recording methods in feline ventricular myocytes.

abstract：:Phospholipase D (PLD) plays a central role in receptor-mediated breakdown of choline phospholipids and formation of phosphatidic acid (PA), an important regulator of cardiac function. However, specific mechanisms that regulate myocardial PLD activity remain largely unknown, particularly in the human heart. We hypothes...

journal_title：Journal of molecular and cellular cardiology

authors： Kurz T,Kemken D,Mier K,Weber I,Richardt G

更新日期：2004-02-01 00:00:00

abstract：:The effects of Cobra venom cardiotoxin (CTX) on the cellular morphology, twitch amplitude and intracellular calcium ([Ca2+]i) of the ventricular myocytes were studied. [Ca2+]i and twitch amplitude were determined with a fluorometric ratio method using Fura-2/AM and Calcium Green-1 as calcium indicators, and a videomic...

journal_title：Journal of molecular and cellular cardiology

authors： Wang HX,Lau SY,Huang SJ,Kwan CY,Wong TM

更新日期：1997-10-01 00:00:00

abstract：:Sensitive to apoptosis gene (SAG) is a novel RING finger protein that has been shown to be involved in protection against apoptotic cell death induced by oxidative stress in various cell types. As SAG has been previously shown to be expressed in the heart, we assessed its role in cardiac myocytes exposed to ischaemic ...

journal_title：Journal of molecular and cellular cardiology

authors： Chanalaris A,Sun Y,Latchman DS,Stephanou A

更新日期：2003-03-01 00:00:00

abstract：:Neutrophil recruitment and activation are principal events in inflammation. Upon activation neutrophils release myeloperoxidase (MPO), a heme enzyme, which binds to and transcytoses endothelial cells. Whereas the significance of the subendothelial deposition of MPO has evolved as a critical prerequisite for the enzyme...

journal_title：Journal of molecular and cellular cardiology

authors： Lau D,Szöcs K,Klinke A,Rudolph T,Rudolph V,Streichert T,Blankenberg S,Baldus S

更新日期：2014-04-01 00:00:00

abstract：:A dose-response study concerning the importance of the flow rate (0.5 to 12 ml/min) and volume (2.5 to 60 ml) of calcium-free coronary perfusion (duration 5 min) in the induction of a calcium paradox on reperfusion (duration 15 min) with calcium-containing medium has been performed in the isolated rat heart (37 degree...

journal_title：Journal of molecular and cellular cardiology

authors： Oksendal AN,Jynge P,Sellevold OF,Rotevatn S,Saetersdal T

更新日期：1985-10-01 00:00:00

abstract：:We examined the relative roles of the mitogen-activated protein kinases (MAPK) in mediating the alpha1-adrenergic receptor (alpha1-AR) stimulated hypertrophic phenotype in adult rat ventricular myocytes (ARVM). Norepinephrine (NE; 1 microM) in the presence of the beta -AR antagonist propranolol (Pro; 2 microM) caused ...

journal_title：Journal of molecular and cellular cardiology

authors： Xiao L,Pimental DR,Amin JK,Singh K,Sawyer DB,Colucci WS

更新日期：2001-04-01 00:00:00

abstract：:Cardiac arrhythmias are one of the main causes of death worldwide. Several studies have shown that inflammation plays a key role in different cardiac diseases and Toll-like receptors (TLRs) seem to be involved in cardiac complications. In the present study, we investigated whether the activation of TLR4 induces cardia...

journal_title：Journal of molecular and cellular cardiology

authors： Monnerat-Cahli G,Alonso H,Gallego M,Alarcón ML,Bassani RA,Casis O,Medei E

更新日期：2014-11-01 00:00:00

abstract：:The concept of metabolic protection of the ischemic myocardium is in constant evolution and has recently been supported by clinical studies. Historically, enhanced glucose metabolism and glycolysis were proposed as anti-ischemic cardioprotection. This hypothesis is supported by the sub-cellular linkage between key gly...

journal_title：Journal of molecular and cellular cardiology

authors： Opie LH,Sack MN

更新日期：2002-09-01 00:00:00

abstract：:We tested the effects of the protein kinase C (PKC) inhibitors bisindolylmaleimide (1 microM) and chelerythrine (2 microM) on myocardial ischemia-reperfusion injury in in situ and isolated perfused rabbit hearts. In non-ischemic isolated hearts, bisindolylmaleimide (1 microM) and chelerythrine (2 microM) blocked sn-1,...

journal_title：Journal of molecular and cellular cardiology

authors： Lasley RD,Noble MA,Mentzer RM Jr

更新日期：1997-12-01 00:00:00

abstract：:The opening of mitochondrial permeability transition pore (PTP) during reperfusion injury of heart has been well demonstrated and thus controlling PTP would attenuate the myocardial damage and cell death. Ursodeoxycholic acid (UDCA) is a hydrophilic bile salt and has been shown to prevent apoptosis in hepatocytes by i...

journal_title：Journal of molecular and cellular cardiology

authors： Rajesh KG,Suzuki R,Maeda H,Yamamoto M,Yutong X,Sasaguri S

更新日期：2005-11-01 00:00:00

abstract：:23Na and 31P NMR spectroscopy were used to follow intracellular [Na+] ([Na+]i) and energy metabolism in isolated, perfused rat hearts. During 30 min of Ca(2+)-free perfusion no significant change in [Na+]i could be detected, but during a subsequent 45 min period of ischemia [Na+]i rose significantly as expected, from ...

journal_title：Journal of molecular and cellular cardiology

authors： Van Echteld CJ,Van Emous JG,Jansen MA,Schreur JH,Ruigrok TJ

更新日期：1998-01-01 00:00:00

abstract：:The regulation of vascular smooth muscle cell (VSMC) proliferation is an important issue because it has major implications for the prevention of pathological vascular conditions. Using microRNA array screen, we found the expression levels of 200 unique miRNAs in hyperplasic tissues. Among them, miR-200c expression sub...

journal_title：Journal of molecular and cellular cardiology

authors： Zheng B,Bernier M,Zhang XH,Suzuki T,Nie CQ,Li YH,Zhang Y,Song LL,Shi HJ,Liu Y,Zheng CY,Wen JK

更新日期：2015-05-01 00:00:00

abstract：:Thromboxane A2 (TXA2) and prostaglandin H2 (PGH2) induce platelet aggregation and are potent vasoconstrictors, and they have been implicated in coronary vasospasm and myocardial infarction. The TXA2 mimetic [1S-(1 alpha, 2 beta (5Z), 3 alpha (1E,3S*), 4 alpha)]-7-[3-(3-hydroxy-4-(4'- iodophenoxy)-1-butenyl)-7-oxabicyc...

journal_title：Journal of molecular and cellular cardiology

authors： Bowling N,Dubé GP,Kurtz WL,Brune KA,Saussy DL Jr,Dorn GW 2nd,Mais DE

更新日期：1994-07-01 00:00:00

abstract：:Satellite cells from adult mouse tongue, diaphragm, vastus lateralis, rectus femoris, tibialis anterior, soleus, and extensor digitorum longus muscles were isolated, expanded, and differentiated under identical culture conditions. Proliferating myoblasts and differentiated myofiber cultures were analyzed via SDS-PAGE,...

journal_title：Journal of molecular and cellular cardiology

authors： LaFramboise WA,Guthrie RD,Scalise D,Elborne V,Bombach KL,Armanious CS,Magovern JA

更新日期：2003-10-01 00:00:00

abstract：:The adult newt cardiac ventricular myocyte has been successfully placed in cell culture and has been shown to undergo in vitro DNA synthesis. Although several growth factors have been reported to increase DNA synthesis in cardiac myocytes in vitro, PDGF has not been reported to do so, but has been shown to be active i...

journal_title：Journal of molecular and cellular cardiology

authors： Soonpaa MH,Oberpriller JO,Oberpriller JC

更新日期：1992-09-01 00:00:00

abstract：:We studied the oxygen diffusion distance in the rabbit myocardium in untreated animals and in animals treated with thyroxine (T4) for 3 days and 16 days. The subepicardial and subendocardial regions were studied separately. Sixteen days of T4 treatment results in significant cardiac hypertrophy. After 16 days, the per...

journal_title：Journal of molecular and cellular cardiology

authors： Seiden D,Navidad P,Weiss HR

更新日期：1988-10-01 00:00:00

abstract：:Chemokines are small molecular weight proteins that play important roles in inflammation. Originally described as chemotactic cytokines, chemokines stimulate the influx of leukocytes into specific tissue compartments. These molecules also modulate gene expression in both infiltrating and resident cells to mediate a va...

journal_title：Journal of molecular and cellular cardiology

authors： Tarzami ST,Cheng R,Miao W,Kitsis RN,Berman JW

更新日期：2002-02-01 00:00:00

abstract：:31P-NMR was used to monitor myocardial bioenergetics in compensated and failing SHHF/MCC-fa(cp) (SHF) rat hearts. The SHHF/Mcc-fa(cp) (spontaneous hypertension and heart failure) rat is a relatively new genetic model in which all individuals spontaneously develop congestive heart failure, most during the second year o...

journal_title：Journal of molecular and cellular cardiology

authors： Michael O'Donnell J,Narayan P,Bailey MQ,Abduljalil AM,Altschuld RA,McCune SA,Robitaille PM

更新日期：1998-02-01 00:00:00

abstract：:Hypertrophic cardiomyopathy (HCM), a relatively common disease, is diagnosed clinically by unexplained cardiac hypertrophy and pathologically by myocyte hypertrophy, disarray, and interstitial fibrosis. HCM is the most common cause of sudden cardiac death (SCD) in the young and a major cause of morbidity and mortality...

journal_title：Journal of molecular and cellular cardiology

authors： Marian AJ,Roberts R

更新日期：2001-04-01 00:00:00

abstract：:In cardiac regenerative therapy, transplantation of stem cells to form new myocardium is limited by their inability to integrate into host myocardium and conduct cardiac electrical activity. It is now hypothesized that refining cell sorting could upgrade the therapeutic result. Here we characterized a subpopulation of...

journal_title：Journal of molecular and cellular cardiology

authors： Poulet C,Wettwer E,Christ T,Ravens U

更新日期：2011-02-01 00:00:00

abstract：:Free radicals and lipid peroxides have recently been identified by us [1, 2, 3] as metabolic intermediates during acute myocardial ischemia. The mechanisms by which evolving myocardial ischemia initiates free radical production are not clear. Based on studies in vitro, it is feasible to consider the following possibil...

journal_title：Journal of molecular and cellular cardiology

authors： Rao PS,Cohen MV,Mueller HS

更新日期：1983-10-01 00:00:00

abstract：:To investigate the contribution of the cardiac renin-angiotensin system to ventricular dilatation after myocardial infarction, we examined the effects of 3-week treatments with an angiotensin converting enzyme inhibitor, delapril, and a selective angiotensin II type 1 (AT1) receptor antagonist, TCV-116, on haemodynami...

journal_title：Journal of molecular and cellular cardiology

authors： Yamagishi H,Kim S,Nishikimi T,Takeuchi K,Takeda T

更新日期：1993-11-01 00:00:00

abstract：:Understanding the process of Ca(2+)/Mg(2+)exchange during muscle excitation and relaxation is fundamental to elucidating the mechanism of Ca(2+)-regulated muscle contraction. During the resting phase, the C-domain of cardiac troponin C may be occupied by either Ca(2+)or Mg(2+). Here, complexes of recombinant cardiac t...

journal_title：Journal of molecular and cellular cardiology

authors： Finley N,Dvoretsky A,Rosevear PR

更新日期：2000-08-01 00:00:00

abstract：:Lidocaine is a Na+ channel blocker that is highly effective for the treatment of ventricular tachyarrhythmias, but is largely ineffective against atrial arrhythmias. If is not known if this differential efficacy is the result of differences in lidocaine inhibition of atrial v ventricular Na+ channels. The purpose of t...

journal_title：Journal of molecular and cellular cardiology

authors： Furukawa T,Koumi S,Sakakibara Y,Singer DH,Jia H,Arentzen CE,Backer CL,Wasserstrom JA

更新日期：1995-02-01 00:00:00

abstract：:The insulin receptor substrate (IRS) family plays important roles in cellular growth, signaling, and survival in the brain. We identified IRS6/Dok-5, a member of the IRS family, also expressed in heart. Dok-5 expression level significantly increased during cardiomyocyte differentiation of P19CL6 cells. To understand t...

journal_title：Journal of molecular and cellular cardiology

authors： Wen J,Xia Q,Wang C,Liu W,Chen Y,Gao J,Gong Y,Yin B,Ke Y,Qiang B,Yuan J,Peng X

更新日期：2009-12-01 00:00:00

abstract：:Lone atrial fibrillation (AF) is associated with various ion channel gene sequence variants, notably the common S38G loss-of-function polymorphism in the KCNE1 K(+) channel ancillary subunit gene. New-onset postoperative AF (POAF) generally occurs 48-72 h after major surgery, particularly following procedures within t...

journal_title：Journal of molecular and cellular cardiology

authors： Heerdt PM,Kant R,Hu Z,Kanda VA,Christini DJ,Malhotra JK,Abbott GW

更新日期：2012-09-01 00:00:00

abstract：:We investigated the role of neuropeptide Y (NPY), abundant in the myocardial sympathetic nervous system and endothelial cells, in angiogenesis during chronic myocardial ischemia. Adult male Yorkshire swine underwent ameroid constrictor placement on the proximal left circumflex coronary artery. After 3 weeks, an osmoti...

journal_title：Journal of molecular and cellular cardiology

authors： Robich MP,Matyal R,Chu LM,Feng J,Xu SH,Laham RJ,Hess PE,Bianchi C,Sellke FW

更新日期：2010-12-01 00:00:00

abstract：:Activation of both mTOR and its downstream target, S6K1 (p70 S6 kinase) have been implicated to affect cardiac hypertrophy. Our earlier work, in a feline model of 1-48 h pressure overload, demonstrated that mTOR/S6K1 activation occurred primarily through a PKC/c-Raf pathway. To further delineate the role of specific P...

journal_title：Journal of molecular and cellular cardiology

authors： Moschella PC,Rao VU,McDermott PJ,Kuppuswamy D

更新日期：2007-12-01 00:00:00

abstract：:Regional depolarization of the mitochondrial network can alter cellular electrical excitability and increase the propensity for reentry, in part, through the opening of sarcolemmal KATP channels. Mitochondrial inner membrane potential (ΔΨm) instability or oscillation can be induced in myocytes by exposure to reactive ...

journal_title：Journal of molecular and cellular cardiology

authors： Solhjoo S,O'Rourke B

更新日期：2015-01-01 00:00:00

abstract：:Cell therapy to prevent cardiac dysfunction after myocardial infarction (MI) is less effective in aged patients because aged cells have decreased regenerative capacity. Allogeneic transplanted stem cells (SCs) from young donors are usually rejected. Maintaining transplanted SC immunoprivilege may dramatically improve ...

journal_title：Journal of molecular and cellular cardiology

authors： Ludke A,Wu J,Nazari M,Hatta K,Shao Z,Li SH,Song H,Ni NC,Weisel RD,Li RK

更新日期：2015-07-01 00:00:00