Abstract:
:The recognition that the wall tone of most arteries and veins can change in response to shear stress has several implications for our understanding of the effects of drugs on the circulation. By a primary action on the heart and vasculature, drugs can cause changes in cardiac output and blood pressure that lead to changes in blood flow. These changes in blood flow can secondarily change vascular diameter, thus complicating the basic response. Furthermore, drugs can modify the local flow-sensitive mechanism directly. The flow-initiated effect seems to depend, both qualitatively and quantitatively, on the level of wall tone and is not entirely endothelium-dependent. If the primary action of a drug is to alter the tone level of vascular smooth muscle directly or if tone changes as a result of a change in blood pressure (and thus in local myogenic control), then it follows that these changes in turn influence the flow response, both quantitatively and qualitatively. The vascular response to flow is complex both in its site of origin and the functional changes initiated. It is not synonymous with the endothelial-dependent action of acetylcholine.
journal_name
Annu Rev Pharmacol Toxicoljournal_title
Annual review of pharmacology and toxicologyauthors
Bevan JA,Henrion Ddoi
10.1146/annurev.pa.34.040194.001133subject
Has Abstractpub_date
1994-01-01 00:00:00pages
173-90eissn
0362-1642issn
1545-4304journal_volume
34pub_type
杂志文章,评审abstract::The presence of druggable, topographically distinct allosteric sites on a wide range of receptor families has offered new paradigms for small molecules to modulate receptor function. Moreover, ligands that target allosteric sites offer significant advantages over the corresponding orthosteric ligands in terms of selec...
journal_title:Annual review of pharmacology and toxicology
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abstract::The realization that there exists a multimembered family of cation channels with structural similarity to Drosophila's Trp channel emerged during the second half of the 1990s. In mammals, depending on the species, the TRP family counts 29 or 30 members which has been subdivided into 6 subfamilies on the basis of seque...
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journal_title:Annual review of pharmacology and toxicology
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journal_title:Annual review of pharmacology and toxicology
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更新日期:2004-01-01 00:00:00
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更新日期:2009-01-01 00:00:00
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journal_title:Annual review of pharmacology and toxicology
pub_type: 杂志文章,评审
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更新日期:1996-01-01 00:00:00
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更新日期:2001-01-01 00:00:00
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journal_title:Annual review of pharmacology and toxicology
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更新日期:2007-01-01 00:00:00
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更新日期:2015-01-01 00:00:00
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journal_title:Annual review of pharmacology and toxicology
pub_type: 杂志文章,评审
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更新日期:1999-01-01 00:00:00
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journal_title:Annual review of pharmacology and toxicology
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更新日期:1995-01-01 00:00:00
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journal_title:Annual review of pharmacology and toxicology
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更新日期:2003-01-01 00:00:00
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journal_title:Annual review of pharmacology and toxicology
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更新日期:2020-01-06 00:00:00
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更新日期:2018-01-06 00:00:00
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journal_title:Annual review of pharmacology and toxicology
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更新日期:2002-01-01 00:00:00
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更新日期:2016-01-01 00:00:00
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更新日期:2019-01-06 00:00:00
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journal_title:Annual review of pharmacology and toxicology
pub_type: 杂志文章,评审
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更新日期:2020-01-06 00:00:00
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journal_title:Annual review of pharmacology and toxicology
pub_type: 杂志文章,评审
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更新日期:2019-01-06 00:00:00
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journal_title:Annual review of pharmacology and toxicology
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更新日期:2015-01-01 00:00:00
abstract::The developing central nervous system (CNS) is more vulnerable to injury than the adult one. Although a great deal of research has been devoted to subtle effects of developmental exposure, such as neurobehavioral changes, this review instead focuses on a number of chemicals that have been shown, in several experimenta...
journal_title:Annual review of pharmacology and toxicology
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doi:10.1146/annurev.pharmtox.44.101802.121424
更新日期:2004-01-01 00:00:00