Plasmid-mediated virulence genes in non-typhoid Salmonella serovars.

Abstract:

:Specific non-typhoid Salmonella serovars carry large virulence plasmids that promote sustained extra-intestinal infections. These plasmids all share a highly conserved 8-kb region containing the spv operon, consisting of the regulatory spvR locus and the four structural spvABCD genes. The SpvR protein belongs to the LysR/MetR family of transcriptional activators, and induces spvABCD expression in the stationary phase in response to nutrient limitation. spv expression also depends on the chromosomal stationary phase sigma factor RpoS (KatF), and is markedly induced when salmonellae enter eukaryotic cells. Additional plasmid genes encode complement resistance including the rck locus which is homologous to ail from Yersinia. Rck blocks formation of the complement membrane attack complex on the bacterial surface. Several loci involved in plasmid replication and stable maintenance have also been identified.

journal_name

FEMS Microbiol Lett

authors

Guiney DG,Fang FC,Krause M,Libby S

doi

10.1111/j.1574-6968.1994.tb07253.x

subject

Has Abstract

pub_date

1994-11-15 00:00:00

pages

1-9

issue

1

eissn

0378-1097

issn

1574-6968

journal_volume

124

pub_type

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