Abstract:
:Lysogenic conversion of Shigella flexneri type antigens was studied with the aid of wild-type and thermosensitive mutant phages. With all wild-type phages, the appearance of glycosylated antigen was accompanied by the appearance of polyprenyl phosphate glucose synthetase activity. With some of the mutant phages, the appearance of glycosylated antigen was not followed by the formation of lipid-linked glucose in the enzyme assay. The reverse has also been observed, i.e., the high rate of formation of lipid-linked glucose and the lack of V-type antigen.
journal_name
Infect Immunjournal_title
Infection and immunityauthors
Financsek I,Ketyi I,Sasak W,Jankowski W,Janczura E,Chojnacki Tdoi
10.1128/IAI.14.6.1290-1292.1976subject
Has Abstractpub_date
1976-12-01 00:00:00pages
1290-2issue
6eissn
0019-9567issn
1098-5522journal_volume
14pub_type
杂志文章abstract::The response to reinfection with Ethiopian Leishmania donovani was evaluated in genetically determined noncure (H-2d) B10.D2 mice that are able to resolve infection due to sublethal irradiation pretreatment after inoculation with a low parasite dose and in C57BL/10 mice that demonstrate the genetically determined cure...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.57.9.2892-2899.1989
更新日期:1989-09-01 00:00:00
abstract::The effects of phagocytosis-stimulating factor (PSF) derived from polymorphonuclear neutrophils on macrophage functions were studied. PSF enhanced the initial rate of phagocytosis of serum-opsonized zymosan particles by macrophages, whereas it did not affect the phagocytosis of immunoglobulin G-sensitized and inert zy...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.55.8.1762-1766.1987
更新日期:1987-08-01 00:00:00
abstract::Enteroaggregative Escherichia coli (EAEC) is an emerging cause of diarrheal illness. Clinical data suggest that diarrhea caused by EAEC is predominantly secretory in nature, but the responsible enterotoxin has not been described. Work from our laboratories has implicated a ca. 108-kDa protein as a heat-labile enteroto...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.66.7.3155-3163.1998
更新日期:1998-07-01 00:00:00
abstract::Porphyromonas gingivalis is a gram-negative anaerobic bacterium that is considered the key etiologic agent of chronic periodontitis. Arg- and Lys-gingipain cysteine proteinases produced by P. gingivalis are key virulence factors and are believed to be essential for significant tissue component degradation, leading to ...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.72.8.4689-4698.2004
更新日期:2004-08-01 00:00:00
abstract::Two murine monoclonal antibodies (immunoglobulin M) evoked against human kidney tissue were examined for cross-reactivity with group A streptococci. A glomerulus-specific antibody, PMII.40.H.2, cross-reacted in an enzyme-linked immunosorbent assay with purified pepsin-extracted M proteins from type 6 and 12 streptococ...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.55.10.2416-2419.1987
更新日期:1987-10-01 00:00:00
abstract::Mannheimia haemolytica, a commensal organism of the upper respiratory tract in cattle, is the principal bacterial pathogen associated with the bovine respiratory disease complex. Adherence to the respiratory mucosa is a crucial event in its pathogenesis. However, the bacterial components that contribute to this proces...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.00312-08
更新日期:2009-01-01 00:00:00
abstract::Delayed-type hypersensitivity (DTH) is the standard measure of T-cell responsiveness to infectious organisms. For leprosy, the Mitsuda reaction, a local immune response to cutaneous challenge with Mycobacterium leprae, is considered to represent a measure of DTH against the pathogen. We analyzed the diversity of the T...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.60.11.4542-4548.1992
更新日期:1992-11-01 00:00:00
abstract::Relapsing fever (RF) is a spirochetal infection characterized by relapses of a febrile illness and spirochetemia due to the sequential appearance and disappearance of isogenic serotypes in the blood. The only difference between isogenic serotypes is the variable major outer membrane lipoprotein. In the absence of spec...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.00538-06
更新日期:2006-11-01 00:00:00
abstract::In experimental visceral leishmaniasis, in which the tissue macrophage is the target, in vivo responsiveness to conventional chemotherapy (pentavalent antimony [Sb]) requires a T-cell-dependent mechanism. To determine if this mechanism involves gamma interferon (IFN-gamma)-induced activation and/or specific IFN-gamma-...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/iai.68.1.288-293.2000
更新日期:2000-01-01 00:00:00
abstract::Conventional dendritic cells (cDCs) are critical for protection against pulmonary infection with the opportunistic fungal pathogen Cryptococcus neoformans; however, the role of plasmacytoid dendritic cells (pDCs) is unknown. We show for the first time that murine pDCs have direct activity against C. neoformans via rea...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.00103-16
更新日期:2016-08-19 00:00:00
abstract::Lesions caused by Leishmania amazonensis normally heal, but relapses occur due to parasite persistence in host tissues. It has been proposed that infection of fibroblasts plays an important role in this process by providing the parasites with a safe haven in which to replicate. However, most previous studies have focu...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/iai.70.8.4571-4580.2002
更新日期:2002-08-01 00:00:00
abstract::Vaccine adjuvants exert critical and unique influences on the quality of immune responses induced during active immunizations. We investigated the mechanisms of action of immunological adjuvants in terms of their requirements for cytokine-mediated pathways for adjuvanticity. Antibody responses potentiated by several a...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.66.11.5329-5336.1998
更新日期:1998-11-01 00:00:00
abstract::A 2.9-kilobase pair locus in Neisseria meningitidis was identified as containing transcriptionally linked open reading frames encoding TolC- and HlyD-like proteins. Although the meningococcal TolC protein was required for extracellular production of the repeats-in-toxin (RTX) FrpC toxin, it could not functionally repl...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.01995-06
更新日期:2007-12-01 00:00:00
abstract::Newly hatched chicks were vaccinated orally with a genetically defined Salmonella enteritidis aroA candidate, strain CVL30. In chickens immunized with 10(5) or 10(9) CFU and challenged by the intravenous route with 10(8) CFU of S. enteritidis 109 Nalr at 8 weeks old, there were similar reductions in colonization of th...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.62.11.4747-4754.1994
更新日期:1994-11-01 00:00:00
abstract::Trefoil family factor 2 (TFF2), also known as spasmolytic peptide, is a low-molecular-weight protein that is upregulated in gastric tissues infected with Helicobacter or having other inflammatory conditions, but a precise function is yet to be elucidated. The role of TFF2 in the development of gastritis, colitis, and ...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.02039-05
更新日期:2007-01-01 00:00:00
abstract::The expression of several virulence determinants of Yersinia pestis is known to be dependent on the in vitro growth temperature. One of these, calcium dependence, is associated with the presence of a 47-megadalton plasmid. We have examined the effects of incubation temperature, calcium in the growth medium, the presen...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.42.3.1092-1101.1983
更新日期:1983-12-01 00:00:00
abstract::We studied seven strains of group G streptococci isolated from clinically severe bacteremic infections in six intravenous drug abusers. These group G strains multiplied luxuriantly in fresh human blood. On electron microscopy, they exhibited surface fibrillae similar to those observed in M-protein-rich group A strepto...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.55.3.753-757.1987
更新日期:1987-03-01 00:00:00
abstract::We purified three proline-rich antimicrobial peptides from elastase-treated extracts of sheep and goat leukocytes and subjected two of them, OaBac5alpha and ChBac5, to detailed analysis. OaBac5alpha and ChBac5 were homologous to each other and to bovine Bac5. Both exhibited potent, broad-spectrum antimicrobial activit...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.67.8.4106-4111.1999
更新日期:1999-08-01 00:00:00
abstract::Oxygen consumption by Treponema pallidum was observed to be glucose dependent. Treponemes consumed O2 to a low dissolved O2 concentration of 0.01 mumol of O2 per ml when respiration ceased. A fermentative degradation of glucose occurred during the maintenance of treponemes at 0.01 mumol of O2 per ml. Although the init...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.31.3.992-997.1981
更新日期:1981-03-01 00:00:00
abstract::Tuberculosis (TB) remains an enormous global health problem, and a new vaccine against TB more potent than the current inadequate vaccine, Mycobacterium bovis BCG, is urgently needed. We describe a recombinant BCG vaccine (rBCG30) expressing and secreting the 30-kDa major secretory protein of Mycobacterium tuberculosi...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/iai.71.4.1672-1679.2003
更新日期:2003-04-01 00:00:00
abstract::In general there is a poor correlation between serum lipopolysaccharide (LPS; the biologically active constituent of endotoxin) levels and mortality in septic patients. The objective of this study was to determine if chemical, structural, or biological differences among LPS from different clinical isolates of gram-neg...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/iai.68.4.1899-1904.2000
更新日期:2000-04-01 00:00:00
abstract::The virulence of Candida albicans in a mouse model of invasive candidiasis is dependent on the phospholipids phosphatidylserine (PS) and phosphatidylethanolamine (PE). Disruption of the PS synthase gene CHO1 (i.e., cho1Δ/Δ) eliminates PS and blocks the de novo pathway for PE biosynthesis. In addition, the cho1Δ/Δ muta...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.01612-14
更新日期:2014-10-01 00:00:00
abstract::Antibodies against the Plasmodium falciparum P0 ribosomal phosphoprotein (PfP0) have been detected exclusively but extensively in malaria-immune persons. Polyclonal rabbit and mice sera were raised against two recombinant polypeptides of P. falciparum P0 protein, PfP0N and PfP0C, covering amino acids 17 to 61 and the ...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/iai.68.7.4312-4318.2000
更新日期:2000-07-01 00:00:00
abstract::The lipid A portion has been identified as the active center responsible for lipopolysaccharide (LPS)-induced macrophage activation. However, we found that Salmonella (Salmonella enterica serovars Abortusequi, Minnesota, and Typhimurium) lipid A is inactive in human macrophages, despite its LPS being highly active. Th...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/iai.70.11.6043-6047.2002
更新日期:2002-11-01 00:00:00
abstract::Invasive aspergillosis is a major threat for patients suffering from chronic granulomatous disease (CGD). Although Aspergillus fumigatus is the most commonly encountered Aspergillus species, the presence of A. nidulans appears to be disproportionately high in CGD patients. The purpose of this study was to investigate ...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.00921-10
更新日期:2011-02-01 00:00:00
abstract::Cell wall proteins with sialidase activity are involved in carbohydrate assimilation, adhesion to mucosal surfaces, and biofilm formation. Gardnerella spp. inhabit the human vaginal microbiome and encode up to three sialidase enzymes, two of which are suspected to be cell wall associated. Here we demonstrate that the ...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.00583-20
更新日期:2020-12-23 00:00:00
abstract::When rabbit peritoneal exudate cells were incubated for 24 and 48 h with phytohemagglutinin-activated lymphocytes or their culture supernatants, two times as many cells remained adherent to culture slides as in the controls. More spreading cells were found among the adherent cells in the stimulated cultures. Eighty pe...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.13.5.1442-1448.1976
更新日期:1976-05-01 00:00:00
abstract::Serial passage of Cryptococcus neoformans in mice increases virulence relative to the nonpassaged line. Postpassaged lines showed no difference in the expression of most known virulence factors, with the exception that the more virulent lines had smaller capsules in vitro. These data imply that other mechanisms of vir...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.73.10.7047-7050.2005
更新日期:2005-10-01 00:00:00
abstract::EspG is a conserved protein encoded by the locus of enterocyte effacement (LEE) of attaching and effacing (A/E) pathogens, including enteropathogenic and enterohemorrhagic Escherichia coli and Citrobacter rodentium. EspG is delivered into infected host cells by a type III secretion system. The role of EspG in virulenc...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.73.5.2586-2594.2005
更新日期:2005-05-01 00:00:00
abstract::Continuous virus production is a characteristic of chicken embryo fibroblasts (CEF) infected and transformed by a nondefective Schmidt-Ruppin subgroup A Rous sarcoma virus. This virus production has been examined with particular attention to the amount of newly budded virus which remained cell-associated, and to the a...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.10.4.834-843.1974
更新日期:1974-10-01 00:00:00