Normal long bone growth and development in type X collagen-null mice.

Abstract:

:To investigate the role of type X collagen in skeletal development, we have generated type X collagen-null mice. Surprisingly, mice without type X collagen were viable and fertile and had no gross abnormalities in long bone growth or development. No differences were detected between the type X collagen-null mice and controls when growth plates of both newborn and 3-week old mice were examined by histology and by immunostaining for extracellular matrix components of bone including osteopontin, osteocalcin and type II collagen. Our results suggest that type X collagen is not required for long bone development. However, mice and humans with dominant acting type X collagen mutations have bone abnormalities, suggesting that only the presence of abnormal type X collagen can modify bone growth and development.

journal_name

Nat Genet

journal_title

Nature genetics

authors

Rosati R,Horan GS,Pinero GJ,Garofalo S,Keene DR,Horton WA,Vuorio E,de Crombrugghe B,Behringer RR

doi

10.1038/ng1094-129

subject

Has Abstract

pub_date

1994-10-01 00:00:00

pages

129-35

issue

2

eissn

1061-4036

issn

1546-1718

journal_volume

8

pub_type

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