Angiotensin II (AII) modulation of steroidogenesis by luteinized granulosa cells in vitro.

Abstract:

PURPOSE:The purpose of the present study was to evaluate the effect of angiotensin II and its inhibitor, saralasin, on steroid production by luteinized human granulosa cells in vitro. Granulosa cells were obtained from follicular fluid aspirations from human in vitro fertilization. Cultures were established in supplemented Ham's F-10 medium. Human chorionic gonadotropin and angiotensin II were added to culture media and the effect on steroid production was measured. RESULTS:Human chorionic gonadotropin alone stimulated production of progesterone, estradiol, and testosterone. The addition of angiotensin II resulted in a dose-dependent increase in progesterone production (428% increase compared to baseline). No effect was seen on estradiol or testosterone. However, a large increase (700%) in estradiol was seen with the addition of the competitive inhibitor of angiotensin II, saralasin. CONCLUSION:We conclude that angiotensin II modulates progesterone production by human luteinized granulosa cells in vitro. The observed enhancement of estradiol production by angiotensin blockade suggests a tonic inhibition of estradiol secretion by endogenous angiotensin II.

journal_name

J Assist Reprod Genet

authors

Morris RS,Francis MM,Do YS,Hsueh WA,Lobo RA,Paulson RJ

doi

10.1007/BF02332088

subject

Has Abstract

pub_date

1994-03-01 00:00:00

pages

117-22

issue

3

eissn

1058-0468

issn

1573-7330

journal_volume

11

pub_type

杂志文章
  • Early timed follicular aspiration prevents severe ovarian hyperstimulation syndrome.

    abstract:PURPOSE:Early timed follicular aspiration (ETFA) of one ovary 10-12 hr after administration of chorionic gonadotropin (hCG) is an attempt to prevent severe ovarian hyperstimulation syndrome (OHSS). After the introduction of early timed follicular aspiration ETFA of one ovary in IVF/ET cycles at high risk for severe OHS...

    journal_title:Journal of assisted reproduction and genetics

    pub_type: 临床试验,杂志文章

    doi:10.1007/BF02070139

    authors: Tomazevic T,Meden-Vrtovec H

    更新日期:1996-04-01 00:00:00

  • The impact of environmental exposure to perfluorinated compounds on oocyte fertilization capacity.

    abstract::In an attempt to assess the effect of perfluorinated compounds (PFC) on oocytes quality and fertilization rate, we studied follicular fluid (FF) PFC levels in 18 patients undergoing IVF-ET cycles. A significant correlation (R = 0.75; P < 0.001) was observed between FF PFC levels and fertilization rate. Moreover, patie...

    journal_title:Journal of assisted reproduction and genetics

    pub_type: 杂志文章

    doi:10.1007/s10815-011-9548-2

    authors: Governini L,Orvieto R,Guerranti C,Gambera L,De Leo V,Piomboni P

    更新日期:2011-05-01 00:00:00

  • Vitrification of human immature oocytes before and after in vitro maturation: a review.

    abstract::The use of immature oocytes subjected to in vitro maturation (IVM) opens interesting perspectives for fertility preservation where ovarian reserves are damaged by pathologies or therapies, as in PCO/PCOS and cancer patients. Human oocyte cryopreservation may offer some advantages compared to embryo freezing, such as f...

    journal_title:Journal of assisted reproduction and genetics

    pub_type: 杂志文章,评审

    doi:10.1007/s10815-017-1005-4

    authors: Khalili MA,Shahedi A,Ashourzadeh S,Nottola SA,Macchiarelli G,Palmerini MG

    更新日期:2017-11-01 00:00:00

  • Disparities in reproductive outcomes according to the endometrial preparation protocol in frozen embryo transfer : The risk of early pregnancy loss in frozen embryo transfer cycles.

    abstract:PURPOSE:The purpose of this study was to determine the effect of stimulated and artificial endometrial preparation protocols on reproductive outcomes in frozen embryo transfer (FET) cycles. METHODS:We performed a retrospective study of 1926 FET cycles over a 3.5-year period in the Fertility Unit at a University Hospit...

    journal_title:Journal of assisted reproduction and genetics

    pub_type: 杂志文章

    doi:10.1007/s10815-017-1078-0

    authors: Hatoum I,Bellon L,Swierkowski N,Ouazana M,Bouba S,Fathallah K,Paillusson B,Bailly M,Boitrelle F,Alter L,Bergère M,Selva J,Wainer R

    更新日期:2018-03-01 00:00:00

  • Coculture of mouse embryos with cryopreserved human oviduct epithelial cells.

    abstract:PURPOSE:The effect of coculturing mouse embryos with cryopreserved human oviduct epithelial cells was investigated. The cryopreserved cells in Cellbanker were thawed and cultured in Richard D. Goldsby culture medium to establish monolayers. Two-cell-stage mouse embryos were cultured alone (control group) or cocultured ...

    journal_title:Journal of assisted reproduction and genetics

    pub_type: 杂志文章

    doi:10.1007/BF02214143

    authors: Hoshi K,Kanno Y,Katayose H,Yanagida K,Suzuki R,Sato A

    更新日期:1994-08-01 00:00:00

  • Role of the Ped gene and apoptosis genes in control of preimplantation development.

    abstract:PURPOSE:The properties of the mouse Ped gene and the genes that mediate apoptosis in mediating preimplantation embryonic survival were reviewed. METHODS:Preimplantation mouse oocytes and embryos were evaluated microscopically and biochemically for rate of development, degree of fragmentation, and gene expression to co...

    journal_title:Journal of assisted reproduction and genetics

    pub_type: 杂志文章,评审

    doi:10.1023/a:1022560914833

    authors: Warner CM,McElhinny AS,Wu L,Cieluch C,Ke X,Cao W,Tang C,Exley GE

    更新日期:1998-05-01 00:00:00

  • The antral follicle count predicts the outcome of pregnancy in a controlled ovarian hyperstimulation/intrauterine insemination program.

    abstract:PURPOSE:Our purpose was to test whether age-related changes in antral follicle counts can predict the pregnancy outcome in the early follicular phase of a controlled ovarian hyperstimulation/intrauterine insemination (COH/IUI) program. METHODS:A selected group of 107 women (36 healthy women requesting child sex presel...

    journal_title:Journal of assisted reproduction and genetics

    pub_type: 杂志文章

    doi:10.1023/a:1022518103368

    authors: Chang MY,Chiang CH,Chiu TH,Hsieh TT,Soong YK

    更新日期:1998-01-01 00:00:00

  • Ovarian hyperstimulation syndrome: pathophysiology and prevention.

    abstract:PURPOSE:To review and discuss the pathophysiology and prevention strategies for ovarian hyperstimulation syndrome (OHSS), which is a condition that may occur in up to 20% of the high risk women submitted to assisted reproductive technology cycles. METHODS:The English language literature on these topics were reviewed t...

    journal_title:Journal of assisted reproduction and genetics

    pub_type: 杂志文章,评审

    doi:10.1007/s10815-010-9387-6

    authors: Nastri CO,Ferriani RA,Rocha IA,Martins WP

    更新日期:2010-02-01 00:00:00

  • Unbalanced human embryos secrete more hyperglycosylated human chorionic gonadotrophin (hCG-H) than balanced ones.

    abstract:PURPOSE:The aim of this study was to compare the levels of hyperglycosylated human chorionic gonadotropin (hCG-H) secreted from balanced and unbalanced human embryos. METHODS:Single-step culture media samples from 155 good quality embryos, derived from 90 good prognosis patients undergoing intracytoplasmic sperm injec...

    journal_title:Journal of assisted reproduction and genetics

    pub_type: 杂志文章

    doi:10.1007/s10815-020-01776-9

    authors: Parvanov D,Nikolova D,Ganeva R,Nikolova K,Vasileva M,Rangelov I,Pancheva M,Serafimova M,Staneva R,Hadjidekova S,Scarpellini F,Stamenov G

    更新日期:2020-06-01 00:00:00

  • Sperm preparation after freezing improves motile sperm count, motility, and viability in frozen-thawed sperm compared with sperm preparation before freezing-thawing process.

    abstract:PURPOSE:The aim of this study is to evaluate which cryopreservation protocol, freezing before or after swim-up, optimizes cryopreservation outcomes in terms of motile sperm count, motility, morphology, and viability, and also to establish whether sperm viability could be assessed based on sperm motility. METHODS:Fifty...

    journal_title:Journal of assisted reproduction and genetics

    pub_type: 杂志文章

    doi:10.1007/s10815-017-1050-z

    authors: Palomar Rios A,Gascón A,Martínez JV,Balasch S,Molina Botella I

    更新日期:2018-02-01 00:00:00

  • Efficacy of low-dose human chorionic gonadotropin (hCG) in a GnRH antagonist protocol.

    abstract:PURPOSE:To examine the efficacy of low-dose hCG using a GnRH antagonist protocol. METHODS:Prospective randomized study was performed at the Kyono Ladies Clinic. One hundred ninety-two women (<40 -years old, <3 previous cycles) were randomly assigned to GnRH agonist (buserelin) long protocol (LP, n = 66), GnRH antagoni...

    journal_title:Journal of assisted reproduction and genetics

    pub_type: 杂志文章,随机对照试验

    doi:10.1007/s10815-006-9036-2

    authors: Koichi K,Yukiko N,Shima K,Sachiko S

    更新日期:2006-05-01 00:00:00

  • Social media in the REI clinic: what do patients want?

    abstract:PURPOSE:To elicit patient preferences for social media utilization and content in the infertility clinic. METHODS:This was a cross-sectional survey study conducted in three US fertility practices. Women presenting to the infertility clinic for an initial or return visit were offered an anonymous voluntary social media...

    journal_title:Journal of assisted reproduction and genetics

    pub_type: 杂志文章

    doi:10.1007/s10815-018-1189-2

    authors: Broughton DE,Schelble A,Cipolla K,Cho M,Franasiak J,Omurtag KR

    更新日期:2018-07-01 00:00:00

  • Is there a critical LH level for hCG trigger after the detection of LH surge in modified natural frozen-thawed single blastocyst transfer cycles?

    abstract:PURPOSE:There is no consensus yet in the literature on an optimal luteinizing hormone (LH) level for human chorionic gonadotrophin (hCG) trigger timing in patients undergoing frozen-thawed embryo transfer (FET) with modified natural cycles (mNC). The objective of our study was to compare the clinical results of hCG tri...

    journal_title:Journal of assisted reproduction and genetics

    pub_type: 杂志文章

    doi:10.1007/s10815-020-01974-5

    authors: Kahraman S,Sahin Y

    更新日期:2020-12-01 00:00:00

  • Combination of cabergoline and embryo cryopreservation after GnRH agonist triggering prevents OHSS in patients with extremely high estradiol levels--a retrospective study.

    abstract:PURPOSE:Embryo cryopreservation after triggering oocyte maturation with GnRH agonist (GnRHa) in GnRH antagonist protocols has been proposed to prevent ovarian hyperstimulation syndrome (OHSS). However, a small percentage of patients still developed severe OHSS. The purpose of the study was to investigate the efficacy o...

    journal_title:Journal of assisted reproduction and genetics

    pub_type: 杂志文章

    doi:10.1007/s10815-013-9997-x

    authors: Lin YH,Huang MZ,Hwang JL,Chen HJ,Hsieh BC,Huang LW,Tzeng CR,Seow KM

    更新日期:2013-06-01 00:00:00

  • The influence of amifostine administration prior to cyclophosphamide on in vitro maturation of mouse oocytes.

    abstract:PURPOSE:The protective effect of amifostine against cyclophosphamide (CP) was evaluated on mouse oocytes. MATERIALS AND METHODS:Female mice were divided into four groups as follows: group1: cyclophosphamide (CP) (75 mg/kg, i.p) injection, group2: amifostine (250 mg/kg, i.p) injection, group3: amifostine (250 mg/kg, i....

    journal_title:Journal of assisted reproduction and genetics

    pub_type: 杂志文章

    doi:10.1007/s10815-013-0035-9

    authors: Golkar-Narenji A,Barekati Z,Eimani H,Shabani F,Gourabi H

    更新日期:2013-07-01 00:00:00

  • Relationship between cytokines and the embryotoxicity of hydrosalpingeal fluid.

    abstract:OBJECTIVE:The exact chemical composition of hydrosalpingeal fluid is unknown. The objective of this study was to characterize cytokines in hydrosalpingeal fluid (HSF) and examine their possible role in the embryo development. STUDY DESIGN:HSF was aspirated at laparoscopic salpingectomy in eight infertile women. Levels...

    journal_title:Journal of assisted reproduction and genetics

    pub_type: 杂志文章

    doi:10.1007/s10815-005-4913-7

    authors: Bedaiwy MA,Falcone T,Goldberg JM,Attaran M,Sharma R,Miller K,Nelson DR,Agarwal A

    更新日期:2005-04-01 00:00:00

  • Prognostic implication of apoptosis in human luteinized granulosa cells during IVF-ET.

    abstract:PURPOSE:To investigate the prognostic significance of apoptosis in granulosa cells recovered from patients participating in IVF-ET. METHODS:Seventy-three women underwent ovarian hyperstimulation for IVF and embryo transfer. After follicle aspiration, recovered granulosa cells were stained by BCL2 monoclonal antibody w...

    journal_title:Journal of assisted reproduction and genetics

    pub_type: 杂志文章

    doi:10.1023/a:1015319617598

    authors: Suh CS,Jee BC,Choi YM,Kim JG,Lee JY,Moon SY,Kim SH

    更新日期:2002-05-01 00:00:00

  • The impact of RABL2B gene (rs144944885) on human male infertility in patients with oligoasthenoteratozoospermia and immotile short tail sperm defects.

    abstract:PURPOSE:Male infertility is a multifactorial disorder with impressively genetic basis; besides, sperm abnormalities are the cause of numerous cases of male infertility. In this study, we evaluated the genetic variants in exons 4 and 5 and their intron-exon boundaries in RABL2B gene in infertile men with oligoasthenoter...

    journal_title:Journal of assisted reproduction and genetics

    pub_type: 杂志文章

    doi:10.1007/s10815-016-0863-5

    authors: Hosseini SH,Sadighi Gilani MA,Meybodi AM,Sabbaghian M

    更新日期:2017-04-01 00:00:00

  • Assessing the impact of delayed blastulation using time lapse morphokinetics and preimplantation genetic testing in an IVF patient population.

    abstract:PURPOSE:There is clinical evidence that early cleavage timing parameters predictive of blastocyst development also correlate with embryo implantation potential. The aim of this study is to determine the developmental competency of embryos with delayed blastulation. METHODS:Retrospective study performed from 2015 to 20...

    journal_title:Journal of assisted reproduction and genetics

    pub_type: 杂志文章

    doi:10.1007/s10815-019-01501-1

    authors: Kimelman D,Confino R,Okeigwe I,Lambe-Steinmiller J,Confino E,Shulman LP,Zhang JX,Pavone ME

    更新日期:2019-08-01 00:00:00

  • Effect of powdered gloves, worn at the time of embryo transfer, on the pregnancy outcome of IVF cycles.

    abstract:PURPOSE:To assess the effect of wearing powdered gloves during embryo transfer as compared to un-powdered gloves on the pregnancy outcome of IVF cycles. METHODS:Patients, undergoing embryo transfer procedures, were prospectively randomized into two groups: In the first (group A, n=356) group embryo transfer was perfor...

    journal_title:Journal of assisted reproduction and genetics

    pub_type: 杂志文章

    doi:10.1007/s10815-008-9285-3

    authors: Hannoun A,Zreik TG,Ghaziri G,Abu Musa A,Awwad J

    更新日期:2009-01-01 00:00:00

  • Behavior of mouse spermatogonial stem-like cells on an electrospun nanofibrillar matrix.

    abstract:PURPOSE:Spermatogonial stem cells are affected by the interactions of extrinsic signals produced by components of the microenvironment niche, in addition to the chemical and physical properties of the extracellular matrix. Therefore, this study was initiated to assess the interaction of these cells on a synthetic nanof...

    journal_title:Journal of assisted reproduction and genetics

    pub_type: 杂志文章

    doi:10.1007/s10815-012-9916-6

    authors: Shakeri M,Kohram H,Shahverdi A,Shahneh AZ,Tavakolifar F,Pirouz M,Shahrebabak HM,Koruji M,Baharvand H

    更新日期:2013-03-01 00:00:00

  • FoxO transcription factors 1 regulate mouse preimplantation embryo development.

    abstract:PURPOSE:The aim of the present study is to investigate role of FoxO transcription factors in preimplantation embryo development by knocking down FoxO1, FoxO3, and FoxO4 genes and also to assess cell cycle arrest related proteins, p53 and p21, and apoptosis-related proteins, fas ligand (FASL), and cleaved caspase 3. ME...

    journal_title:Journal of assisted reproduction and genetics

    pub_type: 杂志文章

    doi:10.1007/s10815-019-01555-1

    authors: Kuscu N,Gungor-Ordueri NE,Sozen B,Adiguzel D,Celik-Ozenci C

    更新日期:2019-10-01 00:00:00

  • Texture profile analysis reveals a stiffer ovarian cortex after testosterone therapy: a pilot study.

    abstract:PURPOSE:The importance of the surrounding ovarian stromal cells and extracellular matrix in the development and maturation of follicles has recently gained attention. An aberrant extracellular matrix has been described in ovaries of patients with polycystic ovary syndrome where a more rigid structural environment, poss...

    journal_title:Journal of assisted reproduction and genetics

    pub_type: 杂志文章

    doi:10.1007/s10815-019-01513-x

    authors: De Roo C,Tilleman K,Vercruysse C,Declercq H,T'Sjoen G,Weyers S,De Sutter P

    更新日期:2019-09-01 00:00:00

  • Pre-embryo research.

    abstract::The subject is first identified in terms of the new understanding of a pre-embryonic phase preceding the traditional embryonic and fetal periods of formation and development. Sample fields and purposes of pre-embryonic research are instanced, some with direct therapeutic intent, others with foreseeable but not immedia...

    journal_title:Journal of assisted reproduction and genetics

    pub_type: 杂志文章

    doi:10.1007/BF02212914

    authors: Dunstan GR

    更新日期:1995-09-01 00:00:00

  • Maternal C-reactive protein and in vitro fertilization (IVF) cycles.

    abstract::Embryo implantation is accompanied by a potent inflammatory response, and a gradient of cytokines and chemokines produced by endometrial cells supports the embryo-endometrial interaction. C-reactive protein (CRP) serves as an early marker of inflammation and recent studies have illustrated that controlled ovarian hype...

    journal_title:Journal of assisted reproduction and genetics

    pub_type: 杂志文章,评审

    doi:10.1007/s10815-020-01924-1

    authors: Diba-Bagtash F,Farshbaf-Khalili A,Ghasemzadeh A,Lotz L,Fattahi A,Shahnazi M,Dittrich R

    更新日期:2020-11-01 00:00:00

  • Chromosomal abnormalities in products of conception of first-trimester miscarriages detected by conventional cytogenetic analysis: a review of 1000 cases.

    abstract:PURPOSE:The purpose of this study is to perform a retrospective analysis of types and frequencies of chromosomal abnormalities detected by conventional cytogenetic studies in first-trimester miscarriages after spontaneous conception and IVF. METHODS:Standard cytogenetic analysis of GTG-banded chromosomes obtained from...

    journal_title:Journal of assisted reproduction and genetics

    pub_type: 杂志文章

    doi:10.1007/s10815-017-1069-1

    authors: Pylyp LY,Spynenko LO,Verhoglyad NV,Mishenko AO,Mykytenko DO,Zukin VD

    更新日期:2018-02-01 00:00:00

  • Is AMH a regulator of follicular atresia?

    abstract::We discuss the hypothesis that AMH is an intraovarian regulator that inhibits follicular atresia within the human ovary. Several indirect lines of evidence derived from clinical and basic science studies in a variety of different patient populations and model systems collectively support this hypothesis. Evidence pres...

    journal_title:Journal of assisted reproduction and genetics

    pub_type: 杂志文章,评审

    doi:10.1007/s10815-014-0328-7

    authors: Seifer DB,Merhi Z

    更新日期:2014-11-01 00:00:00

  • Qualitative and morphometric analysis of the ultrastructure of human oocytes cryopreserved by two alternative slow cooling protocols.

    abstract:PURPOSE:To ascertain possible cell damage from cryopreservation, the ultrastructure of human oocytes cryopreserved by slow cooling was assessed. MATERIALS AND METHODS:Cryopreservation was performed through two protocols with one-step or two-step propanediol. Fresh control oocytes were examined for comparison. Samples ...

    journal_title:Journal of assisted reproduction and genetics

    pub_type: 杂志文章

    doi:10.1007/s10815-010-9394-7

    authors: Coticchio G,Borini A,Distratis V,Maione M,Scaravelli G,Bianchi V,Macchiarelli G,Nottola SA

    更新日期:2010-04-01 00:00:00

  • Does subtle progesterone rise on the day of HCG affect pregnancy rate in long agonist ICSI cycles?

    abstract:PURPOSE:To evaluate the impact of subtle progesterone (P4) rise on the day of HCG on pregnancy outcome in ICSI patients stimulated with long agonist protocol. METHODS:One hundred forty-nine consecutive controlled ovarian hyperstimulation cycles for ICSI using long luteal agonist protocol. RESULTS:Mean serum progester...

    journal_title:Journal of assisted reproduction and genetics

    pub_type: 杂志文章

    doi:10.1007/s10815-009-9309-7

    authors: Saleh HA,Omran MS,Draz M

    更新日期:2009-05-01 00:00:00

  • Fertilization of bovine oocytes induced solely with combined laser microbeam and optical tweezers.

    abstract:PURPOSE:Our purpose was to show that fertilization of oocytes can be obtained solely by laser light-mediated manipulation of gametes. METHOD:A small channel was drilled into the zona pellucida of bovine oocytes using an ultraviolet (UV)-laser microbeam. Highly diluted cattle sperm were not able to fertilize the laser ...

    journal_title:Journal of assisted reproduction and genetics

    pub_type: 杂志文章

    doi:10.1007/BF02065947

    authors: Clement-Sengewald A,Schütze K,Ashkin A,Palma GA,Kerlen G,Brem G

    更新日期:1996-03-01 00:00:00