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Enzymatic production of cephalexin.

Abstract：

:Enzymatic production of cephalexin using immobilized penicillin G acylase was studied. The factors that affect the conversion of 7-amino-3-deacetoxycephalosporanic acid (7-ADCA) to cephalexin, such as pH; temperature; concentrations of 7-ADCA, D(-)-phenylglycine methyl ester (PGME), and immobilized penicillin G acylase (IMPGA); time; and molar ratios of 7-ADCA and PGME, were investigated. Under optimized conditions, 85% conversion of 7-ADCA to cephalexin was achieved. The IMPGA was used for 10 cycles.

journal_name

Enzyme Microb Technol

journal_title

Enzyme and microbial technology

authors

Maladkar NK

doi

10.1016/0141-0229(94)90095-7

subject

Has Abstract

pub_date

1994-08-01 00:00:00

pages

715-8

issue

8

eissn

0141-0229

issn

1879-0909

pii

0141-0229(94)90095-7

journal_volume

16

pub_type

杂志文章

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