Abstract:
:The structural features of a new class of non-nucleoside HIV-1 reverse transcriptase inhibitors (3) are presented. Comparison of the structural and electronic properties with those of TIBO (1) and Nevirapine (2) yields a common three-dimensional model. This model permits the improvement of the lead compound 3 by chemical modification (5,6). Additionally, two new types of inhibitors (4, 7) with similar biological activity can be derived from this model. The structure of the new compounds, including their absolute configuration, are determined by X-ray crystallography.
journal_name
J Med Chemjournal_title
Journal of medicinal chemistryauthors
Schäfer W,Friebe WG,Leinert H,Mertens A,Poll T,von der Saal W,Zilch H,Nuber B,Ziegler MLdoi
10.1021/jm00058a009subject
Has Abstractpub_date
1993-03-19 00:00:00pages
726-32issue
6eissn
0022-2623issn
1520-4804journal_volume
36pub_type
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