Relationships between lead-induced learning impairments and changes in dopaminergic, cholinergic, and glutamatergic neurotransmitter system functions.

Abstract:

:Behavioral consequences of low-level lead (Pb) exposure include impairments in learning processes and in Fixed-Interval schedule-controlled operant behavior. Although the neurobiological bases of these effects remain undetermined, current evidence suggests that inhibitory effects of Pb on the NMDA receptor complex may play a preferential role in the learning deficits. In contrast, alterations in dopaminergic systems, consistent with a decrease in dopamine availability, appear to be related to the changes in Fixed-Interval performance. Hypocholinergic function has also been described, but its relationship to the behavioral changes is not yet known. Explication of these relationships will require more efforts involving direct rather than correlative methods. The answers are critical for understanding risks associated with exposure and for the development of behavioral or chemical therapeutic strategies for dealing with lead neurotoxicity.

authors

Cory-Slechta DA

doi

10.1146/annurev.pa.35.040195.002135

subject

Has Abstract

pub_date

1995-01-01 00:00:00

pages

391-415

eissn

0362-1642

issn

1545-4304

journal_volume

35

pub_type

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