Abstract：
:Twenty patients with rheumatoid arthritis or Still's disease associated with growth failure were treated with human growth hormone, 7.5 to 17 U/m2 body surface per week. Five patients did not respond with better growth. In the remainder the mean growth rate increased from 1.9 cm/year (range: 0 to 3.3) to 6.2 cm/year (range: 3.6 to 12) over 5 to 7 months. Twelve patients treated for longer periods increased their mean growth rate from 2.6 cm/year (range: 0.7 to 5.7) to 6.3 cm/year (range: 2.4 to 9.7) and continued to grow during a second year of treatment. Growth velocity decreased in 6 patients when the hGH therapy was discontinued. The causes for this improvement in growth are possibly multifactorial: the growth rate is depressed by the severity of the disease and high-dose glucocorticoid therapy. Increases of growth rate occurred during improvements in the disease, reduction of steroid medication, as a result of therapy with human growth hormone, and because of puberty in some patients. Human growth hormone seemed to improve the underlying condition of four of the patients but had no influence on the disease in the remaining children.
journal_name
Eur J Pediatrjournal_title
European journal of pediatricsauthors
Butenandt Odoi
10.1007/BF00441894subject
Has Abstractpub_date
1979-01-18 00:00:00pages
15-28issue
1eissn
0340-6199issn
1432-1076journal_volume
130pub_type
杂志文章abstract：:Severe hand, foot, and mouth disease (HFMD) is likely to develop critical complications such as brainstem encephalitis, acute pulmonary edema, and circulatory failure, which cause child mortality during outbreaks. This study aims to investigate factors that predict the severity of HFMD. One hundred sixteen in-patient ...
journal_title：European journal of pediatrics
pub_type： 杂志文章
doi：10.1007/s00431-013-1939-1
更新日期：2013-05-01 00:00:00
abstract：UNLABELLED:Repeated invasive procedures occur routinely in neonates who require intensive care, causing pain at a time when it is developmentally unexpected. Multiple lines of evidence suggest that repeated and prolonged pain exposure alters their subsequent pain processing, long-term development, and behaviour. Primar...
journal_title：European journal of pediatrics
pub_type： 杂志文章,随机对照试验
doi：10.1007/s00431-011-1655-7
更新日期：2012-06-01 00:00:00
abstract：:Anthropometric indices (AI) have been known to be associated with age at menarche (AAM). The aim of this longitudinal study was to evaluate the changes in AI and its association with AAM in a community-based population in Iran. From among 10,192 women, we included 6818, aged ≥ 10 years, who were post-menarche at the t...
journal_title：European journal of pediatrics
pub_type： 杂志文章
doi：10.1007/s00431-020-03575-x
更新日期：2020-09-01 00:00:00
abstract：UNLABELLED:Dent disease is an X-linked tubulopathy mainly caused by inactivating mutations of CLCN5. Features of Bartter syndrome such as hypokalemic metabolic alkalosis are rarely observed in patients with Dent disease. We report a Japanese male patient with Dent disease who also manifested features of Bartter syndrom...
journal_title：European journal of pediatrics
pub_type： 杂志文章
doi：10.1007/s00431-011-1578-3
更新日期：2012-02-01 00:00:00
abstract：INTRODUCTION:Newborns with intrauterine growth retardation (IUGR) have multiple risk factors for developing hypoglycaemia. Hyperinsulinism, both transient and prolonged, is one of the major risk factors responsible for the hypoglycaemia observed in some newborns with IUGR. Once the child has progressed beyond the infan...
journal_title：European journal of pediatrics
pub_type： 杂志文章
doi：10.1007/s00431-006-0371-1
更新日期：2007-10-01 00:00:00
abstract：:Septo-optic dysplasia (SOD) is a heterogeneous brain midline anomaly associated with ophthalmological, endocrinological, and/or neurodevelopmental symptoms. The clinical phenotype correlates with abnormal brain magnetic resonance imaging (MRI) findings. However, variations of the septum pellucidum (SP) appearance and ...
journal_title：European journal of pediatrics
pub_type： 杂志文章
doi：10.1007/s00431-007-0666-x
更新日期：2008-11-01 00:00:00
abstract：UNLABELLED:A 9-year-old boy lost almost all his small bowel after an acute volvulus due to a congenital, but previously unsuspected malrotation. Survival using total parenteral nutrition is possible in these cases, but the medical burden is heavy. Small intestinal transplantation was performed for the first time in the...
journal_title：European journal of pediatrics
pub_type： 杂志文章
doi：10.1007/s00431-003-1294-8
更新日期：2003-11-01 00:00:00
abstract：:The insulin-like growth factors (IGF-I and IGF-II) circulate bound to specific proteins. Two classes of binding proteins have been relatively well characterized differing in size, immunological activity, and physiological function. This review summarizes the more recent data on IGF-binding proteins, focusing on their ...
journal_title：European journal of pediatrics
pub_type： 杂志文章,评审
doi：10.1007/BF01995850
更新日期：1989-11-01 00:00:00
abstract：:This is a report on two mentally retarded sibs with similar anomalies (sagittal craniosynostosis, complex cardiovascular malformations, mandibular ankylosis) and various dysmorphic features. They could represent a "new" probably monogenic syndrome. ...
journal_title：European journal of pediatrics
pub_type： 杂志文章
doi：10.1007/BF00647293
更新日期：1987-01-01 00:00:00
abstract：:Estimation of the total number of infants with DS born each year in Belgium allows evaluation of changes in the proportion of children with DS in whom a karyotype has been established. This proportion steadily increased to 95% of the children with DS born in 1978. ...
journal_title：European journal of pediatrics
pub_type： 杂志文章
doi：10.1007/BF00442300
更新日期：1985-03-01 00:00:00
abstract：:Strategies for the treatment of cystathionine beta-synthase (CBS) deficiency include (1) increasing residual enzyme activity by giving pyridoxine in those patients with vitamin responsive variants, (2) reducing the load on the affected pathway with a low methionine diet and supplementing the diet with cysteine; and (3...
journal_title：European journal of pediatrics
pub_type： 杂志文章
doi：10.1007/pl00014308
更新日期：1998-04-01 00:00:00
abstract：:We describe a preterm infant with severe idiopathic respiratory distress syndrome (iRDS, hyaline membrane disease) who needed artificial ventilation with high inspiratory pressure, high frequencies, 100% oxygen and developed a symptomatic patent ductus arteriosus (sPDA) in the course of the disease. The infant was giv...
journal_title：European journal of pediatrics
pub_type： 杂志文章
doi：10.1007/BF02034756
更新日期：1990-06-01 00:00:00
abstract：:Two patients developed clinical features of intracranial bleeding--which were confirmed by computerized axial tomograms--during their induction therapy for acute lymphocytic leukemia. Coagulation studies showed clotting abnormalities including severe hypofibrinogenemia. These findings most probably were related to the...
journal_title：European journal of pediatrics
pub_type： 杂志文章
doi：10.1007/BF00443266
更新日期：1981-11-01 00:00:00
abstract：:Screening for coeliac disease (CD) with serum antigliadin antibodies (AGA) was performed in 1032 diabetic children and adolescents. In 8 children CD had been diagnosed before study entry. Of the remaining 1024 children, 33 had an elevated AGA titre in the first serum sample. On follow-up an elevated AGA titre was conf...
journal_title：European journal of pediatrics
pub_type： 临床试验,杂志文章,多中心研究
doi：10.1007/BF00445915
更新日期：1988-11-01 00:00:00
abstract：:A patient with a cerebro-hepato-renal syndrome was investigated. The visceral manifestations were those of the Zellweger syndrome (ZS); however, the child exhibited muscular hypertonia and survived into the 2nd year of life. Ultramicroscopically, hepatocytes were lacking peroxisomes, but, contrary to findings in one p...
journal_title：European journal of pediatrics
pub_type： 杂志文章
doi：10.1007/BF00441934
更新日期：1977-03-18 00:00:00
abstract：UNLABELLED:A postal survey of 31 European centres was conducted to document current practices regarding screening and management of hepatitis C virus (HCV)-infected pregnant women and their children. Antenatal HCV prevalence was low. Universal antenatal screening programmes were in place in ten centres, selective scree...
journal_title：European journal of pediatrics
pub_type： 杂志文章
doi：10.1007/s004310051219
更新日期：1999-10-01 00:00:00
abstract：UNLABELLED:We investigated the histological and molecular characteristics of pulmonary alveolar proteinosis (PAP) in two siblings (a brother and sister) who did not exhibit respiratory distress at birth but who each developed symptoms during infancy. Histological analysis of lung specimens showed positive staining for ...
journal_title：European journal of pediatrics
pub_type： 杂志文章
doi：10.1007/s004310051107
更新日期：1999-05-01 00:00:00
abstract：UNLABELLED:The aim of this study was to analyze changes in adipose tissue (AT) distribution, intrahepatic lipids (IHL), and insulin resistance (IR) among a group of obese adolescents undergoing a 7-months low-level lifestyle intervention. Thirty-nine obese Caucasian adolescents (mean age 13.9 years, body mass index sta...
journal_title：European journal of pediatrics
pub_type： 杂志文章
doi：10.1007/s00431-015-2577-6
更新日期：2015-12-01 00:00:00
abstract：UNLABELLED:Hypotension is a commonly diagnosed and treated complication of extremely low gestational age newborns (ELGAN), but enormous variation in diagnosis, management and clinical practice has been documented. We sought to evaluate practice regarding the management of hypotension in ELGANs and developed a web-based...
journal_title：European journal of pediatrics
pub_type： 杂志文章,多中心研究
doi：10.1007/s00431-013-2251-9
更新日期：2014-06-01 00:00:00
abstract：:Of 496 neonates and infants less than 1 year of age admitted to the paediatric surgical intensive care unit (PSICU) over a 5 year period (1983-1987), 94 required total parenteral nutrition (TPN) for more than 14 consecutive days, generally due to congenital anomalies of the digestive tract. Cholestasis occurred in 15 ...
journal_title：European journal of pediatrics
pub_type： 杂志文章
doi：10.1007/BF02171565
更新日期：1990-02-01 00:00:00
abstract：:Two siblings with molybdenum cofactor deficiency are presented. They showed clinical, biochemical and neuroradiological features very similar to those of the few previously described cases. Difficulties in diagnosis are emphasised. ...
journal_title：European journal of pediatrics
pub_type： 杂志文章
doi：10.1007/BF01955243
更新日期：1993-08-01 00:00:00
abstract：:We report three brothers who developed nephrosis between the age of 3-10 years. The parents were nonconsanguineous and of Arab descent. The mother's sister had a son with a similar condition. Patients were steroid responders and frequent relapsers. Renal biopsies in the three brothers showed findings of minimal change...
journal_title：European journal of pediatrics
pub_type： 杂志文章
doi：10.1007/BF01958283
更新日期：1989-12-01 00:00:00
abstract：UNLABELLED:The 6-min walk test is a simple and accurate method to measure functional exercise capacity in children. We provide smooth reference curves for the modified 6-min walk test in 696 healthy children and adolescents aged 4-19 years, enabling calculation of sex-, age-, and height-specific Z-scores. CONCLUSION:T...
journal_title：European journal of pediatrics
pub_type： 杂志文章
doi：10.1007/s00431-014-2454-8
更新日期：2015-06-01 00:00:00
abstract：:Direct measurements of parathyroid activity are available in only small numbers of children with vitamin D deficiency rickets (VDR). Therefore serum immunoreactive parathyroid hormone (iPTH) and the urinary cyclic adenosine-3',5'-monophosphate excretion (UcAMP) were measured together with other important indices of ca...
journal_title：European journal of pediatrics
pub_type： 杂志文章
doi：10.1007/BF00443214
更新日期：1984-01-01 00:00:00
abstract：BACKGROUND:We aimed to determine the status of and factors associated with adolescent health care delivery and training in Europe on behalf of the European Paediatric Association-UNEPSA. MATERIALS AND METHODS:A questionnaire was mailed to the presidents of 48 national paediatric societies in Europe. For statistical an...
journal_title：European journal of pediatrics
pub_type： 杂志文章
doi：10.1007/s00431-008-0759-1
更新日期：2009-04-01 00:00:00
abstract：:A term newborn infant developed a right sciatic nerve palsy after ischaemic necrosis of the gluteal region following umbilical arterial catheterization. The nerve lesion was believed to be caused by entrapment and compression by scar tissue. Recovery was slow and remained incomplete up to 6 months of age. ...
journal_title：European journal of pediatrics
pub_type： 杂志文章
doi：10.1007/BF00439407
更新日期：1986-09-01 00:00:00
abstract：:Breath tests (BT) using stable isotopically labelled substrates seem to fulfill all the demands and desires for a non-invasive investigation. There are no radiation hazards, substrates are given in tracer amounts perorally, breath and urine samples can be collected easily, and tests can be done repeatedly, thus easily...
journal_title：European journal of pediatrics
pub_type： 杂志文章,评审
doi：10.1007/pl00014264
更新日期：1997-08-01 00:00:00
abstract：UNLABELLED:Although bacterial colonisation of bronchi may occur from early childhood onwards, infections extending beyond the lungs are uncommon in patients with cystic fibrosis. A 12-year-old boy with cystic fibrosis, receiving oral corticosteroids for 3 weeks because of allergic bronchopulmonary aspergillosis, experi...
journal_title：European journal of pediatrics
pub_type： 杂志文章
doi：10.1007/pl00008408
更新日期：2000-09-01 00:00:00
abstract：UNLABELLED:Sleep duration has been identified as risk factor for obesity already in children. Besides investigating the role of fat mass (FM), this study addressed the question whether endocrine mechanisms act as intermediates in the association between sleep duration and overweight/obesity. Within the framework of the...
journal_title：European journal of pediatrics
pub_type： 杂志文章,多中心研究
doi：10.1007/s00431-011-1670-8
更新日期：2012-07-01 00:00:00
abstract：:We describe here an infant with a large, solitary, fluid-filled lung cyst and hyperinflation of adjacent lung tissue in the same lobe. The combination of a fluid-filled cyst and ectatic emphysema in the same lobe suggests bronchial collapse and airway obstruction as a contributory mechanism for this unusual roentgenog...
journal_title：European journal of pediatrics
pub_type： 杂志文章
doi：10.1007/BF00447379
更新日期：1979-10-01 00:00:00
