Crystal structure of a DNA decamer showing a novel pseudo four-way helix-helix junction.

abstract：:Pathogenic retroviruses have evolved multiple means for evading host restriction factors such as apolipoprotein B editing complex (APOBEC3) proteins. Here, we show that murine leukemia virus (MLV) has a unique means of counteracting APOBEC3 and other cytosolic sensors of viral nucleic acid. Using virus isolated from i...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Stavrou S,Nitta T,Kotla S,Ha D,Nagashima K,Rein AR,Fan H,Ross SR

更新日期：2013-05-28 00:00:00

abstract：:The Y73 strain of avian sarcoma virus recently isolated in Japan is defective in replication and is associated with subgroup A leukosis virus (YAV). The virus caused sarcoma but not acute leukosis when inoculated into chickens. Studies on the viral RNA showed that a 26S RNA, etimated to be 4.8 kilobases long, was Y73 ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kawai S,Yoshida M,Segawa K,Sugiyama H,Ishizaki R,Toyoshima K

更新日期：1980-10-01 00:00:00

abstract：:Huntington's disease (HD) is an untreatable neurological disorder caused by selective and progressive degeneration of the caudate nucleus and putamen of the basal ganglia. Although the etiology of HD pathology is not fully understood, the observed loss of neuronal cells is thought to occur primarily through apoptosis....

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Keene CD,Rodrigues CM,Eich T,Chhabra MS,Steer CJ,Low WC

更新日期：2002-08-06 00:00:00

abstract：:A central role for phenotypic plasticity in adaptive evolution is often posited yet lacks empirical support. Selection for the stable production of an induced phenotype is hypothesized to modify the regulation of preexisting developmental pathways, producing rapid adaptive change. We examined the role of plasticity in...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Scoville AG,Pfrender ME

更新日期：2010-03-02 00:00:00

abstract：:Complex I functions as a redox-linked proton pump in the respiratory chains of mitochondria and bacteria, driven by the reduction of quinone (Q) by NADH. Remarkably, the distance between the Q reduction site and the most distant proton channels extends nearly 200 Å. To elucidate the molecular origin of this long-range...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Sharma V,Belevich G,Gamiz-Hernandez AP,Róg T,Vattulainen I,Verkhovskaya ML,Wikström M,Hummer G,Kaila VR

更新日期：2015-09-15 00:00:00

abstract：:The immunophilin FK506 binding protein 12 (FKBP12) is associated with and modulates the ryanodine receptor calcium release channel of skeletal muscle. Ryanodine receptor has amino acid homology and functional similarity with another intracellular Ca2+ release channel, the inositol 1,4,5-trisphosphate receptor (IP3R). ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Cameron AM,Steiner JP,Sabatini DM,Kaplin AI,Walensky LD,Snyder SH

更新日期：1995-02-28 00:00:00

abstract：:Interleukin (IL)-33 is an important member of the IL-1 family that has pleiotropic activities in innate and adaptive immune responses in host defense and disease. It signals through its ligand-binding primary receptor ST2 and IL-1 receptor accessory protein (IL-1RAcP), both of which are members of the IL-1 receptor fa...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Liu X,Hammel M,He Y,Tainer JA,Jeng US,Zhang L,Wang S,Wang X

更新日期：2013-09-10 00:00:00

abstract：:Translation initiation of the hepatitis C virus (HCV) RNA genome occurs through an internal ribosome entry site in a cap-independent manner. Here, we have examined the interaction between La antigen and the HCV 5' noncoding region (5'NCR). In this analysis, competitor RNAs derived from HCV 5'NCR carrying deletions and...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ali N,Siddiqui A

更新日期：1997-03-18 00:00:00

abstract：:When a local mechanical perturbation is applied to the surface of a thin film of a mechanically interlocked molecule (a rotaxane), the molecules self-organize into periodic arrays of discrete dots or lines. The dimensionality of the nanostructures depends on whether the mechanical stimulus acts along a 1D line or over...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Biscarini F,Cavallini M,Kshirsagar R,Bottari G,Leigh DA,León S,Zerbetto F

更新日期：2006-11-21 00:00:00

abstract：:Metabolic crossfeeding is an important process that can broadly shape microbial communities. However, little is known about specific crossfeeding principles that drive the formation and maintenance of individuals within a mixed population. Here, we devised a series of synthetic syntrophic communities to probe the comp...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Mee MT,Collins JJ,Church GM,Wang HH

更新日期：2014-05-20 00:00:00

abstract：:Event-related brain potentials (ERPs) to colored slides contained a late positive component that was significantly enhanced when adults recognized the person, place, or painting in the photograph. Additionally, two late components change in amplitude, corresponding to the amount of surprise reported. Because subjects ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Neville H,Snyder E,Woods D,Galambos R

更新日期：1982-03-01 00:00:00

abstract：:Cytological preparations of interphase nuclei and chromosomes from mouse 3T6 cells prepared at various times after infection with the murine sarcomaleukemia virus complex were hybridized with the [(3)H]DNA product of the viral RNA-directed DNA polymerase. While uninfected nuclei had an average of 4 autoradiographic gr...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Loni MC,Green M

更新日期：1974-09-01 00:00:00

abstract：:The DNA in chromatin of isolated thymus nuclei, and in two different preparations of deoxyribonucleoprotein extracted from chromatin, has been digested with DNase. By variation of the time of reaction and the concentration of enzyme, and by comparison of the action of the enzyme on (protein-free) DNA with its action o...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Mirsky AE

更新日期：1971-12-01 00:00:00

abstract：:The peroxidation of polyunsaturated fatty acids leads to numerous products, including 4-hydroxynonenal (HNE). That 4-hydroxy-2-alkenal compounds react with sulfhydryl groups of proteins to form thioether adducts possessing a carbonyl function has been established [Schauenstein, E. & Esterbauer, H. (1979) Ciba Found. S...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Uchida K,Stadtman ER

更新日期：1992-06-15 00:00:00

abstract：:Earlier studies have shown that the DNA of herpes simplex virus 1 consists of two covalently linked components, L and S, each flanked by inverted repeats. The two components can invert, and viral DNA extracted from infected cells or virions consists of equimolar concentrations of four populations differing solely in t...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Poffenberger KL,Tabares E,Roizman B

更新日期：1983-05-01 00:00:00

abstract：:ALOX15 (12/15-lipoxygenase) orthologs have been implicated in maturational degradation of intracellular organelles and in the biosynthesis of antiinflammatory and proresolving eicosanoids. Here we hypothesized that lower mammals (mice, rats, pigs) express 12-lipoxygenating ALOX15 orthologs. In contrast, 15-lipoxygenat...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Adel S,Karst F,González-Lafont À,Pekárová M,Saura P,Masgrau L,Lluch JM,Stehling S,Horn T,Kuhn H,Heydeck D

更新日期：2016-07-26 00:00:00

abstract：:Neuroblastoma-glioma hybrid cells (NG108-15) in suspension accumulate the permeant lipophilic cation [(3)H]tetraphenylphosphonium (TPP(+)) against a concentration gradient. The steady-state level of TPP(+) accumulation is about twice as great in physiological media of low K(+) concentration (i.e., 5 mM K(+)/135 mM Na(...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lichtshtein D,Kaback HR,Blume AJ

更新日期：1979-02-01 00:00:00

abstract：:Sprouty proteins act as intracellular inhibitors of receptor tyrosine kinase signaling. Here we show that the mammalian Sprouty2 protein contains an iron-sulfur complex that can exist in an oxidized, reduced, or nitrosylated state. Purified Sprouty2 assembles into large monodisperse spheres containing approximately 24...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wu X,Alexander PB,He Y,Kikkawa M,Vogel PD,McKnight SL

更新日期：2005-09-27 00:00:00

abstract：:Capsaicin is a unique alkaloid of the plant kingdom restricted to the genus Capsicum. Capsaicin is the pungency factor, a bioactive molecule of food and of medicinal importance. Capsaicin is useful as a counterirritant, antiarthritic, analgesic, antioxidant, and anticancer agent. Capsaicin biosynthesis involves conden...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Prasad BC,Kumar V,Gururaj HB,Parimalan R,Giridhar P,Ravishankar GA

更新日期：2006-09-05 00:00:00

abstract：:Thirty percent of the 189 tumors studied to date express DNA polymerase beta variants. One of these variants was identified in a prostate carcinoma and is altered from isoleucine to methionine at position 260, within the hydrophobic hinge region of the protein. Another variant was identified in a colon carcinoma and i...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Sweasy JB,Lang T,Starcevic D,Sun KW,Lai CC,Dimaio D,Dalal S

更新日期：2005-10-04 00:00:00

abstract：:When rat pancreatic polynucleosomes were poly(ADP-ribosyl)ated with purified calf thymus poly(ADP-ribose) polymerase and examined by electron microscopy, a relaxation of their native zigzag structure was observed. At high ionic strengths control nucleosomes condensed into 250-A-thick fibers, but poly(ADP-ribosyl)ated ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Poirier GG,de Murcia G,Jongstra-Bilen J,Niedergang C,Mandel P

更新日期：1982-06-01 00:00:00

abstract：:The central nervous system both influences and is influenced by the gastrointestinal system. Most research on this gut-brain connection has focused on how ascending signals from the gut and its microbiome alter brain function. Less attention has focused on how descending signals from the central nervous system alter g...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Levinthal DJ,Strick PL

更新日期：2020-06-09 00:00:00

abstract：:Digital droplet assays-in which biological samples are compartmentalized into millions of femtoliter-volume droplets and interrogated individually-have generated enormous enthusiasm for their ability to detect biomarkers with single-molecule sensitivity. These assays have untapped potential for point-of-care diagnosti...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Yelleswarapu V,Buser JR,Haber M,Baron J,Inapuri E,Issadore D

更新日期：2019-03-05 00:00:00

abstract：:Dopamine supersensitivity occurs in schizophrenia and other psychoses, and after hippocampal lesions, antipsychotics, ethanol, amphetamine, phencyclidine, gene knockouts of Dbh (dopamine beta-hydroxylase), Drd4 receptors, Gprk6 (G protein-coupled receptor kinase 6), Comt (catechol-O-methyltransferase), or Th-/-, DbhTh...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Seeman P,Weinshenker D,Quirion R,Srivastava LK,Bhardwaj SK,Grandy DK,Premont RT,Sotnikova TD,Boksa P,El-Ghundi M,O'dowd BF,George SR,Perreault ML,Männistö PT,Robinson S,Palmiter RD,Tallerico T

更新日期：2005-03-01 00:00:00

abstract：:VEGF and angiopoietin-1 (Ang1) are two major angiogenic factors being investigated for the treatment of myocardial infarction (MI). Targeting VEGF and Ang1 expression in the ischemic myocardium can increase their local therapeutic effects and reduce possible adverse effects. Adeno-associated viral vectors (AAVs) expre...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Tao Z,Chen B,Tan X,Zhao Y,Wang L,Zhu T,Cao K,Yang Z,Kan YW,Su H

更新日期：2011-02-01 00:00:00

abstract：:Genetic recombination provides an important mechanism for the repair of DNA double-strand breaks. Homologous pairing and strand exchange lead to the formation of DNA intermediates, in which sister chromatids or homologous chromosomes are covalently linked by four-way Holliday junctions (HJs). Depending on the type of ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Shah Punatar R,Martin MJ,Wyatt HD,Chan YW,West SC

更新日期：2017-01-17 00:00:00

abstract：:The glycine receptor (GlyR) is a pentameric ligand-gated ion channel (pLGIC) mediating inhibitory transmission in the nervous system. Its transmembrane domain (TMD) is the target of allosteric modulators such as general anesthetics and ethanol and is a major locus for hyperekplexic congenital mutations altering the al...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Moraga-Cid G,Sauguet L,Huon C,Malherbe L,Girard-Blanc C,Petres S,Murail S,Taly A,Baaden M,Delarue M,Corringer PJ

更新日期：2015-03-03 00:00:00

abstract：:We have found that poly(L-lysine) can be a very effective agent in preventing the growth of Ehrlich ascites tumors in mice. When given optimal doses of poly(L-lysine) (Mr 60 x 10(3)) intraperitoneally for 5 consecutive days, beginning on day 1 after inoculation with Ehrlich ascites cells. White Swiss mice show nearly ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Arnold LJ Jr,Dagan A,Gutheil J,Kaplan NO

更新日期：1979-07-01 00:00:00

abstract：:Hypoxia-inducible factor-1 (HIF-1) plays an essential role in tumor development and progression by regulating genes that are vital for proliferation, glycolysis, angiogenesis, and metastasis. To identify strategies of targeting the HIF-1 pathway, we screened a siRNA library against the entire druggable genome and a sm...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lin X,David CA,Donnelly JB,Michaelides M,Chandel NS,Huang X,Warrior U,Weinberg F,Tormos KV,Fesik SW,Shen Y

更新日期：2008-01-08 00:00:00

abstract：:Membranes were purified from rat muscle by a differential centrifugation method that avoids the use of salt extraction or incubations at elevated temperature. Three populations of membrane-limited vesicles were defined having average densities of 1.112 (fraction I), 1.141 (fraction II), and 1.158 (fraction III) g/ml i...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Barchi RL,Bonilla E,Wong M

更新日期：1977-01-01 00:00:00