Abstract：
:Double-stranded DNA copies of the RNA gene coding for the haemagglutinin glycoproteins from human H2 and H3 pandemic strains of influenza virus have been cloned. DNA sequence analysis provides the first reported complete nucleotide sequence of an H2 haemagglutinin gene and a partial sequence (45%) of the H3 gene. The H2 haemagglutinin gene consists of 1,773 nucleotides containing an uninterrupted coding sequence of 1,686 nucleotides specifying a protein of 562 amino acids. Comparison of the amino acid sequences of these haemagglutinins with those of other H3 and avian strains reveals the extent of sequence changes in antigenic shifts and drifts.
journal_name
Naturejournal_title
Natureauthors
Gething MJ,Bye J,Skehel J,Waterfield Mdoi
10.1038/287301a0subject
Has Abstractpub_date
1980-09-25 00:00:00pages
301-6issue
5780eissn
0028-0836issn
1476-4687journal_volume
287pub_type
杂志文章相关文献
NATURE文献大全abstract：:The interneuronal messenger nitric oxide (NO) may play a central role in the processing of olfactory information. Several circuit elements in the mammalian olfactory bulb contain NO synthase or its functional equivalent, NADPH diaphorase. The effects of NO on cellular excitability or circuit dynamics in the olfactory ...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/369061a0
更新日期：1994-05-05 00:00:00
abstract：:Because it is so tall, the giraffe, Giraffa camelopardalis, provides an important animal model for investigating adaptive mechanisms to orthostatic (gravitational) pressure changes. Previous physiological studies of the giraffe have concentrated on arterial blood pressures in the heart and neck. Briefly, these investi...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/329059a0
更新日期：1987-09-03 00:00:00
abstract：:Heritable epigenetic polymorphisms, such as differential cytosine methylation, can underlie phenotypic variation. Moreover, wild strains of the plant Arabidopsis thaliana differ in many epialleles, and these can influence the expression of nearby genes. However, to understand their role in evolution, it is imperative ...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/nature10555
更新日期：2011-09-20 00:00:00
abstract：: ...
journal_title：Nature
pub_type： 新闻
doi：10.1038/d41586-019-00028-w
更新日期：2019-01-01 00:00:00
abstract：:A mutant form of the alpha-isoform of protein kinase C (PKC) was recently isolated from an ultraviolet radiation-induced murine fibrosarcoma cell line and reported to transform mouse BALB/c 3T3 fibroblasts on transfection. Four point mutations in the regulatory domain were assumed to be responsible for its oncogenicit...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/353078a0
更新日期：1991-09-05 00:00:00
abstract：:Peroxisomes are among the intracellular organelles of eukaryotic cells that contain specialized sets of enzymes with specific functions. Little is known of membranous components involved in assembly of the intracellular compartments. We isolated two peroxisome-deficient and mutually complementary, Chinese hamster ovar...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/350077a0
更新日期：1991-03-07 00:00:00
abstract：:Cyclin degradation is the key step governing exit from mitosis and progress into the next cell cycle. When a region in the N terminus of cyclin is fused to a foreign protein, it produces a hybrid protein susceptible to proteolysis at mitosis. During the course of degradation, both cyclin and the hybrid form conjugates...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/349132a0
更新日期：1991-01-10 00:00:00
abstract：:Perfusion chromatography is a technique based on fluid dynamics for reducing stagnant mobile phase mass transfer in liquid chromatography. This is achieved by using supports with large pores that allow mobile phase to flow through particles. ...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/350634a0
更新日期：1991-04-18 00:00:00
abstract：:Transmembrane channels and pores have key roles in fundamental biological processes1 and in biotechnological applications such as DNA nanopore sequencing2-4, resulting in considerable interest in the design of pore-containing proteins. Synthetic amphiphilic peptides have been found to form ion channels5,6, and there h...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/s41586-020-2646-5
更新日期：2020-09-01 00:00:00
abstract：:The ability to differentiate stimuli predicting positive or negative outcomes is critical for survival, and perturbations of emotional processing underlie many psychiatric disease states. Synaptic plasticity in the basolateral amygdala complex (BLA) mediates the acquisition of associative memories, both positive and n...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/nature14366
更新日期：2015-04-30 00:00:00
abstract：:Biological dinitrogen fixation provides the largest input of nitrogen to the oceans, therefore exerting important control on the ocean's nitrogen inventory and primary productivity. Nitrogen-isotope data from ocean sediments suggest that the marine-nitrogen inventory has been balanced for the past 3,000 years (ref. 4)...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/nature11338
更新日期：2012-08-16 00:00:00
abstract：:Quantum electrodynamics describes the interactions of electrons and photons. Electric charge (the gauge coupling constant) is energy dependent, and there is a previous claim that charge is affected by gravity (described by general relativity) with the implication that the charge is reduced at high energies. However, t...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/nature09506
更新日期：2010-11-04 00:00:00
abstract：:It is thought that in skeletal muscle excitation-contraction (EC) coupling, the release of Ca2+ from the sarcoplasmic reticulum is controlled by the dihydropyridine (DHP) receptor in the transverse tubular membrane, where it serves as the voltage sensor. We have shown previously that injection of an expression plasmid...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/346567a0
更新日期：1990-08-09 00:00:00
abstract：:Galaxies had their most significant impact on the Universe when they assembled their first generations of stars. Energetic photons emitted by young, massive stars in primeval galaxies ionized the intergalactic medium surrounding their host galaxies, cleared sightlines along which the light of the young galaxies could ...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/nature09462
更新日期：2010-10-21 00:00:00
abstract：:Slower recovery from perturbations near a tipping point and its indirect signatures in fluctuation patterns have been suggested to foreshadow catastrophes in a wide variety of systems. Recent studies of populations in the field and in the laboratory have used time-series data to confirm some of the theoretically predi...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/nature12071
更新日期：2013-04-18 00:00:00
abstract：:Valuable information about proto-oncogenes and their physiological function has been obtained by studying their expression in normal cells. However, expression of the c-mos gene, the cellular homologue of the transforming gene of Moloney murine sarcoma virus, has not been detected in normal mouse cells or tissues. The...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/315516a0
更新日期：1985-06-06 00:00:00
abstract：:Prostaglandins have wide-ranging effects in the body and are thought to be important mediators of inflammation. Cyclooxygenase (COX) plays a key regulatory role in prostaglandin synthesis, and occurs in both constitutive (COX-1) and inducible (COX-2) isoforms. COX-1 is thought to provide cytoprotective effects, wherea...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/378406a0
更新日期：1995-11-23 00:00:00
abstract：:Biochemical and structural studies have shown that the initiation of RNA polymerase II transcription proceeds in the following stages: assembly of the polymerase with general transcription factors and promoter DNA in a 'closed' preinitiation complex (PIC); unwinding of about 15 base pairs of the promoter DNA to form a...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/nature14882
更新日期：2015-09-10 00:00:00
abstract：:Only 10 different V beta gene segments were found when the sequences of 15 variable (V beta) genes of the mouse T-cell receptor were examined. From this analysis we calculate that the total number of expressed V beta gene segments may be 21 or fewer, which makes the expressed germline V beta repertoire much smaller th...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/316517a0
更新日期：1985-08-08 00:00:00
abstract：:Refractoriness to induction chemotherapy and relapse after achievement of remission are the main obstacles to cure in acute myeloid leukaemia (AML). After standard induction chemotherapy, patients are assigned to different post-remission strategies on the basis of cytogenetic and molecular abnormalities that broadly d...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/nature20598
更新日期：2016-12-15 00:00:00
abstract：:The activation of innate immune responses by nucleic acids is crucial to protective and pathological immunities and is mediated by the transmembrane Toll-like receptors (TLRs) and cytosolic receptors. However, it remains unknown whether a mechanism exists that integrates these nucleic-acid-sensing systems. Here we sho...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/nature08512
更新日期：2009-11-05 00:00:00
abstract：:A set of restriction fragments cloned into phage lambda vectors has allowed us to locate a site necessary for full rpoBC expression. We find that these genes for the two large subunits of RNA polymerase and the genes, rplL and rplJ, for two ribosomal proteins, form a single operon. ...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/276033a0
更新日期：1978-11-02 00:00:00
abstract：: ...
journal_title：Nature
pub_type： 评论,新闻
doi：10.1038/d41586-018-07165-8
更新日期：2018-11-01 00:00:00
abstract：:Graphene, or single-layered graphite, with its high crystallinity and interesting semimetal electronic properties, has emerged as an exciting two-dimensional material showing great promise for the fabrication of nanoscale devices. Thin, elongated strips of graphene that possess straight edges, termed graphene ribbons,...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/nature07872
更新日期：2009-04-16 00:00:00
abstract：:Vaccines rarely provide full protection from disease. Nevertheless, partially effective (imperfect) vaccines may be used to protect both individuals and whole populations. We studied the potential impact of different types of imperfect vaccines on the evolution of pathogen virulence (induced host mortality) and the co...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/414751a
更新日期：2001-12-13 00:00:00
abstract：:Quantum states of mechanical motion can be important resources for quantum information, metrology and studies of fundamental physics. Recent demonstrations of superconducting qubits coupled to acoustic resonators have opened up the possibility of performing quantum operations on macroscale motional modes1-3, which can...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/s41586-018-0717-7
更新日期：2018-11-01 00:00:00
abstract：:Schizophrenia is a severe mental illness with a typically chronic course affecting nearly 1% of the human population. It is generally accepted that genetic factors have an important pathogenic role in a substantial portion of schizophrenia cases; however, despite decades of family studies, there is no agreed-upon mode...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/336167a0
更新日期：1988-11-10 00:00:00
abstract：:Human B cell stimulatory factor 2 (BSF-2) was originally characterized and isolated as a T cell-derived factor that caused the terminal maturation of activated B cells to immunoglobulin-producing cells. Molecular cloning of the complementary DNA predicts that BSF-2 is a protein of relative molecular mass (Mr) 26,000 s...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/332083a0
更新日期：1988-03-03 00:00:00
abstract：:In lung diseases such as asthma, expiratory flow becomes limited, airways can collapse and the vital exchange of gases is compromised. Here we model the inflation of collapsed regions of the lung during inspiration in terms of avalanches propagating through a bifurcating network of airways, and find that the accompany...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/417809b
更新日期：2002-06-20 00:00:00
abstract：:Tumour suppressor genes (TSGs) inhibiting normal cellular growth are frequently silenced epigenetically in cancer. DNA methylation is commonly associated with TSG silencing, yet mutations in the DNA methylation initiation and recognition machinery in carcinogenesis are unknown. An intriguing possible mechanism for gen...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/nature06468
更新日期：2008-01-10 00:00:00
