Ultrastructural localization of radiolabelled L-dopa in the endocrine hypothalamus of the rat.

Abstract:

:Light and electron microscopic autoradiography has been employed to define the neuroanatomical patterns of uptake and binding of radiolabelled L-dopa in the endocrine hypothalamus of the rat. A dorsomedial continuum of arcuate and periventricular neurons selectively sequester 3HL-dopa 20 min following its intraventricular infusion. By 40 and 60 min following the infusion labelling of neurons is minimal and supports the notion of rapid degradation. Other cell compartments such as tanycytes demonstrate uptake of 3H L-dopa. The ultrastructural localization and distribution of radiolabelled L-dopa (or its metabolites) in the rodent hypothalamus is discussed with respect to mechanisms and cell compartments involved in neuroendocrine regulatory processes.

journal_name

Cell Tissue Res

journal_title

Cell and tissue research

authors

Scott DE,Scott PM,Krobisch-Dudley G

doi

10.1007/BF00233675

subject

Has Abstract

pub_date

1978-12-14 00:00:00

pages

29-43

issue

1

eissn

0302-766X

issn

1432-0878

journal_volume

195

pub_type

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