Abstract：
:A compound was isolated from the urine of workers exposed to carbon disulfide during the production of rayon. The compound was identified as 2-thiothiazolidine-4-carboxylic acid (TTCA) by GC/MS and NMR. A HPLC method for the quantitative determination of TTCA was elaborated and applied to urine samples. The method allowed detection of TTCA concentrations in urine as low as 5 X 10(-7) M. No TTCA was detected in urine of workers occupationally exposed to organic solvents other than CS2. High concentrations of TTCA (upto 32 X 10(-5) M) were shown to be present in urine of spinners exposed to CS2 concentrations of approximately 100 mg/m3. It is suggested that the assay of urinary TTCA is suitable for detection of occupational exposure to CS2.
journal_name
Arch Toxicoljournal_title
Archives of toxicologyauthors
van Doorn R,Delbressine LP,Leijdekkers CM,Vertin PG,Henderson PTdoi
10.1007/BF00297130subject
Has Abstractpub_date
1981-03-01 00:00:00pages
51-8issue
1eissn
0340-5761issn
1432-0738journal_volume
47pub_type
杂志文章abstract：:The responsiveness of the hepatic supernatant NAD+-dependent aldehyde dehydrogenase with a high Km value (high Km-AldDH) to phenobarbital (PB) and 3-methylcholanthrene (3-MC) treatment was studied in male rats of three strains; Wistar, Long-Evans, and Sprague-Dawley. A remarkable strain difference in the response of t...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/BF00333620
更新日期：1979-12-01 00:00:00
abstract：:Previous histomorphometric studies led us to hypothesize that suppression of hepatocellular regeneration and the repair of the hepatolobular architecture was involved besides bioactivation phenomenon in the progressive and irreversible phase of toxicity resulting from CD + CCl4 interaction. We have recently observed s...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/BF00303125
更新日期：1989-01-01 00:00:00
abstract：:This article is published with the incorrect copyright holder name in the HTML article as "© Springer 2018". The correct copyright line should read "The Author(s) 2018" (as it appears in the article PDF). ...
journal_title：Archives of toxicology
pub_type： 杂志文章,已发布勘误
doi：10.1007/s00204-018-2301-1
更新日期：2018-11-01 00:00:00
abstract：:To evaluate the developmental neurotoxicity of arsenic in offspring rats by transplacental and early life exposure to sodium arsenite in drinking water, the pregnant rats or lactating dams, and weaned pups were given free access to drinking water, which contained arsenic at concentrations of 0, 10, 50, 100 mg/L from G...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/s00204-009-0403-5
更新日期：2009-06-01 00:00:00
abstract：:Inhibition mechanism(s) of protein kinase B/Akt1 and its consequences on related cell signaling were investigated in human neuroblastoma SH-SY5Y cells exposed to 4-hydroxy-trans-2-nonenal (4-HNE), one of the most reactive aldehyde by-products of lipid peroxidation. In silico data indicate that 4-HNE interacts with kin...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/s00204-014-1260-4
更新日期：2015-02-01 00:00:00
abstract：:Vitamin E acetate (VEA) has come under significant scrutiny due to its association with e-cigarette, or vaping, product use-associated lung injury (EVALI). In 1965, Sir Austin Bradford Hill proposed a set of criteria used to critically assess an association for causality. In this article, we apply the Bradford Hill ca...
journal_title：Archives of toxicology
pub_type： 杂志文章,评审
doi：10.1007/s00204-020-02770-x
更新日期：2020-06-01 00:00:00
abstract：:This study aimed to investigate the effect of single and repeated administration of fenarimol on murine liver, kidney and lung microsomal CYP-catalyzed drug metabolism. The modulation of the regio- and stereo-selective hydroxylation of testosterone by fenarimol was considered in evaluating cocarcinogenic properties. I...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/s002040050298
更新日期：1996-01-01 00:00:00
abstract：:Unsaturated compounds are known to cause false-positive reactions in the local lymph node assay (LLNA) but not in the guinea pig maximization test. We have tested a panel of substances (succinic acid, undecylenic acid, 1-octyn-3-ol, fumaric acid, maleic acid, linoleic acid, oleic acid, alpha-linolenic acid, squalene, ...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/s00204-015-1527-4
更新日期：2016-04-01 00:00:00
abstract：:Chronic arsenite exposure induces immunosuppression, but the precise mechanisms remain elusive. Our previous studies demonstrated that arsenite exposure for 24 h induces G0/G1 arrest in mouse B lymphoma A20 cells and the arrest is caused through induction of cyclin-dependent kinase inhibitor p16(INK4a) followed by acc...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/s00204-015-1500-2
更新日期：2016-04-01 00:00:00
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journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/s00204-007-0234-1
更新日期：2008-02-01 00:00:00
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journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/s00204-004-0562-3
更新日期：2004-08-01 00:00:00
abstract：:Manufactured nanomaterials (MNMs) selected from a library of over 120 different MNMs with varied compositions, sizes, and surface coatings were tested by four different laboratories for toxicity by high-throughput/-content (HT/C) techniques. The selected particles comprise 14 MNMs composed of CeO2, Ag, TiO2, ZnO and S...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/s00204-017-2106-7
更新日期：2018-02-01 00:00:00
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journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/s002040050511
更新日期：1998-05-01 00:00:00
abstract：:The circadian rhythms of HMG-CoA reductase and cholesterol-7 alpha-hydroxylase (low values, during light, rising in the evening with maximum at 12.00 p.m.) are investigated in rats under diverse conditions. Intragastral administration of cholestyramine (bile acid-absorbing resin) leads to an increased rhythm of both e...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/BF00340534
更新日期：1976-12-17 00:00:00
abstract：:Heat shock proteins (HSPs) are a group of proteins that are rapidly induced in response to physiological stress, including hyperthermia and exposure to toxicants. Thus they may provide a useful index of toxicity in in vitro systems for screening for toxicity. We have recently developed a rat nasal explant system for i...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/s00204-004-0541-8
更新日期：2004-06-01 00:00:00
abstract：:Cytotoxic effects of cyclophosphamide (CPA), paclitaxel (PCT), and docetaxel (DTX) and their modulation by cytochrome P450 (CYP) metabolism were studied by incubating cell lines L929 and P388D1 with or without rat liver microsomes. The microsomes themselves were not cytotoxic. P388D1 cells were more sensitive to CPA, ...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/s002040000141
更新日期：2000-10-01 00:00:00
abstract：:Hydroxysteroid sulfotransferase 2B1b (SULT2B1b) sulfates cholesterol and oxysterols. Hepatic oval cells (HOCs), thought to be progenitor cells, can be triggered in chemically injured livers. The present study focused on the role of SULT2B1b in HOC proliferation after liver injury. Our experiments revealed that the exp...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/s00204-016-1693-z
更新日期：2017-01-01 00:00:00
abstract：:Using human neuroblastoma SH-SY5Y cells, effects of acrylamide on p53 protein and intracellular signal transducting pathways were examined. Acrylamide increased p53, phosphorylated p53, and p53-associated protein murine double minute 2 (MDM2). The phosphorylation of p53 was specific for the Ser15 site. Among mitogen-a...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/s00204-005-0022-8
更新日期：2006-03-01 00:00:00
abstract：:Pregnane X receptor (PXR) is a nuclear receptor that plays a key regulatory role in xenobiotic metabolism in a ligand-dependent manner. Recently, ethanol was reported to be either an inducer or inhibitor of Cytochrome P450 (CYP) 3A expression. According to our recent microarray data, chronic ethanol upregulates the ex...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/s00204-014-1268-9
更新日期：2015-04-01 00:00:00
abstract：:Although the tumor-promoting effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), coplanar polychlorinated biphenyls (PCBs), and related compounds in liver tissue are primarily attributed to the activation of the aryl hydrocarbon receptor (AhR), the underlying molecular mechanisms are still unclear. Liver progenitor...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/s00204-012-0979-z
更新日期：2013-04-01 00:00:00
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journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/BF01261386
更新日期：1983-10-01 00:00:00
abstract：:Betulinic acid (BA), a compound isolated from the bark of white birch (Betula pubescens), was reported to induce apoptosis in many types of cancer through mitochondrial dysfunction with low side effects in normal cells. Because of these features, BA is regarded as a potential anti-cancer agent. However, the effect of ...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/s00204-013-1162-x
更新日期：2014-03-01 00:00:00
abstract：:The cytotoxicity of trivalent and pentavalent inorganic arsenic salts was determined in mouse fibroblasts in vitro. Concentrations of As (III) in the microM range led to a reduction of proliferation and viability with a concomitant increase in LDH release and stimulation of lactic acid production. Similar effects were...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/BF00290882
更新日期：1985-08-01 00:00:00
abstract：:Due to its unique physical structure and chemical properties, graphene family nanomaterials (GFNs) and derived commodities have been widely used in commercial products, particularly biomedical applications, which has significantly increased the risk of human exposure. There exists significant evidence that GFNs are ac...
journal_title：Archives of toxicology
pub_type： 杂志文章,评审
doi：10.1007/s00204-020-02717-2
更新日期：2020-06-01 00:00:00
abstract：:Long-term exposure of rats to cadmium (Cd) resulted in a marked suppression of erythropoietin (Epo) mRNA expression in the kidneys and the development of severe anemia. A recent report revealed that Cd inhibited hypoxia-inducible factor 1 (HIF-1) binding activity and Epo mRNA expression and protein production. However...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/s00204-003-0444-0
更新日期：2003-05-01 00:00:00
abstract：:The mycotoxin ochratoxin A (OTA) and its metabolite ochratoxin alpha (OT-alpha) were investigated, to examine their potency to induce sister chromatid exchanges (SCE) in cultured porcine urinary bladder epithelial cells (PUBEC) (primary culture). Serum-free cultured PUBEC were incubated for 5 h with either OTA or OT-a...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/s002040050171
更新日期：1995-01-01 00:00:00
abstract：:Chronic exposure to propiverine, a frequently prescribed pharmaceutical for treatment of overactive bladder and incontinence, provokes massive protein accumulation in the cytosol and nucleus of renal proximal tubule epithelial cells in rats. Previously, the accumulating protein was identified as D-amino acid oxidase (...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/s00204-016-1685-z
更新日期：2017-01-01 00:00:00
abstract：:Phenethyl isothiocyanate is a chemopreventive phytochemical present in cruciferous vegetables where it exists as the glucosinolate gluconasturtiin. It is a mechanism-based inhibitor of both rat and human cytochrome P450 enzymes. The principal objective of the present study was to ascertain whether phenethyl isocyanate...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/s00204-010-0522-z
更新日期：2010-10-01 00:00:00
abstract：:In mutagenicity testing of pharmaceuticals it is advisable, whenever possible, to use in vivo mammalian systems where the pharmacokinetic properties of a drug would be more or less similar to those in man. However, although there are a number of different genetic endpoints which are important in mutagen testing, suffi...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/BF00361248
更新日期：1980-11-01 00:00:00
abstract：:The flavonol quercetin shows a wide range of effects in biological systems. We investigated whether quercetin exerts its proposed antioxidant properties via the antioxidant enzyme system. Quercetin in a concentration range from 5 to 100 microM decreased manganese superoxide dismutase, glutathione peroxidase, and coppe...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/s00204-003-0482-7
更新日期：2003-09-01 00:00:00
