Abstract:
:The number and type of stem cells in spleen and bone marrow of mice were determined after exposure to a single dose of 150 R on day 6, to a single dose of 500 R on day 6 or day 9 or to a fractionated dose of 150 R + 350 R on day 6 and 9. The stem cells were assayed on the basis of colony forming units (CFU) in spleen and of incorporation of iododeoxyuridine in spleen and bone marrow of lethally irradiated host mice. During the first months of life, the number of stem cells in non-irradiated mice increases markedly in bone marrow and slightly in spleen. Irradiation causes a long-lasting depression in stem cells, particularly in bone marrow and affecting preferentially erythropoietic precursor cells. Following a dose of only 150 R, the number of CFU in bone marrow is still below control levels 24 days later. An exposure to 500 R fractionated between day 6 and 9 has a markedly greater effect on stem cells in the spleen than the same dose given in a single application either at day 6 or 9.
journal_name
Radiat Environ Biophysjournal_title
Radiation and environmental biophysicsauthors
Gerber GB,Maes Jdoi
10.1007/BF01324267subject
Has Abstractpub_date
1980-01-01 00:00:00pages
249-56issue
4eissn
0301-634Xissn
1432-2099journal_volume
18pub_type
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journal_title:Radiation and environmental biophysics
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journal_title:Radiation and environmental biophysics
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journal_title:Radiation and environmental biophysics
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更新日期:1979-08-10 00:00:00
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