Stem cell kinetics in spleen and bone marrow after single and fractionated irradiation of infant mice.

Abstract:

:The number and type of stem cells in spleen and bone marrow of mice were determined after exposure to a single dose of 150 R on day 6, to a single dose of 500 R on day 6 or day 9 or to a fractionated dose of 150 R + 350 R on day 6 and 9. The stem cells were assayed on the basis of colony forming units (CFU) in spleen and of incorporation of iododeoxyuridine in spleen and bone marrow of lethally irradiated host mice. During the first months of life, the number of stem cells in non-irradiated mice increases markedly in bone marrow and slightly in spleen. Irradiation causes a long-lasting depression in stem cells, particularly in bone marrow and affecting preferentially erythropoietic precursor cells. Following a dose of only 150 R, the number of CFU in bone marrow is still below control levels 24 days later. An exposure to 500 R fractionated between day 6 and 9 has a markedly greater effect on stem cells in the spleen than the same dose given in a single application either at day 6 or 9.

journal_name

Radiat Environ Biophys

authors

Gerber GB,Maes J

doi

10.1007/BF01324267

subject

Has Abstract

pub_date

1980-01-01 00:00:00

pages

249-56

issue

4

eissn

0301-634X

issn

1432-2099

journal_volume

18

pub_type

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