Abstract:
:The size and position of the heterochromatic regions of chromosome 9 were examined in a group of women with histories of recurrent miscarriage and a control group of fertile women. Measurements were made on whole chromosomes (variability between chromosomes was taken to reflect differences in heterochromatin), and corrections for between-cell contraction were made by comparison with chromosome 7. Chromosomes were analysed in pairs and the following results were obtained: (1) The larger of the pairs of chromosomes of the test group were significantly larger than those of the control group: (2) The smaller of the pairs of chromosomes were the same in each group: (3) The differences between the chromosome pairs were significantly greater in the test than the control group: and (4) The sums of the homologous chromosomes were significantly greater in the test than in the control group. Independent assessment also showed that a significantly higher frequency of complete pericentric inversions of chromosome 9 was present in the test than the control group. These results are discussed in the light of two hypotheses: (1) The difference in the size of the homologous chromosomes is critical, and (2) the total heterochromatic content of a chromosome and/or cell is critical. Some evidence is presented to support each hypothesis, but the former is the more favoured by the data.
journal_name
Hum Genetjournal_title
Human geneticsauthors
Ford JH,Callen DF,Jahnke AB,Roberts CGdoi
10.1007/BF00276601subject
Has Abstractpub_date
1982-01-01 00:00:00pages
360-3issue
4eissn
0340-6717issn
1432-1203journal_volume
61pub_type
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