Cadmium-binding proteins in human organs.

abstract：:The environmental neurotoxin β-N-methylamino-L-alanine (BMAA) is not an amino acid that is normally found in proteins. Our previous autoradiographic study of (3)H-labeled BMAA in adult mice unexpectedly revealed a tissue distribution similar to that of protein amino acids. The aim of this study was to characterize the...

journal_title：Toxicology letters

authors： Karlsson O,Jiang L,Andersson M,Ilag LL,Brittebo EB

更新日期：2014-04-07 00:00:00

abstract：BACKGROUND:The epithelial to mesenchymal transition (EMT) contributes to fibrosis during silicosis. Zinc finger CCCH-type containing 4 protein (ZC3H4) is a novel CCCH-type zinc finger protein that activates inflammation in pulmonary macrophages during silicosis. However, whether ZC3H4 is involved in EMT during silicosi...

journal_title：Toxicology letters

authors： Jiang R,Zhou Z,Liao Y,Yang F,Cheng Y,Huang J,Wang J,Chen H,Zhu T,Chao J

更新日期：2019-06-01 00:00:00

abstract：:To clarify a possible mechanism of zinc (Zn)-induced tolerance to cadmium (Cd) toxicity on bone formation, femurs from 9-day-old chick embryos were cultured for 6 days by the roller-tube method in the presence of Cd (2, 4 or 9 microM) and/or Zn (60 microM). Zn prevented a decrease in bone growth caused by Cd at 4 and ...

journal_title：Toxicology letters

authors： Kaji T,Takata M,Hoshino T,Miyahara T,Kozuka H,Kurashige Y,Koizumi F

更新日期：1988-11-01 00:00:00

abstract：:A single s.c. injection of 60 mg/kg of monocrotaline to rats induced pulmonary alterations characterized by hyaline thrombi of capillaries and arterioles, focal necrosis of alveolar walls, and medial thickening and intimal hyalinosis of arteries. Such pathological alterations became apparent 7 days after injection and...

journal_title：Toxicology letters

authors： Hayashi Y,Kokubo T,Takahashi M,Furukawa F,Otsuka H,Hashimoto K

更新日期：1984-04-01 00:00:00

abstract：:Anthocyanins are plant pigments occurring in flowers and berry fruits. Since a phenomenon of food-drug interactions is increasingly emerging, we examined the effects of 21 major anthocyanins and the extracts from 3 food supplements containing anthocyanins on the aryl hydrocarbon receptor (AhR)-cytochrome P450 CYP1A1 s...

journal_title：Toxicology letters

authors： Kamenickova A,Anzenbacherova E,Pavek P,Soshilov AA,Denison MS,Zapletalova M,Anzenbacher P,Dvorak Z

更新日期：2013-07-31 00:00:00

abstract：:Phytosterols (PS) are naturally occurring compounds present in food products of plant origin. Due to reported positive health effects, some food products are also enriched with PS. In the same way as cholesterol is oxidised, PS also oxidise to a variety of oxidation products (POPs). The biological effects and safety a...

journal_title：Toxicology letters

authors： Abramsson-Zetterberg L,Svensson M,Johnsson L

更新日期：2007-09-10 00:00:00

abstract：:The tissue redistribution of accumulated 2,3,7, 8-tetrachlorodibenzo-p-dioxin (TCDD) during infection was studied in adult male A/J mice using a common human virus coxsackievirus B3. Before infection (day 1), all mice were injected intraperitoneally (i.p.) with 1 microCi 3H-TCDD, corresponding to 0.5 microg TCDD kg(-1...

journal_title：Toxicology letters

authors： Funseth E,Wicklund-Glynn A,Friman G,Ilbäck N

更新日期：2000-07-27 00:00:00

abstract：:Development of a fetus into a phenotypic male depends, first, on testis formation and second, on hormone production by the fetal testis. Disorders of testicular hormone production or action can lead in severe cases to phenotypic abnormalities or can predispose towards impaired reproductive health. Evidence for deterio...

journal_title：Toxicology letters

authors： Sharpe RM

更新日期：2001-03-31 00:00:00

abstract：:A teratological test was carried out on triphenyltin acetate (TPTA) used as a fungicide and antifouling agent. Pregnant Wistar rats were treated orally with TPTA at dose levels of 0, 1.5, 3.0, 6.0, 9.0 and 12.0 mg/kg/d during days 7-17 of gestation. Cesarean sections were performed on day 20 of gestation. In the pregn...

journal_title：Toxicology letters

authors： Noda T,Morita S,Yamano T,Shimizu M,Yamada A

更新日期：1991-04-01 00:00:00

abstract：:The development of three generic multi-compartment physiologically based kinetic (PBK) models is described for farm animal species, i.e. cattle, sheep, and swine. The PBK models allow one to quantitatively link external dose and internal dose for risk assessment of chemicals relevant to food and feed safety. Model per...

journal_title：Toxicology letters

authors： Lautz LS,Hoeks S,Oldenkamp R,Hendriks AJ,Dorne JLCM,Ragas AMJ

更新日期：2020-01-01 00:00:00

abstract：:The U.S. EPA first signalled its intention to use benchmark dose risk techniques in 1991. Subsequently, publication of draft Guidelines for the Risk Assessment of Reproductive Toxicity data indicated the Agency's intention for wide use of the technique. In developmental toxicity experiments, a number of factors need t...

journal_title：Toxicology letters

authors： Foster PM,Auton TR

更新日期：1995-12-01 00:00:00

abstract：:Dibenz (b,f)-1-4 oxazepine (CR) was applied to the skin of C3H and Porton-strain mice, daily for 12 weeks. After a further 80 weeks the animals were sacrificed and examined grossly and histologically. The results were compared with appropriate solvent and untreated controls. No abnormalities were found that could be a...

journal_title：Toxicology letters

authors： Marrs TC,Gray MI,Colgrave HF,Gall D

更新日期：1982-10-01 00:00:00

abstract：:Malignant gliomas are the most common and most aggressive primary brain tumor, and for which differentiation therapy has emerged as a promising candidate strategy. In this study, we used in vitro and in vivo assays to examine the differentiation effects of wogonin, a major active constituent of Scutellaria baicalensis...

journal_title：Toxicology letters

authors： Wang Y,Zhang Y,Qian C,Cai M,Li Y,Li Z,You Q,Wang Q,Hu R,Guo Q

更新日期：2013-10-24 00:00:00

abstract：:Effects of isoflavones on estrogen sensitive tissues are discussed controversially. This study was designed to investigate tissue specific effects of an isoflavone exposure through different periods of life in female Wistar rats and to compare the effects of genistein (GEN) to those of mixed dietary isoflavones, GEN a...

journal_title：Toxicology letters

authors： Hertrampf T,Ledwig C,Kulling S,Molzberger A,Möller FJ,Zierau O,Vollmer G,Moors S,Degen GH,Diel P

更新日期：2009-12-15 00:00:00

abstract：:The repeated use of the nerve agent sarin against civilians in Syria in 2013 emphasizes the continuing threat by chemical warfare agents. Multiple studies demonstrated a limited efficacy of standard atropine-oxime treatment in nerve agent poisoning and called for the development of alternative and more effective treat...

journal_title：Toxicology letters

authors： Worek F,Thiermann H,Wille T

更新日期：2016-02-26 00:00:00

abstract：:Work with sub-natural levels of deuterium (D) in animals has demonstrated an anti-cancer effect of low D-concentration in water. Our objective was to investigate whether deuterium-depleted water (DDW) can overturn reverse manganese (Mn)-induced reduction in life span, using the Caenorhabditis elegans (C. elegans) as a...

journal_title：Toxicology letters

authors： Avila DS,Somlyai G,Somlyai I,Aschner M

更新日期：2012-06-20 00:00:00

abstract：:A 13-week subchronic toxicity study of thiamphenicol (TAP) was performed in F344 rats. The minimum lethal dose was estimated to be greater than 10 g/kg body weight, when a single dose of 4-10 g/kg of TAP was given orally. In the subchronic toxicity study, groups of 12 F344 rats of each sex were given solutions contain...

journal_title：Toxicology letters

authors： Ando J,Ishihara R,Imai S,Takano S,Kitamura T,Takahashi M,Yoshida M,Maekawa A

更新日期：1997-04-28 00:00:00

abstract：:Risk assessment of xenobiotics is a qualitative and quantitative assessment of toxic properties conventionally based on data resulting from tests in animals exposed to the substance. The assessment of dose-effect relationship includes evaluation of exposure at the site of action. More recently, emphasis is put on unde...

journal_title：Toxicology letters

authors： Heinrich-Hirsch B,Madle S,Oberemm A,Gundert-Remy U

更新日期：2001-03-31 00:00:00

abstract：:Although CSL box jellyfish antivenom (AV) remains the primary treatment for Chironex fleckeri envenoming, there has been considerable debate regarding its clinical effectiveness. Animal studies have shown that AV is largely ineffective in preventing C. fleckeri-induced cardiovascular collapse. This study examined the ...

journal_title：Toxicology letters

authors： Winter KL,Isbister GK,Jacoby T,Seymour JE,Hodgson WC

更新日期：2009-06-01 00:00:00

abstract：:Aggregation of α-synuclein (α-syn) in the brain is a defining pathological feature of neurodegenerative disorders classified as synucleinopathies. They include Parkinson's disease (PD), dementia with Lewy bodies (DLB), and multiple system atrophy (MSA). Occupational and environmental exposure to manganese (Mn) is asso...

journal_title：Toxicology letters

authors： Verina T,Schneider JS,Guilarte TR

更新日期：2013-03-13 00:00:00

abstract：:Gastrointestinal tract is one of the main targets of cadmium (Cd), an important food and drinking water contaminant. In the present study, the effect of subchronic (30 days) oral (in water) intake of 5ppm and 50ppm of cadmium on immune responses in the gut was examined in rats. Cadmium consumption resulted in reductio...

journal_title：Toxicology letters

authors： Ninkov M,Popov Aleksandrov A,Demenesku J,Mirkov I,Mileusnic D,Petrovic A,Grigorov I,Zolotarevski L,Tolinacki M,Kataranovski D,Brceski I,Kataranovski M

更新日期：2015-09-02 00:00:00

abstract：:Excess alcohol consumption during pregnancy could lead to fetal alcohol syndrome (FAS). However, the molecular mechanism leading to craniofacial abnormality, a feature of FAS, is still poorly understood. The cranial neural crest cells (NCCs) contribute to the formation of the craniofacial bones. Therefore, NCCs expose...

journal_title：Toxicology letters

authors： Zhang P,Wang G,Lin Z,Wu Y,Zhang J,Liu M,Lee KKH,Chuai M,Yang X

更新日期：2017-11-05 00:00:00

abstract：:The assessment of human exposure to chemicals present in the diet is a rapidly developing discipline. The formulation of the "risk analysis paradigm" by the Codex Alimentarius Commission in 1994 defined the exposure assessment as an essential step of the risk assessment process. This has re-enforced demands to those j...

journal_title：Toxicology letters

authors： Luetzow M

更新日期：2003-04-11 00:00:00

abstract：:We observed transient excretion of dark-brown urine after acute exposure to cobalt in rats and investigated the mechanism of it. We injected cobalt into rats s.c. at a dose of 15 mg/kg and collected urine, peripheral blood, and organ samples at the indicated times after injection. Biochemical and histopathological exa...

journal_title：Toxicology letters

authors： Horiguchi H,Oguma E,Nomoto S,Arao Y,Ikeda K,Kayama F

更新日期：2004-08-01 00:00:00

abstract：:The 2,4-dinitrophenylhydrazine (2,4-DNPH) derivatization method mainly used for the determination of airborne formaldehyde was extended for acetaldehyde, acetone, 2-butanone, and cyclohexanone, the next four carbonyl compounds of industrial importance. Sampling devices and sampling conditions were adjusted for the res...

journal_title：Toxicology letters

authors： Binding N,Schilder K,Czeschinski PA,Witting U

更新日期：1998-08-01 00:00:00

abstract：:Recent epidemiological studies in the United States and in Europe indicate, that the coarse fraction (PM-10) of airborne particulates, smaller than 10 microm and particularly the fine fraction (PM-2.5) smaller than 2.5 microm are responsible for adverse health effects, causing an increasing morbidity and mortality. Fu...

journal_title：Toxicology letters

authors： Hornberg C,Maciuleviciute L,Seemayer NH,Kainka E

更新日期：1998-08-01 00:00:00

abstract：:The fast growing applications of ZnO nanoparticles (NPs) in food sector and other fields enhance the exposure possibility of human beings to ZnO NPs including via oral administration route. Although the oral toxicity of ZnO NPs has been studied, most of the research was performed on the normal animal models. Therefore...

journal_title：Toxicology letters

authors： Du LJ,Xiang K,Liu JH,Song ZM,Liu Y,Cao A,Wang H

更新日期：2018-10-01 00:00:00

abstract：:The co-ordinated glucuronidation and export of compounds from cells is an important determinant in the detoxification of many compounds in vivo. Many UDP-glucuronosyltransferases (UGTs) and several multidrug resistance proteins (MRPs) have been cloned and individually expressed to assess specificity of glucuronidation...

journal_title：Toxicology letters

authors： Cuff RL,Wade LT,Rychlik B,Jedlitschky GA,Burchell B

更新日期：2001-03-31 00:00:00

abstract：:Prior research suggests that sex hormones and metabolic changes, such as obesity and hyperglycemia, can alter renal transporter expression in rodents. The purpose of this study was to characterize the expression of kidney efflux transporters and regulatory transcription factors in response to Type I diabetes and pregn...

journal_title：Toxicology letters

authors： Yacovino LL,Aleksunes LM

更新日期：2012-06-20 00:00:00

abstract：:Organophosphate flame retardants (OPFRs) have been used in a wide variety of applications and detected in several environmental matrices, including indoor air and dust. Continuous human exposure to these chemicals is of growing concern. In this study, the agonistic and/or antagonistic activities of 12 primary OPFR-met...

journal_title：Toxicology letters

authors： Kojima H,Takeuchi S,Van den Eede N,Covaci A

更新日期：2016-03-14 00:00:00