Recognition of base pairs by polar peptides in double stranded DNA.

Abstract:

:The resonance Raman spectrum of native DNA has been obtained using excitation at 257 nm. In a first part, the spectral lines are assigned to the different nucleotide bases which provide the resonance effect. In a second part, the interactions of DNA with basic peptides (Arginine Methylester, Lysine Methylester, Arginyl-Arginine) are investigated using excitation at 300 nm and 257 nm, which give complementary information about the DNA. Both Arginine Methylester and Arginyl-arginine recognize the A-T base pairs, the first one in the large groove, the second one in the narrow groove of DNA. The DNA-Lysine Methylester interaction is very likely not specific but can take place in the large groove of DNA.

journal_name

Nucleic Acids Res

journal_title

Nucleic acids research

authors

Laigle A,Chinsky L,Turpin PY

doi

10.1093/nar/10.5.1707

subject

Has Abstract

pub_date

1982-03-11 00:00:00

pages

1707-20

issue

5

eissn

0305-1048

issn

1362-4962

journal_volume

10

pub_type

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