Molecuar model of the DNA interaction site for the cyclic AMP receptor protein.

abstract：:The cytoskeleton provides structural integrity to cells and serves as a key component in mechanotransduction. Tensins are thought to provide a force-bearing linkage between integrins and the actin cytoskeleton; yet, direct evidence of tensin's role in mechanotransduction is lacking. We here report that local force app...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Cheah JS,Jacobs KA,Heinrich V,Lo SH,Yamada S

更新日期：2019-10-01 00:00:00

abstract：:High molecular weight proteins extracted from the walking nerves of the shore crab (Carcinus maenas) exhibit a cycle of phosphorylation-dephosphorylation that is influenced by neurotropic compounds and inorganic ions. The net phosphorylation state of the proteins is increased in the presence of K+ ions and decreased w...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Schoffeniels E,Dandrifosse G

更新日期：1980-02-01 00:00:00

abstract：:The largest known DNA viruses infect Acanthamoeba and belong to two markedly different families. The Megaviridae exhibit pseudo-icosahedral virions up to 0.7 μm in diameter and adenine-thymine (AT)-rich genomes of up to 1.25 Mb encoding a thousand proteins. Like their Mimivirus prototype discovered 10 y ago, they enti...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Legendre M,Bartoli J,Shmakova L,Jeudy S,Labadie K,Adrait A,Lescot M,Poirot O,Bertaux L,Bruley C,Couté Y,Rivkina E,Abergel C,Claverie JM

更新日期：2014-03-18 00:00:00

abstract：:Understanding protein-protein interactions is central to our understanding of almost all complex biological processes. Computational tools exploiting rapidly growing genomic databases to characterize protein-protein interactions are urgently needed. Such methods should connect multiple scales from evolutionary conserv...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Gueudré T,Baldassi C,Zamparo M,Weigt M,Pagnani A

更新日期：2016-10-25 00:00:00

abstract：:Originally recognized for their role in lipoprotein metabolism and cardiovascular disease, apolipoprotein (apo) E isoforms (apoE2, apoE3, and apoE4) have also been implicated to play a key role in several biological processes not directly related to their lipid transport function. For example, apoE4 contributes signif...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Burt TD,Agan BK,Marconi VC,He W,Kulkarni H,Mold JE,Cavrois M,Huang Y,Mahley RW,Dolan MJ,McCune JM,Ahuja SK

更新日期：2008-06-24 00:00:00

abstract：:Interleukin 10 (IL-10) inhibits interferon gamma-induced macrophage activation for cytotoxicity against larvae of the human parasite Schistosoma mansoni by suppressing production of the toxic effector molecule nitric oxide (NO). In this study, the mechanism of IL-10 action was identified as inhibition of endogenous tu...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Oswald IP,Wynn TA,Sher A,James SL

更新日期：1992-09-15 00:00:00

abstract：:Absorbance changes reflecting the formation of a transient radical-pair state, P(F), were measured in reaction centers from Rhodopseudomonas sphaeroides under conditions that blocked electron transfer to a later carrier (a quinone, Q). The temperature dependence of the absorbance changes suggests that P(F) is an equil...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Shuvalov VA,Parson WW

更新日期：1981-02-01 00:00:00

abstract：:A key idea in Lashley's formulation of the problem of serial order in behavior is the postulated neural representation of all serial elements before the action begins. We studied this question by recording the activity of individual neurons simultaneously in small ensembles in prefrontal cortex while monkeys copied ge...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Averbeck BB,Chafee MV,Crowe DA,Georgopoulos AP

更新日期：2002-10-01 00:00:00

abstract：:Although Africa is the origin of modern humans, the pattern and distribution of genetic variation and correlations with cultural and linguistic diversity in Africa have been understudied. Recent advances in genomic technology, however, have led to genomewide studies of African samples. In this article, we discuss gene...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Scheinfeldt LB,Soi S,Tishkoff SA

更新日期：2010-05-11 00:00:00

abstract：:A key functional event in eukaryotic gene activation is the formation of dynamic protein-protein interaction networks between transcriptional activators and transcriptional coactivators. Seemingly incongruent with the tight regulation of transcription, many biochemical and biophysical studies suggest that activators u...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Henley MJ,Linhares BM,Morgan BS,Cierpicki T,Fierke CA,Mapp AK

更新日期：2020-11-03 00:00:00

abstract：:ATP-dependent DNA supercoiling catalyzed by Escherichia coli DNA gyrase was inhibited by oxolinic acid, a compound similar to but more potent than nalidixic acid and a known inhibitor of DNA replication in E. coli. The supercoiling activity of DNA gyrase purified from nalidixic acid-resistant mutant (nalA(R)) bacteria...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Gellert M,Mizuuchi K,O'Dea MH,Itoh T,Tomizawa JI

更新日期：1977-11-01 00:00:00

abstract：:Phages of the Caudovirales order possess a tail that recognizes the host and ensures genome delivery upon infection. The X-ray structure of the approximately 1.8 MDa host adsorption device (baseplate) from the lactococcal phage TP901-1 shows that the receptor-binding proteins are pointing in the direction of the host,...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Veesler D,Spinelli S,Mahony J,Lichière J,Blangy S,Bricogne G,Legrand P,Ortiz-Lombardia M,Campanacci V,van Sinderen D,Cambillau C

更新日期：2012-06-05 00:00:00

abstract：:Recent studies have implicated local inflammation and activation of complement amongst the processes involved in the pathogenesis of age-related macular degeneration (AMD). Several lines of investigation also indicate that bis-retinoid pigments, such as A2E, that accumulate as lipofuscin in retinal pigment epithelial ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Zhou J,Jang YP,Kim SR,Sparrow JR

更新日期：2006-10-31 00:00:00

abstract：:In many cell-signaling pathways, information is transmitted by the diffusion of messenger molecules. Diffusion coefficients characterize the messenger's spatial range and the characteristic times of signal propagation. Inside cells, particles usually diffuse in the presence of immobile binding sites (or traps). It is ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Pando B,Dawson SP,Mak DO,Pearson JE

更新日期：2006-04-04 00:00:00

abstract：:More than two decades ago, the activation mechanism for the membrane-bound photoreceptor and prototypical G protein-coupled receptor (GPCR) rhodopsin was uncovered. Upon light-induced changes in ligand-receptor interaction, movement of specific transmembrane helices within the receptor opens a crevice at the cytoplasm...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Van Eps N,Altenbach C,Caro LN,Latorraca NR,Hollingsworth SA,Dror RO,Ernst OP,Hubbell WL

更新日期：2018-03-06 00:00:00

abstract：:Frame-shift mutations at microsatellites occur as a time-dependent function of polymerase errors followed by failure of postreplicational mismatch repair. A cell-culture system was developed that allows identification of intermediate mutant cells that carry the mutation on a single DNA strand after the initial DNA pol...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Gasche C,Chang CL,Natarajan L,Goel A,Rhees J,Young DJ,Arnold CN,Boland CR

更新日期：2003-02-18 00:00:00

abstract：:What are the neural bases of semantic memory? Traditional beliefs that the temporal lobes subserve the retrieval of semantic knowledge, arising from lesion studies, have been recently called into question by functional neuroimaging studies finding correlations between semantic retrieval and activity in left prefrontal...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Thompson-Schill SL,Swick D,Farah MJ,D'Esposito M,Kan IP,Knight RT

更新日期：1998-12-22 00:00:00

abstract：:Three allelic variants of P-pilus-associated G-adhesins (lectins) with different cell-binding properties were recently described. Here we have analyzed Escherichia coli HB101 strains expressing the recombinant G-adhesin variants for their ability to agglutinate erythrocytes from various species as this relates to the ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Strömberg N,Nyholm PG,Pascher I,Normark S

更新日期：1991-10-15 00:00:00

abstract：:The structural requirements of E. coli formylmethionine tRNA for aminoacylation have been examined by chemical modification of the tRNA, followed by separation of the modified molecules into active and inactive components. Photooxidation of tRNA(fMet) at 50 degrees in the presence of methylene blue results in modifica...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Schulman LH

更新日期：1972-12-01 00:00:00

abstract：:In eukaryotic cells the concentration of dNTP is highest in S phase and lowest in G1 phase and is controlled by ribonucleotide reductase (RNR). RNR activity is eliminated in all eukaryotes in G1 phase by a variety of mechanisms: transcriptional regulation, small inhibitory proteins, and protein degradation. After acti...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Chabes A,Stillman B

更新日期：2007-01-23 00:00:00

abstract：:Type II platelet-activating factor-acetylhydrolase [PAF-AH (II)] is an N-myristoylated enzyme that contains a lipase/esterase catalytic motif and selectively hydrolyzes the sn-2 acetyl ester of PAF and other short-chain acyl groups attached to phosphoglycerides. However, the physiological role of this enzyme remains t...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Inoue T,Sugimoto A,Suzuki Y,Yamamoto M,Tsujimoto M,Inoue K,Aoki J,Arai H

更新日期：2004-09-07 00:00:00

abstract：:Natural killer-22 (NK-22) cells are a human NK cell subset situated in mucosal-associated lymphoid tissues that specialize in IL-22 secretion in response to IL-23. Here we investigated the cytokine requirements for NK-22 cell expansion. IL-7 maintained the survival of NK-22 cells and IL-22 production in response to IL...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Cella M,Otero K,Colonna M

更新日期：2010-06-15 00:00:00

abstract：:We have previously shown that the G protein of vesicular stomatitis virus (VSV-G) can be incorporated into the virions of retroviruses. Since expression of VSV-G is toxic to most mammalian cells, development of stable VSV-G packaging cell lines requires inducible VSV-G expression. We have modified the tetracycline-ind...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Chen ST,Iida A,Guo L,Friedmann T,Yee JK

更新日期：1996-09-17 00:00:00

abstract：:We investigated patterns of genetic diversity of Plasmodium falciparum associated with its two main African vectors: Anopheles gambiae and Anopheles funestus. We dissected 10,296 wild-caught mosquitoes from three tropical sites, two in Cameroon (Simbock and Tibati, separated by 320 km) and one in Kenya (Rota, >2,000 k...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Annan Z,Durand P,Ayala FJ,Arnathau C,Awono-Ambene P,Simard F,Razakandrainibe FG,Koella JC,Fontenille D,Renaud F

更新日期：2007-05-08 00:00:00

abstract：:There is no theoretical limit in using molecular networks to harvest diffusive sun photons on large areas and funnel them onto much smaller areas of highly efficient but also precious energy-converting materials. The most effective concept reported so far is based on a pool of randomly oriented, light-harvesting donor...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Willich MM,Wegener L,Vornweg J,Hohgardt M,Nowak J,Wolter M,Jacob CR,Walla PJ

更新日期：2020-12-29 00:00:00

abstract：:The cytokine IFN-γ is a critical regulator of immune system development and function. Almost all leukocytes express the receptor for IFN-γ, yet each cell type elicits a different response to this cytokine. Cell type-specific effects of IFN-γ make it difficult to predict the outcomes of the systemic IFN-γ blockade and ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Krummel MF,Mahale JN,Uhl LFK,Hardison EA,Mujal AM,Mazet JM,Weber RJ,Gartner ZJ,Gérard A

更新日期：2018-11-06 00:00:00

abstract：:We postulated that a synergistic combination of two innate immune functions, pathogen surface recognition and lysis, in a protein chimera would lead to a robust class of engineered antimicrobial therapeutics for protection against pathogens. In support of our hypothesis, we have engineered such a chimera to protect ag...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Dandekar AM,Gouran H,Ibáñez AM,Uratsu SL,Agüero CB,McFarland S,Borhani Y,Feldstein PA,Bruening G,Nascimento R,Goulart LR,Pardington PE,Chaudhary A,Norvell M,Civerolo E,Gupta G

更新日期：2012-03-06 00:00:00

abstract：:Hsubc9, a human gene encoding a ubiquitin-conjugating enzyme, has been cloned. The 18-kDa HsUbc9 protein is homologous to the ubiquitin-conjugating enzymes Hus5 of Schizosaccharomyces pombe and Ubc9 of Saccharomyces cerevisiae. The Hsubc9 gene complements a ubc9 mutation of S. cerevisiae. It has been mapped to chromos...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kovalenko OV,Plug AW,Haaf T,Gonda DK,Ashley T,Ward DC,Radding CM,Golub EI

更新日期：1996-04-02 00:00:00

abstract：:Dentinal repair in the postnatal organism occurs through the activity of specialized cells, odontoblasts, that are thought to be maintained by an as yet undefined precursor population associated with pulp tissue. In this study, we isolated a clonogenic, rapidly proliferative population of cells from adult human dental...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Gronthos S,Mankani M,Brahim J,Robey PG,Shi S

更新日期：2000-12-05 00:00:00

abstract：:The hypothalamic arcuate nucleus is involved in the control of energy intake and expenditure and may participate in the pathogenesis of eating disorders such as anorexia nervosa (AN) and bulimia nervosa (BN). Two systems are of particular interest in this respect, synthesizing alpha-melanocyte-stimulating hormone (alp...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Fetissov SO,Hallman J,Oreland L,Af Klinteberg B,Grenbäck E,Hulting AL,Hökfelt T

更新日期：2002-12-24 00:00:00