Effect of osmotic blood-brain barrier disruption on methotrexate pharmacokinetics in the dog.

Abstract:

:Infusion of 25% mannitol into the internal carotid artery of the dog results in a reversible disruption of the blood-brain barrier (BBB). This osmotic BBB disruption enhances the penetratin of systemically administered methotrexate (MTX) into the ipsilateral cerebral hemisphere. Brain methotexate levels were maximized by giving this chemotherapeutic drug by the intracarotid rather than the intravenous route after osmotic BBB disruption. Assays of MTX levels in cerebrospinal fluid were found to be a very unreliable and inconsistent monitor of brain MTX levels after osmotic BBB disruption.

journal_name

Neurosurgery

journal_title

Neurosurgery

authors

Neuwelt EA,Frenkel EP,Rapoport S,Barnett P

doi

10.1227/00006123-198007000-00006

subject

Has Abstract

pub_date

1980-07-01 00:00:00

pages

36-43

issue

1

eissn

0148-396X

issn

1524-4040

journal_volume

7

pub_type

杂志文章
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