Abstract:
:The behavior of the space-clamped Hodgkin-Huxley model has been studied using band-limited white noise (0-50 Hz) as the input membrane current and taking the output as a point process in time given by the peaks of the action potentials. The frequency response and coherence functions were measured by use of the Fourier transform and digital filtering of the spike train. The results obtained are in good agreement with those already published for the simple integrator and leaky integrator models of neuronal encoding, as well as the earlier studies on the response of the Hodgkin-Huxley model to steady currents. In addition, the threshold of the model to sinusoidal membrane currents has been measured as a function of frequency over the range of 0.1-100 Hz. This shows a relatively constant level up to 2 Hz and then a clear minimum at 60 Hz, in agreement with measured thresholds of squid axons. These results are discussed in terms of the possible contributions of action potential encoding mechanisms to the frequency responses and sinusoidal thresholds which have been measured for rapidly adapting receptors.
journal_name
Biol Cybernjournal_title
Biological cyberneticsauthors
French ASdoi
10.1007/BF00334462subject
Has Abstractpub_date
1984-01-01 00:00:00pages
169-74issue
3eissn
0340-1200issn
1432-0770journal_volume
49pub_type
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journal_title:Biological cybernetics
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pub_type: 杂志文章
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