Specific antibodies to porcine zona pellucida detected by quantitative radioimmunoassay in both fertile and infertile women.

Abstract:

:The specific radioimmunoassay system was developed for the titration of the antibodies to porcine zona pellucida (ZP) in human sera by using 125I-labeled purified porcine ZP as antigen, which is known to have cross-reactivity with human ZP. The antibodies in human sera were detected in 3 of 11 (27%) women with unexplained infertility, in 16 of 48 (33%) amenorrheic patients, in 4 of 12 (33%) fertile women, and in 3 of 10 (30%) men. Moreover, antibody titers in infertile women were no higher than those in fertile women and in men. These results seem to suggest that the antibodies in human sera that cross-react with porcine ZP may not be an important factor in causing infertility in women.

journal_name

Fertil Steril

journal_title

Fertility and sterility

authors

Kurachi H,Wakimoto H,Sakumoto T,Aono T,Kurachi K

doi

10.1016/s0015-0282(16)47602-8

subject

Has Abstract

pub_date

1984-02-01 00:00:00

pages

265-9

issue

2

eissn

0015-0282

issn

1556-5653

pii

S0015-0282(16)47602-8

journal_volume

41

pub_type

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