Effect of selenium deficiency on cuticle integrity in the Cladocera (Crustacea).

abstract：:Protein synthesis in all living organisms occurs on ribonucleoprotein particles, called ribosomes. Despite the universality of this process, eukaryotic ribosomes are significantly larger in size than their bacterial counterparts due in part to the presence of 80 r proteins rather than 54 in bacteria. Using cryoelectro...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Armache JP,Jarasch A,Anger AM,Villa E,Becker T,Bhushan S,Jossinet F,Habeck M,Dindar G,Franckenberg S,Marquez V,Mielke T,Thomm M,Berninghausen O,Beatrix B,Söding J,Westhof E,Wilson DN,Beckmann R

更新日期：2010-11-16 00:00:00

abstract：:Studies of prostate cancer pathogenesis and development of new therapies have been hampered by a lack of appropriate mouse models. We have generated PSA-Cre-ER(T2) mice that express the tamoxifen-dependent Cre-ER(T2) recombinase selectively in prostatic epithelium, thus allowing us to target floxed genes selectively i...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ratnacaram CK,Teletin M,Jiang M,Meng X,Chambon P,Metzger D

更新日期：2008-02-19 00:00:00

abstract：:A 37-kDa glycoprotein has been described recently, whose synthesis is dramatically increased after injury of the rat sciatic and optic nerves. Cells in the nerve sheath, distal to the site of injury, produce and secrete large amounts of this protein, so that by 3 weeks after injury, it represents 2-5% of the total sol...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ignatius MJ,Gebicke-Härter PJ,Skene JH,Schilling JW,Weisgraber KH,Mahley RW,Shooter EM

更新日期：1986-02-01 00:00:00

abstract：:Biochemically, the syntrophic bacteria constitute the missing link in our understanding of anaerobic flow of carbon in the biosphere. The completed genome sequence of Syntrophus aciditrophicus SB, a model fatty acid- and aromatic acid-degrading syntrophic bacterium, provides a glimpse of the composition and architectu...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： McInerney MJ,Rohlin L,Mouttaki H,Kim U,Krupp RS,Rios-Hernandez L,Sieber J,Struchtemeyer CG,Bhattacharyya A,Campbell JW,Gunsalus RP

更新日期：2007-05-01 00:00:00

abstract：:Amino acid residues that are critical in maintaining the framework structure of immunoglobulin heavy- and light-chain variable (V) regions are strongly conserved in the V alpha and V beta proteins of the alpha beta T-cell antigen receptor (TCR alpha beta). Consequently, it has been proposed that TCR alpha beta has a c...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Gahm SJ,Fowlkes BJ,Jameson SC,Gascoigne NR,Cotterman MM,Kanagawa O,Schwartz RH,Matis LA

更新日期：1991-11-15 00:00:00

abstract：:Calcitonin gene-related peptide (CGRP) is a neuropeptide that coexists with acetylcholine in spinal cord motoneurons. The effects of CGRP on the functional properties of the nicotinic acetylcholine receptor (AcChoR) were examined by electrophysiological methods. Using the whole-cell patch-clamp technique and a mouse c...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Mulle C,Benoit P,Pinset C,Roa M,Changeux JP

更新日期：1988-08-01 00:00:00

abstract：:The TrkC neurotrophin receptor belongs to the functional dependence receptor family, members of which share the ability to induce apoptosis in the absence of their ligands. Such a trait has been hypothesized to confer tumor-suppressor activity. Indeed, cells that express these receptors are thought to be dependent on ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Genevois AL,Ichim G,Coissieux MM,Lambert MP,Lavial F,Goldschneider D,Jarrosson-Wuilleme L,Lepinasse F,Gouysse G,Herceg Z,Scoazec JY,Tauszig-Delamasure S,Mehlen P

更新日期：2013-02-19 00:00:00

abstract：:Accumulating evidence suggests that subcutaneous and visceral adipose tissues are differentially associated with metabolic disorders. In obesity, subcutaneous adipose tissue is beneficial for metabolic homeostasis because of repressed inflammation. However, the underlying mechanism remains unclear. Here, we demonstrat...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hwang I,Jo K,Shin KC,Kim JI,Ji Y,Park YJ,Park J,Jeon YG,Ka S,Suk S,Noh HL,Choe SS,Alfadda AA,Kim JK,Kim S,Kim JB

更新日期：2019-06-11 00:00:00

abstract：:The explosive growth in citizen science combined with a recalcitrance on the part of mainstream science to fully embrace this data collection technique demands a rigorous examination of the factors influencing data quality and project efficacy. Patterns of contributor effort and task performance have been well reviewe...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Parrish JK,Jones T,Burgess HK,He Y,Fortson L,Cavalier D

更新日期：2019-02-05 00:00:00

abstract：:Starting with assignments of proton nuclear magnetic resonance previously made for oxytocin in deuterated dimethylsulfoxide at 220 MHz, we have assigned resonances for the mammalian antidiuretic hormone, lysine vasopressin. The results demonstrate that spectral assignments of neurohypophyseal hormones and their congen...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Walter R,Glickson JD,Schwartz IL,Havran RT,Meienhofer J,Urry DW

更新日期：1972-07-01 00:00:00

abstract：:Dopamine is believed to contribute to the degeneration of dopamine-containing neurons in the brain. However, whether dopamine affects the survival of other neuronal populations has remained unclear. Here we document that mice with persistently elevated extracellular dopamine, resulting from inactivation of the dopamin...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Cyr M,Beaulieu JM,Laakso A,Sotnikova TD,Yao WD,Bohn LM,Gainetdinov RR,Caron MG

更新日期：2003-09-16 00:00:00

abstract：:The structure of the gene encoding human hexabrachion (tenascin) has been determined from overlapping clones isolated from a human genomic bacteriophage library. The genomic inserts were characterized by restriction mapping, Southern blot analysis, PCR, and DNA sequencing. The coding region of the hexabrachion gene sp...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Gulcher JR,Nies DE,Alexakos MJ,Ravikant NA,Sturgill ME,Marton LS,Stefansson K

更新日期：1991-11-01 00:00:00

abstract：:Genetic recombination provides an important mechanism for the repair of DNA double-strand breaks. Homologous pairing and strand exchange lead to the formation of DNA intermediates, in which sister chromatids or homologous chromosomes are covalently linked by four-way Holliday junctions (HJs). Depending on the type of ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Shah Punatar R,Martin MJ,Wyatt HD,Chan YW,West SC

更新日期：2017-01-17 00:00:00

abstract：:The transcription factor and tumor suppressor protein p53 is frequently inactivated in human cancers. In many cases, p53 gene mutations result in high levels of inactive, full-length p53 protein with one amino acid change in the core domain that recognizes p53 DNA-binding sites. The ability to endow function to mutate...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Baroni TE,Wang T,Qian H,Dearth LR,Truong LN,Zeng J,Denes AE,Chen SW,Brachmann RK

更新日期：2004-04-06 00:00:00

abstract：:Chronic stress is known to promote inflammatory bowel disease (IBD), but the underlying mechanism remains largely unresolved. Here, we found chronic stress to sensitize mice to dextran sulfate sodium (DSS)-induced colitis; to increase the infiltration of B cells, neutrophils, and proinflammatory ly6Chi macrophages in ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Gao X,Cao Q,Cheng Y,Zhao D,Wang Z,Yang H,Wu Q,You L,Wang Y,Lin Y,Li X,Wang Y,Bian JS,Sun D,Kong L,Birnbaumer L,Yang Y

更新日期：2018-03-27 00:00:00

abstract：:The impact of rapid climate change on contemporary human populations is of global concern. To contextualize our understanding of human responses to rapid climate change it is necessary to examine the archeological record during past climate transitions. One episode of abrupt climate change has been correlated with soc...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Armit I,Swindles GT,Becker K,Plunkett G,Blaauw M

更新日期：2014-12-02 00:00:00

abstract：:Recent studies have suggested that Paleozoic hyperoxia enabled animal gigantism, and the subsequent hypoxia drove a reduction in animal size. This evolutionary hypothesis depends on the argument that gas exchange in many invertebrates and skin-breathing vertebrates becomes compromised at large sizes because of distanc...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kaiser A,Klok CJ,Socha JJ,Lee WK,Quinlan MC,Harrison JF

更新日期：2007-08-07 00:00:00

abstract：:Molecular mechanisms that initiate meiosis have been studied in fungi and mammals, but little is known about the mechanisms directing the meiosis transition in other organisms. To elucidate meiosis initiation in plants, we characterized and cloned the ameiotic1 (am1) gene, which affects the transition to meiosis and p...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Pawlowski WP,Wang CJ,Golubovskaya IN,Szymaniak JM,Shi L,Hamant O,Zhu T,Harper L,Sheridan WF,Cande WZ

更新日期：2009-03-03 00:00:00

abstract：:The p21 region of human chromosome 9 is thought to contain a gene (MLM) involved in genetic susceptibility to melanoma and a gene or genes that influence progression of certain other tumors. Genomic clones that span a large region in 9p21 surrounding the presumptive tumor suppressor gene(s) have been isolated. A set o...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Weaver-Feldhaus J,Gruis NA,Neuhausen S,Le Paslier D,Stockert E,Skolnick MH,Kamb A

更新日期：1994-08-02 00:00:00

abstract：:The influence of language familiarity upon speaker identification is well established, to such an extent that it has been argued that "Human voice recognition depends on language ability" [Perrachione TK, Del Tufo SN, Gabrieli JDE (2011) Science 333(6042):595]. However, 7-mo-old infants discriminate speakers of their ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Fleming D,Giordano BL,Caldara R,Belin P

更新日期：2014-09-23 00:00:00

abstract：:Levels of inter-male aggression, both in laboratory encounters and in the field, rise dramatically during the breeding season, closely paralleling the seasonal rise in testosterone. However, post-pubertally castrated males also show the dramatic seasonal rise in aggression in laboratory encounters with castrated oppon...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Caldwell GS,Glickman SE,Smith ER

更新日期：1984-08-01 00:00:00

abstract：:Malignant melanoma has one of the highest mortality rates of any cancer because of its aggressive nature and high metastatic potential. Clinical staging of the disease at the time of diagnosis is very important for the prognosis and outcome of melanoma treatment. In this study, we designed and synthesized the 18F-labe...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Pyo A,Kim DY,Kim H,Lim D,Kwon SY,Kang SR,Kim HS,Bom HS,Min JJ

更新日期：2020-06-09 00:00:00

abstract：:The role of the cerebellar cortex in motor learning was investigated by comparing the paramedian lobule of adult rats given difficult acrobatic training to that of rats that had been given extensive physical exercise or had been inactive. The paramedian lobule is activated during limb movements used in both acrobatic ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Black JE,Isaacs KR,Anderson BJ,Alcantara AA,Greenough WT

更新日期：1990-07-01 00:00:00

abstract：:As an alternative pathway of controlled cell death, necroptosis can be triggered by tumor necrosis factor via the kinases RIPK1/RIPK3 and the effector protein mixed-lineage kinase domain-like protein (MLKL). Upon activation, MLKL oligomerizes and integrates into the plasma membrane via its executioner domain. Here, we...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Rübbelke M,Fiegen D,Bauer M,Binder F,Hamilton J,King J,Thamm S,Nar H,Zeeb M

更新日期：2020-12-29 00:00:00

abstract：:During oxygenic photosynthesis in cyanobacteria and chloroplasts of plants and eukaryotic algae, conversion of light energy to biologically useful chemical energy occurs in the specialized thylakoid membranes. Light-induced charge separation at the reaction centers of photosystems I and II, two multisubunit pigment-pr...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Zak E,Norling B,Maitra R,Huang F,Andersson B,Pakrasi HB

更新日期：2001-11-06 00:00:00

abstract：:Recombinant human granulocyte-macrophage colony-stimulating factor (GM-CSF) was found to increase the adherence of purified peripheral blood monocytes to plastic surfaces and to monolayers of human umbilical vein endothelial cells. With plastic surfaces as a model 9-hr culture with GM-CSF was necessary for enhancement...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Gamble JR,Elliott MJ,Jaipargas E,Lopez AF,Vadas MA

更新日期：1989-09-01 00:00:00

abstract：:A procedure is described for selection of temperature-sensitive mutants affecting fatty-acid synthesis based upon radiation suicide of wild-type organisms by tritiated acetate selectively incorporated into fatty acids. At 37 degrees , two of the mutants extensively incorporate fatty-acid supplements provided in the me...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Harder ME,Beacham IR,Cronan JE Jr,Beacham K,Honegger JL,Silbert DF

更新日期：1972-11-01 00:00:00

abstract：:We have isolated a cDNA clone from a human fibroblast cDNA library that contains the entire protein-coding region of a 1.1-kilobase mRNA. This mRNA encodes a 284-amino acid tropomyosin, the primary structure of which most closely resembles smooth muscle tropomyosin. Thus, the expression of both 284-amino acid muscle-t...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： MacLeod AR,Houlker C,Reinach FC,Smillie LB,Talbot K,Modi G,Walsh FS

更新日期：1985-12-01 00:00:00

abstract：:We have recently shown that the expression of nestin, the neural stem cell marker protein, is expressed in bulge-area stem cells of the hair follicle. We used transgenic mice with GFP expression driven by the nestin regulatory element [nestin-driven GFP (ND-GFP)]. The ND-GFP stem cells give rise to the outer-root shea...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Amoh Y,Li L,Katsuoka K,Penman S,Hoffman RM

更新日期：2005-04-12 00:00:00

abstract：:The development of antimicrobials is critical in this time of increasing antibiotic resistance of most clinically relevant bacteria. To date, all current antibiotics focus on inhibiting crucial enzymatic activities of their protein targets (i.e., trimethoprim for dihydrofolate reductase), thus disrupting in vitro esse...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Shakhnovich EA,Hung DT,Pierson E,Lee K,Mekalanos JJ

更新日期：2007-02-13 00:00:00